Lipidomics update - April 2017

The lipidomics update provides an overview of developments in lipid research. Each month we offer a fresh collection of research, news and events for the specialist and the interested non-specialist alike.

LIPID MAPS highlights

LIPID MAPS Classification updates: The LIPID MAPS Classification system, comprised of eight lipid categories -- Fatty Acyls, Glycerolipids, Glycerophospholipids, Sphingolipids, Sterol Lipids, Prenol Lipids, Saccharolipids, and Polyketides, each with its own subclassification hierarchy -- now includes a new Polyketides class, "Phenolic lipids", with 5 subclasses; In addition, there are now 3 new subclasses of Octadecanoids; 3 new subclasses of Eicosanoids; and 7 new subclasses of Docosanoids.

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Lipid of the month

15R-hydroxy-12S,14R-dioxolane-EET

15R-hydroxy-12S,14R-dioxolane-EET (15R-hydroxy-12S,14R-dioxolane-5Z,8Z,10E-eicosatrienoic acid) is an eicosanoid containing a 1,2-dioxolane (cyclic peroxide) group. Dioxolanes of this type have been generated from enantiomers of 14,15-EET by two mammalian LOX enzymes, 15-LOX-1 and platelet-type 12-LOX. This type of transformation could occur naturally with the co-occurrence of LOX and cytochrome P450 or peroxygenase enzymes.

Research library

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LIPID MAPS®
Position Announcements

Key LIPID MAPS® Resources
Publications
- publications related to projects funded through the LIPID MAPS® consortium
Lipid Classification System
- the first internationally accepted lipid classification system
Lipid Standards
- MS/MS spectra, annotations for principal product ions, and acquisition parameters
Experimental Data
- centralized studies on macrophages, lipidomics data on human plasma, and more
Structure Database (LMSD)
- over 40,000 unique structures of biologically relevant lipids
Proteome Database (LMPD)
- over 12,500 lipid-associated proteins from major research species
Pathways
- manually curated lipid metabolism and signaling pathways
LIPID MAPS® REST Service
- web-based/programmatic access to lipid structure and lipid-related gene/protein data
MS analysis tools
- tools for searching various lipid classes by precursor or product ion
Structure Drawing Tools
- draw and save lipid structures using online menus
Protocols
- LIPID MAPS® techniques for lipidomics and macrophage cell culture

LIPID MAPS® is funded by a grant from the Wellcome Trust.

logo LIPID MAPS® is funded by a grant from the Wellcome Trust.