Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Other types of O-glycan biosynthesis (mmu00514)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK086752
KLA  ATP  ATP+KLA
 AK086752 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930049G22 product:hypothetical protein, full insert sequence. [AK086752] KLA 1.04 1.03 .96 1.06 .97 1.03 .95
ATP .99 1.06 1.02 1.01 1.01 1.09 1.00
KLA/ATP 1.01 1.01 1.10 .99 .96 .90 1.08
B3galt4
KLA  ATP  ATP+KLA
 NM_019420 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 (B3galt4), mRNA [NM_019420] KLA .77 .78 .99 1.07 1.51 1.56 1.56
ATP 1.08 1.12 .94 .81 .46 1.04 1.44
KLA/ATP .90 .88 .74 .85 .64 .97 1.21
B3gat1
KLA  ATP  ATP+KLA
 NM_029792 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) (B3gat1), mRNA [NM_029792] KLA .96 .95 .99 .98 .99 .99 1.00
ATP 1.03 1.01 1.03 1.02 .99 1.04 1.00
KLA/ATP 1.00 .98 .93 1.00 1.00 1.04 .95
B3gat2
KLA  ATP  ATP+KLA
 NM_172124 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) (B3gat2), mRNA [NM_172124] KLA 1.07 .91 .96 .99 .97 1.04 .96
ATP 1.00 1.03 1.01 .99 .95 1.09 1.08
KLA/ATP .99 .97 .99 .99 .96 .92 1.09
B4galt1
KLA  ATP  ATP+KLA
 NM_022305 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), mRNA [NM_022305] KLA .58 .56 .55 .59 .75 1.18 1.17
ATP 1.10 1.15 1.07 1.14 1.05 .71 1.11
KLA/ATP .60 .62 .62 .66 .74 .71 1.10
B4galt2
KLA  ATP  ATP+KLA
 NM_017377 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (B4galt2), mRNA [NM_017377] KLA 1.02 .98 .98 1.02 1.04 1.04 1.00
ATP .98 1.01 1.09 1.64 1.22 .96 .94
KLA/ATP .98 1.03 1.04 1.25 1.10 1.00 1.01
B4galt3
KLA  ATP  ATP+KLA
 BC021830 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3, mRNA (cDNA clone IMAGE:3978260), **** WARNING: chimeric clone ****. [BC021830] KLA .94 .90 .98 1.03 .97 .92 1.01
ATP .89 .82 .99 .87 .86 .91 .94
KLA/ATP .94 .93 .95 .97 .91 .96 .97
B4galt3
KLA  ATP  ATP+KLA
 NM_020579 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 (B4galt3), mRNA [NM_020579] KLA 2.83 2.66 2.21 1.34 .99 1.02 1.09
ATP 1.08 1.11 .77 .64 1.24 1.15 1.12
KLA/ATP 3.28 2.99 2.00 1.55 2.04 2.13 1.47
Chst10
KLA  ATP  ATP+KLA
 NM_145142 carbohydrate sulfotransferase 10 (Chst10), mRNA [NM_145142] KLA .80 3.59 .79 .76 .74 .78 .58
ATP .89 .98 1.02 .89 .82 .68 .59
KLA/ATP .74 .75 .85 .79 .69 .74 .53
Fut4
KLA  ATP  ATP+KLA
 NM_010242 fucosyltransferase 4 (Fut4), mRNA [NM_010242] KLA .90 .81 .83 .74 .60 .54 .76
ATP 1.13 .97 .68 .48 1.03 .99 .60
KLA/ATP .89 .89 .65 .50 .67 .78 .43
Fut7
KLA  ATP  ATP+KLA
 NM_013524 fucosyltransferase 7 (Fut7), mRNA [NM_013524] KLA .32 .32 .32 .49 .61 .56 .53
ATP .95 .77 .83 .56 .29 .40 .60
KLA/ATP .28 .28 .35 .29 .29 .26 .40
Fut9
KLA  ATP  ATP+KLA
 NM_010243 fucosyltransferase 9 (Fut9), mRNA [NM_010243] KLA .99 .99 1.02 1.02 1.02 1.02 .98
ATP .99 1.01 .99 .98 1.01 .99 1.04
KLA/ATP 1.00 .97 1.06 1.00 .96 1.01 .96
Glt25d1
KLA  ATP  ATP+KLA
 NM_146211 glycosyltransferase 25 domain containing 1 (Glt25d1), mRNA [NM_146211] KLA .69 .73 .79 .60 .61 .53 .70
ATP 1.08 1.15 .97 1.12 1.03 .71 .81
KLA/ATP .80 .76 .60 .72 .53 .49 .61
Glt25d2
KLA  ATP  ATP+KLA
 NM_177756 glycosyltransferase 25 domain containing 2 (Glt25d2), mRNA [NM_177756] KLA 1.02 1.00 .97 1.01 1.03 .95 .97
ATP .97 1.05 1.03 .97 .97 .96 1.00
KLA/ATP .97 .99 1.03 1.00 .98 1.02 1.02
Glt8d3
KLA  ATP  ATP+KLA
 NM_001033275 glycosyltransferase 8 domain containing 3 (Glt8d3), mRNA [NM_001033275] KLA .66 .61 .69 .67 .70 .84 .78
ATP .90 .83 .94 .61 1.38 2.04 .53
KLA/ATP .55 .55 .79 .59 1.68 1.76 .55
Glt8d4
KLA  ATP  ATP+KLA
 NM_198612 glycosyltransferase 8 domain containing 4 (Glt8d4), mRNA [NM_198612] KLA 1.01 .96 1.00 1.02 1.01 .99 1.01
ATP .98 1.02 1.07 1.44 1.16 1.08 1.08
KLA/ATP 1.05 1.04 1.10 1.10 1.09 1.06 1.38
Ktelc1
KLA  ATP  ATP+KLA
 AK076379 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732474N01 product:unclassifiable, full insert sequence [AK076379] KLA 1.30 1.21 1.20 1.11 1.20 1.00 .96
ATP .96 1.07 .97 .87 .89 .96 .98
KLA/ATP 1.15 1.09 1.12 1.04 .97 .89 .96
Ktelc1
KLA  ATP  ATP+KLA
 NM_172380 KTEL (Lys-Tyr-Glu-Leu) containing 1 (Ktelc1), mRNA [NM_172380] KLA 1.80 2.07 2.28 1.94 2.04 1.26 1.08
ATP 1.05 1.00 .91 .77 .63 .63 .95
KLA/ATP 2.18 2.33 1.80 1.66 1.19 .98 .79
Lfng
KLA  ATP  ATP+KLA
 NM_008494 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Lfng), mRNA [NM_008494] KLA .53 .56 .48 .51 .59 .70 .88
ATP 1.15 1.25 1.22 2.82 1.68 .58 1.00
KLA/ATP .60 .51 .60 1.51 1.11 .52 .54
Mfng
KLA  ATP  ATP+KLA
 NM_008595 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Mfng), mRNA [NM_008595] KLA .54 .59 .50 .53 .49 .53 .62
ATP .91 .85 .66 .67 .49 .46 .38
KLA/ATP .53 .50 .50 .57 .54 .48 .38
Mgat5b
KLA  ATP  ATP+KLA
 NM_172948 mannoside acetylglucosaminyltransferase 5, isoenzyme B (Mgat5b), mRNA [NM_172948] KLA .95 1.02 .99 1.03 1.05 .99 1.05
ATP 1.02 .96 1.00 1.03 1.02 1.01 1.04
KLA/ATP 1.00 1.05 1.02 1.03 1.01 1.02 1.05
Mm.22819
KLA  ATP  ATP+KLA
 158508451 Unknown KLA .72 .64 .62 .73 .72 .77 .67
ATP 1.01 .86 1.02 .58 1.42 2.74 .54
KLA/ATP .51 .55 .99 .61 1.85 2.01 .56
Mm.29376
1
KLA  ATP  ATP+KLA
 84794594 Unknown KLA 1.89 2.03 2.19 2.16 2.50 2.28 1.45
ATP .98 1.00 1.02 .91 1.15 1.02 1.17
KLA/ATP 1.92 2.16 2.09 1.56 1.46 1.15 1.44
Ogt
KLA  ATP  ATP+KLA
 BC037194 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase), mRNA (cDNA clone IMAGE:4500866), complete cds. [BC037194] KLA .99 .94 .94 .89 .96 .81 .90
ATP 1.07 1.04 .77 .71 .87 .81 .77
KLA/ATP .92 .93 .77 .76 .73 .70 .78
Ogt
KLA  ATP  ATP+KLA
 NM_139144 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) (Ogt), mRNA [NM_139144] KLA 1.13 1.15 1.09 .99 1.10 .96 1.06
ATP 1.00 1.03 .77 .59 .59 .95 1.07
KLA/ATP 1.10 1.11 .80 .73 .60 .50 1.03
Plod3
KLA  ATP  ATP+KLA
 NM_011962 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (Plod3), mRNA [NM_011962] KLA 2.26 2.29 2.72 2.51 2.74 2.67 1.80
ATP 1.00 1.07 .98 1.26 1.08 1.20 1.58
KLA/ATP 2.42 2.55 2.57 2.97 2.24 2.17 1.96
Pofut1
KLA  ATP  ATP+KLA
 NM_001039055 protein O-fucosyltransferase 1 (Pofut1), transcript variant 2, mRNA [NM_001039055] KLA 1.97 1.76 1.77 1.98 2.06 2.00 1.34
ATP .98 1.03 1.08 1.11 1.11 1.11 1.24
KLA/ATP 1.80 2.05 2.01 1.87 1.49 1.28 1.42
Pofut2
KLA  ATP  ATP+KLA
 NM_030262 protein O-fucosyltransferase 2 (Pofut2), mRNA [NM_030262] KLA 1.18 1.17 1.08 1.09 1.07 1.15 1.20
ATP .97 .99 1.03 1.32 1.09 1.15 1.63
KLA/ATP 1.23 1.22 1.09 1.58 1.08 1.07 1.98
Pomgnt1
KLA  ATP  ATP+KLA
 NM_029786 protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase (Pomgnt1), transcript variant 2, mRNA [NM_029786] KLA 1.01 1.03 .93 .86 .86 .80 1.01
ATP 1.01 .96 .77 .72 .66 .83 1.14
KLA/ATP 1.02 1.00 .72 .79 .67 .71 .97
Pomt1
KLA  ATP  ATP+KLA
 AK050680 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030002N23 product:protein-O-mannosyltransferase 1, full insert sequence [AK050680] KLA .94 1.01 .87 .98 .96 .97 .95
ATP 1.00 1.01 .92 .97 .95 .92 .92
KLA/ATP 1.04 .92 .95 .92 .99 .95 .93
Pomt1
KLA  ATP  ATP+KLA
 NM_145145 protein-O-mannosyltransferase 1 (Pomt1), mRNA [NM_145145] KLA .84 .83 .80 .74 .71 .69 .85
ATP 1.01 1.07 1.08 1.14 .83 .60 .92
KLA/ATP .86 .86 .81 .90 .73 .60 .82
Pomt2
KLA  ATP  ATP+KLA
 NM_153415 protein-O-mannosyltransferase 2 (Pomt2), mRNA [NM_153415] KLA .97 .97 .96 .91 .95 .93 1.04
ATP 1.06 1.16 1.02 .93 .67 .79 1.17
KLA/ATP .96 1.01 .87 .87 .72 .82 .96
Rfng
KLA  ATP  ATP+KLA
 NM_009053 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Rfng), mRNA [NM_009053] KLA .91 .88 .85 .86 .87 .94 .91
ATP 1.03 1.15 .93 1.46 1.02 .76 1.09
KLA/ATP .99 .89 .73 1.17 .80 .77 .93
St3gal3
KLA  ATP  ATP+KLA
 NM_009176 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (St3gal3), mRNA [NM_009176] KLA 2.87 3.30 2.81 2.78 2.43 1.70 1.08
ATP 1.01 1.10 .89 1.11 .69 .91 .76
KLA/ATP 3.12 3.19 2.25 2.60 1.52 1.00 .98
St6gal1
KLA  ATP  ATP+KLA
 NM_145933 beta galactoside alpha 2,6 sialyltransferase 1 (St6gal1), mRNA [NM_145933] KLA .46 .43 .38 .39 .27 .26 .23
ATP .93 .84 .69 .57 .43 .38 .26
KLA/ATP .46 .41 .40 .39 .35 .41 .32
St6gal2
KLA  ATP  ATP+KLA
 AK129462 mRNA for mKIAA1877 protein [AK129462] KLA 1.03 .98 1.02 .95 1.01 .99 .95
ATP 1.05 .99 1.01 1.03 .96 1.07 .97
KLA/ATP 1.00 .99 .98 1.04 .98 .98 1.04
St6gal2
KLA  ATP  ATP+KLA
 NM_172829 beta galactoside alpha 2,6 sialyltransferase 2 (St6gal2), mRNA [NM_172829] KLA 1.03 1.01 .99 1.10 1.08 1.05 1.00
ATP .95 1.06 1.02 1.07 .99 1.06 1.10
KLA/ATP .94 1.01 1.06 1.08 .99 1.00 1.06