LMPD Database

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LMP013311

UniProt Annotations

Entry Information
Gene Nameprostaglandin D2 receptor 2
Protein EntryPD2R2_RAT
UniProt IDQ6XKD3
SpeciesRat
Comments
Comment typeDescription
DomainThe 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for ADRBK1/GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-351 is a major site for PKC-induced internalization of the receptor (By similarity)
FunctionReceptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity)
PtmPhosphorylated
SimilarityBelongs to the G-protein coupled receptor 1 family
Subcellular LocationCell membrane ; Multi-pass membrane protein . Note=Internalized receptors colocalized with RAB11A