LMPD Database

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LMP012922

UniProt Annotations

Entry Information
Gene Namehydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Protein EntryECHA_RAT
UniProt IDQ64428
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O.
Catalytic ActivityA long-chain (S)-3-hydroxyacyl-CoA + NAD(+) = a long-chain 3-oxoacyl-CoA + NADH.
FunctionBifunctional subunit.
PathwayLipid metabolism; fatty acid beta-oxidation.
Sequence CautionSequence=BAA03939.1; Type=Frameshift; Positions=27, 33, 277, 283; Evidence= ;
SimilarityIn the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family
SimilarityIn the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family
Subcellular LocationMitochondrion matrix.
SubunitOctamer of 4 alpha (HADHA) and 4 beta (HADHB) subunits