Research library

Key Lipidomics Publications

Special issues, with significant contributions from members of the LIPID MAPS Consortium Peer-reviewed journal articles

more key publications

LIPID MAPS Publications

Year published: 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017





    • A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism

      Dinasarapu AR, Gupta S, Ram Maurya M, Fahy E, Min J, Sud M, Gersten MJ, Glass CK, Subramaniam S.

      Bioinformatics (2013)

      PMID: 23981351

    • Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages

      PLoS One.

      2013 Dec 23;8(12):e83145. doi: 10.1371/journal.pone.0083145. eCollection 2013.

    • The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.

      Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, Leber V, Heier C, Taschler U, Blankman JL, Cravatt BF, Lee RG, Crooke RM, Graham MJ, Zimmermann R, Brown HA, Brown JM.

      Cell Rep

      PMID: 24095738 DOI: 10.1016/j.celrep.2013.08.047

    • The polar lipids of Clostridium psychrophilum, an anaerobic psychrophile.

      Guan Z, Tian B, Perfumo A, Goldfine H.

      Biochim Biophys Acta.

      PMID: 23454375

    • Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages

      PLoS One.

      2013 Dec 23;8(12):e83145. doi: 10.1371/journal.pone.0083145. eCollection 2013.

    • The polar lipids of Clostridium psychrophilum, an anaerobic psychrophile.

      Guan Z, Tian B, Perfumo A, Goldfine H.

      Biochim Biophys Acta.

      PMID: 23454375

    • Aberrant dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis.

      Wen R, Lam BL, Guan Z.

      J Lipid Res. 2013 Dec;54(12):3516-22. doi: 10.1194/jlr.M043232. Epub 2013 Sep 27.

      PMID: 24078709 [PubMed - indexed for MEDLINE]

      Lipidomics technologies at the end of the first decade and the beginning of the next.

      Merrill AH, Dennis EA, McDonald JG, Fahy E.

      Adv Nutr. 2013 Sep 1;4(5):565-7. doi: 10.3945/an.113.004333.

      PMID: 24038259 [PubMed - indexed for MEDLINE]

      Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.

      Chung BC, Zhao J, Gillespie RA, Kwon DY, Guan Z, Hong J, Zhou P, Lee SY.

      Science. 2013 Aug 30;341(6149):1012-6. doi: 10.1126/science.1236501.

      PMID: 23990562 [PubMed - indexed for MEDLINE]

      Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice.

      Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum JL, Haddad GG, Li AC.

      J Appl Physiol (1985). 2013 Dec;115(11):1694-704. doi: 10.1152/japplphysiol.00442.2013. Epub 2013 Aug 29.

      PMID: 23990245 [PubMed - in process]

      Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a).

      Leibundgut G, Scipione C, Yin H, Schneider M, Boffa MB, Green S, Yang X, Dennis E, Witztum JL, Koschinsky ML, Tsimikas S.

      J Lipid Res. 2013 Oct;54(10):2815-30. doi: 10.1194/jlr.M040733. Epub 2013 Jul 4.

      PMID: 23828779 [PubMed - indexed for MEDLINE]

      Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification.

      Moon K, Six DA, Lee HJ, Raetz CR, Gottesman S.

      Mol Microbiol. 2013 Jul;89(1):52-64. doi: 10.1111/mmi.12257. Epub 2013 May 31.

      PMID: 23659637 [PubMed - indexed for MEDLINE]

      An ethanolamine-phosphate modified glycolipid in Clostridium acetobutylicum that responds to membrane stress.

      Tian B, Guan Z, Goldfine H.

      Biochim Biophys Acta. 2013 Jun;1831(6):1185-90. doi: 10.1016/j.bbalip.2013.03.005. Epub 2013 Mar 27.

      PMID: 23542061 [PubMed - indexed for MEDLINE]

      Pathogenicity of Yersinia pestis synthesis of 1-dephosphorylated lipid A.

      Sun W, Six DA, Reynolds CM, Chung HS, Raetz CR, Curtiss R 3rd.

      Infect Immun. 2013 Apr;81(4):1172-85. doi: 10.1128/IAI.01403-12. Epub 2013 Jan 28.

      PMID: 23357387 [PubMed - indexed for MEDLINE]

      Single-cell lipidomics: characterizing and imaging lipids on the surface of individual Aplysia californica neurons with cluster secondary ion mass spectrometry.

      Passarelli MK, Ewing AG, Winograd N.

      Anal Chem. 2013 Feb 19;85(4):2231-8. doi: 10.1021/ac303038j. Epub 2013 Feb 4.

      PMID: 23323749 [PubMed - indexed for MEDLINE]

    • Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry.

      Hsu YH, Dumlao DS, Cao J, Dennis EA

      PLoS OneA

      PMID: 23533611

    • A lipidomic perspective on inflammatory macrophage eicosanoid signaling

      Norris PC, Dennis EA

      Adv Biol Regul. (2013)

      PMID: 24113376

    • C(60)-SIMS studies of glycerophospholipid in a LIPID MAPS model system: KDO(2)-Lipid A stimulated RAW 264.7 cells

      Passarelli MK, Ewing AG, Winograd N.

      Surf Interface Anal

      PMID: 23264707

    • The calcium-stimulated lipid A 3-O deacylase from Rhizobium etli is not essential for plant nodulation.

      Sohlenkamp C, Raetz CR, Ingram BO

      Biochim Biophys Acta

      PMID: 23583844

    • Lipidomic Profiling of Influenza Infection Identifies Mediators that Induce and Resolve Inflammation.

      Tam VC, Quehenberger O, Oshansky CM, Suen R, Armando AM, Treuting PM, Thomas PG, Dennis EA, Aderem A.


      PMID: 23827684

    • 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth

      Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, Yuhanna IS, Thompson B, Girard L, Mineo C, Brekken RA, Umetani M, Euhus DM, Xie Y, Shaul PW

      Cell Rep. (2013)

      PMID: 24210818

    • Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.

      Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B.

      Cell Rep

      PMID: 23684610

    • 2012

    • Lipidomics: when apocrypha becomes canonical.

      Brown HA

      Curr Opin Chem Biol 16, 221-226 (2012)

      doi: [10.1016/j.cbpa.2012.02.003]

    • Probing Conformational Changes in Human DNA Topoisomerase II╬▒ by Pulsed Alkylation Mass Spectrometry.

      Chen YT, Collins TR, Guan Z, Chen VB, Hsieh TS.

      J Biol Chem 287, 25660-8 (2012)

      PMID: 22679013

    • A complement-IL-4 regulatory circuit controls liver regeneration.

      DeAngelis RA, Markiewski MM, Kourtzelis I, Rafail S, Syriga M, Sandor A, Maurya MR, Gupta S, Subramaniam S, Lambris JD

      J Immunol 188, 641-8 (2012)

      PMID: 22184721

    • Dietary fish oil substitution dramatically alters the e 1 icosanoid profile in ankle joints of mice during Lyme infection.

      Dumlao DS, Cunningham AM, Wax LE, Norris PC, Hughes-Hanks JM, Halpin RE, Lett KM, Blaho VA, Mitchell WJ, Fritsche KL, Dennis EA, Brown CR

      J Nutrition 142, 1582-9 (2012)

      PMID: 22695969

    • Lipidomics, Technologies and Applications.

      Edited by: Kim Ekroos

      John Wiley & Sons , (2012)

      doi: [10.1002/9783527655946]
      (recommended – but not funded – by LIPID MAPS)

    • Evaluation of normalization methods in mammalian microRNA-Seq data.

      Garmire LX, Subramaniam S.

      RNA 18,1279-88 (2012)

      PMID: 22532701

    • Inflammation and lipid signaling in the etiology of insulin resistance.

      Glass CK, Olefsky JM

      Cell Metab 15, 635-45 (2012)

      PMID: 22560216

    • Spinal 12-lipoxygenase-derived Hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.

      Gregus AM, Dumlao DS, Doolen S, Takasusuki T, Buczynski MW, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL

      Proc Natl Acad Sci U S A 109, 6721-6 (2012)

      PMID: 22493235

    • The co-stimulatory immunogen LPS induces the B-cell clones that infiltrate transplanted human kidneys.

      Grover RK, Cheng J, Peng Y, Jones T, Ruiz D, Ulevitch RJ, Glass J, Dennis EA, Salomon IH, Lerner RA

      Proc Natl Acad Sci U S A 109, 6036-6041 (2012)

      PMID: 22492977

    • Life with too much polyprenol: polyprenol reductase deficiency.

      Grundahl JE, Guan Z, Rust S, Reunert J, Muller B, Du Chesne I, Zerres K, Rudnik-Schoneborn S, Ortiz-Bruchle N, Hausler MG, Siedlecka J, Swiezewska E, Raetz CR, Marquardt T

      Mol Genet Metab 105, 642-51 (2012)

      PMID: 22304929

    • Lipid diversity among botulinum neurotoxin-producing clostridia.

      Guan Z, Johnston NC, Raetz CR, Johnson EA, Goldfine H.

      Microbiology 158, (Pt 10):2577-84. (2012)

      PMID: 22837302

    • Protein glycosylation as an adaptive response in Archaea: growth at different salt concentrations leads to alterations in Haloferax volcanii S-layer glycoprotein N-glycosylation.

      Guan Z, Naparstek S, Calo D, Eichler J

      Environ Microbiol 14, 743-53 (2012)

      PMID: 22029420 doi: [10.1111/j.1462-2920.2011.02625.x]

    • Differential diagnosis in patients with suspected bile acid synthesis defects.

      Haas D, Gan-Schreier H, Langhans CD, Rohrer T, Engelmann G, Heverin M, Russell DW, Clayton PT, Hoffmann GF, Okun JG

      World J Gastroenterol 18, 1067-76 (2012)

      PMID: 22416181 doi: [10.3748/wjg.v18.i10.1067]

    • Sphingosine 1-Phosphate (S1P) Lyase Deficiency Increases Sphingolipid Formation via Recycling at the Expense of de Novo Biosynthesis in Neurons.

      Hagen-Euteneuer N, Lutjohann D, Park H, Merrill AH, Jr., van Echten-Deckert G

      J Biol Chem 287, 9128-36 (2012)

      PMID: 22291021

    • Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function.

      Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, Dennis EA, Zhang K.

      J Biol Chem 287, 11469-80(2012)

      PMID: 22199362

    • Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid.

      Kandiba L, Aitio O, Helin J, Guan Z, Permi P, Bamford DH, Eichler J, Roine E

      Mol Microbiol 84, 578-93 (2012)

      PMID: 22435790 doi: [10.1111/j.1365-2958.2012.08045.x]

    • Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.

      Kanistanon D, Powell DA, Hajjar AM, Pelletier MR, Cohen IE, Way SS, Skerrett SJ, Wang X, Raetz CR, Ernst RK

      Infect Immun 80, 943-51 (2012)

      PMID: 22215738

    • Adiponutrin functions as a nutritionally regulated lysophosphatidic Acid acyltransferase.

      Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R

      Cell Metab 15, 691-702 (2012)

      PMID: 22560221

    • LPS remodeling is an evolved survival strategy for bacteria .

      Li Y, Powell DA, Shafferc SA, Raskod DA, Pelletierb MR, Leszykc JD, Scottb AJ, Masoudie A, Goodlettf DR, Wanga X, Raetz CR, Ernst RK

      Proc Natl Acad Sci U S A , Epub ahead of print (2012)

      PMID: 22586119

    • CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action.

      Lord CC, Betters JL, Ivanova PT, Milne SB, Myers DS, Madenspacher J, Thomas G, Chung S, Liu M, Davis MA, Lee RG, Crooke RM, Graham MJ, Parks JS, Brasaemle DL, Fessler MB, Brown HA, Brown JM

      Diabetes 61, 355-63 (2012)

      PMID: 22228714

    • Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression.

      Lucki NC, Bandyopadhyay S, Wang E, Merrill AH, Sewer MB

      Mol Endocrinol 26, 228-43 (2012)

      PMID: 22261821

    • A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma.

      McDonald JG, Smith DD, Stiles AR, Russell DW

      J Lipid Res , (2012)

      PMID: 22517925

    • LpxI structures reveal how a lipid A precursor is synthesized.

      Metzger LE 4th, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM.

      Nat Struct Mol Biol. Nov;19(11):1132-8.


      PMID: 23042606 doi: [10.1038/nsmb.2393]

    • Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart.

      Mulligan CM, Sparagna GC, Le CH, De Mooy AB, Routh MA, Holmes MG, Hickson-Bick DL, Zarini S, Murphy RC, Xu FY, Hatch GM, McCune SA, Moore RL, Chicco AJ

      Cardiovasc Res , Epub ahead of print (2012)

      PMID: 22411972

    • A predicted geranylgeranyl reductase reduces the omega-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii.

      Naparstek S, Guan Z, Eichler J

      Biochim Biophys Acta 1821, 923-933 (2012)

      PMID: 22469971

    • Omega-3 fatty acids cause dramatic changes in TLR-4 and purinergic signaling.

      Norris PC, Dennis EA

      Proc Natl Acad Sci U S A , Epub ahead of print (2012)

      PMID: 22586114

    • Targeted proteomics of the eicosanoid biosynthetic pathway completes an integrated genomics-proteomics-metabolomics picture of cellular metabolism.

      Sabido E, Quehenberger O, Shen Q, Chang V, Shah I, Armando A, Andreyev A, Vitek O, Dennis EA, Aebersold R

      Mol Cell Proteomics , Epub ahead of print (2012)

      PMID: 22361236

    • Group IVA phospholipase A(2) is necessary for growth cone repulsion and collapse.

      Sanford SD, Yun BG, Leslie CC, Murphy RC, Pfenninger KH

      J Neurochem 120, 974-84 (2012)

      PMID: 22220903 doi: [10.1111/j.1471-4159.2012.07651.x]

    • Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes.

      Silva LC, Ben David O, Pewzner-Jung Y, Laviad EL, Stiban J, Bandyopadhyay S, Merrill AH Jr, Prieto M, Futerman AH

      Journal of Lipid Research 53, 430-6 (2012)

      PMID: 22231783

    • Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

      Spann NJ, Garmire L, McDonald JF, Meyers DS, Milne SB, Shibata N, Reichart D, Fox JN, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown A, Dennis EA, Li AC, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass C

      Cell 151, 138-152 (2012)

      doi: [10.1016/j.cell.2012.06.054]

    • Gene-expression measurement: variance-modeling considerations for robust data analysis.

      Subramaniam S, Hsiao G

      Nat Immunol 13, 199-203 (2012)

      PMID: 22344273

    • LIPID MAPS-Nature Lipidomics Gateway: An online resource for students and educators interested in lipids .

      Sud M, Fahy E, Cotter D, Dennis EA, Subramaniam S

      J Chem Educ 89, 291-292 (2012)

      doi: [10.1021/ed200088u]

    • Template-based combinatorial enumeration of virtual compound libraries for lipids.

      Sud M, Fahy E, Subramaniam S.

      Journal of Cheminformatics 4 23. (2012)

      PMID:23006594 doi: [10.1186/1758-2946-4-23]

    • Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions.

      van Dijk RA, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum JL, Wasserman BA, Otsuka F, Virmani R, Tsimikas S.

      J Lipid Res 53 12. (2012)

      PMID:22969153 doi: [10.1194/jlr.P030890]

    • A complex LuxR-LuxI type quorum sensing network in a roseobacterial marine sponge symbiont activates flagellar motility and inhibits biofilm formation.

      Zan J, Cicirelli EM, Mohamed NM, Sibhatu H, Kroll S, Choi O, Uhlson CL, Wysoczinski CL, Murphy RC, Churchill ME, Hill RT, Fuqua C

      Mol Microbiol 85, 21025-21033. (2012)

      doi: [10.1111/j.1365-2958.2012.08149.x] PMID: 22539345

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