LIPID MAPS

Kaempferol is a flavonoid which is abundant in a variety of plant leaves and fruits. It has diverse physiological activities through both direct and indirect effects.^1,2 For example, kaempferol directly binds estrogen receptors α and β, acting as an inverse agonist or agonist.^3,4 It also acts as an antioxidant, which presumably contributes to its ability to suppress advanced glycation endproduct-induced NADPH oxidase, NF-κB signaling, and hypoxia-inducible factor-related angiogenesis and VEGF expression.^5,6 Kaempferol also suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.^7,8,2

This information has been provided by Cayman Chemical

References

1. Kumamoto, T., Fujii, M., and Hou, D.X. Myricetin directly targets JAK1 to inhibit cell transformation. Cancer Lett. 275(1), 17-26 (2009).

2. Aiyer, H.S., Warri, A.M., Woode, D.R., et al. Influence of berry polyphenols on receptor signaling and cell-death pathways: Implications for breast cancer prevention. J. Agric. Food Chem. 60(23), 5693-5708 (2012).

3. Wang, J., Fang, F., Huang, Z., et al. Kaempferol is an estrogen-related receptor α and γ inverse agonist. FEBS Lett. 583(4), 643-647 (2009).

4. Calderón-Montaño, J.M., Burgos-Morón, E., Pérez-Guerrero, C., et al. A review on the dietary flavonoid kaempferol. Mini Rev. Med. Chem. 11, 298-344 (2011).

5. Guo, A.J., Choi, R.C., Zheng, K.Y., et al. Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. Chin.Med. 7, 1-7 (2012).

6. Kim, J.M., Lee, E.K., Kim, D.H., et al. Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase. Age (Dordr) 32(2), 197-208 (2010).

7. Labbé, D., Provençal, M., Lamy, S., et al. The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration. J. Nutr. 139(4), 646-652 (2009).

8. Luo, H., Rankin, G.O., Liu, L., et al. Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutr. Cancer 61(4), 554-563 (2009).