Structure Database (LMSD)

Common Name
PGF2alpha-dihydroxypropanylamine
Systematic Name
N-(1,3-dihydroxypropan-2-yl)-9S,11R,15S-trihydroxy-5Z,13E-prostadienoyl amine
Synonyms
  • Prostaglandin F2alpha-dihydroxypropanylamine
LM ID
LMFA03010193
Formula
C23H41NO6
Exact Mass
Calculate m/z
427.293389
Status
Curated
Show lipids differing only in stereochemistry/bond geometry

Classification

Category
Main Class
Sub Class
Fatty Acyls [FA]
Eicosanoids [FA03]
Prostaglandins [FA0301]

Biological Context

Prostaglandin F2α serinol amide (PGF2α-SA) is a derivative of the 2-arachidonyl glycerol (2-AG) metabolite PGF2α 2-glyceryl ester (PGF2α-G).1 It induces calcium mobilization in RAW 264.7 macrophages and H1819 cells (EC50s = 3.7 and 1.2 pM, respectively).

This information has been provided by Cayman Chemical

References

1. Richie-Jannetta, R., Nirodi, C.S., Crews, B.C., et al. Structural determinants for calcium mobilization by prostaglandin E2 and prostaglandin F2α glyceryl esters in RAW 264.7 cells and H1819 cells. Prostaglandins Other Lipid Mediat. 92(1-4), 19-24 (2010).

String Representations

InChiKey (Click to copy)
IRAOUIWKWHBHDC-GKUWGJHRSA-N
InChi (Click to copy)
InChI=1S/C23H41NO6/c1-2-3-6-9-18(27)12-13-20-19(21(28)14-22(20)29)10-7-4-5-8-11-23(30)24-17(15-25)16-26/h4,7,12-13,17-22,25-29H,2-3,5-6,8-11,14-16H2,1H3,(H,24,30)/b7-4-,13-12+/t18-,19+,20+,21-,22+/m0/s1
SMILES (Click to copy)
[C@H]1(/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)NC(CO)CO

Other Databases

CHEBI ID
180456
PubChem CID
24778495
Cayman ID
10194

Calculated Physicochemical Properties

Heavy Atoms 30
Rings 1
Aromatic Rings 0
Rotatable Bonds 15
Van der Waals Molecular Volume 449.92
Topological Polar Surface Area 130.25
Hydrogen Bond Donors 6
Hydrogen Bond Acceptors 6
logP 3.14
Molar Refractivity 119.64

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Updated at
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