Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Other glycan degradation (mmu00511)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Aga
KLA  ATP  ATP+KLA
 NM_001005847 aspartylglucosaminidase (Aga), mRNA [NM_001005847] KLA 1.07 1.08 1.08 1.01 1.02 .98 1.30
ATP 1.12 1.12 1.21 1.26 1.14 .91 1.51
KLA/ATP 1.02 1.11 1.21 1.29 .94 .85 .94
AK209324
KLA  ATP  ATP+KLA
 AK209324 cDNA, clone:Y2G0114L23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000060207, based on BLAT search. [AK209324] KLA .48 .51 .55 .57 .80 .90 1.17
ATP 1.01 .96 .73 .60 .76 .78 1.24
KLA/ATP .54 .46 .42 .54 .76 .76 .73
D230014K
01Rik
KLA  ATP  ATP+KLA
 NM_172573 RIKEN cDNA D230014K01 gene (D230014K01Rik), mRNA [NM_172573] KLA .54 .55 .44 .52 .50 .57 .72
ATP 1.02 1.11 .99 .93 .47 .42 .69
KLA/ATP .53 .53 .56 .61 .54 .45 .54
Fuca1
KLA  ATP  ATP+KLA
 NM_024243 fucosidase, alpha-L- 1, tissue (Fuca1), mRNA [NM_024243] KLA .72 .75 .70 .66 .61 .56 .59
ATP .97 1.06 .90 1.25 .93 .67 .99
KLA/ATP .77 .78 .65 .94 .66 .61 .92
Fuca2
KLA  ATP  ATP+KLA
 NM_025799 fucosidase, alpha-L- 2, plasma (Fuca2), mRNA [NM_025799] KLA .83 .85 .80 .77 .68 .69 .90
ATP .98 1.00 1.15 1.07 1.13 .99 1.11
KLA/ATP .82 .83 .93 .85 .76 .72 .81
Gba
KLA  ATP  ATP+KLA
 NM_001077411 glucosidase, beta, acid (Gba), mRNA [NM_001077411] KLA .86 .89 .92 .84 .95 1.11 1.65
ATP .97 .99 .60 .74 .63 .76 2.19
KLA/ATP .95 .85 .52 .74 .50 .81 2.57
Gba2
KLA  ATP  ATP+KLA
 NM_172692 glucosidase beta 2 (Gba2), mRNA [NM_172692] KLA .43 .43 .47 .62 .82 .99 .91
ATP 1.00 1.00 .97 .81 .53 .73 1.03
KLA/ATP .41 .43 .47 .47 .69 .88 1.21
Glb1
KLA  ATP  ATP+KLA
 NM_009752 galactosidase, beta 1 (Glb1), mRNA [NM_009752] KLA .93 .96 1.02 .85 .86 .81 .80
ATP 1.03 1.10 1.01 1.13 .97 .82 .75
KLA/ATP 1.08 1.04 .86 1.06 .81 .81 .66
Hexa
KLA  ATP  ATP+KLA
 NM_010421 hexosaminidase A (Hexa), mRNA [NM_010421] KLA .74 .76 .70 .63 .57 .52 .51
ATP .98 1.04 .82 .81 .68 .52 .64
KLA/ATP .76 .78 .63 .60 .48 .37 .31
Hexb
KLA  ATP  ATP+KLA
 NM_010422 hexosaminidase B (Hexb), mRNA [NM_010422] KLA .82 .90 .81 .70 .64 .64 .71
ATP .95 1.03 1.11 .83 .72 .58 .63
KLA/ATP .80 .83 .77 .68 .53 .45 .50
Hexdc
KLA  ATP  ATP+KLA
 NM_001001333 hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing (Hexdc), mRNA [NM_001001333] KLA .57 .61 .55 .60 .56 .65 1.03
ATP 1.02 1.05 .87 .82 .60 .52 .73
KLA/ATP .63 .61 .58 .52 .48 .52 .77
Man2b1
KLA  ATP  ATP+KLA
 AK054315 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330014I09 product:mannosidase 2, alpha B1, full insert sequence. [AK054315] KLA 1.00 .97 .91 .97 .93 .92 .94
ATP .98 .99 .89 1.01 .92 .94 .97
KLA/ATP .94 .95 .90 .93 1.00 .94 .96
Man2b1
KLA  ATP  ATP+KLA
 NM_010764 mannosidase 2, alpha B1 (Man2b1), mRNA [NM_010764] KLA .78 .76 .76 .67 .59 .51 .37
ATP .90 .94 .92 .84 .74 .54 .43
KLA/ATP .74 .77 .73 .64 .52 .37 .27
Man2b2
KLA  ATP  ATP+KLA
 NM_008550 mannosidase 2, alpha B2 (Man2b2), mRNA [NM_008550] KLA 1.13 1.07 .95 .98 .97 .76 .89
ATP 1.17 1.29 1.18 1.52 1.04 .76 .66
KLA/ATP 1.07 1.28 1.22 1.62 .79 .70 .68
Man2c1
KLA  ATP  ATP+KLA
 NM_028636 mannosidase, alpha, class 2C, member 1 (Man2c1), mRNA [NM_028636] KLA .99 1.00 1.09 .95 .90 .79 .86
ATP 1.05 1.12 1.09 1.19 .92 .71 .66
KLA/ATP 1.04 1.06 1.02 1.10 .79 .72 .62
Manba
KLA  ATP  ATP+KLA
 AK037629 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130030I04 product:unclassifiable, full insert sequence. [AK037629] KLA 1.01 .99 .98 1.09 1.04 1.02 1.01
ATP .97 1.00 .91 .99 .96 1.02 .99
KLA/ATP .97 1.03 .92 .96 1.04 .97 .93
Manba
KLA  ATP  ATP+KLA
 NM_027288 mannosidase, beta A, lysosomal (Manba), mRNA [NM_027288] KLA .60 .62 .56 .49 .42 .55 .77
ATP .98 1.03 1.03 1.12 .93 .47 .75
KLA/ATP .63 .65 .58 .62 .51 .39 .76
Mm.10370
3
KLA  ATP  ATP+KLA
 118131105 Unknown KLA 1.00 1.01 .96 .80 .81 1.04 1.02
ATP .99 1.06 .98 .67 .72 .82 1.06
KLA/ATP 1.02 1.12 .94 .76 .84 1.08 .93
Mm.27513
0
KLA  ATP  ATP+KLA
 47679083 Unknown KLA .55 .51 .47 .48 .52 .68 .89
ATP .98 .82 .91 .61 .47 .57 .66
KLA/ATP .52 .46 .51 .35 .38 .47 .74
Neu1
KLA  ATP  ATP+KLA
 NM_010893 neuraminidase 1 (Neu1), mRNA [NM_010893] KLA .59 .58 .57 .66 .88 1.30 1.59
ATP .98 1.01 1.08 1.31 1.76 2.01 2.47
KLA/ATP .57 .59 .70 .78 1.18 1.73 2.99
Neu2
KLA  ATP  ATP+KLA
 NM_015750 neuraminidase 2 (Neu2), mRNA [NM_015750] KLA 1.07 1.16 1.12 1.24 1.18 1.16 1.17
ATP 1.13 1.11 1.15 1.12 1.08 1.07 1.05
KLA/ATP 1.14 1.22 1.22 1.19 1.11 1.12 1.09
Neu3
KLA  ATP  ATP+KLA
 NM_016720 neuraminidase 3 (Neu3), mRNA [NM_016720] KLA 1.09 1.07 1.02 .92 .82 1.10 1.08
ATP .99 .87 1.06 .72 .82 .92 1.05
KLA/ATP 1.08 1.04 1.02 .86 .94 1.24 1.02
Neu4
KLA  ATP  ATP+KLA
 NM_173772 sialidase 4 (Neu4), mRNA [NM_173772] KLA 1.00 .97 1.03 1.05 1.03 1.04 .99
ATP 1.03 .99 .98 1.02 1.02 1.02 .90
KLA/ATP .92 1.06 1.03 .98 1.04 .95 1.06