Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Pentose and glucuronate interconversions (mmu00040)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2310005E
10Rik
KLA  ATP  ATP+KLA
 BC026843 RIKEN cDNA 2310005E10 gene, mRNA (cDNA clone IMAGE:4487182), complete cds. [BC026843] KLA .70 .65 .65 .65 .83 .90 .89
ATP 1.00 .95 .75 .31 .29 .58 .80
KLA/ATP .69 .54 .49 .28 .36 .56 .53
2310005E
10Rik
KLA  ATP  ATP+KLA
 NM_172398 RIKEN cDNA 2310005E10 gene (2310005E10Rik), mRNA [NM_172398] KLA .78 .71 .71 .71 .69 .90 .82
ATP 1.01 .95 1.18 .89 .68 .44 .62
KLA/ATP .71 .70 .88 .67 .60 .59 .63
AK077927
KLA  ATP  ATP+KLA
 AK077927 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030447B09 product:unclassifiable, full insert sequence. [AK077927] KLA 3.15 2.64 2.14 1.56 1.86 1.87 1.23
ATP .91 .63 .45 .45 1.18 1.41 .90
KLA/ATP 2.53 2.04 1.88 .94 1.59 1.96 1.21
Akr1b3
KLA  ATP  ATP+KLA
 AK054167 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230024H01 product:unclassifiable, full insert sequence [AK054167] KLA 1.06 .92 .98 1.01 1.02 1.04 .96
ATP 1.08 1.02 .99 .97 1.09 1.02 .99
KLA/ATP .99 1.01 .97 .99 1.02 .99 1.08
Akr1b3
KLA  ATP  ATP+KLA
 NM_009658 aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3), mRNA [NM_009658] KLA .97 .99 .96 .91 .92 .93 .77
ATP 1.08 1.13 1.09 1.15 1.00 1.03 1.18
KLA/ATP 1.06 .98 .95 1.15 .89 .88 .82
Akr1b7
KLA  ATP  ATP+KLA
 NM_009731 aldo-keto reductase family 1, member B7 (Akr1b7), mRNA [NM_009731] KLA .92 .93 .93 .93 .97 .96 .84
ATP .97 1.01 .93 .88 .85 .95 .88
KLA/ATP .86 .92 .92 .82 .85 .94 1.02
Akr1b8
KLA  ATP  ATP+KLA
 NM_008012 aldo-keto reductase family 1, member B8 (Akr1b8), mRNA [NM_008012] KLA .64 .56 .49 .46 .31 .25 .25
ATP .95 .97 1.17 .90 .85 2.25 2.02
KLA/ATP .55 .53 .63 .47 .50 1.00 2.18
Aldh1b1
KLA  ATP  ATP+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA 7.51 7.83 9.27 11.57 11.10 10.78 4.79
ATP .93 .91 .90 .89 .73 2.27 2.30
KLA/ATP 6.45 7.40 9.33 9.54 8.82 12.15 10.67
Aldh2
KLA  ATP  ATP+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA .62 .65 .59 .60 .63 .64 .49
ATP 1.01 .91 1.06 .93 1.18 .93 .41
KLA/ATP .70 .68 .70 .84 1.16 .96 .45
Aldh2
KLA  ATP  ATP+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA .74 .81 .77 .65 .60 .53 .50
ATP .98 1.10 .90 1.17 1.04 .82 .60
KLA/ATP .84 .86 .77 .82 .72 .66 .51
Aldh3a2
KLA  ATP  ATP+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA .86 .83 .79 .79 .80 .97 1.00
ATP .93 .98 .94 .89 .77 .87 1.02
KLA/ATP .78 .81 .67 .72 .65 .81 .97
Cryl1
KLA  ATP  ATP+KLA
 AK020717 adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230106J09 product:crystallin, lamda 1, full insert sequence. [AK020717] KLA .45 .49 .55 .54 .60 .51 .76
ATP .89 .88 .99 .73 .60 .51 .87
KLA/ATP .45 .48 .62 .57 .61 .45 .72
Cryl1
KLA  ATP  ATP+KLA
 NM_030004 crystallin, lambda 1 (Cryl1), mRNA [NM_030004] KLA .79 .72 .81 .65 .59 .40 .39
ATP 1.13 1.20 1.20 1.36 1.02 .41 .39
KLA/ATP .88 .87 .87 .99 .73 .46 .24
Dcxr
KLA  ATP  ATP+KLA
 AK161732 adult male thymus cDNA, RIKEN full-length enriched library, clone:5830431D24 product:dicarbonyl L-xylulose reductase, full insert sequence [AK161732] KLA .98 .92 1.04 1.10 1.00 .86 .81
ATP .94 .87 1.16 .99 .91 .72 .93
KLA/ATP .92 .86 1.14 .92 .91 .73 .80
Dcxr
KLA  ATP  ATP+KLA
 NM_026428 dicarbonyl L-xylulose reductase (Dcxr), mRNA [NM_026428] KLA 1.10 1.11 1.23 1.31 1.68 1.35 .62
ATP 1.17 1.23 1.04 1.66 1.10 .59 .64
KLA/ATP 1.23 1.19 .99 1.74 1.06 .87 .82
Dhdh
KLA  ATP  ATP+KLA
 AK032449 adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430549D12 product:unclassifiable, full insert sequence. [AK032449] KLA 1.00 1.00 .97 1.01 1.00 .98 1.02
ATP 1.00 .97 .97 1.00 .96 1.05 1.00
KLA/ATP .99 .97 .97 1.03 1.06 1.03 1.04
Gusb
KLA  ATP  ATP+KLA
 NM_010368 glucuronidase, beta (Gusb), mRNA [NM_010368] KLA .65 .67 .62 .52 .52 .47 .52
ATP 1.07 1.11 .95 1.00 .80 .57 .58
KLA/ATP .72 .71 .56 .62 .52 .48 .38
Kl
KLA  ATP  ATP+KLA
 AB010088 mRNA for secreted isoform of Klotho protein, complete cds [AB010088] KLA 1.02 1.00 1.01 .97 1.02 1.04 1.01
ATP 1.03 1.03 .99 1.00 .99 .97 1.01
KLA/ATP 1.03 .93 .98 .87 .96 .92 .93
Kl
KLA  ATP  ATP+KLA
 NM_013823 klotho (Kl), mRNA [NM_013823] KLA .97 .96 1.08 .95 1.01 .95 1.05
ATP .96 1.07 1.02 1.06 1.05 1.00 1.02
KLA/ATP .95 1.02 1.04 1.04 1.11 1.01 .96
Mm.30009
5
KLA  ATP  ATP+KLA
 145699117 Unknown KLA .70 .74 .85 .84 .90 .85 .90
ATP .83 .77 .93 .98 1.05 1.04 .86
KLA/ATP .72 .70 .86 .97 1.13 .80 .83
Mm.43974
2
KLA  ATP  ATP+KLA
 146141192 Unknown KLA .91 .94 .90 .87 .84 .74 .90
ATP 1.10 1.14 1.00 1.00 .81 .66 .80
KLA/ATP .92 .90 .77 .87 .67 .70 .67
Mm.46685
9
KLA  ATP  ATP+KLA
 145699102 Unknown KLA .65 .64 .75 .87 .83 .79 .82
ATP .80 .77 .97 .86 1.13 1.05 .85
KLA/ATP .64 .65 .85 .86 1.16 .69 .72
Rpe
KLA  ATP  ATP+KLA
 NM_025683 ribulose-5-phosphate-3-epimerase (Rpe), mRNA [NM_025683] KLA 2.06 2.10 2.39 2.33 2.29 2.01 1.45
ATP 1.01 1.14 1.25 1.29 .90 .80 .89
KLA/ATP 1.87 2.38 2.22 2.33 1.57 1.08 1.10
Ugdh
KLA  ATP  ATP+KLA
 NM_009466 UDP-glucose dehydrogenase (Ugdh), mRNA [NM_009466] KLA 1.04 1.06 .96 .95 1.09 1.54 1.30
ATP .99 1.06 .89 .91 1.31 3.29 1.49
KLA/ATP 1.04 .98 .73 .85 1.38 2.91 1.59
Ugp2
KLA  ATP  ATP+KLA
 NM_139297 UDP-glucose pyrophosphorylase 2 (Ugp2), mRNA [NM_139297] KLA .94 1.01 .95 .96 .88 1.01 1.02
ATP .97 .98 1.03 .92 .94 1.19 .82
KLA/ATP .93 .94 .85 .78 .82 1.20 .96
Ugt1a1
KLA  ATP  ATP+KLA
 NM_201645 UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1), mRNA [NM_201645] KLA .95 1.07 1.00 .99 .97 .98 1.02
ATP 1.08 .95 1.02 1.04 1.08 1.03 1.01
KLA/ATP 1.02 .95 .93 1.01 1.01 1.11 1.06
Ugt1a6b
KLA  ATP  ATP+KLA
 NM_201410 UDP glucuronosyltransferase 1 family, polypeptide A6B (Ugt1a6b), mRNA [NM_201410] KLA .89 .86 .93 .93 .89 .86 .89
ATP 1.10 1.05 1.15 1.07 1.01 .99 1.24
KLA/ATP .90 .94 1.02 .89 .87 .81 .92
Ugt1a9
KLA  ATP  ATP+KLA
 NM_201644 UDP glucuronosyltransferase 1 family, polypeptide A9 (Ugt1a9), mRNA [NM_201644] KLA 1.07 .96 .98 1.09 1.03 1.06 1.08
ATP 1.04 .94 1.01 1.07 1.05 1.02 1.06
KLA/ATP 1.05 1.00 .94 1.01 1.03 1.04 1.00
Ugt2a1
KLA  ATP  ATP+KLA
 NM_053184 UDP glucuronosyltransferase 2 family, polypeptide A1 (Ugt2a1), mRNA [NM_053184] KLA 1.01 1.03 .99 .99 .99 1.01 1.02
ATP 1.01 .93 1.04 1.03 1.02 1.01 1.03
KLA/ATP 1.04 1.01 1.01 1.02 1.01 1.02 1.00
Ugt2a3
KLA  ATP  ATP+KLA
 NM_028094 UDP glucuronosyltransferase 2 family, polypeptide A3 (Ugt2a3), mRNA [NM_028094] KLA 1.07 1.01 .97 1.05 1.01 .98 .99
ATP .98 .96 1.04 1.06 .95 .94 1.01
KLA/ATP 1.02 1.00 .94 1.02 1.02 1.01 1.06
Ugt2b1
KLA  ATP  ATP+KLA
 NM_152811 UDP glucuronosyltransferase 2 family, polypeptide B1 (Ugt2b1), mRNA [NM_152811] KLA 1.08 1.01 .95 1.08 1.00 1.04 .97
ATP 1.03 1.14 1.01 1.00 1.01 1.05 1.13
KLA/ATP 1.05 .99 1.06 .98 1.03 .96 .98
Ugt2b34
KLA  ATP  ATP+KLA
 NM_153598 UDP glucuronosyltransferase 2 family, polypeptide B34 (Ugt2b34), mRNA [NM_153598] KLA .98 1.08 .99 1.06 .97 1.05 1.03
ATP 1.06 1.04 .96 1.01 1.03 1.01 .99
KLA/ATP 1.09 .94 1.00 1.07 1.01 1.03 .97
Ugt2b35
KLA  ATP  ATP+KLA
 NM_172881 UDP glucuronosyltransferase 2 family, polypeptide B35 (Ugt2b35), mRNA [NM_172881] KLA .99 1.02 .99 1.01 1.00 .96 1.01
ATP .96 1.02 1.02 .96 .93 1.00 1.02
KLA/ATP 1.01 .99 1.04 1.00 .97 .93 .97
Ugt2b36
KLA  ATP  ATP+KLA
 NM_001029867 UDP glucuronosyltransferase 2 family, polypeptide B36 (Ugt2b36), mRNA [NM_001029867] KLA .95 .95 1.00 1.00 1.03 1.02 .92
ATP 1.02 1.07 1.03 .95 1.01 .93 1.00
KLA/ATP .99 1.05 .98 1.04 1.02 .98 .99
Ugt2b37
KLA  ATP  ATP+KLA
 NM_053215 UDP glucuronosyltransferase 2 family, polypeptide B37 (Ugt2b37), mRNA [NM_053215] KLA 1.02 1.06 1.04 1.05 1.00 1.05 1.03
ATP 1.01 1.03 1.08 1.01 1.05 1.02 1.05
KLA/ATP 1.01 .99 1.11 1.14 1.04 1.08 1.05
Ugt2b38
KLA  ATP  ATP+KLA
 NM_133894 UDP glucuronosyltransferase 2 family, polypeptide B38 (Ugt2b38), mRNA [NM_133894] KLA 1.00 .96 1.04 .99 1.10 .97 .99
ATP 1.02 1.04 1.03 .94 .96 .93 .99
KLA/ATP .98 .97 1.00 .97 .98 1.04 1.02
Ugt2b5
KLA  ATP  ATP+KLA
 NM_009467 UDP glucuronosyltransferase 2 family, polypeptide B5 (Ugt2b5), mRNA [NM_009467] KLA 1.01 .99 1.09 .96 .97 .99 1.01
ATP 1.03 1.02 1.02 1.01 .97 .90 .94
KLA/ATP .99 .99 .98 1.05 1.01 .93 .95
Xylb
KLA  ATP  ATP+KLA
 BC026406 xylulokinase homolog (H. influenzae), mRNA (cDNA clone IMAGE:4211747), partial cds. [BC026406] KLA .73 .71 .74 .69 .65 .60 .85
ATP .99 .99 1.00 1.04 .80 .73 .99
KLA/ATP .68 .75 .77 .91 .91 .78 .63
Xylb
KLA  ATP  ATP+KLA
 NM_001033209 xylulokinase homolog (H. influenzae) (Xylb), mRNA [NM_001033209] KLA .68 .61 .65 .60 .48 .48 .68
ATP 1.08 .93 1.29 1.02 .83 .72 .97
KLA/ATP .66 .61 .87 .82 1.07 .66 .57