Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Cysteine and methionine metabolism (mmu00270)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2410018C
20Rik
KLA  ATP  ATP+KLA
 NM_026423 RIKEN cDNA 2410018C20 gene (2410018C20Rik), mRNA [NM_026423] KLA .59 .58 .51 .47 .41 .42 .60
ATP 1.01 1.04 .99 1.04 .68 .47 .83
KLA/ATP .60 .61 .53 .56 .44 .42 .38
4930438A
08Rik
KLA  ATP  ATP+KLA
 XM_001477470 gb|PREDICTED: Mus musculus RIKEN cDNA 4930438A08 gene (4930438A08Rik), mRNA [XM_001477470] KLA 1.78 1.45 1.69 1.62 1.69 1.48 1.31
ATP 1.07 1.04 1.24 1.13 1.13 1.61 1.67
KLA/ATP 1.83 1.46 1.58 1.30 1.43 1.36 1.95
Adi1
KLA  ATP  ATP+KLA
 NM_134052 acireductone dioxygenase 1 (Adi1), mRNA [NM_134052] KLA .53 .57 .42 .51 .42 .47 .78
ATP 1.21 1.20 1.11 1.26 1.07 .72 1.07
KLA/ATP .59 .52 .53 .58 .56 .71 .68
Ahcy
KLA  ATP  ATP+KLA
 AK154302 NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630016H08 product:S-adenosylhomocysteine hydrolase, full insert sequence. [AK154302] KLA .95 1.05 1.04 1.01 .92 .72 .57
ATP 1.05 1.14 1.15 1.38 1.30 .94 .51
KLA/ATP 1.04 1.15 1.21 1.25 .99 .70 .31
Ahcy
KLA  ATP  ATP+KLA
 L32836 (clone C7/B9) S-adenosyl homocysteine hydrolase (ahcy) mRNA, complete cds. [L32836] KLA 1.04 1.01 1.02 1.06 .90 .78 .61
ATP .97 1.01 1.21 1.44 1.23 .98 .52
KLA/ATP .97 1.06 1.18 1.30 1.05 .79 .32
Ahcy
KLA  ATP  ATP+KLA
 NM_016661 S-adenosylhomocysteine hydrolase (Ahcy), mRNA [NM_016661] KLA 1.07 1.02 1.18 1.07 1.07 .92 .72
ATP 1.04 1.11 1.13 1.51 1.21 .90 .59
KLA/ATP 1.13 1.28 1.17 1.33 .96 .84 .51
Ahcyl1
KLA  ATP  ATP+KLA
 NM_145542 S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), mRNA [NM_145542] KLA 1.19 1.36 1.32 1.12 1.03 .94 1.15
ATP 1.02 1.08 .88 .99 .97 .84 1.43
KLA/ATP 1.32 1.28 .99 1.29 .99 1.13 1.89
Ahcyl2
KLA  ATP  ATP+KLA
 AB041551 brain cDNA, clone MNCb-5555. [AB041551] KLA .99 1.03 .90 .81 .88 .81 .90
ATP 1.38 1.48 1.04 1.22 1.10 .81 .98
KLA/ATP 1.06 .86 .82 .86 1.00 1.02 1.03
Ahcyl2
KLA  ATP  ATP+KLA
 NM_021414 S-adenosylhomocysteine hydrolase-like 2 (Ahcyl2), mRNA [NM_021414] KLA 1.43 1.40 1.57 1.56 1.44 1.03 1.27
ATP 1.12 1.17 1.23 1.45 1.50 1.61 2.13
KLA/ATP 1.60 1.72 1.66 1.45 1.42 2.00 2.84
Amd1
KLA  ATP  ATP+KLA
 NM_009665 S-adenosylmethionine decarboxylase 1 (Amd1), mRNA [NM_009665] KLA .71 .69 .69 .65 .62 .90 1.66
ATP 1.13 1.16 .83 .88 .87 1.04 1.21
KLA/ATP .80 .85 .61 .63 .63 .68 .77
Amd1
KLA  ATP  ATP+KLA
 Z14986 gb|M.musculus mRNA encoding adenosylmethionine decarboxylase. [Z14986] KLA .55 .52 .41 .38 .38 .81 1.42
ATP .87 .85 .86 .52 .84 1.43 1.06
KLA/ATP .50 .46 .41 .33 .49 .60 .59
Apip
KLA  ATP  ATP+KLA
 NM_019735 APAF1 interacting protein (Apip), mRNA [NM_019735] KLA .99 .99 .87 .95 .83 .92 1.04
ATP .86 .83 1.13 1.07 .91 .77 .91
KLA/ATP .84 .92 1.17 1.00 1.02 .86 1.02
Bhmt
KLA  ATP  ATP+KLA
 NM_016668 betaine-homocysteine methyltransferase (Bhmt), mRNA [NM_016668] KLA 1.02 1.04 1.02 .95 1.04 1.03 1.05
ATP .98 .96 1.08 1.02 .98 1.02 1.08
KLA/ATP .96 1.02 1.04 1.01 .98 .94 1.01
Cbs
KLA  ATP  ATP+KLA
 NM_144855 cystathionine beta-synthase (Cbs), transcript variant 1, mRNA [NM_144855] KLA .95 1.02 .94 .94 .99 .99 1.00
ATP 1.00 1.14 1.04 .85 .99 .94 .91
KLA/ATP 1.01 1.08 .97 1.02 .97 .88 .98
Cdo1
KLA  ATP  ATP+KLA
 NM_033037 cysteine dioxygenase 1, cytosolic (Cdo1), mRNA [NM_033037] KLA 1.28 1.33 1.27 1.30 1.24 1.26 1.10
ATP 1.09 1.13 1.79 7.13 7.75 3.67 1.26
KLA/ATP 1.31 1.37 1.77 5.21 6.82 4.19 1.94
Cth
KLA  ATP  ATP+KLA
 NM_145953 cystathionase (cystathionine gamma-lyase) (Cth), mRNA [NM_145953] KLA 1.95 1.88 2.04 1.99 1.70 1.19 1.05
ATP 1.05 1.03 1.17 1.26 1.76 2.05 1.00
KLA/ATP 1.79 2.03 2.06 1.83 1.66 1.53 .99
Dnmt1
KLA  ATP  ATP+KLA
 NM_010066 DNA methyltransferase (cytosine-5) 1 (Dnmt1), mRNA [NM_010066] KLA .32 .30 .28 .26 .32 .58 .51
ATP .94 1.04 .99 .78 .75 .47 .68
KLA/ATP .33 .31 .30 .30 .56 .66 .52
Dnmt3a
KLA  ATP  ATP+KLA
 NM_007872 DNA methyltransferase 3A (Dnmt3a), transcript variant 1, mRNA [NM_007872] KLA .58 .57 .54 .54 .65 .85 .94
ATP 1.01 1.05 1.03 1.60 2.57 1.20 2.38
KLA/ATP .59 .60 .65 1.00 2.83 2.61 2.34
Dnmt3a
KLA  ATP  ATP+KLA
 NM_153743 DNA methyltransferase 3A (Dnmt3a), transcript variant 2, mRNA [NM_153743] KLA .46 .49 .44 .48 .60 .82 .90
ATP .90 .86 .91 1.13 2.27 .71 2.86
KLA/ATP .43 .49 .58 .72 2.57 1.56 2.61
Dnmt3b
KLA  ATP  ATP+KLA
 NM_001003961 DNA methyltransferase 3B (Dnmt3b), transcript variant 1, mRNA [NM_001003961] KLA .74 .72 .79 .63 .66 .62 .62
ATP 1.02 .92 .95 .66 .63 .90 .74
KLA/ATP .68 .74 .78 .61 .59 .69 .58
Dnmt3l
KLA  ATP  ATP+KLA
 NM_019448 DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l), transcript variant 1, mRNA [NM_019448] KLA 1.22 1.26 1.09 1.10 1.00 1.56 4.71
ATP .97 1.05 1.19 1.16 1.91 11.10 2.62
KLA/ATP 1.30 1.33 1.44 1.18 1.29 5.28 5.91
Enoph1
KLA  ATP  ATP+KLA
 NM_026421 enolase-phosphatase 1 (Enoph1), mRNA [NM_026421] KLA .99 1.03 .96 .95 .91 .76 .84
ATP 1.04 1.18 1.13 1.29 1.17 .70 .66
KLA/ATP 1.00 1.06 1.08 1.17 .99 .76 .40
Got1
KLA  ATP  ATP+KLA
 NM_010324 glutamate oxaloacetate transaminase 1, soluble (Got1), mRNA [NM_010324] KLA .68 .70 .66 .56 .50 .57 .99
ATP 1.01 1.24 1.55 1.59 1.47 1.03 1.68
KLA/ATP .68 .71 .66 .77 1.13 2.33 1.89
Got2
KLA  ATP  ATP+KLA
 NM_010325 glutamate oxaloacetate transaminase 2, mitochondrial (Got2), nuclear gene encoding mitochondrial protein, mRNA [NM_010325] KLA .84 .86 .88 .75 .75 .63 .61
ATP 1.02 1.12 .98 1.15 .98 .67 .86
KLA/ATP .92 .89 .75 .89 .68 .70 .77
Il4i1
KLA  ATP  ATP+KLA
 NM_010215 interleukin 4 induced 1 (Il4i1), mRNA [NM_010215] KLA 13.98 13.74 14.90 14.92 13.89 12.12 3.25
ATP 1.02 .98 1.14 1.59 4.45 6.63 2.41
KLA/ATP 16.09 15.56 19.65 19.66 18.47 14.84 12.99
Lao1
KLA  ATP  ATP+KLA
 NM_133892 L-amino acid oxidase 1 (Lao1), mRNA [NM_133892] KLA 1.03 1.03 1.04 1.00 .98 1.01 .98
ATP 1.01 1.03 1.02 .92 1.05 .98 .99
KLA/ATP 1.02 .96 1.04 .94 .96 .97 .97
Ldha
KLA  ATP  ATP+KLA
 NM_010699 lactate dehydrogenase A (Ldha), mRNA [NM_010699] KLA .89 .80 .84 .93 .96 1.04 1.23
ATP 1.05 1.04 .96 .87 1.21 1.43 1.11
KLA/ATP .93 .87 .87 .93 1.24 1.53 .96
Ldhal6b
KLA  ATP  ATP+KLA
 NM_175349 lactate dehydrogenase A-like 6B (Ldhal6b), mRNA [NM_175349] KLA .89 .90 .94 .92 1.04 1.11 1.20
ATP .99 .91 .90 .88 .90 .88 1.17
KLA/ATP .93 .97 .87 .89 .91 1.00 1.20
Ldhb
KLA  ATP  ATP+KLA
 NM_008492 lactate dehydrogenase B (Ldhb), mRNA [NM_008492] KLA 1.00 .97 .96 1.00 .78 .63 .39
ATP .84 .89 1.11 1.24 1.01 .67 .47
KLA/ATP .94 1.03 1.35 1.92 1.40 .85 .47
Ldhc
KLA  ATP  ATP+KLA
 NM_013580 lactate dehydrogenase C (Ldhc), mRNA [NM_013580] KLA .98 1.02 1.04 1.02 .97 .95 .99
ATP 1.02 1.00 .97 .96 1.00 1.00 .95
KLA/ATP .96 1.10 1.07 .95 1.03 1.06 1.03
Mat1a
KLA  ATP  ATP+KLA
 NM_133653 methionine adenosyltransferase I, alpha (Mat1a), mRNA [NM_133653] KLA 1.08 .94 1.05 .99 .99 1.08 1.05
ATP 1.00 1.02 1.03 1.03 1.00 1.06 1.03
KLA/ATP 1.04 1.03 1.00 1.04 .98 .96 .97
Mat2a
KLA  ATP  ATP+KLA
 NM_145569 methionine adenosyltransferase II, alpha (Mat2a), mRNA [NM_145569] KLA .44 .42 .37 .38 .48 .65 .85
ATP .82 .64 .76 .45 .32 .71 .87
KLA/ATP .40 .38 .41 .33 .29 .53 .33
Mat2b
KLA  ATP  ATP+KLA
 AK038303 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130094D24 product:similar to 5 of METHIONINE ADENOSYLTRANSFERASE REGULATORY BETA SUBUNIT (HYPOTHETICAL 37.6 KDA PROTEIN) [Homo sapiens], full insert sequence [AK0383 KLA .97 1.01 1.66 1.00 .96 1.05 1.11
ATP .97 1.01 .93 .95 1.03 1.01 .93
KLA/ATP .96 .90 .91 .97 1.04 .95 .91
Mat2b
KLA  ATP  ATP+KLA
 NM_134017 methionine adenosyltransferase II, beta (Mat2b), mRNA [NM_134017] KLA .81 .85 .89 1.03 1.00 1.02 1.02
ATP .99 1.03 1.00 .99 .77 .96 .84
KLA/ATP .77 .88 .88 .92 1.06 1.26 .98
Mm.42309
9
KLA  ATP  ATP+KLA
 74325340 Unknown KLA .96 1.03 1.01 .90 1.05 1.02 1.05
ATP .97 .94 1.02 1.02 .93 1.05 .99
KLA/ATP .95 .97 .94 1.00 1.05 1.02 .98
Mpst
KLA  ATP  ATP+KLA
 NM_138670 mercaptopyruvate sulfurtransferase (Mpst), nuclear gene encoding mitochondrial protein, mRNA [NM_138670] KLA .87 1.03 .83 .86 .79 1.21 1.35
ATP .99 1.43 1.12 1.05 1.00 .91 1.24
KLA/ATP .91 1.21 1.03 1.10 .87 .73 1.52
Mtap
KLA  ATP  ATP+KLA
 NM_024433 methylthioadenosine phosphorylase (Mtap), mRNA [NM_024433] KLA .83 .89 .73 .73 .55 .39 .64
ATP 1.15 1.28 1.09 1.23 .72 .32 .38
KLA/ATP .98 .95 .79 .89 .52 .29 .20
Mtr
KLA  ATP  ATP+KLA
 AK037599 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130029B16 product:5-methyltetrahydrofolate-homocysteine methyltransferase, full insert sequence. [AK037599] KLA .89 .92 .81 .83 .73 .76 .98
ATP .98 1.11 .85 .93 .68 .72 1.12
KLA/ATP .92 .93 .71 .85 .66 .68 .77
Mtr
KLA  ATP  ATP+KLA
 NM_001081128 5-methyltetrahydrofolate-homocysteine methyltransferase (Mtr), mRNA [NM_001081128] KLA .93 .91 .89 .77 .64 .58 .99
ATP 1.12 1.11 1.05 .87 .71 .69 1.59
KLA/ATP 1.02 .95 .96 .78 .54 .55 .92
Sds
KLA  ATP  ATP+KLA
 NM_145565 serine dehydratase (Sds), mRNA [NM_145565] KLA 1.04 1.04 1.02 1.03 1.07 1.05 .77
ATP .93 .97 .91 .94 1.00 .94 1.00
KLA/ATP .93 .95 1.05 .96 .98 .96 1.05
Sms
KLA  ATP  ATP+KLA
 NM_009214 spermine synthase (Sms), mRNA [NM_009214] KLA 1.18 1.13 1.09 1.03 .91 .68 .62
ATP .99 1.03 .86 .77 .69 .49 .56
KLA/ATP 1.08 1.13 .92 .80 .62 .42 .32
Srm
KLA  ATP  ATP+KLA
 NM_009272 spermidine synthase (Srm), mRNA [NM_009272] KLA .61 .68 .55 .41 .31 .32 .57
ATP .95 1.06 .92 1.19 .94 .50 .61
KLA/ATP .70 .65 .55 .59 .44 .26 .17
Tat
KLA  ATP  ATP+KLA
 NM_146214 tyrosine aminotransferase (Tat), nuclear gene encoding mitochondrial protein, mRNA [NM_146214] KLA 1.13 1.09 1.19 1.17 1.14 1.19 1.10
ATP .97 1.08 1.12 1.25 1.02 1.16 1.18
KLA/ATP 1.16 1.21 1.27 1.23 1.22 1.11 1.08
Tst
KLA  ATP  ATP+KLA
 NM_009437 thiosulfate sulfurtransferase, mitochondrial (Tst), nuclear gene encoding mitochondrial protein, mRNA [NM_009437] KLA .85 .91 .84 .85 .76 .80 1.10
ATP 1.01 1.12 1.44 1.34 .90 .98 1.04
KLA/ATP .84 .98 1.14 1.23 .97 .93 .99