LMPD Database

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LMP013459

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 8
Protein EntryDHB8_RAT
UniProt IDQ6MGB5
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic ActivityTestosterone + NAD(+) = androstenedione + NADH.
FunctionNAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (By similarity). The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria (By similarity)
PathwayLipid metabolism; fatty acid biosynthesis.
PathwaySteroid biosynthesis; estrogen biosynthesis.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular LocationMitochondrion matrix .
SubunitHeterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4