Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Synthesis and degradation of ketone bodies (mmu00072)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Acat1
KLA  ATP  ATP+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
ATP .89 .88 1.21 .99 .67 .36 .47
KLA/ATP .86 .97 1.18 .90 .64 .42 .35
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Bdh1
KLA  ATP  ATP+KLA
 NM_001122683 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), transcript variant 2, mRNA [NM_001122683] KLA .89 .82 .80 .87 .90 .92 1.01
ATP .94 1.00 .89 .90 .82 .91 1.24
KLA/ATP .84 .82 .88 .76 .90 .88 .91
Bdh1
KLA  ATP  ATP+KLA
 NM_175177 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_175177] KLA .61 .62 .57 .76 .75 .63 .64
ATP .95 .95 1.24 1.06 .81 1.28 1.87
KLA/ATP .57 .65 .78 .64 .63 .81 .70
Bdh2
KLA  ATP  ATP+KLA
 NM_027208 3-hydroxybutyrate dehydrogenase, type 2 (Bdh2), mRNA [NM_027208] KLA .85 .86 .78 .83 .75 .88 .83
ATP .95 .96 1.24 1.15 1.27 1.15 .95
KLA/ATP .82 .86 1.01 .97 1.04 1.05 1.09
Hmgcl
KLA  ATP  ATP+KLA
 NM_008254 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl), mRNA [NM_008254] KLA .37 .34 .39 .48 .63 .86 .71
ATP .87 .84 .93 .82 .69 .91 1.21
KLA/ATP .32 .33 .38 .38 .71 1.31 1.25
Hmgcs1
KLA  ATP  ATP+KLA
 AK078743 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030402P03 product:similar to hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) (fragment) [Gallus gallus], full insert sequence. [AK078743] KLA 1.06 1.08 .98 .81 .88 .71 .86
ATP 1.39 1.87 10.43 2.82 1.19 1.14 1.09
KLA/ATP 1.36 1.59 5.22 1.83 1.21 .75 .66
Hmgcs1
KLA  ATP  ATP+KLA
 NM_145942 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942] KLA 1.16 1.10 1.26 1.16 .88 .63 .69
ATP 1.01 1.10 1.87 2.36 1.98 .89 .97
KLA/ATP 1.12 1.20 1.33 1.69 1.39 .67 .51
Hmgcs2
KLA  ATP  ATP+KLA
 NM_008256 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256] KLA .92 1.10 1.00 .99 1.08 1.06 1.14
ATP .99 1.02 1.00 1.00 .98 1.08 .92
KLA/ATP .99 1.00 1.00 1.03 1.28 1.06 1.00
Mm.18966
0
KLA  ATP  ATP+KLA
 160358826 Unknown KLA 1.06 1.13 1.05 1.05 1.02 1.02 .98
ATP 1.01 1.05 1.33 1.61 1.40 1.19 1.10
KLA/ATP 1.04 1.02 1.18 1.50 1.38 1.22 1.48
Mm.29323
3
KLA  ATP  ATP+KLA
 118130035 Unknown KLA .98 1.04 .98 1.05 1.07 .97 .95
ATP 1.02 1.04 1.01 1.02 1.00 1.00 1.00
KLA/ATP 1.03 1.00 .98 .96 1.10 1.03 .98
Oxct1
KLA  ATP  ATP+KLA
 NM_024188 3-oxoacid CoA transferase 1 (Oxct1), nuclear gene encoding mitochondrial protein, mRNA [NM_024188] KLA .91 .98 1.06 1.09 .95 .90 .46
ATP 1.00 .98 1.03 .93 .82 .43 .79
KLA/ATP .89 .94 1.18 .97 .97 .67 .33
Oxct2a
KLA  ATP  ATP+KLA
 NM_022033 3-oxoacid CoA transferase 2A (Oxct2a), mRNA [NM_022033] KLA 1.05 1.04 1.09 1.03 .98 1.05 1.07
ATP 1.03 1.00 1.02 1.31 1.14 1.10 .97
KLA/ATP 1.04 1.07 1.01 1.19 1.12 1.06 1.19