LMPD Database

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LMP013544

UniProt Annotations

Entry Information
Gene Name3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
Protein EntryHMGC2_RAT
UniProt IDD4A5C3
SpeciesRat
Comments
Comment typeDescription
Catalytic Activity(S)-3-hydroxy-3-methylglutaryl-CoA = acetyl- CoA + acetoacetate.
CofactorName=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence= ; Note=Divalent metal cations. ;
FunctionNon-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues
PathwayMetabolic intermediate metabolism; (S)-3-hydroxy-3- methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3- methylglutaryl-CoA: step 1/1.
SimilarityBelongs to the HMG-CoA lyase family
Subcellular LocationCytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein .
Tissue SpecificityPresent at high level in duodenum and small intestine (at protein level)