Pathways

SphinGOMAP©

LIPID MAPS® has contributed a set of 10 pathways to the WikiPathways project. Pathways include metabolism of

  • cholesterol
  • eicosanoids
  • glycerolipids
  • omega fatty acids
  • sphingolipids
Access SphinGOMAP© on the Lipidomics Gateway

References

  • Alfred H. Merrill, Jr. Letter to the Glyco-Forum: SphinGOMAP—A web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Glycobiology, Volume 15, Issue 6, June 2005, Page 15G,
    DOI: 10.1093/glycob/cwi070

SphinGOMAP©

Lipid-related pathways, or portions of pathways are displayed in tabular format with lipid structures and related information organized in columns. Pathways may also be viewed in an enzymatic reaction format, where substrate and product are displayed in separate rows, with an intervening row showing the gene information for the enzyme catalyzing that step.

Pathway table
Access SphinGOMAP© on the Lipidomics Gateway

SphinGOMAP©

SphinGOMAP© is a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids developed during the 2003-2013 grant period by the LIPID MAPS® Consortium's Sphingolipid Core Lab, directed by professor Al Merrill.

SphinGOMAP© includes over four hundred mammalian sphingolipids and glycosphingolipids arranged according to their biosynthetic steps, or in the cases where all of the intermediates have not yet been identified, via hypothesized intermediates. If you notice any errors or pathways that need updating, please contact dcotter@ucsd.edu.

Please visit Dr Merrill's SphinGOMAP© website to learn more.

sphingomap thumbnail
Access SphinGOMAP© on the Lipidomics Gateway

References

  • Alfred H. Merrill, Jr. Letter to the Glyco-Forum: SphinGOMAP—A web-based biosynthetic pathway map of sphingolipids and glycosphingolipids. Glycobiology, Volume 15, Issue 6, June 2005, Page 15G,
    DOI: 10.1093/glycob/cwi070

SphinGOMAP©

These lipid signaling pathway maps are provided courtesy of Cayman Chemical and include:
  • Arachidonic Acid Cascade
    — the three main branches of the Arachidonic Acid Cascade (cyclooxygenase, lipoxygenase, and CYP450 pathways) which produce many of the lipids that serve as second messengers in cellular signaling
  • Lysophospholipid Signaling
    — synthesis and G-protein signaling cascades for lysophospholipids LPA, LysoPS, LPI, and S1P

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Arachidonic_Acid_Cascade

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Lysophospholipid_Signaling