LMPD Database

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LMP012945

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase bubblegum family member 1
Protein EntryACBG1_RAT
UniProt IDQ924N5
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
FunctionMediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids
InductionDown-regulated by gonadotropin
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily
Subcellular LocationCytoplasm . Cytoplasmic vesicle {ECO:0000250}. Microsome . Endoplasmic reticulum .
Tissue SpecificityPresent in testis, at a lower level in brain, and at a very low level in ovary. Not detected in other tissues. tested. Present in Leydig cells of the adult testis and to a lesser degree in the seminiferous tubules in spermatogonia and Sertoli cells (at protein level). {ECO:0000269|PubMed:11381125, ECO:0000269|PubMed:16469493}.