LIPID MAPS

Geranyl acetate is a monoterpene that has been found in C. sativa with diverse biological activities.¹ It reduces compound action potential (CAP) peak amplitude in isolated frog sciatic nerves (IC50 = 0.51 mM).² Geranyl acetate inhibits the radial growth of M. gypsum, T. vercossum, and C. tropicalis on solid media.³ It is sporicidal against B. subtilis when used at a concentration of 1% in an agar diffusion assay.⁴ Geranyl acetate inhibits growth of COLO 205 cells (IC50 = 30 μM) via induction of DNA damage, cell cycle arrest at the G2/M phase, and mitochondrial apoptosis.⁵

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References

1. Fischedick, J.T. Identification of terpenoid chemotypes among high (–)-trans-Δ9-tetrahydrocannabinol-producing Cannabis sativa L. cultivars. Cannabis Cannabinoid Res. 2(1), 34-47 (2017).

2. Ohtsubo, S., Fujita, T., Matsushita, A., et al. Inhibition of the compound action potentials of frog sciatic nerves by aroma oil compounds having various chemical structures. Pharmacol. Res. Perspect. 3(2), e00127 (2015).

3. Khayyat, S.A., and Sameeh, M.Y. Bioactive epoxides and hydroperoxides derived from naturally monoterpene geranyl acetate. Saudi Pharm. J. 26(1), 14-19 (2018).

4. Cho, W.-I., Cheigh, C.-I., Hwang, H.-J., et al. Sporicidal activities of various surfactant components against Bacillus subtilis spores. J. Food Prot. 78(6), 1221-1225 (2015).

5. Qi, F., Yan, Q., Zheng, Z., et al. Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest. J. BUON. 23(2), 346-352 (2018).