Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Alanine, aspartate and glutamate metabolism (mmu00250)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2810423A
18Rik
KLA  ATP  ATP+KLA
 AK013141 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810423A18 product:unclassifiable, full insert sequence [AK013141] KLA 1.03 .97 1.07 .95 1.09 1.26 1.38
ATP .96 .98 1.09 1.02 2.18 2.30 1.52
KLA/ATP .99 .97 .94 .75 1.93 3.39 2.34
4930438A
08Rik
KLA  ATP  ATP+KLA
 XM_001477470 gb|PREDICTED: Mus musculus RIKEN cDNA 4930438A08 gene (4930438A08Rik), mRNA [XM_001477470] KLA 1.78 1.45 1.69 1.62 1.69 1.48 1.31
ATP 1.07 1.04 1.24 1.13 1.13 1.61 1.67
KLA/ATP 1.83 1.46 1.58 1.30 1.43 1.36 1.95
Abat
KLA  ATP  ATP+KLA
 AK083062 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530041H11 product:hypothetical protein, full insert sequence. [AK083062] KLA 1.01 1.09 .97 .99 1.03 1.02 1.06
ATP .96 .99 1.00 1.11 1.04 .98 1.06
KLA/ATP 1.06 1.03 .96 1.06 1.10 1.06 .96
Abat
KLA  ATP  ATP+KLA
 NM_172961 4-aminobutyrate aminotransferase (Abat), nuclear gene encoding mitochondrial protein, mRNA [NM_172961] KLA 1.03 .96 .97 1.00 .92 .97 .96
ATP .97 .93 1.07 1.04 .97 .99 .98
KLA/ATP 1.03 1.01 1.00 .98 .94 .89 .97
Acy3
KLA  ATP  ATP+KLA
 NM_027857 aspartoacylase (aminoacylase) 3 (Acy3), mRNA [NM_027857] KLA .98 1.04 .96 1.06 .88 .89 .93
ATP 1.11 1.06 .99 1.20 1.07 .87 .98
KLA/ATP 1.04 1.01 .98 1.04 .94 .95 1.06
Adsl
KLA  ATP  ATP+KLA
 NM_009634 adenylosuccinate lyase (Adsl), mRNA [NM_009634] KLA .87 .93 .90 .97 .82 .64 1.06
ATP 1.08 1.12 1.06 1.04 .80 .60 .86
KLA/ATP 1.02 .95 1.00 .86 .66 .49 .49
Adss
KLA  ATP  ATP+KLA
 NM_007422 adenylosuccinate synthetase, non muscle (Adss), mRNA [NM_007422] KLA 1.21 1.15 .96 .70 .35 .24 .51
ATP .93 1.08 .97 1.14 .93 .75 .47
KLA/ATP 1.24 1.19 .87 .99 .56 .40 .33
Adssl1
KLA  ATP  ATP+KLA
 NM_007421 adenylosuccinate synthetase like 1 (Adssl1), mRNA [NM_007421] KLA .67 .67 .53 .51 .32 .17 .20
ATP .87 .76 .96 .74 .73 .38 .60
KLA/ATP .58 .59 .64 .48 .62 .49 .37
Agxt
KLA  ATP  ATP+KLA
 NM_016702 alanine-glyoxylate aminotransferase (Agxt), mRNA [NM_016702] KLA 1.01 .95 .96 1.05 1.01 .98 .94
ATP .95 1.03 1.03 .99 .97 .96 1.05
KLA/ATP .94 .99 1.01 1.01 .96 .92 .96
Agxt2
KLA  ATP  ATP+KLA
 NM_001031851 alanine-glyoxylate aminotransferase 2 (Agxt2), nuclear gene encoding mitochondrial protein, mRNA [NM_001031851] KLA .98 .99 1.04 1.05 .93 1.01 1.05
ATP 1.02 1.03 1.03 1.06 1.01 .96 .97
KLA/ATP 1.05 .98 .99 1.04 .99 1.02 1.01
Aldh4a1
KLA  ATP  ATP+KLA
 NM_175438 aldehyde dehydrogenase 4 family, member A1 (Aldh4a1), nuclear gene encoding mitochondrial protein, mRNA [NM_175438] KLA .90 .85 .85 .82 .87 .94 .87
ATP 1.05 1.16 1.03 1.02 .81 .83 1.00
KLA/ATP .92 .88 .84 .92 .82 .88 .91
Aldh5a1
KLA  ATP  ATP+KLA
 AK051603 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130059J11 product:succinate-semialdehyde dehydrogenase (EC 1.2.1.24) (fragment) homolog [Rattus norvegicus], full insert sequence. [AK051603] KLA 1.04 .99 1.06 1.03 1.01 1.09 1.08
ATP .94 .93 1.01 1.04 1.06 1.10 1.02
KLA/ATP 1.00 1.03 .83 1.02 1.06 1.03 1.04
Aldh5a1
KLA  ATP  ATP+KLA
 NM_172532 aldhehyde dehydrogenase family 5, subfamily A1 (Aldh5a1), mRNA [NM_172532] KLA .99 .98 .84 .95 .81 .63 .52
ATP .92 .83 1.21 1.06 .90 .70 .57
KLA/ATP .92 .96 1.24 .95 .89 .62 .59
Asl
KLA  ATP  ATP+KLA
 NM_133768 argininosuccinate lyase (Asl), mRNA [NM_133768] KLA .88 .92 .83 .75 .78 .83 1.05
ATP 1.00 1.09 .93 1.21 1.02 .85 1.41
KLA/ATP .89 .96 .74 1.01 .81 .85 1.55
Asns
KLA  ATP  ATP+KLA
 NM_012055 asparagine synthetase (Asns), mRNA [NM_012055] KLA .89 .91 .75 .69 .53 .85 2.04
ATP .87 .80 1.06 .79 2.07 2.78 1.76
KLA/ATP .85 .80 .84 .58 1.02 1.08 .97
Aspa
KLA  ATP  ATP+KLA
 NM_023113 aspartoacylase (Aspa), mRNA [NM_023113] KLA 1.03 1.06 1.08 1.12 1.10 1.09 1.18
ATP 1.02 .94 1.08 1.09 .97 1.08 1.01
KLA/ATP 1.04 1.03 1.14 1.05 1.07 1.12 1.11
Ass1
KLA  ATP  ATP+KLA
 M31690 gb|Mouse argininosuccinate synthetase (Ass) mRNA, complete cds. [M31690] KLA 4.67 5.37 6.47 6.68 8.75 9.43 8.52
ATP 1.17 1.32 1.27 1.78 2.00 6.66 7.95
KLA/ATP 5.78 6.01 5.41 6.67 6.73 8.48 13.11
Ass1
KLA  ATP  ATP+KLA
 NM_007494 argininosuccinate synthetase 1 (Ass1), mRNA [NM_007494] KLA 4.88 5.58 7.14 7.84 10.68 11.29 9.93
ATP 1.12 1.29 1.28 1.75 2.04 7.76 9.44
KLA/ATP 5.70 6.62 5.49 8.11 6.90 9.65 16.23
Cad
KLA  ATP  ATP+KLA
 NM_023525 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (Cad), mRNA [NM_023525] KLA .88 .82 .73 .65 .53 .46 .59
ATP 1.00 1.00 .94 .86 .74 .60 .67
KLA/ATP .86 .81 .76 .65 .55 .46 .44
Cps1
KLA  ATP  ATP+KLA
 AK028683 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732433M03 product:weakly similar to carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) large chain [Schizosaccharomyces pombe], full insert sequence. [A KLA .99 1.01 1.08 1.02 1.01 .96 1.05
ATP .96 1.00 .94 .97 .98 .98 1.05
KLA/ATP .97 1.09 1.04 .99 1.05 1.03 .96
Cps1
KLA  ATP  ATP+KLA
 AK028683 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732433M03 product:weakly similar to carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) large chain [Schizosaccharomyces pombe], full insert sequence. [AK KLA 1.03 1.04 1.06 .96 1.08 1.08 1.03
ATP .99 .98 1.09 1.07 .97 1.02 1.09
KLA/ATP .98 1.00 .95 1.10 1.00 1.05 1.09
Ddo
KLA  ATP  ATP+KLA
 AK019898 adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330420D20 product:similar to D-ASPARTATE OXIDASE (EC 1.4.3.1) (FRAGMENT) [Bos taurus], full insert sequence. [AK019898] KLA 1.05 .99 .99 1.07 1.04 1.00 .99
ATP .98 1.04 .94 1.05 .98 1.03 1.01
KLA/ATP 1.02 .91 .98 1.01 1.05 1.01 1.01
Ddo
KLA  ATP  ATP+KLA
 NM_027442 D-aspartate oxidase (Ddo), mRNA [NM_027442] KLA 1.03 .93 1.02 .99 .93 1.03 1.07
ATP 1.01 .94 1.13 1.02 .99 1.00 1.02
KLA/ATP 1.03 1.04 1.10 1.02 1.11 .98 1.03
Gad1
KLA  ATP  ATP+KLA
 AK054554 10 days neonate olfactory brain cDNA, RIKEN full-length enriched library, clone:E530004P22 product:glutamic acid decarboxylase 1, full insert sequence. [AK054554] KLA 1.03 1.00 1.00 1.00 1.00 .98 1.10
ATP 1.03 .91 1.01 1.05 .99 .97 1.08
KLA/ATP .97 .99 .99 1.10 1.02 1.09 .96
Gad1
KLA  ATP  ATP+KLA
 NM_008077 glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077] KLA 1.03 .99 1.00 1.01 1.01 .97 .99
ATP 1.02 1.02 1.01 .99 1.02 1.03 .98
KLA/ATP .96 1.03 1.04 .99 .99 1.04 1.01
Gad2
KLA  ATP  ATP+KLA
 NM_008078 glutamic acid decarboxylase 2 (Gad2), mRNA [NM_008078] KLA 1.03 1.07 1.11 1.11 1.04 .99 1.07
ATP .97 .99 1.02 1.02 1.01 .95 .97
KLA/ATP 1.05 1.08 1.04 1.01 1.00 1.06 1.00
Gfpt1
KLA  ATP  ATP+KLA
 NM_013528 glutamine fructose-6-phosphate transaminase 1 (Gfpt1), mRNA [NM_013528] KLA 1.65 1.73 1.88 1.89 1.81 1.81 2.11
ATP 1.13 1.24 1.25 1.43 2.76 2.99 3.85
KLA/ATP 1.78 2.02 1.88 1.75 1.97 3.84 6.84
Gfpt2
KLA  ATP  ATP+KLA
 NM_013529 glutamine fructose-6-phosphate transaminase 2 (Gfpt2), mRNA [NM_013529] KLA 1.28 1.31 1.50 1.32 1.18 1.25 1.11
ATP .98 1.00 1.05 1.72 2.72 2.21 1.07
KLA/ATP 1.34 1.42 1.38 2.19 2.19 1.93 1.54
Gls2
KLA  ATP  ATP+KLA
 NM_001033264 glutaminase 2 (liver, mitochondrial) (Gls2), nuclear gene encoding mitochondrial protein, mRNA [NM_001033264] KLA 1.03 .98 1.02 .97 .98 .88 .80
ATP .94 1.01 1.04 1.08 1.26 1.20 .87
KLA/ATP .95 .98 1.15 1.02 1.29 .99 .87
Glud1
KLA  ATP  ATP+KLA
 NM_008133 glutamate dehydrogenase 1 (Glud1), mRNA [NM_008133] KLA .70 .70 .63 .54 .52 .54 .59
ATP .96 .91 1.01 1.05 .96 .66 .47
KLA/ATP .67 .66 .61 .69 .70 .51 .27
Glul
KLA  ATP  ATP+KLA
 NM_008131 glutamate-ammonia ligase (glutamine synthetase) (Glul), mRNA [NM_008131] KLA .58 .54 .47 .41 .30 .31 .40
ATP .96 .99 1.46 2.55 2.16 2.88 1.34
KLA/ATP .57 .56 .83 1.52 1.27 1.20 .97
Glul
KLA  ATP  ATP+KLA
 X16314 gb|M.musculus mRNA for glutamine synthetase. [X16314] KLA .86 .95 .79 .87 .78 .99 .83
ATP .95 1.03 1.09 1.27 1.14 1.37 1.00
KLA/ATP .88 .97 .89 1.12 1.01 1.19 .91
Got1
KLA  ATP  ATP+KLA
 NM_010324 glutamate oxaloacetate transaminase 1, soluble (Got1), mRNA [NM_010324] KLA .68 .70 .66 .56 .50 .57 .99
ATP 1.01 1.24 1.55 1.59 1.47 1.03 1.68
KLA/ATP .68 .71 .66 .77 1.13 2.33 1.89
Got2
KLA  ATP  ATP+KLA
 NM_010325 glutamate oxaloacetate transaminase 2, mitochondrial (Got2), nuclear gene encoding mitochondrial protein, mRNA [NM_010325] KLA .84 .86 .88 .75 .75 .63 .61
ATP 1.02 1.12 .98 1.15 .98 .67 .86
KLA/ATP .92 .89 .75 .89 .68 .70 .77
Gpt
KLA  ATP  ATP+KLA
 NM_182805 glutamic pyruvic transaminase, soluble (Gpt), mRNA [NM_182805] KLA .82 .81 .80 .82 .78 .83 1.05
ATP 1.01 1.00 1.07 1.23 1.20 .77 1.01
KLA/ATP .85 .86 .93 1.01 1.32 .83 .97
Gpt2
KLA  ATP  ATP+KLA
 NM_173866 glutamic pyruvate transaminase (alanine aminotransferase) 2 (Gpt2), mRNA [NM_173866] KLA .82 .87 .84 .69 .64 .80 .91
ATP .97 1.08 1.06 .95 1.33 2.66 1.89
KLA/ATP .81 .83 .67 .70 1.07 2.66 1.63
Il4i1
KLA  ATP  ATP+KLA
 NM_010215 interleukin 4 induced 1 (Il4i1), mRNA [NM_010215] KLA 13.98 13.74 14.90 14.92 13.89 12.12 3.25
ATP 1.02 .98 1.14 1.59 4.45 6.63 2.41
KLA/ATP 16.09 15.56 19.65 19.66 18.47 14.84 12.99
Lao1
KLA  ATP  ATP+KLA
 NM_133892 L-amino acid oxidase 1 (Lao1), mRNA [NM_133892] KLA 1.03 1.03 1.04 1.00 .98 1.01 .98
ATP 1.01 1.03 1.02 .92 1.05 .98 .99
KLA/ATP 1.02 .96 1.04 .94 .96 .97 .97
Mm.30102
KLA  ATP  ATP+KLA
 142348692 Unknown KLA 1.04 1.04 .97 1.07 1.02 .93 .90
ATP 1.06 .98 1.13 1.06 1.30 1.19 .78
KLA/ATP .94 1.05 1.13 1.05 1.24 1.12 .84
Mm.30384
7
KLA  ATP  ATP+KLA
 73661177 Unknown KLA .94 1.00 1.07 1.05 .96 1.04 1.08
ATP 1.06 1.01 .98 1.02 .98 .99 1.01
KLA/ATP 1.03 .94 1.13 1.06 1.03 1.03 .99
Mm.44046
5
KLA  ATP  ATP+KLA
 164607131 Unknown KLA .65 .56 .59 .51 .33 .20 .24
ATP 1.07 .90 1.30 2.88 3.61 4.46 1.07
KLA/ATP .60 .59 .95 2.38 2.99 2.31 .37
Nit2
KLA  ATP  ATP+KLA
 NM_023175 nitrilase family, member 2 (Nit2), mRNA [NM_023175] KLA 1.33 1.29 1.35 1.24 1.13 .93 1.13
ATP 1.12 1.12 1.21 1.37 1.04 .66 .74
KLA/ATP 1.43 1.43 1.29 1.53 1.29 1.16 .62
Ppat
KLA  ATP  ATP+KLA
 XM_896000 gb|PREDICTED: Mus musculus phosphoribosyl pyrophosphate amidotransferase, transcript variant 3 (Ppat), mRNA [XM_896000] KLA .54 .49 .44 .40 .36 .46 .60
ATP .91 .96 1.03 .85 .83 .81 .67
KLA/ATP .49 .50 .52 .49 .65 .63 .37