Gene/Proteome Database (LMPD)

LMPD ID
LMP006787
Gene ID
80243
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Gene Symbol
PREX2
Synonyms
6230420N16Rik; DEP.2; DEPDC2; P-REX2; PPP1R129
Alternate Names
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; DEP domain-containing protein 2; PtdIns(3,4,5)-dependent Rac exchanger 2; protein phosphatase 1, regulatory subunit 129
Chromosome
8
Map Location
8q13.2

Proteins

phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform a
Refseq ID NP_079146
Protein GI 47578115
UniProt ID Q70Z35
mRNA ID NM_024870
Length 1606
RefSeq Status VALIDATED
MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTSEGIIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPLSVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQLRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACANTACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform b
Refseq ID NP_079446
Protein GI 47578117
UniProt ID Q70Z35
mRNA ID NM_025170
Length 979
RefSeq Status VALIDATED
MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRISSYKKVQASERFYNFTARHAVWEHSFDLHSVSSTFPVPVTMEFLLLPPPLLGISQDGRQHCIPEDLPSQEMLLAERAPV

Gene Information

Entrez Gene ID
80243
Gene Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Gene Symbol
PREX2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030675 IDA:MGI F Rac GTPase activator activity
GO:0030676 IDA:MGI F Rac guanyl-nucleotide exchange factor activity
GO:0007186 IDA:MGI P G-protein coupled receptor signaling pathway
GO:0008344 IEA:Ensembl P adult locomotory behavior
GO:0048813 IEA:Ensembl P dendrite morphogenesis
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0032855 IDA:GOC P positive regulation of Rac GTPase activity

Domain Information

InterPro Annotations

Accession Description
IPR000591 DEP domain
IPR000219 Dbl homology (DH) domain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR011991 Winged helix-turn-helix DNA-binding domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Protein Entry
PREX2_HUMAN
UniProt ID
Q70Z35
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=P-Rex2; IsoId=Q70Z35-1; Sequence=Displayed; Name=2; Synonyms=P-Rexw2A; IsoId=Q70Z35-2; Sequence=VSP_025149, VSP_025151, VSP_025153, VSP_025154, VSP_025155, VSP_025156, VSP_025157, VSP_025158, VSP_025159, VSP_025160, VSP_025161, VSP_025162, VSP_025163; Name=3; IsoId=Q70Z35-3; Sequence=VSP_025150, VSP_025152; Name=4; IsoId=Q70Z35-4; Sequence=VSP_055612, VSP_055613, VSP_055614; Note=No experimental confirmation available.;
Domain DH domain alone was unable to confer substrate specificity and recognition.
Domain PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42.
Function Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase. {ECO
Sequence Caution Sequence=AK024079; Type=Frameshift; Positions=1134; Evidence= ; Sequence=BAB14375.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAG57581.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Contains 1 DH (DBL-homology) domain.
Similarity Contains 1 PH domain. {ECO
Similarity Contains 2 DEP domains. {ECO
Similarity Contains 2 PDZ (DHR) domains. {ECO
Subunit Interacts with RAC1.
Tissue Specificity Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart.

Identical and Related Proteins

Unique RefSeq proteins for LMP006787 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
47578115 RefSeq NP_079146 1606 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform a
47578117 RefSeq NP_079446 979 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform b

Identical Sequences to LMP006787 proteins

Reference Database Accession Length Protein Name
GI:47578115 EMBL CAD26885.2 1606 P-Rex2 protein [Homo sapiens]
GI:47578117 GenBank AAI46370.1 979 Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2, partial [synthetic construct]
GI:47578117 GenBank AAI48796.1 979 Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 [synthetic construct]
GI:47578115 SwissProt Q70Z35.1 1606 RecName: Full=Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; Short=P-Rex2; Short=PtdIns(3,4,5)-dependent Rac exchanger 2; AltName: Full=DEP domain-containing protein 2 [Homo sapiens]
GI:47578117 Third Party Genbank DAA05333.1 979 TPA_exp: PtdIns(3,4,5)-dependent Rac exchanger 2b [Homo sapiens]

Related Sequences to LMP006787 proteins

Reference Database Accession Length Protein Name
GI:47578115 GenBank AAS82571.1 1606 P-Rex2 [Homo sapiens]
GI:47578117 GenBank AAS82572.1 979 P-Rex2B [Homo sapiens]
GI:47578115 GenBank EHH64218.1 1606 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein [Macaca fascicularis]
GI:47578115 RefSeq XP_003274854.1 1606 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 1 [Nomascus leucogenys]
GI:47578117 RefSeq XP_003274855.1 979 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 2 [Nomascus leucogenys]
GI:47578115 RefSeq XP_519798.3 1606 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X2 [Pan troglodytes]
GI:47578117 RefSeq XP_003311791.1 979 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X3 [Pan troglodytes]
GI:47578115 RefSeq XP_003831395.1 1606 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein [Pan paniscus]
GI:47578117 RefSeq XP_003902888.1 979 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein-like [Papio anubis]
GI:47578115 RefSeq XP_005563546.1 1606 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X1 [Macaca fascicularis]
GI:47578117 RefSeq XP_005563547.1 979 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X2 [Macaca fascicularis]
GI:47578117 RefSeq XP_007998994.1 979 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X2 [Chlorocebus sabaeus]