LMPD Database

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LMP012847

UniProt Annotations

Entry Information
Gene Namehydroxyacyl-CoA dehydrogenase
Protein EntryHCDH_RAT
UniProt IDQ9WVK7
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
FunctionPlays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
PathwayLipid metabolism; fatty acid beta-oxidation.
PtmSuccinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity)
SimilarityBelongs to the 3-hydroxyacyl-CoA dehydrogenase family
Subcellular LocationMitochondrion matrix.
SubunitHomodimer