Lipidomics studies on macrophages - bone marrow-derived macrophages treated with 25-hydroxy-cholesterol +/- lipid-depleted media containing compactin

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Averages of biological replicates - (FA) Eicosanoids [media]

Legend:graph_icon: View data/graphs for replicatesgraph_icon: View time course graphs for averages of biological replicates
Ctrl:Untreated BMDM cells (control)
25-OHC: Cells treated with 25-OH-cholesterol at time 0
*: BMDM cells in lipid-depleted media containing compactin
25-OHC*: cells in lipid-depleted media containing compactin and treated with 25-OHC at time 0
DetailsTime course graph
(ave of biol. reps) 		LM_ID Name 25-OHC*
*
25-OHC
Ctrl
 0 hrs		 25-OHC*
*
25-OHC
Ctrl
 30 min		 25-OHC*
*
25-OHC
Ctrl
 1 hr		 25-OHC*
*
25-OHC
Ctrl
 2 hrs		 25-OHC*
*
25-OHC
Ctrl
 4 hrs		 25-OHC*
*
25-OHC
Ctrl
 8 hrs		 25-OHC*
*
25-OHC
Ctrl
 12 hrs		 25-OHC*
*
25-OHC
Ctrl
 24 hrs
Units
. . . .

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000027 10-HDoHE -
0.085
-
0.095		 0.095
0.1
0.1
0.12		 0.105
0.11
0.105
0.115		 0.08
0.1
0.13
0.115		 0.075
0.075
0.085
0.08		 0.1
0.11
-
0.125		 0.08
0.08
0.11
0.14		 0.11
0.09
0.105
0.105		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010060 11beta-PGE2 -
0.085
-
0.3		 0.14
0.195
0.37
0.22		 0.105
0.12
0.26
0.285		 0.08
0.1
0.205
0.24		 0.075
0.075
0.25
0.205		 0.11
0.11
0.13
0.18		 0.09
0.08
0.175
0.145		 0.1
0.09
0.155
0.155		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000028 11-HDoHE -
0.1
-
0.145		 0.095
0.1
0.155
0.155		 0.12
0.12
0.155
0.115		 0.08
0.09
0.14
0.115		 0.07
0.075
0.125
0.08		 0.11
0.11
0.14
0.125		 0.1
0.08
0.125
0.145		 0.11
0.09
0.155
0.16		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03060085 11-HETE -
0.75
-
0.835		 0.98
0.92
1.05
1.1		 1.03
0.93
0.925
0.85		 0.86
0.88
0.995
0.97		 0.665
0.64
0.75
0.74		 0.625
0.6
0.64
0.745		 0.37
0.395
0.615
0.72		 0.325
0.265
0.415
0.645		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03070031 12-HEPE -
0.27
-
0.25		 0.35
0.3
0.415
0.375		 0.34
0.335
0.365
0.395		 0.275
0.29
0.335
0.295		 0.15
0.19
0.25
0.25		 0.22
0.11
0.195
0.2		 0.09
0.09
0.125
0.22		 0.12
0.09
0.155
0.22		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03060088 12-HETE -
5.54
-
2.01		 8.11
8.21
4.06
3.32		 7.68
7.47
2.83
2.87		 5.76
6.16
2.34
2.25		 4.35
4.19
1.87
1.74		 2.14
2.04
0.93
0.835		 0.715
0.695
0.585
0.74		 0.225
0.43
0.41
0.5		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03050002 12S-HHTrE -
3.85
-
3.82		 5.17
5.05
5.74
5.07		 4.5
4.41
4.98
4.5		 3.65
3.57
4.21
4.05		 3.74
3.52
4.17
3.96		 2.62
2.98
2.66
2.9		 1.56
1.86
1.35
1.85		 1.25
1.05
0.98
0.9		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010022 13,14-dihydro-15-keto-PGD2 -
0.18
-
0.805		 0.255
0.3
0.81
0.6		 0.28
0.335
1.27
0.845		 0.195
0.275
0.975
1.01		 0.33
0.335
1.05
1		 0.31
0.325
0.99
1.04		 0.275
0.31
1.25
0.89		 0.22
0.31
0.92
1.04		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000029 13-HDoHE -
0.175
-
0.24		 0.14
0.195
0.245
0.33		 0.155
0.16
0.255
0.225		 0.155
0.145
0.19
0.23		 0.15
0.17
0.255
0.275		 0.105
0.16
0.255
0.18		 0.135
0.09
0.3
0.145		 0.16
0.09
0.26
0.37		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA01050349 13-HODE -
0.775
-
1.33		 0.755
0.675
1.34
1.38		 0.74
0.595
1.29
1.26		 0.66
0.69
1.26
1.26		 0.635
0.9
1.42
1.23		 0.78
0.71
1.39
1.36		 0.725
0.67
1.34
1.37		 0.705
0.665
1.41
1.48		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA01050145 13-HOTrE(y) -
0.21
-
0.49		 0.24
0.195
0.4
0.52		 0.155
0.16
0.515
0.455		 0.155
0.145
0.4
0.46		 0.185
0.21
0.59
0.475		 0.21
0.16
0.385
0.485		 0.185
0.23
0.365
0.5		 0.16
0.18
0.31
0.53		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03050010 14,15-diHETrE -
0.125
-
0.585		 0.14
0.195
0.59
0.625		 0.155
0.16
0.62
0.455		 0.195
0.2
0.59
0.63		 0.15
0.18
0.635
0.53		 0.155
0.215
0.64
0.615		 0.185
0.18
0.545
0.575		 0.22
0.18
0.525
0.635		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000030 14-HDoHE -
0.32
-
0.745		 0.35
0.395
0.825
0.885		 0.28
0.385
0.835
0.785		 0.235
0.33
0.75
0.765		 0.26
0.305
0.74
0.795		 0.215
0.28
0.59
0.665		 0.235
0.22
0.505
0.735		 0.22
0.215
0.51
0.76		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010051 15-deoxy-delta-12,14-PGD2 -
1.89
-
5.77		 1.38
1.87
8.01
7.05		 2.4
1.69
8.15
7.8		 1.72
1.95
7.76
7.83		 2.08
2.33
7.15
6.18		 1.85
1.97
7.03
7.53		 1.54
1.63
7.2
6.73		 2.19
1.64
6.36
6.42		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03070032 15-HEPE -
-
-
0.145		 0.08
0.09
0.1
0.155		 -
-
0.105
0.115		 0.08
0.11
0.13
0.115		 -
-
0.085
0.08		 -
-
0.13
0.125		 -
-
-
0.145		 -
-
0.105
0.105		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03060087 15-HETE -
0.175
-
0.445		 0.2
0.14
0.4
0.43		 0.105
0.17
0.31
0.4		 0.155
0.145
0.33
0.28		 0.11
0.115
0.3
0.31		 0.155
0.16
0.255
0.305		 0.09
0.135
0.245
0.36		 0.11
0.13
0.31
0.37		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03050007 15-HETrE -
0.515
-
1.14		 0.6
0.63
1.22
1.34		 0.65
0.665
1.14
1.14		 0.585
0.58
1.07
1.27		 0.52
0.6
0.975
1.13		 0.47
0.55
0.965
1.02		 0.465
0.475
1.04
1.02		 0.435
0.355
1.05
0.96		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000031 16-HDoHE -
0.175
-
0.395		 0.2
0.195
0.4
0.455		 0.22
0.22
0.415
0.34		 0.195
0.2
0.4
0.345		 0.225
0.225
0.38
0.4		 0.21
0.215
0.445
0.435		 0.185
0.22
0.42
0.435		 0.22
0.225
0.47
0.53		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000032 17-HDoHE -
0.175
-
0.54		 0.24
0.24
0.58
0.56		 0.105
0.16
0.465
0.455		 0.155
0.155
0.45
0.345		 0.185
0.17
0.39
0.395		 0.105
0.215
0.445
0.36		 0.09
0.135
0.355
0.435		 0.16
0.13
0.365
0.425		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03060091 17-HETE -
0.515
-
0.79		 0.53
0.48
0.705
0.86		 0.535
0.555
0.675
0.795		 0.505
0.535
0.665
0.755		 0.595
0.53
0.715
0.695		 0.475
0.55
0.71
0.715		 0.515
0.435
0.63
0.795		 0.435
0.615
0.62
0.7		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03070033 18-HEPE -
0.175
-
0.24		 0.14
0.095
0.345
0.31		 0.105
0.22
0.26
0.28		 0.155
0.145
0.265
0.295		 0.15
0.145
0.295
0.285		 0.16
0.11
0.255
0.33		 0.135
0.135
0.245
0.365		 0.16
0.13
0.31
0.325		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03060092 18-HETE -
4.05
-
6.1		 3.94
3.68
6.05
6.31		 4.02
4.06
5.99
5.96		 3.83
4.33
5.45
6.03		 4.1
4.21
5.97
5.84		 3.54
4.49
5.48
6.3		 3.85
3.85
5.61
6.56		 3.53
4.36
5.84
6.84		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000043 19,20 DiHDPA -
0.81
-
2.9		 0.82
0.87
2.91
3.07		 0.905
0.875
2.99
2.56		 0.98
0.925
2.98
3.24		 1.09
1.04
3.42
2.89		 1.05
1.26
3.45
3.78		 1.19
1.2
3.95
4.42		 1.81
1.78
4.77
4.78		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000038 19(20) EpDPE -
0.48
-
0.585		 0.57
0.385
0.545
0.725		 0.475
0.545
0.62
0.685		 0.585
0.535
0.59
0.69		 0.56
0.595
0.63
0.61		 0.525
0.545
0.64
0.615		 0.455
0.53
0.735
0.725		 0.535
0.48
0.67
0.7		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03060074 19-HETE -
0.49
-
0.53		 0.375
0.555
0.51
0.455		 0.6
0.475
0.46
0.345		 0.66
0.5
0.265
0.39		 0.49
0.54
0.53
0.545		 0.525
0.44
0.25
0.41		 0.275
0.58
0.31
0.575		 0.32
0.4
0.365
0.32		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010042 19oh PGF2a -
0.75
-
2.13		 0.9
0.715
1.17
1.18		 0.45
0.77
0.96
1.14		 0.545
0.515
1.02
1.07		 0.38
0.14
0.89
0.87		 0.61
0.375
0.76
0.9		 0.225
0.32
0.58
0.575		 0.32
0.41
0.58
0.9		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000033 20-HDoHE -
0.255
-
0.49		 0.295
0.29
0.5
0.54		 0.325
0.325
0.465
0.565		 0.35
0.29
0.53
0.575		 0.26
0.265
0.375
0.485		 0.265
0.215
0.45
0.46		 0.275
0.255
0.49
0.44		 0.22
0.175
0.47
0.48		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010029 20oh PGF2a -
0.86
-
1.99		 0.87
1.13
1.58
1.14		 1.05
0.755
1.22
0.965		 0.85
0.685
0.85
1.35		 0.69
0.725
1.18
1.12		 0.715
1.03
1.07
1.29		 0.395
0.55
1.18
0.925		 0.42
0.68
0.84
1.12		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000024 4-HDoHE -
0.21
-
0.395		 0.24
0.195
0.4
0.455		 0.22
0.22
0.31
0.455		 0.155
0.145
0.335
0.345		 0.19
0.145
0.255
0.275		 0.215
0.215
0.325
0.305		 0.185
0.22
0.245
0.29		 0.11
0.13
0.31
0.32		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03060084 5-HETE -
0.21
-
0.345		 0.2
0.195
0.39
0.365		 0.22
0.22
0.415
0.51		 0.12
0.145
0.265
0.345		 0.15
0.18
0.3
0.31		 0.16
0.11
0.385
0.33		 0.09
0.135
0.245
0.22		 0.21
0.18
0.365
0.37		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03050005 5-HETrE -
0.07
-
0.1		 0.08
-
0.09
0.09		 0.09
-
0.1
0.115		 -
-
-
-		 -
0.07
0.09
0.07		 0.11
-
0.14
-		 -
0.08
-
-		 -
0.09
0.1
-		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03110011 5-iPF2alpha-VI -
0.655
-
1.36		 0.625
0.65
1.15
0.865		 0.51
0.625
1.17
1.15		 0.62
0.58
1.28
1.23		 0.61
0.625
1.19
1.14		 0.77
0.805
1.36
1.42		 0.825
0.655
1.35
1.41		 1.03
1.05
1.59
1.91		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010001 6k PGF1a -
0.505
-
0.25		 0.53
0.435
0.245
0.275		 0.63
0.435
0.26
0.285		 0.54
0.545
0.265
0.295		 0.485
0.475
0.21
0.24		 0.47
0.49
0.255
0.255		 0.36
0.27
0.3
0.22		 0.485
0.41
0.205
0.21		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000025 7-HDoHE -
0.16
-
0.195		 0.14
0.14
0.2
0.275		 0.155
0.16
0.26
0.225		 0.195
0.2
0.255
0.28		 0.115
0.21
0.255
0.23		 0.155
0.16
0.19
0.255		 0.135
0.135
0.175
0.215		 0.16
0.18
0.205
0.32		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03050006 8,9-diHETrE -
-
-
0.53		 -
-
0.67
0.475		 -
-
0.565
0.515		 -
-
0.58
0.51		 -
-
0.615
0.43		 -
-
0.505
0.515		 -
-
0.41
0.565		 -
-
0.42
0.47		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA04000026 8-HDoHE -
0.255
-
0.445		 0.28
0.28
0.545
0.59		 0.31
0.37
0.465
0.455		 0.315
0.29
0.47
0.51		 0.265
0.29
0.42
0.44		 0.26
0.27
0.385
0.435		 0.185
0.27
0.365
0.365		 0.27
0.27
0.365
0.535		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03060086 8-HETE -
0.415
-
0.25		 0.465
0.4
0.27
0.29		 0.4
0.455
0.265
0.285		 0.35
0.375
0.275
0.24		 0.33
0.355
0.29
0.215		 0.27
0.33
0.195
0.2		 0.19
0.215
0.195
0.22		 0.225
0.215
0.205
0.275		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA01050350 9,10 diHOME -
0.21
-
0.24		 0.32
0.185
0.245
0.175		 0.22
0.21
0.255
0.225		 0.235
0.245
0.19
0.23		 0.225
0.19
0.255
0.195		 0.155
0.215
0.19
0.18		 0.175
0.175
0.125
0.145		 0.16
0.18
0.105
0.155		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA01050278 9-HODE -
0.415
-
0.145		 0.31
0.245
0.85
0.43		 0.49
0.22
0.32
0.57		 0.115
1.01
0.4
0.175		 0.39
0.46
0.47
0.21		 0.5
0.21
0.565
0.69		 0.225
0.425
0.285
0.28		 0.24
0.275
0.205
0.27		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA02000024 9-HOTrE -
0.15
-
0.195		 0.11
-
0.1
0.175		 -
0.1
0.155
0.225		 -
-
0.13
0.23		 -
-
0.175
0.16		 -
-
0.13
0.18		 0.08
0.1
0.175
0.215		 -
-
0.205
0.155		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA01030001 Arachidonic acid -
71.7
-
160		 73.2
69.8
183
158		 70.7
70.4
162
163		 60
63.2
147
155		 57.2
59.9
140
131		 49.7
54.4
120
121		 44
39.2
106
119		 52.7
47.1
106
157		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010149 d17 6k PGF1a -
16.5
-
0.645		 16.7
15.7
0.76
0.79		 16.3
16
1.14
0.79		 12.9
11.8
0.995
0.99		 9.62
11.2
0.765
1.21		 11.5
11.4
0.83
0.895		 11
10.6
0.94
0.725		 5.6
7.2
0.725
0.75		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03090003 HXB3 -
0.1
-
0.99		 0.2
0.095
1.04
1.13		 0.17
0.11
0.98
0.905		 0.195
0.145
1.01
1.06		 0.15
0.18
0.985
0.895		 0.155
0.215
0.905
0.915		 0.14
0.175
0.925
1.02		 0.17
0.13
0.88
0.98		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010004 PGD2 -
0.18
-
0.495		 0.24
0.195
0.51
0.485		 0.155
0.16
0.63
0.51		 0.155
0.145
0.625
0.475		 0.19
0.115
0.575
0.55		 0.105
0.165
0.39
0.41		 0.185
0.175
0.505
0.44		 0.11
0.13
0.46
0.43		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010134 PGE1 -
0.57
-
0.565		 0.59
0.535
0.64
0.535		 0.57
0.57
0.71
0.69		 0.855
0.58
0.85
0.68		 0.675
0.775
0.78
0.81		 0.77
0.705
0.82
0.77		 0.71
0.64
1.07
0.935		 0.685
0.765
0.995
0.845		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010003 PGE2 -
0.25
-
0.24		 0.14
0.14
0.245
0.21		 0.105
0.17
0.155
0.115		 0.16
0.145
0.13
0.23		 0.11
0.18
0.255
0.16		 0.105
0.165
0.255
0.18		 0.09
0.135
0.245
0.215		 0.11
0.09
0.105
0.16		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010137 PGF1a -
0.735
-
0.28		 1.13
0.87
0.365
0.33		 1.23
1.2
0.405
0.7		 1.95
1.79
0.575
0.44		 1.73
1.28
0.535
0.63		 1.78
1.75
0.74
0.565		 1.9
2.21
0.515
0.85		 2.18
2.07
0.635
0.575		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03010002 PGF2a -
0.63
-
0.35		 0.93
0.525
0.245
0.175		 0.615
0.635
0.26
0.28		 1.13
0.79
0.39
0.51		 1.03
0.64
0.705
0.395		 1.29
1.19
0.63
0.515		 1.19
1.07
0.9
0.78		 1.6
1.31
0.79
0.935		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA01050143 tetranor 12 HETE -
8.9
-
8.4		 11.3
10.6
10.7
9.89		 10.4
10.1
10.6
10		 9.29
9.88
10.2
9.31		 9.12
9.68
10.3
10.2		 6.57
7.77
7.36
8.26		 4.06
5.06
5.23
7.15		 2.65
2.52
2.84
4.49		 pmol/sample

Ratio plot
Legend: :Ctrl  :25-OHC  :Comp  :25-OHC + Comp
LMFA03030002 TxB2 -
24.8
-
12.7		 24.1
24.1
13.1
11.4		 24.1
24.5
13
12.7		 24.5
24
12.6
12.8		 23.9
20.2
13.2
12.9		 24.4
24.6
13.1
12.5		 23.6
23.5
12.7
12.8		 25.9
24.1
12.7
13		 pmol/sample