Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Histidine metabolism (mmu00340)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
1700055N
04Rik
KLA  ATP  ATP+KLA
 AK081788 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130077J09 product:weakly similar to ALDEHYDE DEHYDROGENASE 7 (EC 1.2.1.5) [Homo sapiens], full insert sequence [AK081788] KLA .96 .98 .95 .97 .97 .96 1.06
ATP 1.01 1.00 .97 1.10 .95 .99 1.02
KLA/ATP .99 1.00 .97 1.00 1.00 .96 .97
Abp1
KLA  ATP  ATP+KLA
 NM_029638 amiloride binding protein 1 (amine oxidase, copper-containing) (Abp1), mRNA [NM_029638] KLA 1.18 1.09 .99 1.08 1.08 .96 1.03
ATP 1.01 1.02 1.01 .97 1.00 1.00 1.05
KLA/ATP 1.14 1.10 1.12 1.02 .99 1.04 1.14
Acy3
KLA  ATP  ATP+KLA
 NM_027857 aspartoacylase (aminoacylase) 3 (Acy3), mRNA [NM_027857] KLA .98 1.04 .96 1.06 .88 .89 .93
ATP 1.11 1.06 .99 1.20 1.07 .87 .98
KLA/ATP 1.04 1.01 .98 1.04 .94 .95 1.06
AI790298
KLA  ATP  ATP+KLA
 AK129347 mRNA for mKIAA1394 protein [AK129347] KLA .97 .95 .93 .98 .95 1.00 1.11
ATP .98 1.03 .98 .97 1.23 1.22 1.05
KLA/ATP .96 .99 .94 .92 1.17 1.27 1.07
Aldh1a3
KLA  ATP  ATP+KLA
 AK086764 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930050B08 product:aldehyde dehydrogenase family 1, subfamily A3, full insert sequence. [AK086764] KLA .97 1.05 1.05 1.01 1.00 .98 .97
ATP 1.00 1.03 .99 .92 1.01 1.09 1.02
KLA/ATP 1.01 .99 1.06 1.00 .97 .98 1.00
Aldh1a3
KLA  ATP  ATP+KLA
 NM_053080 aldehyde dehydrogenase family 1, subfamily A3 (Aldh1a3), mRNA [NM_053080] KLA 1.03 .96 1.03 1.03 .96 .98 1.01
ATP .98 1.04 1.01 1.06 .98 1.01 1.08
KLA/ATP 1.02 1.00 1.02 .94 1.03 .99 .99
Aldh1b1
KLA  ATP  ATP+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA 7.51 7.83 9.27 11.57 11.10 10.78 4.79
ATP .93 .91 .90 .89 .73 2.27 2.30
KLA/ATP 6.45 7.40 9.33 9.54 8.82 12.15 10.67
Aldh2
KLA  ATP  ATP+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA .62 .65 .59 .60 .63 .64 .49
ATP 1.01 .91 1.06 .93 1.18 .93 .41
KLA/ATP .70 .68 .70 .84 1.16 .96 .45
Aldh2
KLA  ATP  ATP+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA .74 .81 .77 .65 .60 .53 .50
ATP .98 1.10 .90 1.17 1.04 .82 .60
KLA/ATP .84 .86 .77 .82 .72 .66 .51
Aldh3a1
KLA  ATP  ATP+KLA
 NM_007436 aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1), transcript variant 1, mRNA [NM_007436] KLA .98 .98 1.03 1.01 1.03 1.04 .97
ATP .98 1.01 1.06 .95 1.00 .96 1.02
KLA/ATP 1.07 1.08 .99 .98 1.03 .93 .98
Aldh3a2
KLA  ATP  ATP+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA .86 .83 .79 .79 .80 .97 1.00
ATP .93 .98 .94 .89 .77 .87 1.02
KLA/ATP .78 .81 .67 .72 .65 .81 .97
Aldh3b1
KLA  ATP  ATP+KLA
 NM_026316 aldehyde dehydrogenase 3 family, member B1 (Aldh3b1), mRNA [NM_026316] KLA .82 .77 .69 .77 .72 .97 1.31
ATP .88 .85 1.13 .89 .71 .56 1.25
KLA/ATP .66 .72 .84 .66 .66 .52 1.17
Aldh3b2
KLA  ATP  ATP+KLA
 XM_129134 gb|PREDICTED: Mus musculus aldehyde dehydrogenase 3 family, member B2 (Aldh3b2), mRNA [XM_129134] KLA .91 .93 .85 .88 1.01 .99 1.37
ATP 1.12 1.11 .99 1.19 .87 .61 1.31
KLA/ATP .86 1.02 .90 1.01 .72 .54 1.21
Aldh7a1
KLA  ATP  ATP+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA .98 1.03 1.08 1.12 1.08 .94 .99
ATP 1.01 1.03 1.00 1.03 .98 .82 .91
KLA/ATP 1.15 1.12 1.01 1.02 .90 .89 .83
Aldh9a1
KLA  ATP  ATP+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA .64 .64 .67 .48 .42 .24 .33
ATP 1.07 1.02 .75 .94 .68 .46 .42
KLA/ATP .72 .65 .43 .55 .37 .31 .24
Amdhd1
KLA  ATP  ATP+KLA
 XM_125854 gb|PREDICTED: Mus musculus amidohydrolase domain containing 1 (Amdhd1), mRNA [XM_125854] KLA 1.09 .88 1.02 1.27 1.11 1.07 .97
ATP .99 1.00 .98 .98 .94 .99 1.04
KLA/ATP 1.03 1.05 1.07 1.01 .98 .96 1.02
Aspa
KLA  ATP  ATP+KLA
 NM_023113 aspartoacylase (Aspa), mRNA [NM_023113] KLA 1.03 1.06 1.08 1.12 1.10 1.09 1.18
ATP 1.02 .94 1.08 1.09 .97 1.08 1.01
KLA/ATP 1.04 1.03 1.14 1.05 1.07 1.12 1.11
Cndp1
KLA  ATP  ATP+KLA
 NM_177450 carnosine dipeptidase 1 (metallopeptidase M20 family) (Cndp1), mRNA [NM_177450] KLA .98 1.00 1.00 1.00 .99 .93 1.04
ATP 1.02 .96 .98 .97 .97 .95 .96
KLA/ATP 1.04 1.04 .95 .94 .98 .96 .94
Cndp2
KLA  ATP  ATP+KLA
 NM_023149 CNDP dipeptidase 2 (metallopeptidase M20 family) (Cndp2), mRNA [NM_023149] KLA .88 .96 1.08 .98 1.35 1.73 1.59
ATP 1.09 1.27 .77 1.02 1.04 1.30 1.67
KLA/ATP 1.17 1.04 .63 1.09 .95 1.78 2.70
Ddc
KLA  ATP  ATP+KLA
 NM_016672 dopa decarboxylase (Ddc), mRNA [NM_016672] KLA 1.27 1.28 1.34 1.33 1.34 1.21 1.05
ATP 1.02 .99 1.05 .98 1.02 1.02 1.14
KLA/ATP 1.24 1.22 1.28 1.25 1.12 1.20 1.35
Ftcd
KLA  ATP  ATP+KLA
 NM_080845 formiminotransferase cyclodeaminase (Ftcd), mRNA [NM_080845] KLA 1.01 .93 .98 .93 .99 1.06 1.05
ATP 1.01 1.00 .96 .96 .95 .93 1.04
KLA/ATP 1.00 .99 .99 .97 .98 .92 .93
Hal
KLA  ATP  ATP+KLA
 NM_010401 histidine ammonia lyase (Hal), mRNA [NM_010401] KLA .97 1.01 1.01 .99 .83 .90 .97
ATP 1.03 1.12 1.05 1.07 1.20 1.74 1.70
KLA/ATP .96 1.00 .97 .99 1.07 1.72 1.29
Hdc
KLA  ATP  ATP+KLA
 NM_008230 histidine decarboxylase (Hdc), mRNA [NM_008230] KLA 27.59 25.41 24.74 28.27 21.96 24.39 9.08
ATP 1.04 1.03 1.59 2.85 3.81 12.00 3.74
KLA/ATP 25.83 28.35 36.64 27.70 32.70 29.32 26.26
Hemk1
KLA  ATP  ATP+KLA
 NM_133984 HemK methyltransferase family member 1 (Hemk1), mRNA [NM_133984] KLA 1.05 1.10 1.13 1.07 1.10 1.12 1.20
ATP 1.01 1.00 .82 .81 .67 .82 1.26
KLA/ATP 1.11 1.15 1.03 .79 .76 .90 1.47
Hnmt
KLA  ATP  ATP+KLA
 NM_080462 histamine N-methyltransferase (Hnmt), mRNA [NM_080462] KLA .75 .74 .74 .75 .70 .67 .36
ATP .92 1.00 1.34 1.36 1.07 .63 .68
KLA/ATP .72 .77 1.01 1.00 .81 .60 .81
Maoa
KLA  ATP  ATP+KLA
 NM_173740 monoamine oxidase A (Maoa), nuclear gene encoding mitochondrial protein, mRNA [NM_173740] KLA 1.14 1.11 1.06 1.07 .84 .55 .53
ATP 1.10 1.07 1.33 1.20 1.44 2.37 1.38
KLA/ATP .97 1.11 1.75 1.33 1.27 1.21 1.09
Maob
KLA  ATP  ATP+KLA
 NM_172778 monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA [NM_172778] KLA 1.01 .97 1.01 1.05 1.01 .95 1.01
ATP 1.09 .98 .99 .97 1.03 1.03 .94
KLA/ATP 1.02 1.05 .99 1.02 1.00 .98 .98
Mettl2
KLA  ATP  ATP+KLA
 NM_172567 methyltransferase like 2 (Mettl2), mRNA [NM_172567] KLA 1.19 1.15 1.16 .93 .84 .77 1.13
ATP .91 .87 .72 .71 .65 .82 .87
KLA/ATP 1.17 1.15 .94 .93 .59 .58 .53
Mettl6
KLA  ATP  ATP+KLA
 NM_025907 methyltransferase like 6 (Mettl6), mRNA [NM_025907] KLA 1.52 1.55 1.68 1.94 2.26 1.84 1.56
ATP 1.05 .96 .83 1.01 3.44 3.01 1.33
KLA/ATP 1.49 1.59 1.71 1.69 4.57 3.72 2.58
Mm.26684
3
KLA  ATP  ATP+KLA
 94405693 Unknown KLA 1.12 .99 .99 1.00 .97 .98 .96
ATP 1.02 1.08 1.01 .90 1.02 .97 .91
KLA/ATP 1.03 .96 .98 .91 1.05 .90 .97
Mm.34137
KLA  ATP  ATP+KLA
 94405716 Unknown KLA 1.11 1.12 1.10 1.07 1.08 1.13 1.36
ATP 1.09 1.14 1.01 1.25 .95 .79 1.23
KLA/ATP 1.01 1.24 .95 1.14 .83 .78 1.30
Uroc1
KLA  ATP  ATP+KLA
 NM_144940 urocanase domain containing 1 (Uroc1), mRNA [NM_144940] KLA .98 .97 .93 .99 1.01 .97 .99
ATP .94 .94 1.07 1.08 1.03 .99 .99
KLA/ATP .88 .97 1.00 1.02 1.00 .93 1.00
Wbscr22
KLA  ATP  ATP+KLA
 NM_025375 Williams Beuren syndrome chromosome region 22 (Wbscr22), mRNA [NM_025375] KLA 1.07 1.03 1.02 1.00 1.03 .95 .95
ATP 1.14 1.21 .99 1.11 .94 .85 1.05
KLA/ATP 1.07 1.08 1.19 1.08 .80 .68 .74