Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Fatty acid metabolism (mmu00071)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Acaa1a
KLA  ATP  ATP+KLA
 NM_130864 acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA 1.53 1.60 1.88 2.07 2.41 2.64 1.82
ATP 1.07 .99 .98 1.10 .94 .83 1.58
KLA/ATP 1.64 1.64 1.73 1.75 1.61 1.39 1.85
Acaa1b
KLA  ATP  ATP+KLA
 NM_146230 acetyl-Coenzyme A acyltransferase 1B (Acaa1b), mRNA [NM_146230] KLA 1.52 1.66 1.93 2.04 2.32 2.51 1.83
ATP 1.04 .95 1.06 1.12 1.03 .93 1.59
KLA/ATP 1.76 1.72 1.76 1.95 1.76 1.51 1.86
Acaa2
KLA  ATP  ATP+KLA
 NM_177470 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) (Acaa2), nuclear gene encoding mitochondrial protein, mRNA [NM_177470] KLA .98 .94 1.00 1.00 .90 .81 .60
ATP 1.03 1.00 1.12 1.10 .84 .48 .50
KLA/ATP .98 .98 1.03 1.05 .99 .85 .40
Acadl
KLA  ATP  ATP+KLA
 NM_007381 acyl-Coenzyme A dehydrogenase, long-chain (Acadl), nuclear gene encoding mitochondrial protein, mRNA [NM_007381] KLA 1.67 1.61 2.27 1.98 1.98 1.62 .89
ATP 1.24 1.19 1.25 1.30 1.36 1.15 .69
KLA/ATP 1.83 1.95 2.01 2.22 1.71 1.18 .84
Acadm
KLA  ATP  ATP+KLA
 NM_007382 acyl-Coenzyme A dehydrogenase, medium chain (Acadm), nuclear gene encoding mitochondrial protein, mRNA [NM_007382] KLA .57 .50 .50 .37 .34 .34 .54
ATP 1.09 1.08 1.16 .92 .67 .43 .51
KLA/ATP .55 .56 .57 .46 .41 .36 .29
Acads
KLA  ATP  ATP+KLA
 NM_007383 acyl-Coenzyme A dehydrogenase, short chain (Acads), nuclear gene encoding mitochondrial protein, mRNA [NM_007383] KLA .76 .78 .76 .69 .71 .71 .70
ATP 1.02 1.11 1.01 1.28 .75 .58 .79
KLA/ATP .80 .76 .66 .82 .56 .56 .53
Acadsb
KLA  ATP  ATP+KLA
 NM_025826 acyl-Coenzyme A dehydrogenase, short/branched chain (Acadsb), nuclear gene encoding mitochondrial protein, mRNA [NM_025826] KLA 1.30 1.38 1.39 1.23 1.50 1.35 1.26
ATP 1.18 1.36 1.31 1.24 .91 .73 1.18
KLA/ATP 1.44 1.26 1.22 1.41 .78 .68 1.19
Acadvl
KLA  ATP  ATP+KLA
 NM_017366 acyl-Coenzyme A dehydrogenase, very long chain (Acadvl), nuclear gene encoding mitochondrial protein, mRNA [NM_017366] KLA .88 .79 .75 .87 .66 .63 .90
ATP 1.07 .89 1.24 1.04 .91 .76 .88
KLA/ATP .78 .84 1.16 .90 .81 .64 .62
Acat1
KLA  ATP  ATP+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
ATP .89 .88 1.21 .99 .67 .36 .47
KLA/ATP .86 .97 1.18 .90 .64 .42 .35
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Acox1
KLA  ATP  ATP+KLA
 NM_015729 acyl-Coenzyme A oxidase 1, palmitoyl (Acox1), mRNA [NM_015729] KLA .79 .81 .78 .68 .66 .69 .82
ATP .97 1.09 .93 .90 .81 .78 1.22
KLA/ATP .81 .82 .69 .68 .59 .70 .88
Acox3
KLA  ATP  ATP+KLA
 NM_030721 acyl-Coenzyme A oxidase 3, pristanoyl (Acox3), mRNA [NM_030721] KLA .56 .56 .63 .55 .50 .48 .68
ATP 1.10 1.00 .85 .76 .87 .44 .73
KLA/ATP .61 .66 .57 .49 .57 .48 .47
Acsbg1
KLA  ATP  ATP+KLA
 NM_053178 acyl-CoA synthetase bubblegum family member 1 (Acsbg1), mRNA [NM_053178] KLA .54 .60 .46 .48 .43 .54 .84
ATP .93 .86 .66 .53 .41 .96 1.25
KLA/ATP .60 .52 .44 .39 .38 .67 1.36
Acsbg2
KLA  ATP  ATP+KLA
 NM_001039114 acyl-CoA synthetase bubblegum family member 2 (Acsbg2), mRNA [NM_001039114] KLA .96 .99 1.05 1.00 .98 1.02 1.03
ATP 1.03 1.02 1.04 .97 1.00 1.03 .96
KLA/ATP 1.02 .98 .99 1.00 .92 1.00 .98
Acsl1
KLA  ATP  ATP+KLA
 NM_007981 acyl-CoA synthetase long-chain family member 1 (Acsl1), mRNA [NM_007981] KLA 6.45 6.43 6.31 6.46 7.76 10.38 13.72
ATP 1.02 1.14 1.04 1.69 2.56 4.02 2.69
KLA/ATP 6.36 6.25 5.41 6.54 4.81 4.79 9.93
Acsl3
KLA  ATP  ATP+KLA
 NM_001033606 acyl-CoA synthetase long-chain family member 3 (Acsl3), transcript variant 2, mRNA [NM_001033606] KLA .29 .27 .29 .29 .30 .32 .39
ATP 1.06 .98 1.19 1.92 2.34 .67 .75
KLA/ATP .27 .26 .39 .88 1.31 .50 .24
Acsl4
KLA  ATP  ATP+KLA
 NM_207625 acyl-CoA synthetase long-chain family member 4 (Acsl4), transcript variant 1, mRNA [NM_207625] KLA 1.16 1.03 1.01 1.21 1.21 1.51 1.70
ATP .89 .88 1.64 1.60 2.24 5.91 2.42
KLA/ATP .92 1.00 1.90 1.71 1.83 3.23 3.56
Acsl5
KLA  ATP  ATP+KLA
 NM_027976 acyl-CoA synthetase long-chain family member 5 (Acsl5), mRNA [NM_027976] KLA 1.32 1.46 1.54 1.51 2.04 2.20 2.31
ATP 1.02 1.10 .89 1.03 .92 .84 .99
KLA/ATP 1.42 1.54 1.17 1.29 .97 1.11 1.35
Acsl6
KLA  ATP  ATP+KLA
 AK147421 adult male brain UNDEFINED_CELL_LINE cDNA, RIKEN full-length enriched library, clone:M5C1038B08 product:acyl-CoA synthetase long-chain family member 6, full insert sequence [AK147421] KLA 1.00 .97 1.02 .99 .97 1.02 1.03
ATP .97 .96 .95 .97 1.00 1.03 1.04
KLA/ATP .99 .96 1.08 .96 1.01 .96 1.00
Acsl6
KLA  ATP  ATP+KLA
 NM_001033599 acyl-CoA synthetase long-chain family member 6 (Acsl6), transcript variant 4, mRNA [NM_001033599] KLA .97 .99 1.02 1.02 1.00 1.01 .99
ATP 1.01 1.01 1.02 1.00 1.00 1.01 1.04
KLA/ATP .97 1.06 1.00 1.02 .94 1.00 1.02
Adh1
KLA  ATP  ATP+KLA
 AK082149 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230014D21 product:unclassifiable, full insert sequence [AK082149] KLA .94 .96 .97 .95 1.01 .95 .96
ATP .99 1.05 .93 .91 1.02 1.04 1.00
KLA/ATP .87 .88 .94 .92 .86 1.04 .93
Adh1
KLA  ATP  ATP+KLA
 NM_007409 alcohol dehydrogenase 1 (class I) (Adh1), mRNA [NM_007409] KLA 1.02 .98 .96 1.04 1.01 1.04 1.08
ATP .96 1.03 1.00 1.03 1.05 1.01 1.04
KLA/ATP 1.02 1.03 1.04 1.01 1.04 1.09 1.04
Adh4
KLA  ATP  ATP+KLA
 NM_011996 alcohol dehydrogenase 4 (class II), pi polypeptide (Adh4), mRNA [NM_011996] KLA .95 .94 .93 1.07 1.04 .96 .99
ATP .95 .95 .95 .99 1.02 .93 .97
KLA/ATP 1.03 1.02 .92 .97 1.02 1.01 .99
Adh5
KLA  ATP  ATP+KLA
 NM_007410 alcohol dehydrogenase 5 (class III), chi polypeptide (Adh5), mRNA [NM_007410] KLA .93 .76 .71 .83 .61 .63 .76
ATP 1.02 .98 1.19 1.06 1.08 .85 .86
KLA/ATP .77 .76 1.06 .86 .87 .84 .62
Adh7
KLA  ATP  ATP+KLA
 NM_009626 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (Adh7), mRNA [NM_009626] KLA 1.07 1.01 1.02 .98 1.03 .99 1.01
ATP 1.03 1.09 1.02 1.08 1.03 1.09 1.01
KLA/ATP 1.10 1.03 1.06 1.02 1.05 1.06 1.13
Aldh1b1
KLA  ATP  ATP+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA 7.51 7.83 9.27 11.57 11.10 10.78 4.79
ATP .93 .91 .90 .89 .73 2.27 2.30
KLA/ATP 6.45 7.40 9.33 9.54 8.82 12.15 10.67
Aldh2
KLA  ATP  ATP+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA .62 .65 .59 .60 .63 .64 .49
ATP 1.01 .91 1.06 .93 1.18 .93 .41
KLA/ATP .70 .68 .70 .84 1.16 .96 .45
Aldh2
KLA  ATP  ATP+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA .74 .81 .77 .65 .60 .53 .50
ATP .98 1.10 .90 1.17 1.04 .82 .60
KLA/ATP .84 .86 .77 .82 .72 .66 .51
Aldh3a2
KLA  ATP  ATP+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA .86 .83 .79 .79 .80 .97 1.00
ATP .93 .98 .94 .89 .77 .87 1.02
KLA/ATP .78 .81 .67 .72 .65 .81 .97
Aldh7a1
KLA  ATP  ATP+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA .98 1.03 1.08 1.12 1.08 .94 .99
ATP 1.01 1.03 1.00 1.03 .98 .82 .91
KLA/ATP 1.15 1.12 1.01 1.02 .90 .89 .83
Aldh9a1
KLA  ATP  ATP+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA .64 .64 .67 .48 .42 .24 .33
ATP 1.07 1.02 .75 .94 .68 .46 .42
KLA/ATP .72 .65 .43 .55 .37 .31 .24
Cpt1a
KLA  ATP  ATP+KLA
 NM_013495 carnitine palmitoyltransferase 1a, liver (Cpt1a), nuclear gene encoding mitochondrial protein, mRNA [NM_013495] KLA .84 .84 1.00 .93 .89 1.02 1.02
ATP 1.03 1.11 .93 .95 .67 .54 .67
KLA/ATP .92 .94 .77 .86 .77 .76 1.02
Cpt1b
KLA  ATP  ATP+KLA
 NM_009948 carnitine palmitoyltransferase 1b, muscle (Cpt1b), nuclear gene encoding mitochondrial protein, mRNA [NM_009948] KLA 1.00 1.04 1.04 1.08 1.10 1.08 .99
ATP 1.05 1.05 1.17 1.43 1.47 1.20 .84
KLA/ATP 1.09 1.06 1.13 1.37 1.77 1.29 .94
Cpt1c
KLA  ATP  ATP+KLA
 NM_153679 carnitine palmitoyltransferase 1c (Cpt1c), mRNA [NM_153679] KLA .91 .92 .92 .93 .85 .84 .76
ATP .99 1.00 .93 .94 .81 .79 .74
KLA/ATP .96 .89 .84 .88 .82 .78 .70
Cpt2
KLA  ATP  ATP+KLA
 NM_009949 carnitine palmitoyltransferase 2 (Cpt2), nuclear gene encoding mitochondrial protein, mRNA [NM_009949] KLA .92 .87 .81 .87 .78 .96 .85
ATP .95 .91 1.13 .74 .52 1.20 .94
KLA/ATP .79 .83 .96 .65 .74 1.63 1.32
Cyp4a10
KLA  ATP  ATP+KLA
 NM_010011 cytochrome P450, family 4, subfamily a, polypeptide 10 (Cyp4a10), mRNA [NM_010011] KLA 1.14 1.13 1.13 1.13 1.15 1.12 1.06
ATP 1.02 1.01 1.09 1.03 1.10 1.11 1.00
KLA/ATP 1.09 1.11 1.36 1.23 1.25 1.09 1.02
Cyp4a10
KLA  ATP  ATP+KLA
 X71478 gb|M.musculus Cyp4a-10 mRNA. [X71478] KLA .94 .97 .93 1.01 1.01 1.09 1.26
ATP .96 1.07 1.04 1.18 .88 .77 1.18
KLA/ATP 1.00 .99 .98 .98 .84 .80 1.24
Cyp4a12a
KLA  ATP  ATP+KLA
 NM_177406 cytochrome P450, family 4, subfamily a, polypeptide 12a (Cyp4a12a), mRNA [NM_177406] KLA 1.08 1.04 1.02 1.06 .98 1.05 1.05
ATP .98 1.00 1.10 .99 .96 1.04 .98
KLA/ATP 1.07 1.05 1.11 .96 1.06 1.02 .97
Cyp4a12b
KLA  ATP  ATP+KLA
 NM_172306 cytochrome P450, family 4, subfamily a, polypeptide 12B (Cyp4a12b), mRNA [NM_172306] KLA 1.03 1.05 .95 .99 .94 1.02 1.12
ATP .93 .99 .95 1.00 .93 .95 1.01
KLA/ATP .98 1.01 1.09 1.00 .90 .91 .93
Cyp4a14
KLA  ATP  ATP+KLA
 NM_007822 cytochrome P450, family 4, subfamily a, polypeptide 14 (Cyp4a14), mRNA [NM_007822] KLA .99 1.00 1.00 .97 .96 .97 1.01
ATP .95 .95 .93 .90 .93 .99 1.03
KLA/ATP .97 .99 1.04 .93 .95 .96 .97
Cyp4a29
KLA  ATP  ATP+KLA
 NM_001100183 cytochrome P450, family 4, subfamily a, polypeptide 29 (Cyp4a29), mRNA [NM_001100183] KLA .94 .98 1.04 1.00 .98 1.06 1.03
ATP 1.01 1.02 1.03 1.02 1.01 1.02 .97
KLA/ATP 1.05 1.09 1.03 1.03 .97 1.02 .91
Cyp4a31
KLA  ATP  ATP+KLA
 NM_201640 cytochrome P450, family 4, subfamily a, polypeptide 31 (Cyp4a31), mRNA [NM_201640] KLA 1.14 .99 1.00 .98 1.06 1.03 .96
ATP 1.01 1.05 1.04 .91 .98 .99 .99
KLA/ATP .99 1.03 1.04 .99 .95 .97 1.06
Dci
KLA  ATP  ATP+KLA
 NM_010023 dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isomerase) (Dci), nuclear gene encoding mitochondrial protein, mRNA [NM_010023] KLA .89 .94 .89 .78 .70 .54 .90
ATP 1.00 1.00 1.12 1.32 1.11 .61 .86
KLA/ATP .95 .99 1.03 1.14 1.00 .67 .68
Echs1
KLA  ATP  ATP+KLA
 NM_053119 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119] KLA .57 .55 .52 .54 .60 .82 .90
ATP .99 .97 1.07 1.15 .77 .37 .81
KLA/ATP .55 .56 .55 .66 .53 .39 .41
Ehhadh
KLA  ATP  ATP+KLA
 NM_023737 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737] KLA .74 .77 .80 .88 .71 .67 .74
ATP 1.02 1.06 1.04 .90 .70 .84 .83
KLA/ATP .79 .81 .80 .65 .59 .79 .55
Gcdh
KLA  ATP  ATP+KLA
 U18992 glutaryl-CoA dehydrogenase mRNA, complete cds. [U18992] KLA .93 .79 .71 .83 .76 .74 .79
ATP 1.03 1.08 1.25 1.15 .86 .56 .75
KLA/ATP .72 .82 1.12 .93 .68 .50 .48
Hadh
KLA  ATP  ATP+KLA
 NM_008212 hydroxyacyl-Coenzyme A dehydrogenase (Hadh), nuclear gene encoding mitochondrial protein, mRNA [NM_008212] KLA .75 .75 .72 .64 .54 .37 .49
ATP 1.12 1.19 1.08 1.28 .96 .43 .41
KLA/ATP .76 .81 .68 .85 .56 .42 .21
Hadha
KLA  ATP  ATP+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA .96 .92 .91 .80 .97 .92 .90
ATP .72 .64 .63 .71 .91 .93 .93
KLA/ATP .79 .72 .68 .73 .87 .90 .88
Hadha
KLA  ATP  ATP+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.10 1.17 1.36 1.16 1.23 1.10 1.00
ATP 1.16 1.22 1.03 1.40 1.09 .79 1.11
KLA/ATP 1.33 1.35 1.16 1.41 1.00 .92 1.31
Hadhb
KLA  ATP  ATP+KLA
 NM_145558 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit (Hadhb), nuclear gene encoding mitochondrial protein, mRNA [NM_145558] KLA .85 .88 .76 .77 .70 .54 .58
ATP 1.08 1.13 1.05 1.01 .84 .53 .58
KLA/ATP .79 .91 .83 .80 .61 .46 .44
Mm.17942
1
KLA  ATP  ATP+KLA
 84993735 Unknown KLA .93 1.00 1.05 1.00 .99 1.01 1.01
ATP 1.02 1.03 1.03 1.05 1.08 .98 1.01
KLA/ATP 1.05 .97 1.04 .99 1.09 1.10 1.00
Mm.29150
3
KLA  ATP  ATP+KLA
 34328333 Unknown KLA .61 .60 .60 .53 .51 .56 .69
ATP 1.05 .96 .93 .75 .81 .44 .78
KLA/ATP .66 .58 .67 .52 .58 .47 .55
Mm.29323
3
KLA  ATP  ATP+KLA
 118130035 Unknown KLA .98 1.04 .98 1.05 1.07 .97 .95
ATP 1.02 1.04 1.01 1.02 1.00 1.00 1.00
KLA/ATP 1.03 1.00 .98 .96 1.10 1.03 .98
Mm.44829
2
KLA  ATP  ATP+KLA
 86198313 Unknown KLA 1.12 1.03 1.02 1.14 1.04 1.07 1.02
ATP .95 .98 1.18 1.06 1.12 1.07 1.04
KLA/ATP 1.04 1.15 1.29 1.11 1.16 1.21 1.14
Mm.46661
0
KLA  ATP  ATP+KLA
 82894546 Unknown KLA .86 .90 .99 .94 1.02 .83 .91
ATP 1.10 1.04 1.04 1.15 1.03 .93 .84
KLA/ATP .86 .85 1.00 1.10 .94 .85 .90
Peci
KLA  ATP  ATP+KLA
 NM_011868 peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase (Peci), transcript variant 2, mRNA [NM_011868] KLA 1.29 1.20 1.14 1.30 1.02 1.11 1.17
ATP .86 .81 1.05 .76 .62 .67 .59
KLA/ATP 1.03 1.04 1.34 1.01 .93 .89 .67