Pathway Maps with Timecourse Data for Corresponding Lipids and Genes

Pathway maps were developed by the LIPID MAPS Consortium using VANTED, a tool for the visualization and analysis of networks. Pathways are annotated with timecourse data for lipids and genes, with links to timecourse graphs and data for technical and biological replicates..

Eicosanoids media


Structure Tables for Lipid Pathways

Lipid-related pathways, or portions of pathways are displayed in tabular format with lipid structures and related information organized in columns. Pathways may also be viewed in an enzymatic reaction format, where substrate and product are displayed in separate rows, with an intervening row showing the gene information for the enzyme catalyzing that step.

Pathway table

Lipid Signaling Pathways

These lipid signaling pathway maps are provided courtesy of Cayman Chemical Company and include:
  • Arachidonic Acid Cascade
    — the three main branches of the Arachidonic Acid Cascade (cyclooxygenase, lipoxygenase, and CYP450 pathways) which produce many of the lipids that serve as second messengers in cellular signaling
  • Eicosanoid GPCRs
    — eicosanoid G-protein-coupled receptors (GPCRs) with major lipid mediators, major biological functions, receptor agonists and antagonists
  • Lysophospholipid Signaling
    — synthesis and G-protein signaling cascades for lysophospholipids LPA, LysoPS, LPI, and S1P
  • Specialized Pro-Resolving Mediators
    — the roles of specialized pro-resolving mediators (SPMs) arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) in inflammation