Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Valine, leucine and isoleucine degradation (mmu00280)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
4930438A
08Rik
KLA  ATP  ATP+KLA
 XM_001477470 gb|PREDICTED: Mus musculus RIKEN cDNA 4930438A08 gene (4930438A08Rik), mRNA [XM_001477470] KLA 1.78 1.45 1.69 1.62 1.69 1.48 1.31
ATP 1.07 1.04 1.24 1.13 1.13 1.61 1.67
KLA/ATP 1.83 1.46 1.58 1.30 1.43 1.36 1.95
Abat
KLA  ATP  ATP+KLA
 AK083062 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530041H11 product:hypothetical protein, full insert sequence. [AK083062] KLA 1.01 1.09 .97 .99 1.03 1.02 1.06
ATP .96 .99 1.00 1.11 1.04 .98 1.06
KLA/ATP 1.06 1.03 .96 1.06 1.10 1.06 .96
Abat
KLA  ATP  ATP+KLA
 NM_172961 4-aminobutyrate aminotransferase (Abat), nuclear gene encoding mitochondrial protein, mRNA [NM_172961] KLA 1.03 .96 .97 1.00 .92 .97 .96
ATP .97 .93 1.07 1.04 .97 .99 .98
KLA/ATP 1.03 1.01 1.00 .98 .94 .89 .97
Acaa1a
KLA  ATP  ATP+KLA
 NM_130864 acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA 1.53 1.60 1.88 2.07 2.41 2.64 1.82
ATP 1.07 .99 .98 1.10 .94 .83 1.58
KLA/ATP 1.64 1.64 1.73 1.75 1.61 1.39 1.85
Acaa1b
KLA  ATP  ATP+KLA
 NM_146230 acetyl-Coenzyme A acyltransferase 1B (Acaa1b), mRNA [NM_146230] KLA 1.52 1.66 1.93 2.04 2.32 2.51 1.83
ATP 1.04 .95 1.06 1.12 1.03 .93 1.59
KLA/ATP 1.76 1.72 1.76 1.95 1.76 1.51 1.86
Acaa2
KLA  ATP  ATP+KLA
 NM_177470 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) (Acaa2), nuclear gene encoding mitochondrial protein, mRNA [NM_177470] KLA .98 .94 1.00 1.00 .90 .81 .60
ATP 1.03 1.00 1.12 1.10 .84 .48 .50
KLA/ATP .98 .98 1.03 1.05 .99 .85 .40
Acad8
KLA  ATP  ATP+KLA
 NM_025862 acyl-Coenzyme A dehydrogenase family, member 8 (Acad8), mRNA [NM_025862] KLA .89 .84 .95 .94 .84 .78 .82
ATP 1.07 .98 .99 .74 .53 .57 .69
KLA/ATP .89 .88 .85 .65 .52 .60 .60
Acadm
KLA  ATP  ATP+KLA
 NM_007382 acyl-Coenzyme A dehydrogenase, medium chain (Acadm), nuclear gene encoding mitochondrial protein, mRNA [NM_007382] KLA .57 .50 .50 .37 .34 .34 .54
ATP 1.09 1.08 1.16 .92 .67 .43 .51
KLA/ATP .55 .56 .57 .46 .41 .36 .29
Acads
KLA  ATP  ATP+KLA
 NM_007383 acyl-Coenzyme A dehydrogenase, short chain (Acads), nuclear gene encoding mitochondrial protein, mRNA [NM_007383] KLA .76 .78 .76 .69 .71 .71 .70
ATP 1.02 1.11 1.01 1.28 .75 .58 .79
KLA/ATP .80 .76 .66 .82 .56 .56 .53
Acadsb
KLA  ATP  ATP+KLA
 NM_025826 acyl-Coenzyme A dehydrogenase, short/branched chain (Acadsb), nuclear gene encoding mitochondrial protein, mRNA [NM_025826] KLA 1.30 1.38 1.39 1.23 1.50 1.35 1.26
ATP 1.18 1.36 1.31 1.24 .91 .73 1.18
KLA/ATP 1.44 1.26 1.22 1.41 .78 .68 1.19
Acat1
KLA  ATP  ATP+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
ATP .89 .88 1.21 .99 .67 .36 .47
KLA/ATP .86 .97 1.18 .90 .64 .42 .35
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Aldh1b1
KLA  ATP  ATP+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA 7.51 7.83 9.27 11.57 11.10 10.78 4.79
ATP .93 .91 .90 .89 .73 2.27 2.30
KLA/ATP 6.45 7.40 9.33 9.54 8.82 12.15 10.67
Aldh2
KLA  ATP  ATP+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA .62 .65 .59 .60 .63 .64 .49
ATP 1.01 .91 1.06 .93 1.18 .93 .41
KLA/ATP .70 .68 .70 .84 1.16 .96 .45
Aldh2
KLA  ATP  ATP+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA .74 .81 .77 .65 .60 .53 .50
ATP .98 1.10 .90 1.17 1.04 .82 .60
KLA/ATP .84 .86 .77 .82 .72 .66 .51
Aldh3a2
KLA  ATP  ATP+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA .86 .83 .79 .79 .80 .97 1.00
ATP .93 .98 .94 .89 .77 .87 1.02
KLA/ATP .78 .81 .67 .72 .65 .81 .97
Aldh6a1
KLA  ATP  ATP+KLA
 NM_134042 aldehyde dehydrogenase family 6, subfamily A1 (Aldh6a1), nuclear gene encoding mitochondrial protein, mRNA [NM_134042] KLA 1.02 .97 .98 1.15 1.31 1.39 .67
ATP .96 .92 1.21 .87 .64 .54 .55
KLA/ATP .82 .97 1.04 .87 .80 .59 .36
Aldh7a1
KLA  ATP  ATP+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA .98 1.03 1.08 1.12 1.08 .94 .99
ATP 1.01 1.03 1.00 1.03 .98 .82 .91
KLA/ATP 1.15 1.12 1.01 1.02 .90 .89 .83
Aldh9a1
KLA  ATP  ATP+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA .64 .64 .67 .48 .42 .24 .33
ATP 1.07 1.02 .75 .94 .68 .46 .42
KLA/ATP .72 .65 .43 .55 .37 .31 .24
Aox1
KLA  ATP  ATP+KLA
 NM_009676 aldehyde oxidase 1 (Aox1), mRNA [NM_009676] KLA .87 .83 .82 .82 .71 .98 1.65
ATP 1.01 1.02 1.05 .84 .72 .86 .80
KLA/ATP .82 .84 .90 .73 .72 .82 1.06
Aox3
KLA  ATP  ATP+KLA
 NM_023617 aldehyde oxidase 3 (Aox3), mRNA [NM_023617] KLA .95 1.02 1.01 1.00 .99 1.01 1.04
ATP 1.04 1.03 1.01 .94 1.03 .92 .96
KLA/ATP 1.09 1.11 1.00 .97 .95 1.01 .94
Aox4
KLA  ATP  ATP+KLA
 NM_023631 aldehyde oxidase 4 (Aox4), mRNA [NM_023631] KLA .95 .97 .98 1.00 .98 .91 1.06
ATP .93 .99 .95 .99 .94 .95 1.00
KLA/ATP 1.05 1.00 .94 .98 .89 1.00 .93
Auh
KLA  ATP  ATP+KLA
 NM_016709 AU RNA binding protein/enoyl-coenzyme A hydratase (Auh), nuclear gene encoding mitochondrial protein, mRNA [NM_016709] KLA 1.02 .97 1.20 1.24 1.26 1.18 .91
ATP 1.11 .97 1.26 1.31 1.10 .88 .62
KLA/ATP 1.06 1.11 1.48 1.24 1.57 1.08 .90
Bcat1
KLA  ATP  ATP+KLA
 NM_001024468 branched chain aminotransferase 1, cytosolic (Bcat1), transcript variant 1, mRNA [NM_001024468] KLA 1.04 1.03 .98 1.04 .99 1.02 1.03
ATP 1.00 1.01 1.02 1.01 1.12 1.25 1.09
KLA/ATP .99 1.00 1.04 1.04 1.01 1.08 1.15
Bcat2
KLA  ATP  ATP+KLA
 NM_009737 branched chain aminotransferase 2, mitochondrial (Bcat2), nuclear gene encoding mitochondrial protein, mRNA [NM_009737] KLA 1.06 1.05 1.08 .97 1.08 .96 1.61
ATP 1.07 1.42 .96 1.55 .87 .66 .96
KLA/ATP 1.27 1.29 .84 1.36 .81 .76 .92
Bckdha
KLA  ATP  ATP+KLA
 NM_007533 branched chain ketoacid dehydrogenase E1, alpha polypeptide (Bckdha), mRNA [NM_007533] KLA .81 .83 .84 .77 .72 .67 .73
ATP 1.14 1.20 1.15 1.50 1.10 .74 .69
KLA/ATP .97 .94 .83 1.03 .86 .75 .71
Bckdhb
KLA  ATP  ATP+KLA
 NM_199195 branched chain ketoacid dehydrogenase E1, beta polypeptide (Bckdhb), nuclear gene encoding mitochondrial protein, mRNA [NM_199195] KLA 2.08 2.24 2.30 2.39 2.45 1.95 1.17
ATP .95 1.02 1.24 1.37 .98 .41 .44
KLA/ATP 2.12 2.34 2.71 3.07 2.12 1.25 .54
Dbt
KLA  ATP  ATP+KLA
 NM_010022 dihydrolipoamide branched chain transacylase E2 (Dbt), nuclear gene encoding mitochondrial protein, mRNA [NM_010022] KLA .98 1.06 1.02 1.14 1.31 1.11 1.09
ATP 1.04 .96 .97 1.07 .71 .84 1.09
KLA/ATP .97 1.09 .96 .96 .79 .81 .68
Dld
KLA  ATP  ATP+KLA
 NM_007861 dihydrolipoamide dehydrogenase (Dld), mRNA [NM_007861] KLA 1.60 1.66 1.84 1.66 1.47 1.16 1.17
ATP 1.05 1.08 1.21 1.06 1.15 1.24 .93
KLA/ATP 1.52 1.63 1.65 1.42 1.17 1.05 .79
Dld
KLA  ATP  ATP+KLA
 U73445 dihydrolipoamide dehydrogenase (Dld) mRNA, complete cds. [U73445] KLA 1.48 1.43 1.43 1.47 1.25 1.05 1.16
ATP .94 .93 1.18 .86 1.02 1.46 .97
KLA/ATP 1.39 1.37 1.50 1.10 1.11 1.14 .85
Echs1
KLA  ATP  ATP+KLA
 NM_053119 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119] KLA .57 .55 .52 .54 .60 .82 .90
ATP .99 .97 1.07 1.15 .77 .37 .81
KLA/ATP .55 .56 .55 .66 .53 .39 .41
Ehhadh
KLA  ATP  ATP+KLA
 NM_023737 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737] KLA .74 .77 .80 .88 .71 .67 .74
ATP 1.02 1.06 1.04 .90 .70 .84 .83
KLA/ATP .79 .81 .80 .65 .59 .79 .55
Hadh
KLA  ATP  ATP+KLA
 NM_008212 hydroxyacyl-Coenzyme A dehydrogenase (Hadh), nuclear gene encoding mitochondrial protein, mRNA [NM_008212] KLA .75 .75 .72 .64 .54 .37 .49
ATP 1.12 1.19 1.08 1.28 .96 .43 .41
KLA/ATP .76 .81 .68 .85 .56 .42 .21
Hadha
KLA  ATP  ATP+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA .96 .92 .91 .80 .97 .92 .90
ATP .72 .64 .63 .71 .91 .93 .93
KLA/ATP .79 .72 .68 .73 .87 .90 .88
Hadha
KLA  ATP  ATP+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.10 1.17 1.36 1.16 1.23 1.10 1.00
ATP 1.16 1.22 1.03 1.40 1.09 .79 1.11
KLA/ATP 1.33 1.35 1.16 1.41 1.00 .92 1.31
Hadhb
KLA  ATP  ATP+KLA
 NM_145558 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit (Hadhb), nuclear gene encoding mitochondrial protein, mRNA [NM_145558] KLA .85 .88 .76 .77 .70 .54 .58
ATP 1.08 1.13 1.05 1.01 .84 .53 .58
KLA/ATP .79 .91 .83 .80 .61 .46 .44
Hibadh
KLA  ATP  ATP+KLA
 NM_145567 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA [NM_145567] KLA 1.18 1.20 1.52 1.58 1.53 1.48 .93
ATP 1.13 1.04 1.21 1.15 1.07 .87 .79
KLA/ATP 1.27 1.34 1.79 1.40 1.49 1.17 .93
Hibch
KLA  ATP  ATP+KLA
 NM_146108 3-hydroxyisobutyryl-Coenzyme A hydrolase (Hibch), mRNA [NM_146108] KLA .47 .44 .40 .33 .30 .39 .82
ATP .92 .92 1.45 1.12 .69 .61 .91
KLA/ATP .42 .41 .56 .40 .34 .45 .55
Hmgcl
KLA  ATP  ATP+KLA
 NM_008254 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl), mRNA [NM_008254] KLA .37 .34 .39 .48 .63 .86 .71
ATP .87 .84 .93 .82 .69 .91 1.21
KLA/ATP .32 .33 .38 .38 .71 1.31 1.25
Hmgcs1
KLA  ATP  ATP+KLA
 AK078743 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030402P03 product:similar to hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) (fragment) [Gallus gallus], full insert sequence. [AK078743] KLA 1.06 1.08 .98 .81 .88 .71 .86
ATP 1.39 1.87 10.43 2.82 1.19 1.14 1.09
KLA/ATP 1.36 1.59 5.22 1.83 1.21 .75 .66
Hmgcs1
KLA  ATP  ATP+KLA
 NM_145942 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942] KLA 1.16 1.10 1.26 1.16 .88 .63 .69
ATP 1.01 1.10 1.87 2.36 1.98 .89 .97
KLA/ATP 1.12 1.20 1.33 1.69 1.39 .67 .51
Hmgcs2
KLA  ATP  ATP+KLA
 NM_008256 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256] KLA .92 1.10 1.00 .99 1.08 1.06 1.14
ATP .99 1.02 1.00 1.00 .98 1.08 .92
KLA/ATP .99 1.00 1.00 1.03 1.28 1.06 1.00
Hsd17b10
KLA  ATP  ATP+KLA
 NM_016763 hydroxysteroid (17-beta) dehydrogenase 10 (Hsd17b10), nuclear gene encoding mitochondrial protein, mRNA [NM_016763] KLA .90 .86 .78 .80 .83 .71 1.06
ATP 1.11 1.05 1.19 1.30 1.25 .80 .80
KLA/ATP .83 .95 1.30 1.16 1.00 .86 .88
Il4i1
KLA  ATP  ATP+KLA
 NM_010215 interleukin 4 induced 1 (Il4i1), mRNA [NM_010215] KLA 13.98 13.74 14.90 14.92 13.89 12.12 3.25
ATP 1.02 .98 1.14 1.59 4.45 6.63 2.41
KLA/ATP 16.09 15.56 19.65 19.66 18.47 14.84 12.99
Ivd
KLA  ATP  ATP+KLA
 NM_019826 isovaleryl coenzyme A dehydrogenase (Ivd), nuclear gene encoding mitochondrial protein, mRNA [NM_019826] KLA .93 .88 .91 .89 .82 .81 .61
ATP 1.02 1.01 1.17 1.19 .90 1.34 1.05
KLA/ATP .92 .96 1.01 .98 .79 .91 1.24
Lao1
KLA  ATP  ATP+KLA
 NM_133892 L-amino acid oxidase 1 (Lao1), mRNA [NM_133892] KLA 1.03 1.03 1.04 1.00 .98 1.01 .98
ATP 1.01 1.03 1.02 .92 1.05 .98 .99
KLA/ATP 1.02 .96 1.04 .94 .96 .97 .97
Mccc1
KLA  ATP  ATP+KLA
 NM_023644 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) (Mccc1), mRNA [NM_023644] KLA .89 .88 .81 .85 .73 .82 1.18
ATP .93 .88 1.22 1.07 .88 .65 1.26
KLA/ATP .83 .88 1.12 .86 .77 .56 .79
Mccc2
KLA  ATP  ATP+KLA
 NM_030026 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) (Mccc2), nuclear gene encoding mitochondrial protein, mRNA [NM_030026] KLA .99 1.00 1.03 .76 .65 .55 .61
ATP 1.04 1.11 .80 .97 .53 .37 .51
KLA/ATP .96 1.03 .63 .76 .49 .39 .35
Mcee
KLA  ATP  ATP+KLA
 NM_028626 methylmalonyl CoA epimerase (Mcee), mRNA [NM_028626] KLA .94 .93 .88 .92 .77 .71 .87
ATP .93 .97 1.28 1.51 1.31 .87 .80
KLA/ATP .88 .96 1.18 1.37 1.28 .95 .83
Mm.13732
7
KLA  ATP  ATP+KLA
 116686108 Unknown KLA .93 .84 .81 .69 .58 .47 .53
ATP .94 .87 .87 .75 .38 .23 .41
KLA/ATP .82 .80 .63 .63 .39 .27 .18
Mm.18966
0
KLA  ATP  ATP+KLA
 160358826 Unknown KLA 1.06 1.13 1.05 1.05 1.02 1.02 .98
ATP 1.01 1.05 1.33 1.61 1.40 1.19 1.10
KLA/ATP 1.04 1.02 1.18 1.50 1.38 1.22 1.48
Mm.25203
4
KLA  ATP  ATP+KLA
 116268114 Unknown KLA 1.22 1.14 1.15 1.25 1.52 1.40 .89
ATP 1.08 1.16 1.22 1.27 1.07 .83 .62
KLA/ATP 1.02 1.21 1.56 1.55 1.39 .93 .84
Mm.28924
4
KLA  ATP  ATP+KLA
 118403321 Unknown KLA .84 .83 .89 .94 .83 .96 .76
ATP .79 .69 .94 .64 .55 .66 .71
KLA/ATP .66 .68 .83 .63 .66 .78 .65
Mm.29323
3
KLA  ATP  ATP+KLA
 118130035 Unknown KLA .98 1.04 .98 1.05 1.07 .97 .95
ATP 1.02 1.04 1.01 1.02 1.00 1.00 1.00
KLA/ATP 1.03 1.00 .98 .96 1.10 1.03 .98
Mut
KLA  ATP  ATP+KLA
 X51941 gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941] KLA .57 .56 .51 .56 .55 .63 .69
ATP .89 .83 1.05 .71 .41 .29 .88
KLA/ATP .52 .51 .62 .40 .29 .23 .38
Oxct1
KLA  ATP  ATP+KLA
 NM_024188 3-oxoacid CoA transferase 1 (Oxct1), nuclear gene encoding mitochondrial protein, mRNA [NM_024188] KLA .91 .98 1.06 1.09 .95 .90 .46
ATP 1.00 .98 1.03 .93 .82 .43 .79
KLA/ATP .89 .94 1.18 .97 .97 .67 .33
Oxct2a
KLA  ATP  ATP+KLA
 NM_022033 3-oxoacid CoA transferase 2A (Oxct2a), mRNA [NM_022033] KLA 1.05 1.04 1.09 1.03 .98 1.05 1.07
ATP 1.03 1.00 1.02 1.31 1.14 1.10 .97
KLA/ATP 1.04 1.07 1.01 1.19 1.12 1.06 1.19
Pcca
KLA  ATP  ATP+KLA
 NM_144844 propionyl-Coenzyme A carboxylase, alpha polypeptide (Pcca), mRNA [NM_144844] KLA 1.00 1.07 1.11 1.16 1.07 1.01 .68
ATP .90 .97 1.10 1.14 .93 .53 .60
KLA/ATP .99 1.12 1.16 1.19 .84 .59 .56
Pccb
KLA  ATP  ATP+KLA
 NM_025835 propionyl Coenzyme A carboxylase, beta polypeptide (Pccb), mRNA [NM_025835] KLA .76 .77 .67 .65 .45 .41 .42
ATP .97 1.12 .94 1.15 .90 .51 .37
KLA/ATP .83 .82 .80 .88 .65 .46 .28