Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Mucin type O-Glycan biosynthesis (mmu00512)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
4930431L
04Rik
KLA  ATP  ATP+KLA
 NM_175032 RIKEN cDNA 4930431L04 gene (4930431L04Rik), mRNA [NM_175032] KLA .96 1.04 1.08 1.08 1.11 .98 .98
ATP .96 1.02 1.02 1.00 1.07 .98 .99
KLA/ATP .99 1.01 1.05 .93 1.02 1.11 .97
B4galt5
KLA  ATP  ATP+KLA
 NM_019835 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 (B4galt5), mRNA [NM_019835] KLA 2.19 2.08 2.53 2.84 2.46 2.30 1.44
ATP .97 1.18 1.27 1.47 2.36 2.22 1.76
KLA/ATP 2.04 2.41 2.65 3.00 3.12 3.11 2.64
C1galt1
KLA  ATP  ATP+KLA
 AK008884 adult male stomach cDNA, RIKEN full-length enriched library, clone:2210410E06 product:hypothetical protein, full insert sequence. [AK008884] KLA .54 .48 .42 .32 .28 .45 .72
ATP 1.17 1.18 1.11 .81 1.43 1.00 .59
KLA/ATP .51 .48 .48 .44 .68 .64 .27
C1galt1
KLA  ATP  ATP+KLA
 NM_052993 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1galt1), mRNA [NM_052993] KLA .93 .90 .80 .78 .68 .99 1.98
ATP 1.02 1.14 1.15 1.19 1.43 2.25 2.52
KLA/ATP .87 .85 .75 .89 .81 1.82 3.06
C1galt1c
1
KLA  ATP  ATP+KLA
 AK161729 adult male thymus cDNA, RIKEN full-length enriched library, clone:5830428K17 product:hypothetical protein, full insert sequence. [AK161729] KLA .93 .94 .93 .99 .96 1.04 1.00
ATP .99 .95 .97 .97 1.00 .95 .95
KLA/ATP 1.02 .97 .99 .87 .91 .92 .90
C1galt1c
1
KLA  ATP  ATP+KLA
 NM_021550 C1GALT1-specific chaperone 1 (C1galt1c1), mRNA [NM_021550] KLA 1.20 1.10 1.28 1.27 1.23 1.09 1.29
ATP 1.13 1.00 1.24 1.01 .86 1.05 1.48
KLA/ATP 1.17 1.25 1.55 1.15 1.24 1.14 1.63
Galnt1
KLA  ATP  ATP+KLA
 NM_013814 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (Galnt1), mRNA [NM_013814] KLA .93 1.00 .93 .94 .87 .95 .98
ATP 1.13 1.22 1.08 1.18 .89 .59 .75
KLA/ATP 1.11 1.10 .91 1.11 .60 .53 .49
Galnt10
KLA  ATP  ATP+KLA
 BC016585 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10, mRNA (cDNA clone MGC:27969 IMAGE:3595220), complete cds. [BC016585] KLA .83 .86 .89 .79 .73 .64 .74
ATP 1.11 .96 .89 1.06 .81 .71 1.01
KLA/ATP .92 .94 .85 .86 .70 .67 .94
Galnt10
KLA  ATP  ATP+KLA
 NM_134189 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (Galnt10), mRNA [NM_134189] KLA .74 .71 .67 .70 .55 .58 .62
ATP .82 .75 1.10 .88 .68 .74 .94
KLA/ATP .63 .69 .91 .72 .68 .64 .82
Galnt11
KLA  ATP  ATP+KLA
 AK079811 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430075I06 product:unclassifiable, full insert sequence. [AK079811] KLA 1.05 .98 .97 .97 .99 .96 1.01
ATP .99 1.04 .96 .95 .95 .93 1.01
KLA/ATP .98 1.04 1.04 .90 .93 1.01 1.01
Galnt11
KLA  ATP  ATP+KLA
 NM_144908 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (Galnt11), mRNA [NM_144908] KLA .57 .54 .46 .38 .41 .48 .71
ATP .93 1.00 .94 .92 .58 .32 .55
KLA/ATP .52 .57 .50 .47 .40 .33 .23
Galnt12
KLA  ATP  ATP+KLA
 NM_172693 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (Galnt12), mRNA [NM_172693] KLA .40 .35 .35 .28 .18 .19 .29
ATP 1.16 1.05 1.10 .93 .58 .27 .37
KLA/ATP .42 .38 .41 .26 .27 .18 .15
Galnt13
KLA  ATP  ATP+KLA
 AK035964 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630021K14 product:unclassifiable, full insert sequence [AK035964] KLA .99 1.03 1.05 .98 1.00 .99 .99
ATP .99 1.02 .98 .98 .97 1.04 .98
KLA/ATP .97 1.02 1.01 .94 1.01 .99 .95
Galnt13
KLA  ATP  ATP+KLA
 NM_173030 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (Galnt13), mRNA [NM_173030] KLA 1.01 1.03 1.04 1.06 1.02 1.02 .99
ATP .98 .95 1.02 .98 1.03 .99 1.04
KLA/ATP 1.01 .97 1.00 1.09 1.02 1.00 1.03
Galnt14
KLA  ATP  ATP+KLA
 AK002747 adult male kidney cDNA, RIKEN full-length enriched library, clone:0610033M06 product:RIKEN cDNA 0610033M06 gene, full insert sequence. [AK002747] KLA 1.07 1.00 1.08 1.05 .96 1.02 .97
ATP .96 1.05 1.04 1.00 1.04 .99 1.06
KLA/ATP 1.05 .97 1.00 .98 1.06 .99 1.02
Galnt14
KLA  ATP  ATP+KLA
 NM_027864 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (Galnt14), mRNA [NM_027864] KLA 1.05 1.07 1.08 1.06 1.03 1.06 1.08
ATP 1.06 1.04 1.05 1.00 1.00 .97 1.04
KLA/ATP 1.04 1.08 1.03 1.02 1.02 1.00 1.06
Galnt2
KLA  ATP  ATP+KLA
 NM_139272 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (Galnt2), mRNA [NM_139272] KLA .75 .72 .72 .68 .70 .97 1.07
ATP 1.14 1.14 .98 1.07 .88 .76 1.42
KLA/ATP .85 .80 .61 .70 .53 .78 1.52
Galnt3
KLA  ATP  ATP+KLA
 AK087219 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030036B02 product:UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3, full insert sequence. [AK087219] KLA 1.04 1.00 .95 .98 .95 1.00 .98
ATP 1.02 1.01 1.02 .95 1.15 .96 .96
KLA/ATP .96 .94 .92 .94 1.02 .96 .97
Galnt3
KLA  ATP  ATP+KLA
 NM_015736 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (Galnt3), mRNA [NM_015736] KLA 1.28 1.22 1.16 1.13 .85 .79 .57
ATP .90 .93 1.04 .95 1.43 2.94 .63
KLA/ATP 1.12 1.21 1.17 1.08 1.08 1.17 .79
Galnt3
KLA  ATP  ATP+KLA
 U70538 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3 mRNA, complete cds. [U70538] KLA 1.21 1.09 1.14 1.04 .82 .70 .57
ATP .91 .91 1.08 .91 1.33 2.59 .52
KLA/ATP 1.03 1.11 1.11 .90 .89 1.08 .57
Galnt4
KLA  ATP  ATP+KLA
 NM_015737 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (Galnt4), mRNA [NM_015737] KLA .79 .79 .66 .65 .52 .57 .71
ATP .90 .78 .52 .44 .34 .70 .82
KLA/ATP .74 .67 .50 .54 .41 .42 .47
Galnt6
KLA  ATP  ATP+KLA
 NM_172451 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (Galnt6), mRNA [NM_172451] KLA .58 .53 .62 .59 .79 1.35 1.55
ATP 1.06 1.06 .76 1.03 2.22 2.64 3.21
KLA/ATP .63 .59 .51 .55 1.24 2.04 2.79
Galnt7
KLA  ATP  ATP+KLA
 NM_144731 UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7 (Galnt7), mRNA [NM_144731] KLA 1.89 2.01 1.94 1.67 1.45 .84 .63
ATP 1.03 1.12 1.07 1.12 .68 .44 .76
KLA/ATP 2.08 2.11 1.58 1.78 .87 .62 .53
Galntl1
KLA  ATP  ATP+KLA
 NM_001081421 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 (Galntl1), mRNA [NM_001081421] KLA 1.03 1.01 1.01 .96 .91 .99 .97
ATP 1.03 1.01 1.02 .95 .94 .92 .99
KLA/ATP 1.02 1.03 .97 .92 .97 .89 .96
Galntl2
KLA  ATP  ATP+KLA
 AK019470 0 day neonate skin cDNA, RIKEN full-length enriched library, clone:4631401E18 product:similar to UDP-N-ACETYL-ALPHA-D-GALACTOSAMINE:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 7 [Homo sapiens], full insert sequence [AK019470] KLA .90 .94 .88 .98 .81 1.02 1.21
ATP .99 .92 1.16 1.48 2.08 1.48 1.01
KLA/ATP .98 .99 .93 1.14 2.12 1.85 1.11
Galntl4
KLA  ATP  ATP+KLA
 AK084671 13 days embryo heart cDNA, RIKEN full-length enriched library, clone:D330027L06 product:hypothetical protein, full insert sequence. [AK084671] KLA .99 1.05 .99 1.02 .86 1.02 1.03
ATP .98 .97 1.07 1.03 .95 .93 .98
KLA/ATP 1.05 .99 .95 .99 .99 .95 1.04
Galntl4
KLA  ATP  ATP+KLA
 NM_173739 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4 (Galntl4), mRNA [NM_173739] KLA 1.07 1.00 1.04 .94 1.04 1.03 1.03
ATP 1.05 1.02 .99 1.00 .95 .99 .96
KLA/ATP 1.01 1.01 .98 .96 1.00 .98 1.00
Galntl5
KLA  ATP  ATP+KLA
 NM_026449 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5 (Galntl5), mRNA [NM_026449] KLA .98 1.09 1.04 1.00 .97 .90 .96
ATP 1.06 1.03 1.01 1.00 1.11 .92 .99
KLA/ATP 1.08 .99 1.04 .93 .98 .97 .96
Gcnt1
KLA  ATP  ATP+KLA
 NM_010265 glucosaminyl (N-acetyl) transferase 1, core 2 (Gcnt1), mRNA [NM_010265] KLA .33 .30 .26 .23 .20 .22 .28
ATP 1.02 .99 1.11 .96 1.12 .71 1.76
KLA/ATP .31 .27 .29 .31 .34 .38 .42
Gcnt1
KLA  ATP  ATP+KLA
 NM_173442 glucosaminyl (N-acetyl) transferase 1, core 2 (Gcnt1), mRNA [NM_173442] KLA .13 .10 .07 .06 .05 .08 .12
ATP .91 .82 1.08 .69 1.32 .45 .88
KLA/ATP .11 .10 .08 .06 .23 .25 .12
Gcnt3
KLA  ATP  ATP+KLA
 NM_028087 glucosaminyl (N-acetyl) transferase 3, mucin type (Gcnt3), mRNA [NM_028087] KLA 1.01 1.07 .98 .93 1.07 1.03 1.01
ATP 1.06 1.00 1.02 1.00 1.01 1.07 1.03
KLA/ATP 1.10 1.01 .95 .97 .97 1.04 .98
Mm.40681
KLA  ATP  ATP+KLA
 153792802 Unknown KLA .96 1.01 1.08 .98 1.07 1.15 1.09
ATP 1.04 1.02 1.03 1.13 1.11 1.13 1.16
KLA/ATP 1.06 1.07 .57 1.13 1.25 1.20 1.10
St3gal1
KLA  ATP  ATP+KLA
 NM_009177 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (St3gal1), mRNA [NM_009177] KLA 9.07 8.10 8.07 8.61 6.32 6.17 4.65
ATP .97 .87 1.27 4.14 10.38 21.66 8.10
KLA/ATP 8.21 8.67 10.15 8.82 11.00 12.94 21.26
St3gal2
KLA  ATP  ATP+KLA
 NM_009179 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (St3gal2), mRNA [NM_009179] KLA .70 .72 .72 .65 .58 .53 .65
ATP .96 .96 .88 .76 .61 .60 1.17
KLA/ATP .75 .71 .67 .63 .50 .47 .68
St6galna
c1
KLA  ATP  ATP+KLA
 NM_011371 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (St6galnac1), mRNA [NM_011371] KLA 1.05 .99 1.02 .95 .97 .98 .98
ATP .96 1.02 1.04 .94 1.02 1.02 1.04
KLA/ATP 1.02 1.01 .98 .95 .99 .92 1.01
Wbscr17
KLA  ATP  ATP+KLA
 NM_145218 Williams-Beuren syndrome chromosome region 17 homolog (human) (Wbscr17), mRNA [NM_145218] KLA .97 1.01 .99 .98 1.06 1.01 1.03
ATP 1.05 .95 1.01 1.08 1.01 1.05 1.01
KLA/ATP 1.04 1.00 .98 1.00 1.02 1.03 1.01