Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glycine, serine and threonine metabolism (mmu00260)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Agxt
KLA  ATP  ATP+KLA
 NM_016702 alanine-glyoxylate aminotransferase (Agxt), mRNA [NM_016702] KLA 1.01 .95 .96 1.05 1.01 .98 .94
ATP .95 1.03 1.03 .99 .97 .96 1.05
KLA/ATP .94 .99 1.01 1.01 .96 .92 .96
Agxt2
KLA  ATP  ATP+KLA
 NM_001031851 alanine-glyoxylate aminotransferase 2 (Agxt2), nuclear gene encoding mitochondrial protein, mRNA [NM_001031851] KLA .98 .99 1.04 1.05 .93 1.01 1.05
ATP 1.02 1.03 1.03 1.06 1.01 .96 .97
KLA/ATP 1.05 .98 .99 1.04 .99 1.02 1.01
Alas1
KLA  ATP  ATP+KLA
 NM_020559 aminolevulinic acid synthase 1 (Alas1), mRNA [NM_020559] KLA 1.90 2.05 1.99 2.15 2.41 2.00 1.62
ATP .96 1.03 .87 .98 2.70 9.15 6.49
KLA/ATP 1.88 2.04 1.63 1.99 3.06 7.03 8.41
Alas2
KLA  ATP  ATP+KLA
 NM_009653 aminolevulinic acid synthase 2, erythroid (Alas2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_009653] KLA .94 1.05 1.03 .98 .93 .99 1.00
ATP 1.00 1.03 1.02 1.05 .95 .96 1.04
KLA/ATP 1.07 1.08 1.03 .94 .97 .98 .98
Aldh7a1
KLA  ATP  ATP+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA .98 1.03 1.08 1.12 1.08 .94 .99
ATP 1.01 1.03 1.00 1.03 .98 .82 .91
KLA/ATP 1.15 1.12 1.01 1.02 .90 .89 .83
Aoc2
KLA  ATP  ATP+KLA
 NM_178932 amine oxidase, copper containing 2 (retina-specific) (Aoc2), mRNA [NM_178932] KLA 1.21 1.19 1.15 1.00 1.15 1.21 1.18
ATP 1.13 1.13 1.14 1.36 1.85 1.32 .76
KLA/ATP 1.27 1.34 1.12 1.32 1.67 1.37 1.05
Aoc3
KLA  ATP  ATP+KLA
 NM_009675 amine oxidase, copper containing 3 (Aoc3), mRNA [NM_009675] KLA .95 1.06 1.00 1.05 1.00 1.02 1.01
ATP 1.01 .90 1.04 1.07 1.06 1.06 .97
KLA/ATP 1.06 .98 .92 1.10 1.11 1.09 1.01
Bhmt
KLA  ATP  ATP+KLA
 NM_016668 betaine-homocysteine methyltransferase (Bhmt), mRNA [NM_016668] KLA 1.02 1.04 1.02 .95 1.04 1.03 1.05
ATP .98 .96 1.08 1.02 .98 1.02 1.08
KLA/ATP .96 1.02 1.04 1.01 .98 .94 1.01
Bpgm
KLA  ATP  ATP+KLA
 NM_007563 2,3-bisphosphoglycerate mutase (Bpgm), mRNA [NM_007563] KLA .78 .85 .78 .85 .98 1.02 1.07
ATP .98 .81 .61 .49 .38 .73 1.33
KLA/ATP .74 .74 .64 .57 .51 .73 .97
Cbs
KLA  ATP  ATP+KLA
 NM_144855 cystathionine beta-synthase (Cbs), transcript variant 1, mRNA [NM_144855] KLA .95 1.02 .94 .94 .99 .99 1.00
ATP 1.00 1.14 1.04 .85 .99 .94 .91
KLA/ATP 1.01 1.08 .97 1.02 .97 .88 .98
Chdh
KLA  ATP  ATP+KLA
 AK052715 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630034H06 product:CHOLINE DEHYDROGENASE (FRAGMENT) homolog [Homo sapiens], full insert sequence [AK052715] KLA 1.05 1.02 1.04 1.10 1.06 1.17 .88
ATP .96 1.01 .99 1.00 1.01 .98 .97
KLA/ATP .99 1.01 1.00 1.04 .99 .99 1.06
Chdh
KLA  ATP  ATP+KLA
 NM_175343 choline dehydrogenase (Chdh), mRNA [NM_175343] KLA .97 .99 1.07 1.01 .81 .98 1.15
ATP .98 1.06 1.04 1.17 1.02 1.00 .99
KLA/ATP 1.06 1.01 1.01 .99 .98 .99 1.12
Cth
KLA  ATP  ATP+KLA
 NM_145953 cystathionase (cystathionine gamma-lyase) (Cth), mRNA [NM_145953] KLA 1.95 1.88 2.04 1.99 1.70 1.19 1.05
ATP 1.05 1.03 1.17 1.26 1.76 2.05 1.00
KLA/ATP 1.79 2.03 2.06 1.83 1.66 1.53 .99
Dao1
KLA  ATP  ATP+KLA
 NM_010018 D-amino acid oxidase 1 (Dao1), mRNA [NM_010018] KLA 1.00 .95 1.02 1.00 .97 1.03 .99
ATP 1.00 .93 .99 .92 1.02 .98 1.03
KLA/ATP 1.00 1.01 1.05 .99 1.03 1.00 1.08
Dld
KLA  ATP  ATP+KLA
 NM_007861 dihydrolipoamide dehydrogenase (Dld), mRNA [NM_007861] KLA 1.60 1.66 1.84 1.66 1.47 1.16 1.17
ATP 1.05 1.08 1.21 1.06 1.15 1.24 .93
KLA/ATP 1.52 1.63 1.65 1.42 1.17 1.05 .79
Dld
KLA  ATP  ATP+KLA
 U73445 dihydrolipoamide dehydrogenase (Dld) mRNA, complete cds. [U73445] KLA 1.48 1.43 1.43 1.47 1.25 1.05 1.16
ATP .94 .93 1.18 .86 1.02 1.46 .97
KLA/ATP 1.39 1.37 1.50 1.10 1.11 1.14 .85
Dmgdh
KLA  ATP  ATP+KLA
 NM_028772 dimethylglycine dehydrogenase precursor (Dmgdh), nuclear gene encoding mitochondrial protein, mRNA [NM_028772] KLA .97 1.02 .98 .99 1.02 .92 .99
ATP 1.04 .94 .91 1.03 1.04 .94 1.01
KLA/ATP .95 .97 .99 .99 .98 1.06 1.02
Gamt
KLA  ATP  ATP+KLA
 NM_010255 guanidinoacetate methyltransferase (Gamt), mRNA [NM_010255] KLA .83 .81 .79 .71 .64 .49 .39
ATP 1.01 1.05 1.07 1.29 1.03 .50 .40
KLA/ATP .84 .88 .86 1.02 .84 .52 .21
Gatm
KLA  ATP  ATP+KLA
 NM_025961 glycine amidinotransferase (L-arginine:glycine amidinotransferase) (Gatm), nuclear gene encoding mitochondrial protein, mRNA [NM_025961] KLA 1.12 1.10 1.08 1.22 1.29 1.64 .65
ATP 1.02 1.14 1.14 1.48 .82 .21 .15
KLA/ATP 1.15 1.11 1.08 1.36 .67 .26 .17
Gcat
KLA  ATP  ATP+KLA
 NM_013847 glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) (Gcat), nuclear gene encoding mitochondrial protein, mRNA [NM_013847] KLA .88 .88 .77 .83 .57 .37 .24
ATP .97 .91 1.24 1.20 1.00 .58 .43
KLA/ATP .82 .73 1.01 .89 .80 .42 .19
Gldc
KLA  ATP  ATP+KLA
 NM_138595 glycine decarboxylase (Gldc), mRNA [NM_138595] KLA .77 .75 .63 .67 .70 .76 .89
ATP .98 1.02 .97 1.03 1.33 2.46 2.61
KLA/ATP .84 .69 .75 .73 .87 2.08 2.77
Glyctk
KLA  ATP  ATP+KLA
 NM_174846 glycerate kinase (Glyctk), transcript variant 1, mRNA [NM_174846] KLA .98 1.05 1.12 1.07 1.13 1.16 1.11
ATP 1.04 1.07 .93 .93 .72 .97 1.22
KLA/ATP 1.02 1.02 .94 .89 .82 1.00 1.26
Gnmt
KLA  ATP  ATP+KLA
 NM_010321 glycine N-methyltransferase (Gnmt), mRNA [NM_010321] KLA 1.14 1.20 1.25 1.23 1.35 1.39 1.26
ATP .97 .99 1.06 1.11 1.23 1.42 1.17
KLA/ATP 1.21 1.20 1.26 1.37 1.57 1.73 1.52
Grhpr
KLA  ATP  ATP+KLA
 NM_080289 glyoxylate reductase/hydroxypyruvate reductase (Grhpr), mRNA [NM_080289] KLA .82 .79 .68 .60 .42 .28 .56
ATP .93 .99 1.24 1.33 .91 .54 .71
KLA/ATP .74 .78 .84 .86 .61 .31 .39
Maoa
KLA  ATP  ATP+KLA
 NM_173740 monoamine oxidase A (Maoa), nuclear gene encoding mitochondrial protein, mRNA [NM_173740] KLA 1.14 1.11 1.06 1.07 .84 .55 .53
ATP 1.10 1.07 1.33 1.20 1.44 2.37 1.38
KLA/ATP .97 1.11 1.75 1.33 1.27 1.21 1.09
Maob
KLA  ATP  ATP+KLA
 NM_172778 monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA [NM_172778] KLA 1.01 .97 1.01 1.05 1.01 .95 1.01
ATP 1.09 .98 .99 .97 1.03 1.03 .94
KLA/ATP 1.02 1.05 .99 1.02 1.00 .98 .98
Mm.30384
7
KLA  ATP  ATP+KLA
 73661177 Unknown KLA .94 1.00 1.07 1.05 .96 1.04 1.08
ATP 1.06 1.01 .98 1.02 .98 .99 1.01
KLA/ATP 1.03 .94 1.13 1.06 1.03 1.03 .99
Mm.42309
9
KLA  ATP  ATP+KLA
 74325340 Unknown KLA .96 1.03 1.01 .90 1.05 1.02 1.05
ATP .97 .94 1.02 1.02 .93 1.05 .99
KLA/ATP .95 .97 .94 1.00 1.05 1.02 .98
Mm.7329
KLA  ATP  ATP+KLA
 158508431 Unknown KLA 1.07 1.00 .89 .83 .87 .58 .44
ATP 1.19 1.31 1.06 1.47 1.11 .56 .46
KLA/ATP .94 1.10 1.03 1.33 .87 .55 .27
Pgam1
KLA  ATP  ATP+KLA
 NM_023418 phosphoglycerate mutase 1 (Pgam1), mRNA [NM_023418] KLA .71 .69 .75 .85 .89 .84 1.30
ATP 1.02 1.10 1.00 .99 1.47 2.02 1.36
KLA/ATP .83 .83 .74 .76 1.24 1.73 1.11
Pgam2
KLA  ATP  ATP+KLA
 NM_018870 phosphoglycerate mutase 2 (Pgam2), mRNA [NM_018870] KLA .99 1.05 1.11 1.10 1.10 1.14 1.30
ATP 1.09 1.08 1.17 1.17 1.31 1.63 1.18
KLA/ATP 1.07 1.08 1.06 1.09 1.27 1.42 1.13
Phgdh
KLA  ATP  ATP+KLA
 NM_016966 3-phosphoglycerate dehydrogenase (Phgdh), mRNA [NM_016966] KLA 1.06 1.11 .97 .89 .82 .80 .91
ATP 1.02 1.03 1.17 1.33 3.31 3.86 .74
KLA/ATP 1.07 1.06 1.15 1.38 1.78 1.84 .40
Pipox
KLA  ATP  ATP+KLA
 NM_008952 pipecolic acid oxidase (Pipox), mRNA [NM_008952] KLA .97 .94 1.00 1.00 .98 1.06 1.01
ATP 1.04 1.01 1.03 1.03 1.06 .93 1.01
KLA/ATP 1.03 1.12 1.07 1.06 .98 1.07 .97
Psat1
KLA  ATP  ATP+KLA
 NM_177420 phosphoserine aminotransferase 1 (Psat1), mRNA [NM_177420] KLA 1.02 1.21 1.24 1.27 1.64 1.59 .38
ATP 1.02 1.01 1.04 1.17 1.27 1.09 .43
KLA/ATP 1.16 1.11 1.04 1.37 1.04 .70 .24
Psph
KLA  ATP  ATP+KLA
 NM_133900 phosphoserine phosphatase (Psph), mRNA [NM_133900] KLA .94 .88 .76 .88 .65 .87 .75
ATP .77 .61 .53 .35 1.23 1.85 .73
KLA/ATP .71 .64 .54 .31 .46 .78 .61
Sardh
KLA  ATP  ATP+KLA
 NM_138665 sarcosine dehydrogenase (Sardh), mRNA [NM_138665] KLA .91 .92 .92 .95 .79 .75 .70
ATP .98 .90 .98 .94 .75 .74 .67
KLA/ATP .94 .92 .88 .89 .78 .73 .67
Sds
KLA  ATP  ATP+KLA
 NM_145565 serine dehydratase (Sds), mRNA [NM_145565] KLA 1.04 1.04 1.02 1.03 1.07 1.05 .77
ATP .93 .97 .91 .94 1.00 .94 1.00
KLA/ATP .93 .95 1.05 .96 .98 .96 1.05
Shmt1
KLA  ATP  ATP+KLA
 NM_009171 serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA [NM_009171] KLA .85 .89 .82 .83 .82 .88 .83
ATP .93 .81 .85 .82 .85 .86 .72
KLA/ATP .81 .83 .91 .86 .85 .86 .72
Shmt2
KLA  ATP  ATP+KLA
 NM_028230 serine hydroxymethyltransferase 2 (mitochondrial) (Shmt2), nuclear gene encoding mitochondrial protein, mRNA [NM_028230] KLA .82 .90 .78 .63 .51 .39 .63
ATP 1.04 1.21 .97 1.44 1.32 .85 .64
KLA/ATP .94 .92 .62 1.01 .59 .49 .32
Srr
KLA  ATP  ATP+KLA
 AK002636 adult male kidney cDNA, RIKEN full-length enriched library, clone:0610015N12 product:serine racemase, full insert sequence. [AK002636] KLA .86 .84 .89 .89 .84 .91 .85
ATP .98 .88 .88 .73 .78 .84 .76
KLA/ATP .83 .80 .81 .70 .90 .78 .84
Srr
KLA  ATP  ATP+KLA
 NM_013761 serine racemase (Srr), mRNA [NM_013761] KLA .98 .93 .96 .97 .95 1.04 1.22
ATP 1.04 .93 .88 .89 .84 .90 1.24
KLA/ATP .95 .92 .86 .85 .80 1.04 1.42
Tdh
KLA  ATP  ATP+KLA
 NM_021480 L-threonine dehydrogenase (Tdh), mRNA [NM_021480] KLA 1.05 1.01 1.04 1.09 1.06 1.06 1.07
ATP .88 .99 1.02 .99 1.03 1.04 1.05
KLA/ATP 1.03 .91 1.14 1.08 1.11 1.09 1.15
Tha1
KLA  ATP  ATP+KLA
 NM_027919 threonine aldolase 1 (Tha1), mRNA [NM_027919] KLA 3.92 4.62 4.23 4.99 4.59 2.42 2.04
ATP .98 .92 .78 .74 .78 1.21 1.03
KLA/ATP 4.35 4.64 3.33 2.80 1.63 1.41 1.50