Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Starch and sucrose metabolism (mmu00500)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2010204N
08Rik
KLA  ATP  ATP+KLA
 NM_001081137 RIKEN cDNA 2010204N08 gene (2010204N08Rik), mRNA [NM_001081137] KLA .99 .98 1.00 .96 .98 .98 .99
ATP .96 .98 1.06 1.14 .98 .97 .99
KLA/ATP .98 1.05 1.06 1.04 .99 .98 1.94
Agl
KLA  ATP  ATP+KLA
 AK036225 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630046L06 product:similar to GLYCOGEN DEBRANCHING ENZYME (GLYCOGEN DEBRANCHER) [INCLUDES: 4-ALPHA-GLUCANOTRANSFERASE (EC 2.4.1.25) (OLIGO-1,4-1,4-GLUCANTRANSFERAS KLA .94 .95 .94 .94 .97 .97 1.01
ATP 1.00 1.08 1.01 .86 1.03 1.02 1.01
KLA/ATP 1.05 1.02 .93 .85 .93 1.01 .94
Agl
KLA  ATP  ATP+KLA
 NM_001081326 amylo-1,6-glucosidase, 4-alpha-glucanotransferase (Agl), mRNA [NM_001081326] KLA .58 .51 .44 .39 .43 .64 .92
ATP .99 .98 1.01 .68 .90 1.23 .65
KLA/ATP .51 .50 .45 .33 .54 .85 .49
Amy1
KLA  ATP  ATP+KLA
 NM_007446 amylase 1, salivary (Amy1), transcript variant 1, mRNA [NM_007446] KLA 1.03 1.01 1.14 1.07 1.06 1.13 1.16
ATP .99 .98 1.08 1.06 1.09 1.18 1.11
KLA/ATP 1.06 1.10 1.19 1.13 1.16 1.43 1.21
Enpp1
KLA  ATP  ATP+KLA
 ENSMUST00000105520 ens|Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E- NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Lymphocyte antigen 41) (Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1 KLA .71 .79 .64 .61 .55 .51 .32
ATP .85 .97 .85 .72 .62 .45 .28
KLA/ATP .72 .73 .61 .66 .60 .55 .27
Enpp1
KLA  ATP  ATP+KLA
 NM_008813 ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1), mRNA [NM_008813] KLA .82 .83 .77 .83 .65 .64 .51
ATP .89 .90 1.21 1.00 .98 .87 .64
KLA/ATP .72 .76 .96 .87 1.00 .94 .51
Enpp3
KLA  ATP  ATP+KLA
 BC005527 ectonucleotide pyrophosphatase [BC005527] KLA 1.06 .99 .98 1.01 .97 .99 .96
ATP .93 1.08 .99 1.05 .94 1.05 1.10
KLA/ATP .95 .96 1.10 .99 .95 .94 1.03
Enpp3
KLA  ATP  ATP+KLA
 BC006944 ectonucleotide pyrophosphatase/phosphodiesterase 3, mRNA (cDNA clone IMAGE:2655671), complete cds. [BC006944] KLA 1.02 1.01 1.03 1.08 1.04 1.01 1.01
ATP .97 1.01 .96 1.00 .98 1.07 .99
KLA/ATP 1.01 .99 1.07 1.02 .97 .98 .92
Enpp3
KLA  ATP  ATP+KLA
 NM_134005 ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA [NM_134005] KLA 1.01 .95 .99 .98 1.05 1.04 .98
ATP .98 .98 1.03 .98 .96 1.00 .98
KLA/ATP .97 1.03 1.04 .93 1.02 .99 1.04
G6pc
KLA  ATP  ATP+KLA
 NM_008061 glucose-6-phosphatase, catalytic (G6pc), mRNA [NM_008061] KLA .96 .94 1.04 1.07 1.09 1.06 1.02
ATP .98 1.05 1.09 1.04 1.05 1.00 1.01
KLA/ATP 1.03 1.05 1.06 .96 1.02 1.00 .99
G6pc2
KLA  ATP  ATP+KLA
 NM_021331 glucose-6-phosphatase, catalytic, 2 (G6pc2), mRNA [NM_021331] KLA .99 1.03 1.00 .98 .95 1.02 .98
ATP .95 1.06 .97 1.08 1.16 1.26 1.04
KLA/ATP .94 .99 1.05 6.99 3.55 1.48 1.11
G6pc3
KLA  ATP  ATP+KLA
 NM_175935 glucose 6 phosphatase, catalytic, 3 (G6pc3), mRNA [NM_175935] KLA .88 .89 .89 .80 .75 .68 .88
ATP .99 1.05 .95 1.14 .92 .64 .81
KLA/ATP .92 .90 .79 .94 .70 .62 .58
Gaa
KLA  ATP  ATP+KLA
 NM_008064 glucosidase, alpha, acid (Gaa), mRNA [NM_008064] KLA .85 .84 .84 .78 .83 .87 1.18
ATP .97 .96 .75 .78 .74 .72 1.01
KLA/ATP .88 .91 .78 .78 .71 .71 .86
Ganc
KLA  ATP  ATP+KLA
 NM_172672 glucosidase, alpha; neutral C (Ganc), mRNA [NM_172672] KLA 1.02 .97 1.02 1.00 1.00 .98 .98
ATP 1.06 1.04 1.03 1.00 .71 .71 1.05
KLA/ATP 1.02 1.09 1.18 .97 .83 .79 1.07
Gbe1
KLA  ATP  ATP+KLA
 NM_028803 glucan (1,4-alpha-), branching enzyme 1 (Gbe1), mRNA [NM_028803] KLA 1.04 1.04 .96 .99 .65 .63 .96
ATP .90 .75 1.15 .71 .93 3.49 .88
KLA/ATP .92 1.00 1.08 .79 .86 1.22 .74
Gck
KLA  ATP  ATP+KLA
 NM_010292 glucokinase (Gck), mRNA [NM_010292] KLA 1.03 .99 1.04 1.02 .97 .98 1.00
ATP 1.01 .97 1.08 .99 1.06 .98 .96
KLA/ATP 1.06 1.01 .96 .98 .98 1.01 1.01
Gpi1
KLA  ATP  ATP+KLA
 L09104 glucose phosphate isomerase mRNA, 3 end. [L09104] KLA .92 1.02 .99 1.01 .92 1.04 1.07
ATP 1.05 1.06 1.11 1.14 1.01 1.00 1.04
KLA/ATP 1.06 1.09 1.01 .96 .93 .93 1.04
Gpi1
KLA  ATP  ATP+KLA
 NM_008155 glucose phosphate isomerase 1 (Gpi1), mRNA [NM_008155] KLA .77 .76 .69 .66 .61 .59 .85
ATP .96 .97 .97 .93 .90 .73 .77
KLA/ATP .75 .76 .73 .69 .66 .54 .59
Gusb
KLA  ATP  ATP+KLA
 NM_010368 glucuronidase, beta (Gusb), mRNA [NM_010368] KLA .65 .67 .62 .52 .52 .47 .52
ATP 1.07 1.11 .95 1.00 .80 .57 .58
KLA/ATP .72 .71 .56 .62 .52 .48 .38
Gys1
KLA  ATP  ATP+KLA
 NM_030678 glycogen synthase 1, muscle (Gys1), mRNA [NM_030678] KLA .89 .89 .88 .80 .91 1.07 1.78
ATP 1.02 1.15 .91 1.01 .72 .73 1.14
KLA/ATP .96 .94 .73 .87 .63 .64 1.24
Gys2
KLA  ATP  ATP+KLA
 NM_145572 glycogen synthase 2 (Gys2), mRNA [NM_145572] KLA 1.01 .96 .99 1.06 1.02 1.00 .92
ATP .99 .98 .98 1.02 .95 1.12 1.10
KLA/ATP 1.03 .97 1.00 1.03 1.01 1.05 1.09
Hk1
KLA  ATP  ATP+KLA
 J05277 gb|Mouse hexokinase mRNA, complete cds [J05277] KLA 1.49 1.45 1.66 1.78 1.51 1.29 .99
ATP 1.11 1.05 1.15 1.20 2.31 2.17 1.09
KLA/ATP 1.63 1.51 1.70 1.47 1.94 1.92 1.40
Hk1
KLA  ATP  ATP+KLA
 NM_010438 hexokinase 1 (Hk1), nuclear gene encoding mitochondrial protein, mRNA [NM_010438] KLA 1.58 1.75 2.05 1.84 1.96 1.67 1.31
ATP 1.06 1.25 1.01 1.49 2.23 1.79 1.20
KLA/ATP 1.87 1.96 1.51 1.93 1.71 1.94 1.72
Hk2
KLA  ATP  ATP+KLA
 NM_013820 hexokinase 2 (Hk2), mRNA [NM_013820] KLA 4.09 4.09 3.17 2.37 1.53 1.62 2.02
ATP .98 .92 1.08 2.24 3.82 3.86 .97
KLA/ATP 4.07 3.94 4.17 3.53 5.42 4.65 1.54
Hk3
KLA  ATP  ATP+KLA
 NM_001033245 hexokinase 3 (Hk3), nuclear gene encoding mitochondrial protein, mRNA [NM_001033245] KLA 1.52 1.68 1.94 1.85 2.21 2.89 1.98
ATP 1.01 1.07 .87 .99 1.01 1.26 2.62
KLA/ATP 1.63 1.74 1.67 1.69 1.44 2.01 3.53
Hkdc1
KLA  ATP  ATP+KLA
 NM_145419 hexokinase domain containing 1 (Hkdc1), mRNA [NM_145419] KLA 1.10 1.08 1.12 1.12 1.02 1.07 1.04
ATP .96 1.04 1.06 4.28 10.50 3.91 1.34
KLA/ATP .98 1.04 1.14 5.33 12.44 8.68 1.77
Kl
KLA  ATP  ATP+KLA
 AB010088 mRNA for secreted isoform of Klotho protein, complete cds [AB010088] KLA 1.02 1.00 1.01 .97 1.02 1.04 1.01
ATP 1.03 1.03 .99 1.00 .99 .97 1.01
KLA/ATP 1.03 .93 .98 .87 .96 .92 .93
Kl
KLA  ATP  ATP+KLA
 NM_013823 klotho (Kl), mRNA [NM_013823] KLA .97 .96 1.08 .95 1.01 .95 1.05
ATP .96 1.07 1.02 1.06 1.05 1.00 1.02
KLA/ATP .95 1.02 1.04 1.04 1.11 1.01 .96
Mgam
KLA  ATP  ATP+KLA
 AK033548 adult male colon cDNA, RIKEN full-length enriched library, clone:9030616M21 product:hypothetical protein, full insert sequence. [AK033548] KLA 1.16 1.20 1.22 1.21 1.01 1.02 1.07
ATP 1.01 1.01 1.11 2.86 5.71 5.58 1.53
KLA/ATP 1.24 1.24 1.29 1.64 3.84 3.69 1.98
Mgam
KLA  ATP  ATP+KLA
 XM_001481277 gb|PREDICTED: Mus musculus maltase-glucoamylase (Mgam), mRNA [XM_001481277] KLA 1.03 1.04 1.03 1.04 .95 .98 1.06
ATP 1.06 .94 1.05 1.42 2.38 2.12 1.16
KLA/ATP 1.10 1.06 1.06 1.15 1.52 1.64 1.20
Mm.26105
4
KLA  ATP  ATP+KLA
 124487274 Unknown KLA .95 1.04 .97 .98 1.01 .94 1.10
ATP 1.00 1.06 .94 1.07 1.01 1.00 .98
KLA/ATP 1.04 .99 .93 1.01 1.11 1.07 1.04
Mm.30009
5
KLA  ATP  ATP+KLA
 145699117 Unknown KLA .70 .74 .85 .84 .90 .85 .90
ATP .83 .77 .93 .98 1.05 1.04 .86
KLA/ATP .72 .70 .86 .97 1.13 .80 .83
Mm.33401
KLA  ATP  ATP+KLA
 149255058 Unknown KLA 1.03 1.07 1.00 1.03 1.01 1.03 1.06
ATP 1.12 .98 1.12 1.36 2.32 2.03 1.10
KLA/ATP 1.03 1.00 .99 1.21 1.39 1.58 1.20
Mm.46685
9
KLA  ATP  ATP+KLA
 145699102 Unknown KLA .65 .64 .75 .87 .83 .79 .82
ATP .80 .77 .97 .86 1.13 1.05 .85
KLA/ATP .64 .65 .85 .86 1.16 .69 .72
Pgm1
KLA  ATP  ATP+KLA
 NM_025700 phosphoglucomutase 1 (Pgm1), mRNA [NM_025700] KLA 1.08 1.03 .95 .75 .59 .55 .73
ATP 1.02 1.23 1.22 1.42 1.07 .75 1.01
KLA/ATP 1.01 1.10 .84 1.12 .69 .61 .51
Pgm2
KLA  ATP  ATP+KLA
 NM_028132 phosphoglucomutase 2 (Pgm2), mRNA [NM_028132] KLA 1.13 1.21 1.26 1.48 1.52 1.81 1.81
ATP .90 .92 1.07 .99 .80 1.60 1.17
KLA/ATP 1.01 1.16 1.40 1.25 1.48 1.99 1.94
Pgm2l1
KLA  ATP  ATP+KLA
 NM_027629 phosphoglucomutase 2-like 1 (Pgm2l1), mRNA [NM_027629] KLA .63 .60 .56 .53 .38 .30 .41
ATP .89 .74 .67 .47 .47 .46 .44
KLA/ATP .56 .51 .53 .43 .43 .33 .25
Pygb
KLA  ATP  ATP+KLA
 NM_153781 brain glycogen phosphorylase (Pygb), mRNA [NM_153781] KLA .91 .83 .91 .78 .88 .87 .81
ATP 1.12 1.17 .92 1.03 .75 .51 .83
KLA/ATP .92 .91 .81 .88 .67 .61 .63
Pygl
KLA  ATP  ATP+KLA
 AK083075 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530044G15 product:weakly similar to GLYCOGEN PHOSPHORYLASE (EC 2.4.1.1) (ALPHA-GLUCAN PHOSPHORYLASE) (STARCH PHOSPHORYLASE) [Mus musculus], full insert sequence [ KLA .85 .87 .84 .91 .88 .84 .95
ATP 1.04 1.03 .99 1.07 .95 .80 .83
KLA/ATP .88 .88 .95 .97 .98 .87 .76
Pygl
KLA  ATP  ATP+KLA
 NM_133198 liver glycogen phosphorylase (Pygl), mRNA [NM_133198] KLA .79 .76 .73 .67 .52 .42 .66
ATP 1.01 .94 1.24 1.10 .92 .55 .44
KLA/ATP .76 .81 .93 .81 .76 .45 .14
Pygm
KLA  ATP  ATP+KLA
 NM_011224 muscle glycogen phosphorylase (Pygm), mRNA [NM_011224] KLA 1.11 1.08 .97 1.00 1.09 1.13 1.19
ATP 1.02 .98 .97 2.09 1.91 1.71 1.11
KLA/ATP 1.15 1.06 .87 1.65 1.87 1.99 1.42
Treh
KLA  ATP  ATP+KLA
 NM_021481 trehalase (brush-border membrane glycoprotein) (Treh), mRNA [NM_021481] KLA .91 1.00 1.05 .95 1.03 1.04 1.09
ATP 1.00 1.05 1.11 1.06 1.07 .97 1.01
KLA/ATP 1.04 .98 .97 1.15 1.13 1.09 1.04
Ugdh
KLA  ATP  ATP+KLA
 NM_009466 UDP-glucose dehydrogenase (Ugdh), mRNA [NM_009466] KLA 1.04 1.06 .96 .95 1.09 1.54 1.30
ATP .99 1.06 .89 .91 1.31 3.29 1.49
KLA/ATP 1.04 .98 .73 .85 1.38 2.91 1.59
Ugp2
KLA  ATP  ATP+KLA
 NM_139297 UDP-glucose pyrophosphorylase 2 (Ugp2), mRNA [NM_139297] KLA .94 1.01 .95 .96 .88 1.01 1.02
ATP .97 .98 1.03 .92 .94 1.19 .82
KLA/ATP .93 .94 .85 .78 .82 1.20 .96
Ugt1a1
KLA  ATP  ATP+KLA
 NM_201645 UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1), mRNA [NM_201645] KLA .95 1.07 1.00 .99 .97 .98 1.02
ATP 1.08 .95 1.02 1.04 1.08 1.03 1.01
KLA/ATP 1.02 .95 .93 1.01 1.01 1.11 1.06
Ugt1a6b
KLA  ATP  ATP+KLA
 NM_201410 UDP glucuronosyltransferase 1 family, polypeptide A6B (Ugt1a6b), mRNA [NM_201410] KLA .89 .86 .93 .93 .89 .86 .89
ATP 1.10 1.05 1.15 1.07 1.01 .99 1.24
KLA/ATP .90 .94 1.02 .89 .87 .81 .92
Ugt1a9
KLA  ATP  ATP+KLA
 NM_201644 UDP glucuronosyltransferase 1 family, polypeptide A9 (Ugt1a9), mRNA [NM_201644] KLA 1.07 .96 .98 1.09 1.03 1.06 1.08
ATP 1.04 .94 1.01 1.07 1.05 1.02 1.06
KLA/ATP 1.05 1.00 .94 1.01 1.03 1.04 1.00
Ugt2a1
KLA  ATP  ATP+KLA
 NM_053184 UDP glucuronosyltransferase 2 family, polypeptide A1 (Ugt2a1), mRNA [NM_053184] KLA 1.01 1.03 .99 .99 .99 1.01 1.02
ATP 1.01 .93 1.04 1.03 1.02 1.01 1.03
KLA/ATP 1.04 1.01 1.01 1.02 1.01 1.02 1.00
Ugt2a3
KLA  ATP  ATP+KLA
 NM_028094 UDP glucuronosyltransferase 2 family, polypeptide A3 (Ugt2a3), mRNA [NM_028094] KLA 1.07 1.01 .97 1.05 1.01 .98 .99
ATP .98 .96 1.04 1.06 .95 .94 1.01
KLA/ATP 1.02 1.00 .94 1.02 1.02 1.01 1.06
Ugt2b1
KLA  ATP  ATP+KLA
 NM_152811 UDP glucuronosyltransferase 2 family, polypeptide B1 (Ugt2b1), mRNA [NM_152811] KLA 1.08 1.01 .95 1.08 1.00 1.04 .97
ATP 1.03 1.14 1.01 1.00 1.01 1.05 1.13
KLA/ATP 1.05 .99 1.06 .98 1.03 .96 .98
Ugt2b34
KLA  ATP  ATP+KLA
 NM_153598 UDP glucuronosyltransferase 2 family, polypeptide B34 (Ugt2b34), mRNA [NM_153598] KLA .98 1.08 .99 1.06 .97 1.05 1.03
ATP 1.06 1.04 .96 1.01 1.03 1.01 .99
KLA/ATP 1.09 .94 1.00 1.07 1.01 1.03 .97
Ugt2b35
KLA  ATP  ATP+KLA
 NM_172881 UDP glucuronosyltransferase 2 family, polypeptide B35 (Ugt2b35), mRNA [NM_172881] KLA .99 1.02 .99 1.01 1.00 .96 1.01
ATP .96 1.02 1.02 .96 .93 1.00 1.02
KLA/ATP 1.01 .99 1.04 1.00 .97 .93 .97
Ugt2b36
KLA  ATP  ATP+KLA
 NM_001029867 UDP glucuronosyltransferase 2 family, polypeptide B36 (Ugt2b36), mRNA [NM_001029867] KLA .95 .95 1.00 1.00 1.03 1.02 .92
ATP 1.02 1.07 1.03 .95 1.01 .93 1.00
KLA/ATP .99 1.05 .98 1.04 1.02 .98 .99
Ugt2b37
KLA  ATP  ATP+KLA
 NM_053215 UDP glucuronosyltransferase 2 family, polypeptide B37 (Ugt2b37), mRNA [NM_053215] KLA 1.02 1.06 1.04 1.05 1.00 1.05 1.03
ATP 1.01 1.03 1.08 1.01 1.05 1.02 1.05
KLA/ATP 1.01 .99 1.11 1.14 1.04 1.08 1.05
Ugt2b38
KLA  ATP  ATP+KLA
 NM_133894 UDP glucuronosyltransferase 2 family, polypeptide B38 (Ugt2b38), mRNA [NM_133894] KLA 1.00 .96 1.04 .99 1.10 .97 .99
ATP 1.02 1.04 1.03 .94 .96 .93 .99
KLA/ATP .98 .97 1.00 .97 .98 1.04 1.02
Ugt2b5
KLA  ATP  ATP+KLA
 NM_009467 UDP glucuronosyltransferase 2 family, polypeptide B5 (Ugt2b5), mRNA [NM_009467] KLA 1.01 .99 1.09 .96 .97 .99 1.01
ATP 1.03 1.02 1.02 1.01 .97 .90 .94
KLA/ATP .99 .99 .98 1.05 1.01 .93 .95