LMPD Database

LMP013072

UniProt Annotations

Entry Information
Gene Namelipase, endothelial
Protein EntryLIPE_RAT
UniProt IDQ8VBX1
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
FunctionHas phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin (By similarity)
MiscellaneousIt is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.
SimilarityBelongs to the AB hydrolase superfamily. Lipase family
SimilarityContains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular LocationSecreted .
SubunitHead to tail Homodimer. Interacts with apolipoprotein C-2 (By similarity)