Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Selenocompound metabolism (mmu00450)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
BB135800
KLA  ATP  ATP+KLA
 BB135800 gb|BB135800 RIKEN full-length enriched, adult male bone Mus musculus cDNA clone 9830130K22 3. [BB135800] KLA 1.36 1.43 1.30 1.43 1.57 2.06 1.47
ATP 1.10 1.08 .99 1.05 1.12 1.64 1.99
KLA/ATP 1.45 1.58 1.65 1.46 1.76 2.32 6.28
Ccbl1
KLA  ATP  ATP+KLA
 NM_172404 cysteine conjugate-beta lyase 1 (Ccbl1), mRNA [NM_172404] KLA .68 .64 .61 .59 .58 .75 .89
ATP 1.02 .96 .89 .80 .63 .48 .97
KLA/ATP .71 .68 .61 .64 .53 .50 .60
Ccbl2
KLA  ATP  ATP+KLA
 NM_173763 cysteine conjugate-beta lyase 2 (Ccbl2), mRNA [NM_173763] KLA 2.01 2.14 2.03 1.98 1.40 .85 .65
ATP .96 .91 1.14 .95 .81 1.04 .68
KLA/ATP 2.05 2.10 2.27 1.79 1.55 1.00 .57
Cth
KLA  ATP  ATP+KLA
 NM_145953 cystathionase (cystathionine gamma-lyase) (Cth), mRNA [NM_145953] KLA 1.95 1.88 2.04 1.99 1.70 1.19 1.05
ATP 1.05 1.03 1.17 1.26 1.76 2.05 1.00
KLA/ATP 1.79 2.03 2.06 1.83 1.66 1.53 .99
Inmt
KLA  ATP  ATP+KLA
 NM_009349 indolethylamine N-methyltransferase (Inmt), mRNA [NM_009349] KLA 1.93 2.09 2.34 2.04 2.49 1.90 1.81
ATP .97 1.13 .96 1.21 1.04 1.02 1.40
KLA/ATP 2.00 2.00 1.37 1.91 1.41 1.31 1.62
Mars
KLA  ATP  ATP+KLA
 NM_001003913 methionine-tRNA synthetase (Mars), mRNA [NM_001003913] KLA .82 .84 .78 .65 .59 .79 1.13
ATP .92 .99 1.04 1.19 1.17 .87 1.42
KLA/ATP .86 .83 .85 .85 .74 .76 1.06
Mars2
KLA  ATP  ATP+KLA
 NM_175439 methionine-tRNA synthetase 2 (mitochondrial) (Mars2), nuclear gene encoding mitochondrial protein, mRNA [NM_175439] KLA .55 .60 .56 .53 .52 .61 .83
ATP .91 .85 .65 .48 .79 .71 1.01
KLA/ATP .55 .56 .53 .45 .47 .62 .61
Mm.28173
KLA  ATP  ATP+KLA
 51491851 Unknown KLA .67 .68 .50 .52 .39 .62 .93
ATP .89 .83 1.21 .91 1.09 .95 1.27
KLA/ATP .61 .61 .75 .54 .63 .63 .88
Mtr
KLA  ATP  ATP+KLA
 AK037599 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130029B16 product:5-methyltetrahydrofolate-homocysteine methyltransferase, full insert sequence. [AK037599] KLA .89 .92 .81 .83 .73 .76 .98
ATP .98 1.11 .85 .93 .68 .72 1.12
KLA/ATP .92 .93 .71 .85 .66 .68 .77
Mtr
KLA  ATP  ATP+KLA
 NM_001081128 5-methyltetrahydrofolate-homocysteine methyltransferase (Mtr), mRNA [NM_001081128] KLA .93 .91 .89 .77 .64 .58 .99
ATP 1.12 1.11 1.05 .87 .71 .69 1.59
KLA/ATP 1.02 .95 .96 .78 .54 .55 .92
Papss1
KLA  ATP  ATP+KLA
 NM_011863 3-phosphoadenosine 5-phosphosulfate synthase 1 (Papss1), mRNA [NM_011863] KLA .86 .95 .84 .89 .77 .70 .81
ATP .99 1.02 1.06 1.10 .74 .64 .75
KLA/ATP .93 .89 .86 .93 .68 .56 .69
Papss2
KLA  ATP  ATP+KLA
 AK029185 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4831410G12 product:3-phosphoadenosine 5-phosphosulfate synthase 2, full insert sequence. [AK029185] KLA 1.04 1.07 .97 .95 1.08 1.07 .94
ATP .96 1.01 1.00 1.02 .96 1.01 .97
KLA/ATP .99 1.01 1.02 1.11 1.01 .98 1.02
Papss2
KLA  ATP  ATP+KLA
 NM_011864 3-phosphoadenosine 5-phosphosulfate synthase 2 (Papss2), mRNA [NM_011864] KLA 1.72 1.84 1.85 1.50 1.56 1.01 1.14
ATP 1.07 1.14 1.07 1.00 1.19 1.75 1.07
KLA/ATP 1.64 1.73 1.57 1.58 1.46 1.54 1.10
Pstk
KLA  ATP  ATP+KLA
 AK017332 6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430423O14 product:unclassifiable, full insert sequence. [AK017332] KLA .57 .54 .54 .59 .71 .59 .77
ATP .68 .50 .48 .40 .52 .63 .84
KLA/ATP .45 .47 .50 .49 .56 .53 .50
Pstk
KLA  ATP  ATP+KLA
 NM_001039534 phosphoseryl-tRNA kinase (Pstk), mRNA [NM_001039534] KLA .46 .46 .41 .45 .47 .54 .88
ATP .93 .81 1.00 .82 .49 .55 .77
KLA/ATP .43 .42 .48 .47 .41 .45 .36
Scly
KLA  ATP  ATP+KLA
 NM_016717 selenocysteine lyase (Scly), mRNA [NM_016717] KLA 1.01 .98 1.02 1.06 1.13 1.12 1.31
ATP 1.13 1.20 .97 1.14 .76 .60 1.20
KLA/ATP 1.18 1.16 .99 1.21 .76 .64 1.49
Sephs1
KLA  ATP  ATP+KLA
 NM_175400 selenophosphate synthetase 1 (Sephs1), mRNA [NM_175400] KLA .92 .97 .99 .96 .87 .77 .73
ATP 1.04 1.08 .95 .89 .70 .70 .55
KLA/ATP .91 1.05 .85 .92 .75 .73 .46
Sephs2
KLA  ATP  ATP+KLA
 NM_009266 selenophosphate synthetase 2 (Sephs2), mRNA [NM_009266] KLA .74 .81 .66 .57 .59 .85 1.22
ATP 1.00 1.11 .95 .90 .80 .65 .67
KLA/ATP .73 .81 .61 .72 .58 .61 .65
Sepsecs
KLA  ATP  ATP+KLA
 AK088165 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430005G07 product:unclassifiable, full insert sequence. [AK088165] KLA .92 .97 1.01 .94 .96 .93 .95
ATP 1.01 1.04 1.04 1.15 1.01 1.03 .94
KLA/ATP 1.02 1.01 .92 1.04 .89 .91 .77
Sepsecs
KLA  ATP  ATP+KLA
 NM_172490 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (Sepsecs), mRNA [NM_172490] KLA 1.29 1.33 1.42 1.25 1.15 1.02 1.29
ATP 1.09 1.14 .97 .88 1.09 1.22 1.52
KLA/ATP 1.38 1.53 1.26 1.05 .80 .97 1.41
Txnrd1
KLA  ATP  ATP+KLA
 NM_001042523 thioredoxin reductase 1 (Txnrd1), transcript variant 1, mRNA [NM_001042523] KLA 1.52 1.48 1.01 .65 .59 .68 .96
ATP .97 .98 .74 .89 3.11 6.97 1.02
KLA/ATP 1.41 1.37 .78 .72 1.65 4.48 1.36
Txnrd2
KLA  ATP  ATP+KLA
 AK008004 adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010001F03 product:ADULT MALE SMALL INTESTINE CDNA, RIKEN FULL-LENGTH ENRICHED LIBRARY, CLONE:2010001F03, FULL INSERT SEQUENCE, full insert sequence. [AK008004] KLA 1.35 1.23 1.26 1.32 1.07 1.01 .94
ATP .91 .87 1.52 1.79 1.51 1.21 1.00
KLA/ATP 1.15 1.41 2.12 1.88 1.76 1.23 .91
Txnrd2
KLA  ATP  ATP+KLA
 NM_013711 thioredoxin reductase 2 (Txnrd2), nuclear gene encoding mitochondrial protein, mRNA [NM_013711] KLA .84 .83 .83 .78 .75 .64 .92
ATP 1.12 1.20 1.08 1.25 .87 .44 .88
KLA/ATP .95 .90 .82 .93 .65 .43 .50
Txnrd3
KLA  ATP  ATP+KLA
 NM_153162 thioredoxin reductase 3 (Txnrd3), mRNA [NM_153162] KLA .99 .95 .69 .52 .49 .61 1.04
ATP .95 1.01 .95 .86 1.80 1.87 1.10
KLA/ATP .99 .89 .72 .72 1.20 1.46 .82