Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glutathione metabolism (mmu00480)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2310016C
16Rik
KLA  ATP  ATP+KLA
 NM_027127 RIKEN cDNA 2310016C16 gene (2310016C16Rik), mRNA [NM_027127] KLA .94 1.03 1.06 1.07 .99 1.05 .96
ATP .97 1.01 1.01 1.04 1.01 1.07 1.05
KLA/ATP 1.04 1.08 1.09 1.01 1.03 1.02 .98
A030007L
17Rik
KLA  ATP  ATP+KLA
 AK141474 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530031D20 product:hypothetical protein, full insert sequence [AK141474] KLA 1.26 1.19 1.43 1.39 1.24 1.31 1.56
ATP .97 .99 1.12 1.08 1.10 1.16 .89
KLA/ATP 1.23 1.32 1.43 1.48 1.28 1.19 1.15
A030007L
17Rik
KLA  ATP  ATP+KLA
 NM_026637 RIKEN cDNA A030007L17 gene (A030007L17Rik), mRNA [NM_026637] KLA 6.22 6.74 6.79 7.51 6.56 6.78 7.05
ATP .93 .89 1.27 1.51 1.86 3.50 1.36
KLA/ATP 6.28 6.62 9.59 9.74 8.71 5.46 5.01
Anpep
KLA  ATP  ATP+KLA
 NM_008486 alanyl (membrane) aminopeptidase (Anpep), mRNA [NM_008486] KLA .93 .81 .87 .91 1.05 1.06 .71
ATP .99 .98 1.00 1.08 1.04 .93 1.45
KLA/ATP .85 .89 .82 .97 .97 .93 .90
G6pd2
KLA  ATP  ATP+KLA
 NM_019468 glucose-6-phosphate dehydrogenase 2 (G6pd2), mRNA [NM_019468] KLA 1.07 1.13 1.31 .96 1.22 1.19 1.70
ATP 1.23 1.51 .85 1.48 .93 .89 1.34
KLA/ATP 1.56 1.52 .71 1.40 .72 1.04 2.61
G6pdx
KLA  ATP  ATP+KLA
 NM_008062 glucose-6-phosphate dehydrogenase X-linked (G6pdx), mRNA [NM_008062] KLA .77 .81 .85 .74 .84 .90 1.44
ATP 1.11 1.12 .85 .85 .76 .86 1.07
KLA/ATP .96 .88 .63 .72 .58 .77 1.91
Gclc
KLA  ATP  ATP+KLA
 NM_010295 glutamate-cysteine ligase, catalytic subunit (Gclc), mRNA [NM_010295] KLA .42 .38 .24 .19 .22 .26 .59
ATP 1.07 1.03 1.24 2.13 4.71 25.45 1.33
KLA/ATP .35 .36 .44 1.21 2.16 4.41 1.54
Gclm
KLA  ATP  ATP+KLA
 NM_008129 glutamate-cysteine ligase , modifier subunit (Gclm), mRNA [NM_008129] KLA .87 .91 .79 .58 .46 .46 1.30
ATP 1.26 1.41 .93 1.28 2.39 5.57 2.40
KLA/ATP .98 1.10 .59 .93 .97 2.74 2.75
Ggt1
KLA  ATP  ATP+KLA
 NM_008116 gamma-glutamyltransferase 1 (Ggt1), mRNA [NM_008116] KLA 1.03 1.00 1.00 1.05 1.00 1.02 1.02
ATP 1.00 1.00 .96 1.00 1.03 1.02 .99
KLA/ATP .98 .99 1.04 1.00 .99 .98 .98
Ggt5
KLA  ATP  ATP+KLA
 NM_011820 gamma-glutamyltransferase 5 (Ggt5), mRNA [NM_011820] KLA .89 .91 .92 .89 .86 .79 .58
ATP 1.00 1.03 .93 .97 .84 .80 .59
KLA/ATP 1.00 .92 .93 .98 .83 .79 .68
Ggt6
KLA  ATP  ATP+KLA
 NM_027819 gamma-glutamyltransferase 6 (Ggt6), mRNA [NM_027819] KLA 1.03 .90 .98 1.07 1.00 1.02 .98
ATP 1.02 1.07 .90 1.02 1.03 1.03 .94
KLA/ATP .99 1.04 .98 .97 1.02 1.01 .96
Ggt7
KLA  ATP  ATP+KLA
 NM_144786 gamma-glutamyltransferase 7 (Ggt7), mRNA [NM_144786] KLA .96 1.03 .97 1.01 1.00 .98 .89
ATP 1.03 1.02 1.01 .92 .94 .97 1.00
KLA/ATP .98 .95 1.05 .89 .92 .94 .94
Gpx1
KLA  ATP  ATP+KLA
 NM_008160 glutathione peroxidase 1 (Gpx1), mRNA [NM_008160] KLA .63 .68 .67 .51 .52 .48 .64
ATP 1.02 1.01 .85 .91 .66 .41 .97
KLA/ATP .76 .73 .47 .61 .45 .39 .70
Gpx2
KLA  ATP  ATP+KLA
 NM_030677 glutathione peroxidase 2 (Gpx2), mRNA [NM_030677] KLA .69 .71 .59 .69 .72 .69 .69
ATP 1.08 1.10 .74 .79 .77 .66 .64
KLA/ATP .70 .65 .69 .74 .78 .76 .53
Gpx3
KLA  ATP  ATP+KLA
 NM_008161 glutathione peroxidase 3 (Gpx3), transcript variant 2, mRNA [NM_008161] KLA 1.14 1.14 1.20 1.09 1.07 .85 .50
ATP 1.15 1.15 1.00 1.84 1.10 .96 .62
KLA/ATP 1.14 1.17 .93 1.48 .90 .99 .64
Gpx4
KLA  ATP  ATP+KLA
 NM_001037741 glutathione peroxidase 4 (Gpx4), transcript variant 1, mRNA [NM_001037741] KLA .80 .72 .64 .64 .66 .58 .94
ATP 1.08 1.14 .98 1.11 1.06 1.00 1.28
KLA/ATP .79 .80 .76 .86 .82 .97 1.24
Gpx5
KLA  ATP  ATP+KLA
 X53780 gb|Mouse mRNA for 24kDa major androgen regulated protein, arMEP24. [X53780] KLA .95 1.02 .99 .99 .97 1.06 .98
ATP 1.04 .94 .96 1.05 1.02 1.01 .98
KLA/ATP .98 1.00 .98 .93 1.00 1.07 .99
Gpx6
KLA  ATP  ATP+KLA
 NM_145451 glutathione peroxidase 6 (Gpx6), mRNA [NM_145451] KLA 1.00 1.05 1.02 .99 1.04 1.03 .94
ATP .98 1.03 1.04 .91 .92 1.03 1.05
KLA/ATP .99 1.01 1.04 .99 .96 .89 1.02
Gpx7
KLA  ATP  ATP+KLA
 NM_024198 glutathione peroxidase 7 (Gpx7), mRNA [NM_024198] KLA .91 1.00 .95 .96 .87 .90 .83
ATP 1.00 1.07 1.06 1.07 .94 .93 .88
KLA/ATP .96 1.01 .95 .98 .82 .90 .86
Gsr
KLA  ATP  ATP+KLA
 NM_010344 glutathione reductase (Gsr), mRNA [NM_010344] KLA 1.18 1.27 1.29 1.51 1.98 1.54 2.62
ATP 1.04 1.20 .99 1.27 1.39 4.78 1.69
KLA/ATP 1.22 1.40 1.01 1.50 1.19 2.85 4.25
Gss
KLA  ATP  ATP+KLA
 NM_008180 glutathione synthetase (Gss), mRNA [NM_008180] KLA 1.21 1.26 1.25 1.17 1.00 .75 1.11
ATP 1.06 1.12 1.04 1.21 3.15 7.87 2.60
KLA/ATP 1.24 1.35 1.22 1.38 2.28 4.32 2.63
Gsta1
KLA  ATP  ATP+KLA
 NM_008181 glutathione S-transferase, alpha 1 (Ya) (Gsta1), mRNA [NM_008181] KLA .94 1.06 1.07 .99 .99 1.13 1.08
ATP 1.01 1.00 1.07 1.04 1.13 1.82 3.26
KLA/ATP 1.04 .96 .98 1.12 1.15 1.07 1.39
Gsta2
KLA  ATP  ATP+KLA
 NM_008182 glutathione S-transferase, alpha 2 (Yc2) (Gsta2), mRNA [NM_008182] KLA 1.01 .97 .99 .97 .98 1.02 .93
ATP 1.04 1.03 .98 .93 1.05 1.54 2.11
KLA/ATP 1.00 .97 1.05 1.01 .97 1.03 1.14
Gsta3
KLA  ATP  ATP+KLA
 NM_001077353 glutathione S-transferase, alpha 3 (Gsta3), transcript variant 1, mRNA [NM_001077353] KLA .93 .95 .88 .86 .60 .52 .91
ATP 1.00 .95 1.30 1.00 .97 2.01 4.26
KLA/ATP .93 1.03 1.22 .97 .77 .75 3.30
Gsta4
KLA  ATP  ATP+KLA
 NM_010357 glutathione S-transferase, alpha 4 (Gsta4), mRNA [NM_010357] KLA 1.03 1.00 1.00 .99 .99 .98 .96
ATP .99 1.03 .98 .99 .99 1.09 1.25
KLA/ATP 1.02 1.01 1.01 .99 .96 1.00 1.04
Gstk1
KLA  ATP  ATP+KLA
 AK002661 adult male kidney cDNA, RIKEN full-length enriched library, clone:0610025I19 product:GLUTATHIONE S-TRANSFERASE, MITOCHONDRIAL (EC 2.5.1.18) (GST 13-13) (GLUTATHIONE S-TRANSFERASE SUBUNIT 13) (GST CLASS-KAPPA) homolog [Rattus norvegicus], KLA 1.05 1.02 1.06 1.05 .91 .81 .60
ATP .93 .85 1.40 1.29 1.23 1.00 .72
KLA/ATP .98 1.09 1.61 1.33 1.36 .86 .62
Gstm1
KLA  ATP  ATP+KLA
 NM_010358 glutathione S-transferase, mu 1 (Gstm1), mRNA [NM_010358] KLA .94 .95 1.04 .94 .85 .74 .76
ATP 1.12 1.15 1.17 1.92 1.78 2.30 2.03
KLA/ATP 1.12 1.15 1.06 1.74 1.66 2.20 3.26
Gstm2
KLA  ATP  ATP+KLA
 NM_008183 glutathione S-transferase, mu 2 (Gstm2), mRNA [NM_008183] KLA 1.23 1.15 1.23 1.24 1.20 1.07 .96
ATP 1.11 1.06 1.37 1.96 2.12 2.41 5.20
KLA/ATP 1.18 1.33 1.57 1.98 1.96 1.90 3.42
Gstm3
KLA  ATP  ATP+KLA
 NM_010359 glutathione S-transferase, mu 3 (Gstm3), mRNA [NM_010359] KLA .88 .88 .84 .79 .78 .69 .70
ATP .99 1.04 1.13 1.58 1.64 1.88 1.81
KLA/ATP .93 .94 .99 1.47 1.54 1.92 2.72
Gstm4
KLA  ATP  ATP+KLA
 NM_026764 glutathione S-transferase, mu 4 (Gstm4), mRNA [NM_026764] KLA .91 .98 .95 .98 1.04 .94 1.45
ATP 1.08 1.15 .86 1.13 .83 .63 1.19
KLA/ATP 1.03 1.07 .90 .92 .64 .76 1.82
Gstm5
KLA  ATP  ATP+KLA
 NM_010360 glutathione S-transferase, mu 5 (Gstm5), mRNA [NM_010360] KLA 1.00 1.11 .97 .99 .88 .64 .53
ATP 1.02 1.13 1.18 1.47 1.17 .86 .76
KLA/ATP 1.16 1.13 1.09 1.38 1.01 .73 .62
Gstm6
KLA  ATP  ATP+KLA
 NM_008184 glutathione S-transferase, mu 6 (Gstm6), mRNA [NM_008184] KLA 1.00 .99 .99 1.02 1.05 .98 .99
ATP .96 .97 .98 .99 1.10 .95 .99
KLA/ATP .98 .92 1.02 1.01 1.05 .97 1.00
Gstm7
KLA  ATP  ATP+KLA
 AK002213 adult male kidney cDNA, RIKEN full-length enriched library, clone:0610005A07 product:GLUTATHIONE S-TRANSFERASE, MU TYPE 3 (YB3) homolog [Mus musculus], full insert sequence. [AK002213] KLA .99 .93 .95 .98 1.04 .98 .92
ATP 1.03 1.01 .98 .97 .98 .98 .98
KLA/ATP .92 .92 .98 .91 1.00 .92 .99
Gstm7
KLA  ATP  ATP+KLA
 NM_026672 glutathione S-transferase, mu 7 (Gstm7), mRNA [NM_026672] KLA .97 1.03 .96 1.02 .91 .96 .95
ATP 1.02 .99 1.00 1.00 1.00 .88 .90
KLA/ATP 1.00 1.03 .95 .96 1.01 .95 .89
Gsto1
KLA  ATP  ATP+KLA
 NM_010362 glutathione S-transferase omega 1 (Gsto1), mRNA [NM_010362] KLA .84 .81 .84 .76 .62 .54 .61
ATP 1.09 1.04 1.23 1.78 1.95 1.75 .96
KLA/ATP .88 .87 1.05 1.30 1.31 1.18 .77
Gsto2
KLA  ATP  ATP+KLA
 NM_026619 glutathione S-transferase omega 2 (Gsto2), mRNA [NM_026619] KLA 1.03 1.07 1.03 1.00 .98 1.12 1.10
ATP .94 .90 1.01 2.25 1.86 1.00 1.03
KLA/ATP .98 .96 1.02 1.87 2.11 1.15 1.21
Gstp1
KLA  ATP  ATP+KLA
 NM_013541 glutathione S-transferase, pi 1 (Gstp1), mRNA [NM_013541] KLA .99 .99 .98 .92 .92 .79 .85
ATP 1.06 1.10 1.06 1.27 1.13 1.62 2.31
KLA/ATP .98 1.02 1.03 1.22 1.02 1.25 2.47
Gstt1
KLA  ATP  ATP+KLA
 NM_008185 glutathione S-transferase, theta 1 (Gstt1), mRNA [NM_008185] KLA 1.23 1.46 1.64 1.80 2.33 3.37 4.15
ATP 1.02 1.03 1.10 1.18 1.01 1.05 .99
KLA/ATP 1.43 1.61 1.40 1.58 1.37 1.43 2.11
Gstt2
KLA  ATP  ATP+KLA
 NM_010361 glutathione S-transferase, theta 2 (Gstt2), mRNA [NM_010361] KLA 1.05 1.08 1.02 1.08 1.33 1.48 1.33
ATP .96 .98 .96 1.15 1.07 .76 1.12
KLA/ATP 1.02 1.07 1.20 1.41 1.41 1.23 2.59
Gstt3
KLA  ATP  ATP+KLA
 NM_133994 glutathione S-transferase, theta 3 (Gstt3), mRNA [NM_133994] KLA .78 .79 .76 .74 .68 .65 .61
ATP .96 .87 .93 .82 .63 .42 .74
KLA/ATP .76 .75 .89 .76 .68 .74 2.44
Idh1
KLA  ATP  ATP+KLA
 NM_010497 isocitrate dehydrogenase 1 (NADP+), soluble (Idh1), transcript variant 2, mRNA [NM_010497] KLA .71 .74 .69 .70 .54 .45 .63
ATP 1.22 1.28 1.00 1.28 1.06 .62 .81
KLA/ATP .76 .81 .68 .88 .55 .47 .40
Idh2
KLA  ATP  ATP+KLA
 NM_173011 isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), nuclear gene encoding mitochondrial protein, mRNA [NM_173011] KLA .83 .83 .88 .94 .66 .31 .38
ATP 1.04 1.09 1.14 1.48 1.26 .39 .49
KLA/ATP .90 .92 1.04 1.10 .82 .41 .20
Lap3
KLA  ATP  ATP+KLA
 NM_024434 leucine aminopeptidase 3 (Lap3), mRNA [NM_024434] KLA 2.95 3.13 3.13 3.67 3.18 2.01 1.07
ATP 1.02 1.02 1.23 1.18 1.30 1.63 .91
KLA/ATP 2.72 3.04 4.11 3.89 3.99 3.42 .86
Mgst1
KLA  ATP  ATP+KLA
 NM_019946 microsomal glutathione S-transferase 1 (Mgst1), mRNA [NM_019946] KLA 1.00 1.03 1.02 1.00 1.03 1.03 1.68
ATP 1.01 1.02 1.12 1.22 1.38 2.86 2.13
KLA/ATP 1.01 1.06 1.06 1.28 1.38 2.77 3.05
Mgst2
KLA  ATP  ATP+KLA
 NM_174995 microsomal glutathione S-transferase 2 (Mgst2), mRNA [NM_174995] KLA 2.87 2.54 2.80 3.26 2.70 2.43 1.43
ATP 1.04 1.05 1.48 1.33 1.13 1.39 6.05
KLA/ATP 2.10 2.54 4.49 3.33 2.57 1.87 3.13
Mgst3
KLA  ATP  ATP+KLA
 AK008211 adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010012L10 product:RIKEN cDNA 2010012L10 gene, full insert sequence. [AK008211] KLA 1.04 .98 .89 .88 .69 .44 .15
ATP 1.05 1.16 1.34 1.66 1.17 .70 .25
KLA/ATP .94 1.02 1.07 1.41 1.02 .72 .15
Mgst3
KLA  ATP  ATP+KLA
 NM_025569 microsomal glutathione S-transferase 3 (Mgst3), mRNA [NM_025569] KLA 1.04 1.03 .87 .83 .69 .47 .17
ATP 1.00 1.13 1.18 1.47 1.16 .69 .26
KLA/ATP 1.02 .98 .92 1.29 .93 .74 .17
Mm.1332
KLA  ATP  ATP+KLA
 171543845 Unknown KLA .95 .97 .87 .99 .98 .98 1.04
ATP 1.00 .93 1.00 1.08 .95 1.02 .92
KLA/ATP 1.03 1.12 .94 .98 1.01 .91 1.10
Mm.39459
3
KLA  ATP  ATP+KLA
 116325998 Unknown KLA .96 1.01 .98 .95 .98 .93 1.03
ATP 1.00 .98 .97 1.12 1.01 1.00 1.12
KLA/ATP 1.02 1.00 1.00 .98 1.04 1.01 1.05
Mm.42277
8
KLA  ATP  ATP+KLA
 118130920 Unknown KLA 1.00 1.01 1.08 1.04 .99 .98 1.01
ATP 1.07 1.11 1.03 .98 1.08 2.66 3.31
KLA/ATP .95 1.05 1.04 .96 1.00 1.14 1.44
Odc1
KLA  ATP  ATP+KLA
 NM_013614 ornithine decarboxylase, structural 1 (Odc1), mRNA [NM_013614] KLA 2.10 1.85 1.51 1.36 1.07 .99 .71
ATP 1.15 1.53 4.90 11.04 12.87 14.66 2.00
KLA/ATP 2.01 1.77 3.11 5.19 5.52 7.17 4.50
Oplah
KLA  ATP  ATP+KLA
 NM_153122 5-oxoprolinase (ATP-hydrolysing) (Oplah), mRNA [NM_153122] KLA .96 .99 .99 .95 .95 1.05 .90
ATP 1.02 1.02 .95 .96 .93 1.28 .83
KLA/ATP 1.01 .93 .91 .93 1.09 1.48 1.16
Pgd
KLA  ATP  ATP+KLA
 NM_001081274 phosphogluconate dehydrogenase (Pgd), mRNA [NM_001081274] KLA .91 .94 .94 .76 .80 .67 .93
ATP 1.11 1.22 .84 .96 1.20 1.82 1.59
KLA/ATP 1.01 1.10 .79 .90 .83 1.30 1.75
Rrm1
KLA  ATP  ATP+KLA
 AK049601 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530001L22 product:ribonucleotide reductase M1, full insert sequence. [AK049601] KLA .99 .96 1.17 1.00 1.00 .88 .97
ATP 1.07 .98 .94 .96 .92 .86 .99
KLA/ATP 1.00 1.03 1.00 .96 1.02 1.00 .95
Rrm1
KLA  ATP  ATP+KLA
 NM_009103 ribonucleotide reductase M1 (Rrm1), mRNA [NM_009103] KLA .47 .46 .38 .28 .18 .21 .17
ATP .97 1.01 1.06 .97 .65 .27 .18
KLA/ATP .46 .42 .39 .36 .23 .16 .11
Rrm2
KLA  ATP  ATP+KLA
 NM_009104 ribonucleotide reductase M2 (Rrm2), mRNA [NM_009104] KLA .32 .27 .23 .17 .13 .13 .12
ATP .98 1.00 1.17 1.28 .66 .20 .08
KLA/ATP .28 .25 .30 .30 .23 .13 .08
Rrm2b
KLA  ATP  ATP+KLA
 NM_199476 ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), mRNA [NM_199476] KLA .93 .90 .89 .95 .97 1.00 1.13
ATP .96 .95 .95 .87 .75 .80 .90
KLA/ATP .84 .85 .89 .84 .78 .78 .88
Sms
KLA  ATP  ATP+KLA
 NM_009214 spermine synthase (Sms), mRNA [NM_009214] KLA 1.18 1.13 1.09 1.03 .91 .68 .62
ATP .99 1.03 .86 .77 .69 .49 .56
KLA/ATP 1.08 1.13 .92 .80 .62 .42 .32
Srm
KLA  ATP  ATP+KLA
 NM_009272 spermidine synthase (Srm), mRNA [NM_009272] KLA .61 .68 .55 .41 .31 .32 .57
ATP .95 1.06 .92 1.19 .94 .50 .61
KLA/ATP .70 .65 .55 .59 .44 .26 .17
Txndc12
KLA  ATP  ATP+KLA
 NM_025334 thioredoxin domain containing 12 (endoplasmic reticulum) (Txndc12), mRNA [NM_025334] KLA .83 .84 .83 .73 .92 1.20 1.29
ATP .99 1.06 1.05 1.19 .98 .78 1.24
KLA/ATP .84 .84 .77 .92 .82 1.12 1.70