Sennoside B is a glycoside that has been found in C. acutifolia and has laxative and gastroprotective activities.^1,2 It inhibits H+/K+-ATPase activity in isolated rat stomach mucosa and increases levels of prostaglandin E2 (PGE2) in AGS gastric cells when used at a concentration of 100 µM.² Sennoside B (100 mg/kg) increases the intestinal transport rate by 72.2% but has no effect on the gastric emptying rate in mice. It reduces lesion indices by 39.9 and 62.9% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcers, respectively, in rats when administered at a dose of 100 mg/kg. Formulations containing sennoside B have been used in the treatment of constipation.