LMPD Database

LMP012939

UniProt Annotations

Entry Information
Gene Nameenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
Protein EntryECHP_RAT
UniProt IDP07896
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O.
Catalytic Activity(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA.
Catalytic Activity(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
Enzyme RegulationEnzyme activity enhanced by acetylation
PathwayLipid metabolism; fatty acid beta-oxidation.
PtmAcetylated, leading to enhanced enzyme activity. Acetylation is enhanced by up to 80% after treatment either with trichostin A (TCA) or with nicotinamide (NAM) with highest increase on Lys-345. Acetylation and enzyme activity increased by about 1.5% on addition of fatty acids (By similarity)
SimilarityIn the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family
SimilarityIn the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family
Subcellular LocationPeroxisome.
SubunitMonomer