Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Ascorbate and aldarate metabolism (mmu00053)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Aldh1b1
KLA  ATP  ATP+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA 7.51 7.83 9.27 11.57 11.10 10.78 4.79
ATP .93 .91 .90 .89 .73 2.27 2.30
KLA/ATP 6.45 7.40 9.33 9.54 8.82 12.15 10.67
Aldh2
KLA  ATP  ATP+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA .62 .65 .59 .60 .63 .64 .49
ATP 1.01 .91 1.06 .93 1.18 .93 .41
KLA/ATP .70 .68 .70 .84 1.16 .96 .45
Aldh2
KLA  ATP  ATP+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA .74 .81 .77 .65 .60 .53 .50
ATP .98 1.10 .90 1.17 1.04 .82 .60
KLA/ATP .84 .86 .77 .82 .72 .66 .51
Aldh3a2
KLA  ATP  ATP+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA .86 .83 .79 .79 .80 .97 1.00
ATP .93 .98 .94 .89 .77 .87 1.02
KLA/ATP .78 .81 .67 .72 .65 .81 .97
Aldh7a1
KLA  ATP  ATP+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA .98 1.03 1.08 1.12 1.08 .94 .99
ATP 1.01 1.03 1.00 1.03 .98 .82 .91
KLA/ATP 1.15 1.12 1.01 1.02 .90 .89 .83
Aldh9a1
KLA  ATP  ATP+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA .64 .64 .67 .48 .42 .24 .33
ATP 1.07 1.02 .75 .94 .68 .46 .42
KLA/ATP .72 .65 .43 .55 .37 .31 .24
Gulo
KLA  ATP  ATP+KLA
 NM_178747 gulonolactone (L-) oxidase (Gulo), mRNA [NM_178747] KLA 1.01 .97 1.03 1.04 1.01 .98 .99
ATP 1.00 .99 .99 .98 1.04 1.02 .98
KLA/ATP .97 .98 1.03 1.00 .98 .94 .97
Miox
KLA  ATP  ATP+KLA
 AF197127 unknown mRNA. [AF197127] KLA .99 1.00 1.02 1.01 1.08 1.11 .94
ATP .99 1.04 1.22 1.12 1.12 1.03 1.04
KLA/ATP 1.04 1.01 1.17 1.14 1.03 1.07 1.09
Mm.30009
5
KLA  ATP  ATP+KLA
 145699117 Unknown KLA .70 .74 .85 .84 .90 .85 .90
ATP .83 .77 .93 .98 1.05 1.04 .86
KLA/ATP .72 .70 .86 .97 1.13 .80 .83
Mm.46685
9
KLA  ATP  ATP+KLA
 145699102 Unknown KLA .65 .64 .75 .87 .83 .79 .82
ATP .80 .77 .97 .86 1.13 1.05 .85
KLA/ATP .64 .65 .85 .86 1.16 .69 .72
Rgn
KLA  ATP  ATP+KLA
 NM_009060 regucalcin (Rgn), mRNA [NM_009060] KLA .99 .94 .99 .93 .97 1.00 1.04
ATP .98 1.03 .95 .98 .95 .96 .91
KLA/ATP .93 1.03 1.01 .98 .94 .93 .94
Ugdh
KLA  ATP  ATP+KLA
 NM_009466 UDP-glucose dehydrogenase (Ugdh), mRNA [NM_009466] KLA 1.04 1.06 .96 .95 1.09 1.54 1.30
ATP .99 1.06 .89 .91 1.31 3.29 1.49
KLA/ATP 1.04 .98 .73 .85 1.38 2.91 1.59
Ugt1a1
KLA  ATP  ATP+KLA
 NM_201645 UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1), mRNA [NM_201645] KLA .95 1.07 1.00 .99 .97 .98 1.02
ATP 1.08 .95 1.02 1.04 1.08 1.03 1.01
KLA/ATP 1.02 .95 .93 1.01 1.01 1.11 1.06
Ugt1a6b
KLA  ATP  ATP+KLA
 NM_201410 UDP glucuronosyltransferase 1 family, polypeptide A6B (Ugt1a6b), mRNA [NM_201410] KLA .89 .86 .93 .93 .89 .86 .89
ATP 1.10 1.05 1.15 1.07 1.01 .99 1.24
KLA/ATP .90 .94 1.02 .89 .87 .81 .92
Ugt1a9
KLA  ATP  ATP+KLA
 NM_201644 UDP glucuronosyltransferase 1 family, polypeptide A9 (Ugt1a9), mRNA [NM_201644] KLA 1.07 .96 .98 1.09 1.03 1.06 1.08
ATP 1.04 .94 1.01 1.07 1.05 1.02 1.06
KLA/ATP 1.05 1.00 .94 1.01 1.03 1.04 1.00
Ugt2a1
KLA  ATP  ATP+KLA
 NM_053184 UDP glucuronosyltransferase 2 family, polypeptide A1 (Ugt2a1), mRNA [NM_053184] KLA 1.01 1.03 .99 .99 .99 1.01 1.02
ATP 1.01 .93 1.04 1.03 1.02 1.01 1.03
KLA/ATP 1.04 1.01 1.01 1.02 1.01 1.02 1.00
Ugt2a3
KLA  ATP  ATP+KLA
 NM_028094 UDP glucuronosyltransferase 2 family, polypeptide A3 (Ugt2a3), mRNA [NM_028094] KLA 1.07 1.01 .97 1.05 1.01 .98 .99
ATP .98 .96 1.04 1.06 .95 .94 1.01
KLA/ATP 1.02 1.00 .94 1.02 1.02 1.01 1.06
Ugt2b1
KLA  ATP  ATP+KLA
 NM_152811 UDP glucuronosyltransferase 2 family, polypeptide B1 (Ugt2b1), mRNA [NM_152811] KLA 1.08 1.01 .95 1.08 1.00 1.04 .97
ATP 1.03 1.14 1.01 1.00 1.01 1.05 1.13
KLA/ATP 1.05 .99 1.06 .98 1.03 .96 .98
Ugt2b34
KLA  ATP  ATP+KLA
 NM_153598 UDP glucuronosyltransferase 2 family, polypeptide B34 (Ugt2b34), mRNA [NM_153598] KLA .98 1.08 .99 1.06 .97 1.05 1.03
ATP 1.06 1.04 .96 1.01 1.03 1.01 .99
KLA/ATP 1.09 .94 1.00 1.07 1.01 1.03 .97
Ugt2b35
KLA  ATP  ATP+KLA
 NM_172881 UDP glucuronosyltransferase 2 family, polypeptide B35 (Ugt2b35), mRNA [NM_172881] KLA .99 1.02 .99 1.01 1.00 .96 1.01
ATP .96 1.02 1.02 .96 .93 1.00 1.02
KLA/ATP 1.01 .99 1.04 1.00 .97 .93 .97
Ugt2b36
KLA  ATP  ATP+KLA
 NM_001029867 UDP glucuronosyltransferase 2 family, polypeptide B36 (Ugt2b36), mRNA [NM_001029867] KLA .95 .95 1.00 1.00 1.03 1.02 .92
ATP 1.02 1.07 1.03 .95 1.01 .93 1.00
KLA/ATP .99 1.05 .98 1.04 1.02 .98 .99
Ugt2b37
KLA  ATP  ATP+KLA
 NM_053215 UDP glucuronosyltransferase 2 family, polypeptide B37 (Ugt2b37), mRNA [NM_053215] KLA 1.02 1.06 1.04 1.05 1.00 1.05 1.03
ATP 1.01 1.03 1.08 1.01 1.05 1.02 1.05
KLA/ATP 1.01 .99 1.11 1.14 1.04 1.08 1.05
Ugt2b38
KLA  ATP  ATP+KLA
 NM_133894 UDP glucuronosyltransferase 2 family, polypeptide B38 (Ugt2b38), mRNA [NM_133894] KLA 1.00 .96 1.04 .99 1.10 .97 .99
ATP 1.02 1.04 1.03 .94 .96 .93 .99
KLA/ATP .98 .97 1.00 .97 .98 1.04 1.02
Ugt2b5
KLA  ATP  ATP+KLA
 NM_009467 UDP glucuronosyltransferase 2 family, polypeptide B5 (Ugt2b5), mRNA [NM_009467] KLA 1.01 .99 1.09 .96 .97 .99 1.01
ATP 1.03 1.02 1.02 1.01 .97 .90 .94
KLA/ATP .99 .99 .98 1.05 1.01 .93 .95