Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Galactose metabolism (mmu00052)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2010204N
08Rik
KLA  ATP  ATP+KLA
 NM_001081137 RIKEN cDNA 2010204N08 gene (2010204N08Rik), mRNA [NM_001081137] KLA .99 .98 1.00 .96 .98 .98 .99
ATP .96 .98 1.06 1.14 .98 .97 .99
KLA/ATP .98 1.05 1.06 1.04 .99 .98 1.94
2310005E
10Rik
KLA  ATP  ATP+KLA
 BC026843 RIKEN cDNA 2310005E10 gene, mRNA (cDNA clone IMAGE:4487182), complete cds. [BC026843] KLA .70 .65 .65 .65 .83 .90 .89
ATP 1.00 .95 .75 .31 .29 .58 .80
KLA/ATP .69 .54 .49 .28 .36 .56 .53
2310005E
10Rik
KLA  ATP  ATP+KLA
 NM_172398 RIKEN cDNA 2310005E10 gene (2310005E10Rik), mRNA [NM_172398] KLA .78 .71 .71 .71 .69 .90 .82
ATP 1.01 .95 1.18 .89 .68 .44 .62
KLA/ATP .71 .70 .88 .67 .60 .59 .63
AK209324
KLA  ATP  ATP+KLA
 AK209324 cDNA, clone:Y2G0114L23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000060207, based on BLAT search. [AK209324] KLA .48 .51 .55 .57 .80 .90 1.17
ATP 1.01 .96 .73 .60 .76 .78 1.24
KLA/ATP .54 .46 .42 .54 .76 .76 .73
Akr1b3
KLA  ATP  ATP+KLA
 AK054167 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230024H01 product:unclassifiable, full insert sequence [AK054167] KLA 1.06 .92 .98 1.01 1.02 1.04 .96
ATP 1.08 1.02 .99 .97 1.09 1.02 .99
KLA/ATP .99 1.01 .97 .99 1.02 .99 1.08
Akr1b3
KLA  ATP  ATP+KLA
 NM_009658 aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3), mRNA [NM_009658] KLA .97 .99 .96 .91 .92 .93 .77
ATP 1.08 1.13 1.09 1.15 1.00 1.03 1.18
KLA/ATP 1.06 .98 .95 1.15 .89 .88 .82
Akr1b7
KLA  ATP  ATP+KLA
 NM_009731 aldo-keto reductase family 1, member B7 (Akr1b7), mRNA [NM_009731] KLA .92 .93 .93 .93 .97 .96 .84
ATP .97 1.01 .93 .88 .85 .95 .88
KLA/ATP .86 .92 .92 .82 .85 .94 1.02
Akr1b8
KLA  ATP  ATP+KLA
 NM_008012 aldo-keto reductase family 1, member B8 (Akr1b8), mRNA [NM_008012] KLA .64 .56 .49 .46 .31 .25 .25
ATP .95 .97 1.17 .90 .85 2.25 2.02
KLA/ATP .55 .53 .63 .47 .50 1.00 2.18
B4galt1
KLA  ATP  ATP+KLA
 NM_022305 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), mRNA [NM_022305] KLA .58 .56 .55 .59 .75 1.18 1.17
ATP 1.10 1.15 1.07 1.14 1.05 .71 1.11
KLA/ATP .60 .62 .62 .66 .74 .71 1.10
B4galt2
KLA  ATP  ATP+KLA
 NM_017377 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (B4galt2), mRNA [NM_017377] KLA 1.02 .98 .98 1.02 1.04 1.04 1.00
ATP .98 1.01 1.09 1.64 1.22 .96 .94
KLA/ATP .98 1.03 1.04 1.25 1.10 1.00 1.01
G6pc
KLA  ATP  ATP+KLA
 NM_008061 glucose-6-phosphatase, catalytic (G6pc), mRNA [NM_008061] KLA .96 .94 1.04 1.07 1.09 1.06 1.02
ATP .98 1.05 1.09 1.04 1.05 1.00 1.01
KLA/ATP 1.03 1.05 1.06 .96 1.02 1.00 .99
G6pc2
KLA  ATP  ATP+KLA
 NM_021331 glucose-6-phosphatase, catalytic, 2 (G6pc2), mRNA [NM_021331] KLA .99 1.03 1.00 .98 .95 1.02 .98
ATP .95 1.06 .97 1.08 1.16 1.26 1.04
KLA/ATP .94 .99 1.05 6.99 3.55 1.48 1.11
G6pc3
KLA  ATP  ATP+KLA
 NM_175935 glucose 6 phosphatase, catalytic, 3 (G6pc3), mRNA [NM_175935] KLA .88 .89 .89 .80 .75 .68 .88
ATP .99 1.05 .95 1.14 .92 .64 .81
KLA/ATP .92 .90 .79 .94 .70 .62 .58
Gaa
KLA  ATP  ATP+KLA
 NM_008064 glucosidase, alpha, acid (Gaa), mRNA [NM_008064] KLA .85 .84 .84 .78 .83 .87 1.18
ATP .97 .96 .75 .78 .74 .72 1.01
KLA/ATP .88 .91 .78 .78 .71 .71 .86
Gale
KLA  ATP  ATP+KLA
 NM_178389 galactose-4-epimerase, UDP (Gale), mRNA [NM_178389] KLA .74 .68 .72 .72 .67 .68 .54
ATP 1.13 .96 1.10 .91 .82 1.20 1.42
KLA/ATP .74 .69 .84 .71 .93 1.03 1.13
Galk1
KLA  ATP  ATP+KLA
 NM_016905 galactokinase 1 (Galk1), mRNA [NM_016905] KLA .85 .85 .76 .72 .63 .46 .50
ATP 1.02 1.07 1.02 1.33 1.01 .53 .62
KLA/ATP .90 .94 .87 1.00 .79 .50 .35
Galk2
KLA  ATP  ATP+KLA
 NM_175154 galactokinase 2 (Galk2), mRNA [NM_175154] KLA .86 .78 .66 .78 .65 .65 .67
ATP .96 .83 .79 .61 .54 .66 .95
KLA/ATP .62 .68 .67 .50 .42 .70 .94
Galt
KLA  ATP  ATP+KLA
 NM_016658 galactose-1-phosphate uridyl transferase (Galt), mRNA [NM_016658] KLA .63 .59 .54 .59 .57 .79 1.08
ATP .88 .77 .92 .79 .74 .88 .95
KLA/ATP .53 .53 .60 .49 .59 .80 1.10
Ganc
KLA  ATP  ATP+KLA
 NM_172672 glucosidase, alpha; neutral C (Ganc), mRNA [NM_172672] KLA 1.02 .97 1.02 1.00 1.00 .98 .98
ATP 1.06 1.04 1.03 1.00 .71 .71 1.05
KLA/ATP 1.02 1.09 1.18 .97 .83 .79 1.07
Gck
KLA  ATP  ATP+KLA
 NM_010292 glucokinase (Gck), mRNA [NM_010292] KLA 1.03 .99 1.04 1.02 .97 .98 1.00
ATP 1.01 .97 1.08 .99 1.06 .98 .96
KLA/ATP 1.06 1.01 .96 .98 .98 1.01 1.01
Gla
KLA  ATP  ATP+KLA
 NM_013463 galactosidase, alpha (Gla), mRNA [NM_013463] KLA .91 .95 1.02 .93 1.02 1.35 1.99
ATP 1.06 1.22 1.08 1.49 1.31 1.44 3.32
KLA/ATP 1.01 1.05 .89 1.54 1.26 1.98 5.13
Gla
KLA  ATP  ATP+KLA
 U34071 alpha-galactosidase A mRNA, complete cds. [U34071] KLA .99 .99 1.18 1.28 1.30 1.59 1.66
ATP 1.12 1.20 1.32 1.74 1.93 1.44 1.50
KLA/ATP 1.12 1.24 1.28 1.98 2.55 2.85 2.82
Glb1
KLA  ATP  ATP+KLA
 NM_009752 galactosidase, beta 1 (Glb1), mRNA [NM_009752] KLA .93 .96 1.02 .85 .86 .81 .80
ATP 1.03 1.10 1.01 1.13 .97 .82 .75
KLA/ATP 1.08 1.04 .86 1.06 .81 .81 .66
Hk1
KLA  ATP  ATP+KLA
 J05277 gb|Mouse hexokinase mRNA, complete cds [J05277] KLA 1.49 1.45 1.66 1.78 1.51 1.29 .99
ATP 1.11 1.05 1.15 1.20 2.31 2.17 1.09
KLA/ATP 1.63 1.51 1.70 1.47 1.94 1.92 1.40
Hk1
KLA  ATP  ATP+KLA
 NM_010438 hexokinase 1 (Hk1), nuclear gene encoding mitochondrial protein, mRNA [NM_010438] KLA 1.58 1.75 2.05 1.84 1.96 1.67 1.31
ATP 1.06 1.25 1.01 1.49 2.23 1.79 1.20
KLA/ATP 1.87 1.96 1.51 1.93 1.71 1.94 1.72
Hk2
KLA  ATP  ATP+KLA
 NM_013820 hexokinase 2 (Hk2), mRNA [NM_013820] KLA 4.09 4.09 3.17 2.37 1.53 1.62 2.02
ATP .98 .92 1.08 2.24 3.82 3.86 .97
KLA/ATP 4.07 3.94 4.17 3.53 5.42 4.65 1.54
Hk3
KLA  ATP  ATP+KLA
 NM_001033245 hexokinase 3 (Hk3), nuclear gene encoding mitochondrial protein, mRNA [NM_001033245] KLA 1.52 1.68 1.94 1.85 2.21 2.89 1.98
ATP 1.01 1.07 .87 .99 1.01 1.26 2.62
KLA/ATP 1.63 1.74 1.67 1.69 1.44 2.01 3.53
Hkdc1
KLA  ATP  ATP+KLA
 NM_145419 hexokinase domain containing 1 (Hkdc1), mRNA [NM_145419] KLA 1.10 1.08 1.12 1.12 1.02 1.07 1.04
ATP .96 1.04 1.06 4.28 10.50 3.91 1.34
KLA/ATP .98 1.04 1.14 5.33 12.44 8.68 1.77
Lalba
KLA  ATP  ATP+KLA
 NM_010679 lactalbumin, alpha (Lalba), mRNA [NM_010679] KLA 1.22 1.08 1.11 1.30 1.21 1.45 1.04
ATP .90 .93 1.44 1.16 1.30 1.43 1.24
KLA/ATP 1.10 1.20 1.71 1.50 1.52 1.69 1.47
Lct
KLA  ATP  ATP+KLA
 NM_001081078 lactase (Lct), mRNA [NM_001081078] KLA .93 .83 .71 .83 .89 .99 .84
ATP 1.03 .98 .86 .92 .82 .85 .85
KLA/ATP .80 .88 .75 .78 .89 .87 .86
Mgam
KLA  ATP  ATP+KLA
 AK033548 adult male colon cDNA, RIKEN full-length enriched library, clone:9030616M21 product:hypothetical protein, full insert sequence. [AK033548] KLA 1.16 1.20 1.22 1.21 1.01 1.02 1.07
ATP 1.01 1.01 1.11 2.86 5.71 5.58 1.53
KLA/ATP 1.24 1.24 1.29 1.64 3.84 3.69 1.98
Mgam
KLA  ATP  ATP+KLA
 XM_001481277 gb|PREDICTED: Mus musculus maltase-glucoamylase (Mgam), mRNA [XM_001481277] KLA 1.03 1.04 1.03 1.04 .95 .98 1.06
ATP 1.06 .94 1.05 1.42 2.38 2.12 1.16
KLA/ATP 1.10 1.06 1.06 1.15 1.52 1.64 1.20
Mm.26105
4
KLA  ATP  ATP+KLA
 124487274 Unknown KLA .95 1.04 .97 .98 1.01 .94 1.10
ATP 1.00 1.06 .94 1.07 1.01 1.00 .98
KLA/ATP 1.04 .99 .93 1.01 1.11 1.07 1.04
Mm.26930
KLA  ATP  ATP+KLA
 124487296 Unknown KLA 1.16 1.07 1.03 1.13 1.13 1.32 1.25
ATP .99 1.00 1.05 1.24 1.38 1.37 1.06
KLA/ATP 1.03 1.16 1.14 1.22 1.32 1.29 1.32
Mm.33401
KLA  ATP  ATP+KLA
 149255058 Unknown KLA 1.03 1.07 1.00 1.03 1.01 1.03 1.06
ATP 1.12 .98 1.12 1.36 2.32 2.03 1.10
KLA/ATP 1.03 1.00 .99 1.21 1.39 1.58 1.20
Pfkl
KLA  ATP  ATP+KLA
 NM_008826 phosphofructokinase, liver, B-type (Pfkl), mRNA [NM_008826] KLA 1.19 1.33 1.34 1.23 1.57 1.49 2.02
ATP 1.17 1.34 1.04 1.45 .92 1.53 .97
KLA/ATP 1.54 1.64 1.36 1.91 1.17 .89 1.61
Pfkm
KLA  ATP  ATP+KLA
 NM_021514 phosphofructokinase, muscle (Pfkm), mRNA [NM_021514] KLA .73 .74 .70 .88 .80 .61 .55
ATP 1.09 1.05 1.01 1.06 .80 .50 .52
KLA/ATP .76 .83 .86 .75 .57 .57 .46
Pfkp
KLA  ATP  ATP+KLA
 BC050264 gb|Mus musculus, clone IMAGE:4503748, mRNA [BC050264] KLA 4.07 3.58 3.25 2.41 1.31 .76 .81
ATP 1.26 1.26 2.77 2.20 4.63 2.57 4.92
KLA/ATP 4.81 4.66 8.95 3.50 3.96 1.60 .91
Pfkp
KLA  ATP  ATP+KLA
 NM_019703 phosphofructokinase, platelet (Pfkp), mRNA [NM_019703] KLA 1.94 1.99 2.15 2.05 1.90 1.20 .85
ATP 1.08 1.05 1.18 1.20 1.40 1.38 .93
KLA/ATP 1.94 2.12 2.35 2.26 1.91 1.36 .88
Pgm1
KLA  ATP  ATP+KLA
 NM_025700 phosphoglucomutase 1 (Pgm1), mRNA [NM_025700] KLA 1.08 1.03 .95 .75 .59 .55 .73
ATP 1.02 1.23 1.22 1.42 1.07 .75 1.01
KLA/ATP 1.01 1.10 .84 1.12 .69 .61 .51
Pgm2
KLA  ATP  ATP+KLA
 NM_028132 phosphoglucomutase 2 (Pgm2), mRNA [NM_028132] KLA 1.13 1.21 1.26 1.48 1.52 1.81 1.81
ATP .90 .92 1.07 .99 .80 1.60 1.17
KLA/ATP 1.01 1.16 1.40 1.25 1.48 1.99 1.94
Ugp2
KLA  ATP  ATP+KLA
 NM_139297 UDP-glucose pyrophosphorylase 2 (Ugp2), mRNA [NM_139297] KLA .94 1.01 .95 .96 .88 1.01 1.02
ATP .97 .98 1.03 .92 .94 1.19 .82
KLA/ATP .93 .94 .85 .78 .82 1.20 .96