Microarray analysis of bone marrow-derived macrophage cells treated with Kdo₂-lipid A (KLA) and ATP

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Heatmap of ATP/KLA timecourse data for lipid category ST (Ratio to control values)

Gene Time course graph Description Treatment 15min 30min 1min 2min 4min 8min 20min Ch25h KLA  ATP  ATP+KLA cholesterol 25-hydroxylase (Ch25h), mRNA [NM_009890] KLA 11.10 11.52 17.64 19.84 9.53 5.76 0.63   ATP 1.63 1.73 2.93 3.18 4.70 2.08 0.09   ATP+KLA 10.54 12.32 25.05 31.45 23.23 8.11 0.78 Cyp51 KLA  ATP  ATP+KLA cytochrome P450, family 51 (Cyp51), mRNA [NM_020010] KLA 1.05 1.08 1.11 0.93 0.82 0.50 0.52   ATP 1.01 1.07 1.27 1.22 0.98 0.75 1.09   ATP+KLA 1.06 1.10 1.09 1.03 0.72 0.44 0.39 Dhcr24 KLA  ATP  ATP+KLA 24-dehydrocholesterol reductase (Dhcr24), mRNA [NM_053272] KLA 0.50 0.50 0.43 0.41 0.34 0.28 0.36   ATP 1.09 1.12 1.01 1.08 0.72 0.43 1.04   ATP+KLA 0.51 0.54 0.46 0.54 0.33 0.21 0.18 Dhcr7 KLA  ATP  ATP+KLA 7-dehydrocholesterol reductase (Dhcr7), mRNA [NM_007856] KLA 0.57 0.54 0.52 0.48 0.39 0.47 0.70   ATP 1.00 1.08 1.17 1.19 0.70 0.39 0.74   ATP+KLA 0.58 0.56 0.57 0.64 0.47 0.45 0.32 Ebp KLA  ATP  ATP+KLA phenylalkylamine Ca2+ antagonist (emopamil) binding protein (Ebp), mRNA [NM_007898] KLA 0.77 0.75 0.66 0.77 0.61 0.71 0.67   ATP 0.83 0.83 1.15 0.99 0.88 0.83 0.95   ATP+KLA 0.67 0.72 0.95 0.79 0.86 0.75 0.74 Fdft1 KLA  ATP  ATP+KLA farnesyl diphosphate farnesyl transferase 1 (Fdft1), mRNA [NM_010191] KLA 0.96 0.98 0.97 0.99 0.88 0.78 0.77   ATP 1.00 1.01 1.08 1.10 0.93 1.02 1.28   ATP+KLA 0.98 0.97 0.98 1.04 0.97 0.87 0.73 Fdps KLA  ATP  ATP+KLA 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030492I17 product:farnesyl diphosphate synthetase, full insert sequence. [AK077979] KLA 0.76 0.79 0.79 0.69 0.65 0.37 0.49   ATP 0.63 0.70 0.85 0.30 0.46 0.89 0.86   ATP+KLA 0.54 0.52 0.63 0.39 0.42 0.40 0.31 Fdps KLA  ATP  ATP+KLA farnesyl diphosphate synthetase (Fdps), mRNA [NM_134469] KLA 0.87 0.93 0.89 0.97 0.76 0.43 0.48   ATP 1.12 1.10 1.05 1.23 1.05 0.60 0.88   ATP+KLA 0.93 0.99 1.00 1.02 0.70 0.45 0.33 Ggps1 KLA  ATP  ATP+KLA adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330064P13 product:geranylgeranyl diphosphate synthase 1, full insert sequence [AK138564] KLA 1.17 1.19 1.22 1.09 1.12 1.25 1.22   ATP 1.02 1.06 0.90 0.91 1.06 1.11 0.92   ATP+KLA 1.23 1.10 1.10 1.19 1.22 1.09 0.89 Ggps1 KLA  ATP  ATP+KLA geranylgeranyl diphosphate synthase 1 (Ggps1), mRNA [NM_010282] KLA 1.17 1.17 1.29 1.28 1.22 1.57 1.73   ATP 0.88 0.84 0.98 0.85 0.96 2.02 2.04   ATP+KLA 1.08 1.09 1.33 1.11 1.23 1.95 2.71 Hmgcr KLA  ATP  ATP+KLA 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), mRNA [NM_008255] KLA 2.15 2.09 2.02 1.44 1.13 0.88 1.02   ATP 1.05 1.16 1.43 1.53 1.83 2.60 1.87   ATP+KLA 2.16 2.23 1.99 1.81 1.34 1.81 1.78 Hmgcs2 KLA  ATP  ATP+KLA 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256] KLA 0.92 1.10 1.00 0.99 1.08 1.06 1.14   ATP 0.99 1.02 1.00 1.00 0.98 1.08 0.92   ATP+KLA 0.99 1.00 1.00 1.03 1.28 1.06 1.00 Hsd17b7 KLA  ATP  ATP+KLA hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7), mRNA [NM_010476] KLA 0.87 0.86 0.78 0.84 0.86 0.76 0.77   ATP 1.05 0.94 1.22 0.86 0.69 0.67 1.48   ATP+KLA 0.88 0.76 0.91 0.69 0.53 0.34 0.36 Idi1 KLA  ATP  ATP+KLA isopentenyl-diphosphate delta isomerase (Idi1), transcript variant 2, mRNA [NM_177960] KLA 1.43 1.49 1.51 1.22 0.89 0.45 0.52   ATP 1.01 1.06 1.43 1.31 0.85 0.62 1.15   ATP+KLA 1.36 1.35 1.52 1.45 0.84 0.35 0.32 Lss KLA  ATP  ATP+KLA adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1106O04 product:lanosterol synthase, full insert sequence [AK147680] KLA 0.52 0.46 0.46 0.47 0.49 0.43 0.44   ATP 0.93 0.92 1.44 0.97 0.55 0.39 0.46   ATP+KLA 0.46 0.45 0.56 0.47 0.44 0.32 0.15 Lss KLA  ATP  ATP+KLA lanosterol synthase (Lss), mRNA [NM_146006] KLA 0.77 0.80 0.87 0.80 0.90 0.69 0.80   ATP 1.04 1.08 1.03 1.18 0.73 0.67 1.62   ATP+KLA 0.79 0.89 0.86 0.88 0.56 0.46 0.42 Mvd KLA  ATP  ATP+KLA mevalonate (diphospho) decarboxylase (Mvd), mRNA [NM_138656] KLA 0.53 0.53 0.53 0.53 0.54 0.48 0.81   ATP 0.95 0.97 1.05 1.29 1.06 0.87 1.80   ATP+KLA 0.54 0.57 0.60 0.73 0.77 0.56 0.47 Mvk KLA  ATP  ATP+KLA mevalonate kinase (Mvk), mRNA [NM_023556] KLA 0.87 0.90 0.89 0.91 0.90 0.94 0.98   ATP 0.91 0.79 0.56 0.58 0.35 0.47 1.40   ATP+KLA 0.89 0.73 0.56 0.60 0.42 0.42 0.65 Nsdhl KLA  ATP  ATP+KLA activated spleen cDNA, RIKEN full-length enriched library, clone:F830111P16 product:unclassifiable, full insert sequence [AK156993] KLA 1.05 0.94 0.94 0.88 1.08 0.85 0.76   ATP 1.14 1.03 1.03 0.75 0.74 0.92 1.02   ATP+KLA 1.04 0.98 0.92 0.70 0.84 0.70 0.76 Nsdhl KLA  ATP  ATP+KLA NAD(P) dependent steroid dehydrogenase-like (Nsdhl), mRNA [NM_010941] KLA 0.98 1.05 1.03 0.95 0.97 0.87 0.89   ATP 1.02 1.16 1.11 1.33 0.91 0.57 1.05   ATP+KLA 1.08 1.02 0.86 1.20 0.77 0.58 0.47 Pmvk KLA  ATP  ATP+KLA phosphomevalonate kinase (Pmvk), mRNA [NM_026784] KLA 0.89 0.91 0.96 0.99 0.92 0.78 0.88   ATP 1.12 0.97 1.07 1.10 0.70 0.51 1.19   ATP+KLA 0.94 0.94 1.05 0.91 0.80 0.44 0.53 Sc4mol KLA  ATP  ATP+KLA sterol-C4-methyl oxidase-like (Sc4mol), mRNA [NM_025436] KLA 0.43 0.37 0.41 0.44 0.44 0.41 0.54   ATP 0.95 0.92 1.30 0.92 0.70 0.47 1.36   ATP+KLA 0.41 0.37 0.45 0.38 0.35 0.23 0.37 Sc5d KLA  ATP  ATP+KLA 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830073K23 product:unclassifiable, full insert sequence [AK080673] KLA 0.62 0.56 0.53 0.46 0.38 0.29 0.35   ATP 0.87 0.91 1.37 0.86 0.56 0.43 0.33   ATP+KLA 0.54 0.49 0.72 0.72 0.72 0.39 0.20 Sc5d KLA  ATP  ATP+KLA sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) (Sc5d), mRNA [NM_172769] KLA 1.18 1.19 1.17 1.08 0.94 0.63 0.70   ATP 0.99 1.00 1.31 1.09 0.83 1.04 1.51   ATP+KLA 1.08 1.07 1.29 1.20 1.04 0.88 0.76 Soat1 KLA  ATP  ATP+KLA sterol O-acyltransferase 1 (Soat1), mRNA [NM_009230] KLA 0.68 0.68 0.62 0.63 0.59 0.84 1.33   ATP 1.06 1.16 1.02 1.10 0.92 0.79 1.51   ATP+KLA 0.72 0.71 0.57 0.72 0.64 0.66 1.29 Soat2 KLA  ATP  ATP+KLA sterol O-acyltransferase 2 (Soat2), mRNA [NM_146064] KLA 1.03 0.91 1.03 1.07 1.52 1.83 2.92   ATP 0.97 0.99 1.06 0.84 0.81 0.93 2.17   ATP+KLA 0.99 0.93 1.01 0.94 0.94 1.07 2.74 Sqle KLA  ATP  ATP+KLA squalene epoxidase (Sqle), mRNA [NM_009270] KLA 0.41 0.38 0.35 0.27 0.26 0.24 0.42   ATP 1.00 1.02 1.10 0.92 0.83 0.65 1.37   ATP+KLA 0.43 0.42 0.32 0.31 0.26 0.23 0.31 Tm7sf2 KLA  ATP  ATP+KLA transmembrane 7 superfamily member 2 (Tm7sf2), mRNA [NM_028454] KLA 0.93 0.90 0.79 0.88 0.63 0.52 0.33   ATP 0.84 0.94 0.97 1.03 0.76 0.60 0.51   ATP+KLA 0.82 0.94 0.90 0.95 0.67 0.47 0.27