Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Fructose and mannose metabolism (mmu00051)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2310005E
10Rik
KLA  ATP  ATP+KLA
 BC026843 RIKEN cDNA 2310005E10 gene, mRNA (cDNA clone IMAGE:4487182), complete cds. [BC026843] KLA .70 .65 .65 .65 .83 .90 .89
ATP 1.00 .95 .75 .31 .29 .58 .80
KLA/ATP .69 .54 .49 .28 .36 .56 .53
2310005E
10Rik
KLA  ATP  ATP+KLA
 NM_172398 RIKEN cDNA 2310005E10 gene (2310005E10Rik), mRNA [NM_172398] KLA .78 .71 .71 .71 .69 .90 .82
ATP 1.01 .95 1.18 .89 .68 .44 .62
KLA/ATP .71 .70 .88 .67 .60 .59 .63
9630033F
20Rik
KLA  ATP  ATP+KLA
 NM_177003 RIKEN cDNA 9630033F20 gene (9630033F20Rik), mRNA [NM_177003] KLA 1.09 .99 1.00 1.01 .94 .96 1.14
ATP 1.03 1.07 1.02 .91 .71 .95 1.09
KLA/ATP 1.11 1.08 1.02 .95 .76 .85 .91
Akr1b3
KLA  ATP  ATP+KLA
 AK054167 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230024H01 product:unclassifiable, full insert sequence [AK054167] KLA 1.06 .92 .98 1.01 1.02 1.04 .96
ATP 1.08 1.02 .99 .97 1.09 1.02 .99
KLA/ATP .99 1.01 .97 .99 1.02 .99 1.08
Akr1b3
KLA  ATP  ATP+KLA
 NM_009658 aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3), mRNA [NM_009658] KLA .97 .99 .96 .91 .92 .93 .77
ATP 1.08 1.13 1.09 1.15 1.00 1.03 1.18
KLA/ATP 1.06 .98 .95 1.15 .89 .88 .82
Akr1b7
KLA  ATP  ATP+KLA
 NM_009731 aldo-keto reductase family 1, member B7 (Akr1b7), mRNA [NM_009731] KLA .92 .93 .93 .93 .97 .96 .84
ATP .97 1.01 .93 .88 .85 .95 .88
KLA/ATP .86 .92 .92 .82 .85 .94 1.02
Akr1b8
KLA  ATP  ATP+KLA
 NM_008012 aldo-keto reductase family 1, member B8 (Akr1b8), mRNA [NM_008012] KLA .64 .56 .49 .46 .31 .25 .25
ATP .95 .97 1.17 .90 .85 2.25 2.02
KLA/ATP .55 .53 .63 .47 .50 1.00 2.18
Aldoa
KLA  ATP  ATP+KLA
 NM_007438 aldolase 1, A isoform (Aldoa), mRNA [NM_007438] KLA .81 .83 .75 .81 .83 .80 1.22
ATP .97 .93 .78 .78 1.01 1.14 1.35
KLA/ATP .80 .86 .84 .70 .80 .81 1.12
Aldoart1
KLA  ATP  ATP+KLA
 AK016845 adult male testis cDNA, RIKEN full-length enriched library, clone:4933417I20 product:ALDOLASE 1, A ISOFORM homolog [Mus musculus], full insert sequence [AK016845] KLA 1.01 1.01 1.03 .98 .95 .96 1.03
ATP 1.00 1.01 .98 .90 .99 1.03 .91
KLA/ATP .97 1.01 1.04 .99 1.07 1.00 .98
Aldob
KLA  ATP  ATP+KLA
 NM_144903 aldolase 2, B isoform (Aldob), mRNA [NM_144903] KLA .99 1.01 1.02 1.02 1.02 1.03 1.04
ATP 1.02 1.02 1.00 1.05 1.02 1.02 1.01
KLA/ATP 1.01 1.04 1.00 1.03 1.03 1.02 .97
Aldoc
KLA  ATP  ATP+KLA
 AK039267 adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330009L16 product:aldolase 3, C isoform, full insert sequence [AK039267] KLA .84 .77 .75 .78 .51 .34 .14
ATP .86 .84 1.15 1.01 .85 .60 .33
KLA/ATP .71 .78 .94 .76 .60 .34 .14
Aldoc
KLA  ATP  ATP+KLA
 NM_009657 aldolase 3, C isoform (Aldoc), mRNA [NM_009657] KLA .88 .94 .93 .76 .72 .46 .16
ATP 1.02 1.17 1.00 1.29 1.00 .62 .76
KLA/ATP .99 1.00 .82 1.04 .71 .46 .18
Fbp1
KLA  ATP  ATP+KLA
 NM_019395 fructose bisphosphatase 1 (Fbp1), mRNA [NM_019395] KLA .91 .95 1.03 1.01 1.00 1.02 .80
ATP .96 .96 .99 .95 .86 .84 .64
KLA/ATP .88 .96 .87 .92 .92 .84 .70
Fbp2
KLA  ATP  ATP+KLA
 NM_007994 fructose bisphosphatase 2 (Fbp2), mRNA [NM_007994] KLA 1.03 1.03 .95 1.02 1.02 1.03 1.06
ATP 1.03 1.03 1.05 1.01 .97 1.01 1.17
KLA/ATP .96 .92 1.06 .85 1.07 .97 1.12
Fpgt
KLA  ATP  ATP+KLA
 AK030969 adult male thymus cDNA, RIKEN full-length enriched library, clone:5830472G17 product:unclassifiable, full insert sequence. [AK030969] KLA .98 1.01 1.03 1.02 .99 .99 1.07
ATP 1.04 .96 .98 .98 .99 1.02 .99
KLA/ATP 1.03 .94 .87 1.01 1.02 1.01 1.03
Fpgt
KLA  ATP  ATP+KLA
 NM_029330 fucose-1-phosphate guanylyltransferase (Fpgt), mRNA [NM_029330] KLA 1.06 1.10 1.12 1.10 1.13 1.14 1.23
ATP .99 .98 .91 .84 1.02 1.31 1.51
KLA/ATP 1.05 1.02 .93 .87 .99 1.52 1.55
Fuk
KLA  ATP  ATP+KLA
 NM_172283 fucokinase (Fuk), transcript variant 1, mRNA [NM_172283] KLA .74 .78 .76 .78 .75 .87 .85
ATP .91 .92 1.22 .75 .54 1.26 1.16
KLA/ATP .73 .74 .95 .64 .72 1.37 1.01
Gmds
KLA  ATP  ATP+KLA
 NM_146041 GDP-mannose 4, 6-dehydratase (Gmds), mRNA [NM_146041] KLA 1.08 1.19 1.08 1.00 .87 .56 .41
ATP .97 1.07 1.05 1.30 1.03 .55 .37
KLA/ATP 1.18 1.12 .98 1.11 .75 .53 .27
Gmppa
KLA  ATP  ATP+KLA
 NM_133708 GDP-mannose pyrophosphorylase A (Gmppa), mRNA [NM_133708] KLA 1.03 1.04 1.03 .92 1.02 1.04 1.35
ATP 1.05 1.17 .81 1.16 .73 .59 1.61
KLA/ATP 1.19 1.16 .74 1.16 .72 .72 1.46
Gmppb
KLA  ATP  ATP+KLA
 NM_177910 GDP-mannose pyrophosphorylase B (Gmppb), mRNA [NM_177910] KLA 2.41 2.66 2.76 3.33 3.47 3.38 1.74
ATP .91 .92 .78 .74 .43 1.76 2.06
KLA/ATP 2.31 2.72 2.59 2.32 1.87 2.93 2.37
Hk1
KLA  ATP  ATP+KLA
 J05277 gb|Mouse hexokinase mRNA, complete cds [J05277] KLA 1.49 1.45 1.66 1.78 1.51 1.29 .99
ATP 1.11 1.05 1.15 1.20 2.31 2.17 1.09
KLA/ATP 1.63 1.51 1.70 1.47 1.94 1.92 1.40
Hk1
KLA  ATP  ATP+KLA
 NM_010438 hexokinase 1 (Hk1), nuclear gene encoding mitochondrial protein, mRNA [NM_010438] KLA 1.58 1.75 2.05 1.84 1.96 1.67 1.31
ATP 1.06 1.25 1.01 1.49 2.23 1.79 1.20
KLA/ATP 1.87 1.96 1.51 1.93 1.71 1.94 1.72
Hk2
KLA  ATP  ATP+KLA
 NM_013820 hexokinase 2 (Hk2), mRNA [NM_013820] KLA 4.09 4.09 3.17 2.37 1.53 1.62 2.02
ATP .98 .92 1.08 2.24 3.82 3.86 .97
KLA/ATP 4.07 3.94 4.17 3.53 5.42 4.65 1.54
Hk3
KLA  ATP  ATP+KLA
 NM_001033245 hexokinase 3 (Hk3), nuclear gene encoding mitochondrial protein, mRNA [NM_001033245] KLA 1.52 1.68 1.94 1.85 2.21 2.89 1.98
ATP 1.01 1.07 .87 .99 1.01 1.26 2.62
KLA/ATP 1.63 1.74 1.67 1.69 1.44 2.01 3.53
Hkdc1
KLA  ATP  ATP+KLA
 NM_145419 hexokinase domain containing 1 (Hkdc1), mRNA [NM_145419] KLA 1.10 1.08 1.12 1.12 1.02 1.07 1.04
ATP .96 1.04 1.06 4.28 10.50 3.91 1.34
KLA/ATP .98 1.04 1.14 5.33 12.44 8.68 1.77
Khk
KLA  ATP  ATP+KLA
 NM_008439 ketohexokinase (Khk), mRNA [NM_008439] KLA .83 .86 .78 .75 .63 .49 .44
ATP .95 .97 1.06 1.25 1.05 .65 .50
KLA/ATP .84 .89 .92 1.03 .85 .57 .40
Mm.23951
KLA  ATP  ATP+KLA
 145864487 Unknown KLA .97 1.03 1.12 .96 1.08 .98 1.33
ATP 1.11 1.26 .84 1.26 .75 .60 1.62
KLA/ATP 1.27 1.25 .70 1.19 .72 .64 1.43
Mpi
KLA  ATP  ATP+KLA
 NM_025837 mannose phosphate isomerase (Mpi), mRNA [NM_025837] KLA 1.54 1.45 1.45 1.54 1.57 1.73 1.47
ATP 1.14 1.14 1.15 1.20 1.21 1.34 1.76
KLA/ATP 1.60 1.57 1.94 1.67 1.51 1.73 2.21
Mtmr1
KLA  ATP  ATP+KLA
 NM_016985 myotubularin related protein 1 (Mtmr1), mRNA [NM_016985] KLA 1.17 1.18 1.13 1.04 .86 .73 .89
ATP 1.04 1.10 1.02 1.01 .93 .77 .90
KLA/ATP 1.12 1.19 1.02 1.01 .73 .64 .71
Mtmr2
KLA  ATP  ATP+KLA
 NM_023858 myotubularin related protein 2 (Mtmr2), mRNA [NM_023858] KLA 1.17 1.22 1.25 1.17 1.15 1.27 1.35
ATP 1.02 1.17 1.07 1.14 .66 .78 1.08
KLA/ATP 1.20 1.20 .92 1.18 .62 .81 1.01
Mtmr6
KLA  ATP  ATP+KLA
 NM_144843 myotubularin related protein 6 (Mtmr6), mRNA [NM_144843] KLA 1.47 1.33 1.26 1.31 1.22 1.26 1.30
ATP .85 .89 .98 .75 .92 .95 1.04
KLA/ATP 1.24 1.23 1.18 .88 .86 .98 1.52
Mtmr7
KLA  ATP  ATP+KLA
 NM_001040699 myotubularin related protein 7 (Mtmr7), mRNA [NM_001040699] KLA 2.06 2.17 2.57 2.23 2.59 2.15 1.49
ATP 1.02 1.00 1.05 1.25 1.84 3.16 1.94
KLA/ATP 2.37 2.22 1.87 2.37 1.96 3.38 5.01
Pfkfb1
KLA  ATP  ATP+KLA
 NM_008824 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (Pfkfb1), mRNA [NM_008824] KLA .98 .94 .94 1.08 .86 .91 .96
ATP .94 .86 .86 .57 .49 .77 .56
KLA/ATP .96 .90 .87 .58 .62 .68 .63
Pfkfb2
KLA  ATP  ATP+KLA
 BC018418 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, mRNA (cDNA clone MGC:25723 IMAGE:3979400), complete cds. [BC018418] KLA .88 1.00 .92 .91 1.00 .99 1.01
ATP 1.13 1.04 .99 .92 .94 .95 1.37
KLA/ATP .86 .87 .88 .84 .90 .89 1.05
Pfkfb2
KLA  ATP  ATP+KLA
 NM_008825 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (Pfkfb2), mRNA [NM_008825] KLA .65 .68 .68 .67 .70 .79 .84
ATP .97 .99 1.01 .87 .68 .70 1.16
KLA/ATP .67 .69 .70 .67 .69 .65 .78
Pfkfb3
KLA  ATP  ATP+KLA
 NM_133232 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3), mRNA [NM_133232] KLA 7.38 8.57 9.97 10.42 11.55 7.07 6.18
ATP .99 1.07 1.47 3.74 5.65 9.34 2.84
KLA/ATP 7.53 8.77 9.99 13.46 15.00 19.74 21.11
Pfkfb4
KLA  ATP  ATP+KLA
 NM_173019 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (Pfkfb4), mRNA [NM_173019] KLA .27 .28 .28 .31 .58 .84 .74
ATP 1.00 .79 .91 .44 .57 1.19 1.01
KLA/ATP .29 .25 .30 .19 .31 .65 .88
Pfkl
KLA  ATP  ATP+KLA
 NM_008826 phosphofructokinase, liver, B-type (Pfkl), mRNA [NM_008826] KLA 1.19 1.33 1.34 1.23 1.57 1.49 2.02
ATP 1.17 1.34 1.04 1.45 .92 1.53 .97
KLA/ATP 1.54 1.64 1.36 1.91 1.17 .89 1.61
Pfkm
KLA  ATP  ATP+KLA
 NM_021514 phosphofructokinase, muscle (Pfkm), mRNA [NM_021514] KLA .73 .74 .70 .88 .80 .61 .55
ATP 1.09 1.05 1.01 1.06 .80 .50 .52
KLA/ATP .76 .83 .86 .75 .57 .57 .46
Pfkp
KLA  ATP  ATP+KLA
 BC050264 gb|Mus musculus, clone IMAGE:4503748, mRNA [BC050264] KLA 4.07 3.58 3.25 2.41 1.31 .76 .81
ATP 1.26 1.26 2.77 2.20 4.63 2.57 4.92
KLA/ATP 4.81 4.66 8.95 3.50 3.96 1.60 .91
Pfkp
KLA  ATP  ATP+KLA
 NM_019703 phosphofructokinase, platelet (Pfkp), mRNA [NM_019703] KLA 1.94 1.99 2.15 2.05 1.90 1.20 .85
ATP 1.08 1.05 1.18 1.20 1.40 1.38 .93
KLA/ATP 1.94 2.12 2.35 2.26 1.91 1.36 .88
Phpt1
KLA  ATP  ATP+KLA
 NM_029293 phosphohistidine phosphatase 1 (Phpt1), mRNA [NM_029293] KLA 1.09 1.01 .91 1.01 .87 .72 .61
ATP .96 1.04 1.17 1.38 1.21 .90 .46
KLA/ATP .95 1.06 1.25 1.40 1.11 .75 .35
Pmm1
KLA  ATP  ATP+KLA
 NM_013872 phosphomannomutase 1 (Pmm1), mRNA [NM_013872] KLA .55 .55 .47 .42 .36 .34 .70
ATP 1.03 1.07 1.03 1.09 .86 .49 .80
KLA/ATP .57 .56 .55 .54 .46 .36 .44
Pmm2
KLA  ATP  ATP+KLA
 NM_016881 phosphomannomutase 2 (Pmm2), mRNA [NM_016881] KLA 1.22 1.31 1.38 1.28 1.64 1.62 1.69
ATP 1.11 1.26 .84 1.15 .84 1.12 1.63
KLA/ATP 1.39 1.48 .86 1.51 .92 1.24 2.24
Sord
KLA  ATP  ATP+KLA
 NM_146126 sorbitol dehydrogenase (Sord), mRNA [NM_146126] KLA .59 .64 .61 .54 .45 .41 .37
ATP 1.09 1.19 .99 1.21 1.46 1.09 .74
KLA/ATP .69 .69 .59 .66 1.06 1.06 .47
Tpi1
KLA  ATP  ATP+KLA
 NM_009415 triosephosphate isomerase 1 (Tpi1), mRNA [NM_009415] KLA .70 .79 .73 .61 .66 .67 1.32
ATP 1.04 1.22 .90 1.30 .95 .86 1.24
KLA/ATP .84 .82 .55 .90 .66 .74 1.54
Tsta3
KLA  ATP  ATP+KLA
 NM_031201 tissue specific transplantation antigen P35B (Tsta3), mRNA [NM_031201] KLA 1.02 1.05 1.08 1.10 1.15 1.34 1.35
ATP .94 1.05 .99 1.14 .93 .96 1.14
KLA/ATP 1.09 1.11 1.02 1.21 1.08 1.13 1.51