Gene/Proteome Database (LMPD)

LMPD ID
LMP006035
Gene ID
77805
Species
Mus musculus (Mouse)
Gene Name
establishment of cohesion 1 homolog 1 (S. cerevisiae)
Gene Symbol
Esco1
Synonyms
A930014I12Rik
Alternate Names
N-acetyltransferase ESCO1; ECO1 homolog 1; establisment of cohesion 1 homolog 1
Chromosome
18
Map Location
18|18 A2
EC Number
2.3.1.-

Proteins

N-acetyltransferase ESCO1
Refseq ID NP_001074691
Protein GI 124487021
UniProt ID Q69Z69
mRNA ID NM_001081222
Length 843
RefSeq Status PROVISIONAL
MSIQEKSKENSSIVTKESEDENLEEEVESSQNSPTKKSGSKEAVKTPVRFSNKSKTNESEFGMRMSTRSASCSADKTATNSFNKNTVTLKGQSQESSKTKKLCQEKLSLGILKGNEQLHRRSQRLQQLTECTTRSLRSREIHGQIQTVKQNQQSARREQCNSTQSKCNKVKVNQKHVKRKVLEIKSDCKEDRHSVTNEVINSPKGKKRKVQHQTTSTCSSQCNQGSEKCLQKTSRKEEIKPVPVTADIRKLKAATSVVSKKNELRKSAHTQVSTSTKRPQIPLPLVPEHSDDQELEQAGKSKRGSILQLCEEIAGEIESDTVEVKKESSCVESVKEEKPAEVKLQGTDAERQILHHKEANQDVRSNRFFPSRKTKPVKCVLNGINSSTKKNSNWTKIKLSKFNSVQQHKLDSQVSPKLNLLQTGLSTSVLEMPHPVSQSTFLEMKAHGNVTCQRDKMKGIKSEEVKINNIAIEINKATKRDPGNCNLDNHIKPSPDSSLDNQMKLSCESAPDQNFSICSASEVETNPLENTAAASTLLSQAKIDEDRTFPGSAPNQQHSVLSDEASINRKNRDVPPNHSQLKHDSHLEITIPKSLKLKDSEKVDEKQLVIDAGHKRFGAVSCNICGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNTT

Gene Information

Entrez Gene ID
77805
Gene Name
establishment of cohesion 1 homolog 1 (S. cerevisiae)
Gene Symbol
Esco1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000785 ISS:UniProtKB C chromatin
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016746 IEA:UniProtKB-KW F transferase activity, transferring acyl groups
GO:0034421 IEA:Ensembl P post-translational protein acetylation
GO:0006275 ISS:UniProtKB P regulation of DNA replication
GO:0007062 IEA:InterPro P sister chromatid cohesion

REACTOME Pathway Links

REACTOME Pathway ID Description
5892715 Cell Cycle
5892714 Cell Cycle, Mitotic
5894093 Establishment of Sister Chromatid Cohesion
5892724 S Phase

Domain Information

InterPro Annotations

Accession Description
IPR028009 N-acetyltransferase ESCO, acetyl-transferase domain
IPR028005 N-acetyltransferase ESCO, zinc-finger
IPR026656 N-acetyltransferase ESCO1

UniProt Annotations

Entry Information

Gene Name
establishment of cohesion 1 homolog 1 (S. cerevisiae)
Protein Entry
ESCO1_MOUSE
UniProt ID
Q69Z69
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q69Z69-1; Sequence=Displayed; Name=2; IsoId=Q69Z69-2; Sequence=VSP_014031, VSP_014032; Note=No experimental confirmation available.; Name=3; IsoId=Q69Z69-3; Sequence=VSP_014033, VSP_014034; Note=No experimental confirmation available.;
Function Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAH08220.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC33830.1; Type=Frameshift; Positions=743; Evidence={ECO:0000305}; Sequence=BAD32575.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the acetyltransferase family. ECO subfamily. {ECO:0000305}.
Subcellular Location Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Nuclear at interphase, associated with chromosomes during mitosis. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006035 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
124487021 RefSeq NP_001074691 843 N-acetyltransferase ESCO1

Identical Sequences to LMP006035 proteins

Reference Database Accession Length Protein Name
GI:124487021 GenBank AAI51070.1 843 Establishment of cohesion 1 homolog 1 (S. cerevisiae) [Mus musculus]
GI:124487021 GenBank AAI51078.1 843 Establishment of cohesion 1 homolog 1 (S. cerevisiae) [Mus musculus]
GI:124487021 SwissProt Q69Z69.2 843 RecName: Full=N-acetyltransferase ESCO1; AltName: Full=Establishment of cohesion 1 homolog 1; Short=ECO1 homolog 1 [Mus musculus]

Related Sequences to LMP006035 proteins

Reference Database Accession Length Protein Name
GI:124487021 DBBJ BAE26373.1 843 unnamed protein product [Mus musculus]
GI:124487021 GenBank AAI66441.1 840 Esco1 protein [Rattus norvegicus]
GI:124487021 RefSeq NP_001119771.2 840 N-acetyltransferase ESCO1 [Rattus norvegicus]
GI:124487021 RefSeq XP_006254474.1 840 PREDICTED: N-acetyltransferase ESCO1 isoform X1 [Rattus norvegicus]
GI:124487021 RefSeq XP_006254475.1 840 PREDICTED: N-acetyltransferase ESCO1 isoform X1 [Rattus norvegicus]
GI:124487021 RefSeq XP_006994258.1 842 PREDICTED: N-acetyltransferase ESCO1 isoform X2 [Peromyscus maniculatus bairdii]