Gene/Proteome Database (LMPD)

LMPD ID
LMP005508
Gene ID
5738
Species
Homo sapiens (Human)
Gene Name
prostaglandin F2 receptor inhibitor
Gene Symbol
PTGFRN
Synonyms
CD315; CD9P-1; EWI-F; FPRP; SMAP-6
Alternate Names
prostaglandin F2 receptor negative regulator; CD9 partner 1; glu-Trp-Ile EWI motif-containing protein F; prostaglandin F2-alpha receptor regulatory protein; prostaglandin F2-alpha receptor-associated protein
Chromosome
1
Map Location
1p13.1

Proteins

prostaglandin F2 receptor negative regulator precursor
Refseq ID NP_065173
Protein GI 41152506
UniProt ID Q9P2B2
mRNA ID NM_020440
Length 879
RefSeq Status PROVISIONAL
MGRLASRPLLLALLSLALCRGRVVRVPTATLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSLGSSFVELASTWEVGFPAQLYQERLQRGEILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTVQVKVLADSLHVGPSARPPPSLSLREGEPFELRCTAASASPLHTHLALLWEVHRGPARRSVLALTHEGRFHPGLGYEQRYHSGDVRLDTVGSDAYRLSVSRALSADQGSYRCIVSEWIAEQGNWQEIQEKAVEVATVVIQPSVLRAAVPKNVSVAEGKELDLTCNITTDRADDVRPEVTWSFSRMPDSTLPGSRVLARLDRDSLVHSSPHVALSHVDARSYHLLVRDVSKENSGYYYCHVSLWAPGHNRSWHKVAEAVSSPAGVGVTWLEPDYQVYLNASKVPGFADDPTELACRVVDTKSGEANVRFTVSWYYRMNRRSDNVVTSELLAVMDGDWTLKYGERSKQRAQDGDFIFSKEHTDTFNFRIQRTTEEDRGNYYCVVSAWTKQRNNSWVKSKDVFSKPVNIFWALEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLIMAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPVRGSLWREAATSLSNPIEIDFQTSGPIFNASVHSDTPSVIRGDLIKLFCIITVEGAALDPDDMAFDVSWFAVHSFGLDKAPVLLSSLDRKGIVTTSRRDWKSDLSLERVSVLEFLLQVHGSEDQDFGNYYCSVTPWVKSPTGSWQKEAEIHSKPVFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSHWCCKKEVQETRRERRRLMSMEMD
sig_peptide: 1..25 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q9P2B2.2) calculated_mol_wt: 2735 peptide sequence: MGRLASRPLLLALLSLALCRGRVVR mat_peptide: 26..879 product: Prostaglandin F2 receptor negative regulator experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9P2B2.2) calculated_mol_wt: 95840 peptide sequence: VPTATLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSLGSSFVELASTWEVGFPAQLYQERLQRGEILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTVQVKVLADSLHVGPSARPPPSLSLREGEPFELRCTAASASPLHTHLALLWEVHRGPARRSVLALTHEGRFHPGLGYEQRYHSGDVRLDTVGSDAYRLSVSRALSADQGSYRCIVSEWIAEQGNWQEIQEKAVEVATVVIQPSVLRAAVPKNVSVAEGKELDLTCNITTDRADDVRPEVTWSFSRMPDSTLPGSRVLARLDRDSLVHSSPHVALSHVDARSYHLLVRDVSKENSGYYYCHVSLWAPGHNRSWHKVAEAVSSPAGVGVTWLEPDYQVYLNASKVPGFADDPTELACRVVDTKSGEANVRFTVSWYYRMNRRSDNVVTSELLAVMDGDWTLKYGERSKQRAQDGDFIFSKEHTDTFNFRIQRTTEEDRGNYYCVVSAWTKQRNNSWVKSKDVFSKPVNIFWALEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLIMAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPVRGSLWREAATSLSNPIEIDFQTSGPIFNASVHSDTPSVIRGDLIKLFCIITVEGAALDPDDMAFDVSWFAVHSFGLDKAPVLLSSLDRKGIVTTSRRDWKSDLSLERVSVLEFLLQVHGSEDQDFGNYYCSVTPWVKSPTGSWQKEAEIHSKPVFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSHWCCKKEVQETRRERRRLMSMEMD

Gene Information

Entrez Gene ID
5738
Gene Name
prostaglandin F2 receptor inhibitor
Gene Symbol
PTGFRN
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0009986 IDA:UniProtKB C cell surface
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034389 IEA:Ensembl P lipid particle organization

Domain Information

InterPro Annotations

Accession Description
IPR013106 Immunoglobulin V-set domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold

UniProt Annotations

Entry Information

Gene Name
prostaglandin F2 receptor inhibitor
Protein Entry
FPRP_HUMAN
UniProt ID
Q9P2B2
Species
Human

Comments

Comment Type Description
Function Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).
Sequence Caution Sequence=BAA92674.1; Type=Erroneous initiation; Evidence= ; Sequence=BAC11104.1; Type=Erroneous termination; Positions=864; Note=Translated as Gln.; Evidence= ;
Similarity Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Subcellular Location Endoplasmic reticulum membrane {ECO
Subunit Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.

Identical and Related Proteins

Unique RefSeq proteins for LMP005508 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
41152506 RefSeq NP_065173 879 prostaglandin F2 receptor negative regulator precursor

Identical Sequences to LMP005508 proteins

Reference Database Accession Length Protein Name
GI:41152506 GenBank AAI68364.1 879 Prostaglandin F2 receptor negative regulator [synthetic construct]
GI:41152506 GenBank ADT47018.1 879 Sequence 679 from patent US 7842466
GI:41152506 GenBank AED39235.1 879 Sequence 1279 from patent US 7883858
GI:41152506 GenBank AFL25702.1 879 Sequence 51 from patent US 8168586
GI:41152506 GenBank AGV81729.1 879 Sequence 51 from patent US 8524238
GI:41152506 GenBank AHD78242.1 879 Sequence 25579 from patent US 8586006

Related Sequences to LMP005508 proteins

Reference Database Accession Length Protein Name
GI:41152506 DBBJ BAA92674.1 924 KIAA1436 protein, partial [Homo sapiens]
GI:41152506 GenBank ABH72657.1 879 Sequence 90 from patent US 7034132
GI:41152506 GenBank ACW56265.1 879 Sequence 136 from patent US 7585953
GI:41152506 GenBank ADS55053.1 924 Sequence 6 from patent US 7803906
GI:41152506 GenBank AED64723.1 924 Sequence 2 from patent US 7906621
GI:41152506 GenBank AFX01557.1 879 Sequence 136 from patent US 8278042