Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Amino sugar and nucleotide sugar metabolism (mmu00520)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2810423A
18Rik
KLA  ATP  ATP+KLA
 AK013141 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810423A18 product:unclassifiable, full insert sequence [AK013141] KLA 1.03 .97 1.07 .95 1.09 1.26 1.38
ATP .96 .98 1.09 1.02 2.18 2.30 1.52
KLA/ATP .99 .97 .94 .75 1.93 3.39 2.34
Amdhd2
KLA  ATP  ATP+KLA
 AK078259 adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430547H16 product:hypothetical Metallo-dependent hydrolase, composite containing protein, full insert sequence. [AK078259] KLA .61 .57 .60 .67 .65 .72 .72
ATP .85 .78 1.20 1.02 .72 .88 3.96
KLA/ATP .53 .53 .76 .79 .66 .74 1.57
Amdhd2
KLA  ATP  ATP+KLA
 NM_172935 amidohydrolase domain containing 2 (Amdhd2), mRNA [NM_172935] KLA .64 .63 .61 .61 .57 .70 1.03
ATP .96 .90 1.03 .98 .77 .40 1.20
KLA/ATP .63 .64 .75 .71 .68 .45 .75
Chi3l1
KLA  ATP  ATP+KLA
 NM_007695 chitinase 3-like 1 (Chi3l1), mRNA [NM_007695] KLA 1.46 1.53 1.65 1.35 1.31 1.16 1.29
ATP 1.24 1.33 1.19 1.47 1.80 1.46 1.04
KLA/ATP 1.64 1.70 1.56 1.90 1.48 1.29 1.28
Chia
KLA  ATP  ATP+KLA
 NM_023186 chitinase, acidic (Chia), mRNA [NM_023186] KLA 1.08 1.03 1.07 1.06 1.06 1.03 1.06
ATP 1.05 1.04 1.05 1.03 1.02 .97 1.01
KLA/ATP 1.09 1.08 1.17 1.00 .97 1.00 1.00
Chit1
KLA  ATP  ATP+KLA
 NM_027979 chitinase 1 (chitotriosidase) (Chit1), mRNA [NM_027979] KLA 10.65 10.93 9.79 11.03 10.05 10.21 7.50
ATP 1.01 1.03 1.55 1.80 2.17 4.88 7.34
KLA/ATP 9.41 10.16 13.80 13.12 13.57 10.71 15.80
Cmah
KLA  ATP  ATP+KLA
 NM_007717 cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah), transcript variant 1, mRNA [NM_007717] KLA .81 .78 .83 .82 .82 .69 .50
ATP 1.01 1.07 .90 .91 .86 .68 .48
KLA/ATP .82 .78 .80 .82 .80 .65 .51
Cmas
KLA  ATP  ATP+KLA
 NM_009908 cytidine monophospho-N-acetylneuraminic acid synthetase (Cmas), mRNA [NM_009908] KLA .47 .49 .45 .51 .54 .58 .90
ATP 1.08 1.07 .97 1.19 1.07 .58 .84
KLA/ATP .53 .54 .48 .48 .46 .51 .61
Cyb5r1
KLA  ATP  ATP+KLA
 NM_028057 cytochrome b5 reductase 1 (Cyb5r1), mRNA [NM_028057] KLA .65 .69 .63 .58 .58 .63 1.11
ATP 1.05 1.02 .86 .87 .77 .52 .75
KLA/ATP .68 .71 .56 .58 .42 .31 .48
Cyb5r2
KLA  ATP  ATP+KLA
 NM_177216 cytochrome b5 reductase 2 (Cyb5r2), mRNA [NM_177216] KLA .99 1.01 .94 1.02 1.00 1.01 .96
ATP 1.02 1.04 1.02 .99 .94 1.08 1.08
KLA/ATP 1.00 .96 1.04 .95 .98 .97 1.06
Cyb5r3
KLA  ATP  ATP+KLA
 NM_029787 cytochrome b5 reductase 3 (Cyb5r3), mRNA [NM_029787] KLA .93 .96 1.03 .93 1.06 1.03 .96
ATP 1.09 1.19 1.08 1.42 1.25 .95 1.48
KLA/ATP 1.09 1.16 .99 1.30 .92 1.04 1.45
Fpgt
KLA  ATP  ATP+KLA
 AK030969 adult male thymus cDNA, RIKEN full-length enriched library, clone:5830472G17 product:unclassifiable, full insert sequence. [AK030969] KLA .98 1.01 1.03 1.02 .99 .99 1.07
ATP 1.04 .96 .98 .98 .99 1.02 .99
KLA/ATP 1.03 .94 .87 1.01 1.02 1.01 1.03
Fpgt
KLA  ATP  ATP+KLA
 NM_029330 fucose-1-phosphate guanylyltransferase (Fpgt), mRNA [NM_029330] KLA 1.06 1.10 1.12 1.10 1.13 1.14 1.23
ATP .99 .98 .91 .84 1.02 1.31 1.51
KLA/ATP 1.05 1.02 .93 .87 .99 1.52 1.55
Fuk
KLA  ATP  ATP+KLA
 NM_172283 fucokinase (Fuk), transcript variant 1, mRNA [NM_172283] KLA .74 .78 .76 .78 .75 .87 .85
ATP .91 .92 1.22 .75 .54 1.26 1.16
KLA/ATP .73 .74 .95 .64 .72 1.37 1.01
Gale
KLA  ATP  ATP+KLA
 NM_178389 galactose-4-epimerase, UDP (Gale), mRNA [NM_178389] KLA .74 .68 .72 .72 .67 .68 .54
ATP 1.13 .96 1.10 .91 .82 1.20 1.42
KLA/ATP .74 .69 .84 .71 .93 1.03 1.13
Galk1
KLA  ATP  ATP+KLA
 NM_016905 galactokinase 1 (Galk1), mRNA [NM_016905] KLA .85 .85 .76 .72 .63 .46 .50
ATP 1.02 1.07 1.02 1.33 1.01 .53 .62
KLA/ATP .90 .94 .87 1.00 .79 .50 .35
Galk2
KLA  ATP  ATP+KLA
 NM_175154 galactokinase 2 (Galk2), mRNA [NM_175154] KLA .86 .78 .66 .78 .65 .65 .67
ATP .96 .83 .79 .61 .54 .66 .95
KLA/ATP .62 .68 .67 .50 .42 .70 .94
Galt
KLA  ATP  ATP+KLA
 NM_016658 galactose-1-phosphate uridyl transferase (Galt), mRNA [NM_016658] KLA .63 .59 .54 .59 .57 .79 1.08
ATP .88 .77 .92 .79 .74 .88 .95
KLA/ATP .53 .53 .60 .49 .59 .80 1.10
Gck
KLA  ATP  ATP+KLA
 NM_010292 glucokinase (Gck), mRNA [NM_010292] KLA 1.03 .99 1.04 1.02 .97 .98 1.00
ATP 1.01 .97 1.08 .99 1.06 .98 .96
KLA/ATP 1.06 1.01 .96 .98 .98 1.01 1.01
Gfpt1
KLA  ATP  ATP+KLA
 NM_013528 glutamine fructose-6-phosphate transaminase 1 (Gfpt1), mRNA [NM_013528] KLA 1.65 1.73 1.88 1.89 1.81 1.81 2.11
ATP 1.13 1.24 1.25 1.43 2.76 2.99 3.85
KLA/ATP 1.78 2.02 1.88 1.75 1.97 3.84 6.84
Gfpt2
KLA  ATP  ATP+KLA
 NM_013529 glutamine fructose-6-phosphate transaminase 2 (Gfpt2), mRNA [NM_013529] KLA 1.28 1.31 1.50 1.32 1.18 1.25 1.11
ATP .98 1.00 1.05 1.72 2.72 2.21 1.07
KLA/ATP 1.34 1.42 1.38 2.19 2.19 1.93 1.54
Gmds
KLA  ATP  ATP+KLA
 NM_146041 GDP-mannose 4, 6-dehydratase (Gmds), mRNA [NM_146041] KLA 1.08 1.19 1.08 1.00 .87 .56 .41
ATP .97 1.07 1.05 1.30 1.03 .55 .37
KLA/ATP 1.18 1.12 .98 1.11 .75 .53 .27
Gmppa
KLA  ATP  ATP+KLA
 NM_133708 GDP-mannose pyrophosphorylase A (Gmppa), mRNA [NM_133708] KLA 1.03 1.04 1.03 .92 1.02 1.04 1.35
ATP 1.05 1.17 .81 1.16 .73 .59 1.61
KLA/ATP 1.19 1.16 .74 1.16 .72 .72 1.46
Gmppb
KLA  ATP  ATP+KLA
 NM_177910 GDP-mannose pyrophosphorylase B (Gmppb), mRNA [NM_177910] KLA 2.41 2.66 2.76 3.33 3.47 3.38 1.74
ATP .91 .92 .78 .74 .43 1.76 2.06
KLA/ATP 2.31 2.72 2.59 2.32 1.87 2.93 2.37
Gne
KLA  ATP  ATP+KLA
 AK033507 adult male colon cDNA, RIKEN full-length enriched library, clone:9030414E18 product:UDP-N-acetylglucosamine-2-epimerase [AK033507] KLA .70 .66 .67 .69 .61 .68 .75
ATP .86 .72 .65 .66 .94 .74 .60
KLA/ATP .66 .56 .66 .60 .67 .64 .51
Gne
KLA  ATP  ATP+KLA
 NM_015828 glucosamine (Gne), mRNA [NM_015828] KLA .60 .61 .65 .67 .62 .56 .62
ATP .92 .78 .51 .54 .98 .55 .73
KLA/ATP .57 .47 .37 .36 .54 .39 .27
Gnpda1
KLA  ATP  ATP+KLA
 NM_011937 glucosamine-6-phosphate deaminase 1 (Gnpda1), mRNA [NM_011937] KLA .33 .30 .29 .21 .22 .42 .62
ATP .98 1.09 .86 .92 .71 .43 1.17
KLA/ATP .36 .34 .29 .31 .35 .54 .75
Gnpda2
KLA  ATP  ATP+KLA
 NM_001038015 glucosamine-6-phosphate deaminase 2 (Gnpda2), mRNA [NM_001038015] KLA .86 .82 .76 .87 .74 .89 1.14
ATP .92 .83 1.04 .83 .77 .88 .72
KLA/ATP .75 .81 .97 .79 .85 1.04 .88
Gnpnat1
KLA  ATP  ATP+KLA
 NM_019425 glucosamine-phosphate N-acetyltransferase 1 (Gnpnat1), mRNA [NM_019425] KLA .81 .85 .70 .84 .74 .72 .76
ATP .88 .83 1.10 .80 .67 .76 .68
KLA/ATP .73 .74 .83 .70 .83 .77 .39
Gpi1
KLA  ATP  ATP+KLA
 L09104 glucose phosphate isomerase mRNA, 3 end. [L09104] KLA .92 1.02 .99 1.01 .92 1.04 1.07
ATP 1.05 1.06 1.11 1.14 1.01 1.00 1.04
KLA/ATP 1.06 1.09 1.01 .96 .93 .93 1.04
Gpi1
KLA  ATP  ATP+KLA
 NM_008155 glucose phosphate isomerase 1 (Gpi1), mRNA [NM_008155] KLA .77 .76 .69 .66 .61 .59 .85
ATP .96 .97 .97 .93 .90 .73 .77
KLA/ATP .75 .76 .73 .69 .66 .54 .59
Hexa
KLA  ATP  ATP+KLA
 NM_010421 hexosaminidase A (Hexa), mRNA [NM_010421] KLA .74 .76 .70 .63 .57 .52 .51
ATP .98 1.04 .82 .81 .68 .52 .64
KLA/ATP .76 .78 .63 .60 .48 .37 .31
Hexb
KLA  ATP  ATP+KLA
 NM_010422 hexosaminidase B (Hexb), mRNA [NM_010422] KLA .82 .90 .81 .70 .64 .64 .71
ATP .95 1.03 1.11 .83 .72 .58 .63
KLA/ATP .80 .83 .77 .68 .53 .45 .50
Hk1
KLA  ATP  ATP+KLA
 J05277 gb|Mouse hexokinase mRNA, complete cds [J05277] KLA 1.49 1.45 1.66 1.78 1.51 1.29 .99
ATP 1.11 1.05 1.15 1.20 2.31 2.17 1.09
KLA/ATP 1.63 1.51 1.70 1.47 1.94 1.92 1.40
Hk1
KLA  ATP  ATP+KLA
 NM_010438 hexokinase 1 (Hk1), nuclear gene encoding mitochondrial protein, mRNA [NM_010438] KLA 1.58 1.75 2.05 1.84 1.96 1.67 1.31
ATP 1.06 1.25 1.01 1.49 2.23 1.79 1.20
KLA/ATP 1.87 1.96 1.51 1.93 1.71 1.94 1.72
Hk2
KLA  ATP  ATP+KLA
 NM_013820 hexokinase 2 (Hk2), mRNA [NM_013820] KLA 4.09 4.09 3.17 2.37 1.53 1.62 2.02
ATP .98 .92 1.08 2.24 3.82 3.86 .97
KLA/ATP 4.07 3.94 4.17 3.53 5.42 4.65 1.54
Hk3
KLA  ATP  ATP+KLA
 NM_001033245 hexokinase 3 (Hk3), nuclear gene encoding mitochondrial protein, mRNA [NM_001033245] KLA 1.52 1.68 1.94 1.85 2.21 2.89 1.98
ATP 1.01 1.07 .87 .99 1.01 1.26 2.62
KLA/ATP 1.63 1.74 1.67 1.69 1.44 2.01 3.53
Hkdc1
KLA  ATP  ATP+KLA
 NM_145419 hexokinase domain containing 1 (Hkdc1), mRNA [NM_145419] KLA 1.10 1.08 1.12 1.12 1.02 1.07 1.04
ATP .96 1.04 1.06 4.28 10.50 3.91 1.34
KLA/ATP .98 1.04 1.14 5.33 12.44 8.68 1.77
Mm.23951
KLA  ATP  ATP+KLA
 145864487 Unknown KLA .97 1.03 1.12 .96 1.08 .98 1.33
ATP 1.11 1.26 .84 1.26 .75 .60 1.62
KLA/ATP 1.27 1.25 .70 1.19 .72 .64 1.43
Mpi
KLA  ATP  ATP+KLA
 NM_025837 mannose phosphate isomerase (Mpi), mRNA [NM_025837] KLA 1.54 1.45 1.45 1.54 1.57 1.73 1.47
ATP 1.14 1.14 1.15 1.20 1.21 1.34 1.76
KLA/ATP 1.60 1.57 1.94 1.67 1.51 1.73 2.21
Nagk
KLA  ATP  ATP+KLA
 NM_019542 N-acetylglucosamine kinase (Nagk), mRNA [NM_019542] KLA .68 .76 .70 .68 .76 .78 .67
ATP 1.09 1.03 .79 .89 .40 .25 .82
KLA/ATP .78 .72 .60 .65 .41 .24 .46
Nanp
KLA  ATP  ATP+KLA
 NM_026086 N-acetylneuraminic acid phosphatase (Nanp), mRNA [NM_026086] KLA .56 .58 .56 .59 .66 .93 .79
ATP .92 .82 .70 .42 .61 .53 .68
KLA/ATP .52 .49 .52 .44 .64 .66 .47
Nans
KLA  ATP  ATP+KLA
 NM_053179 N-acetylneuraminic acid synthase (sialic acid synthase) (Nans), mRNA [NM_053179] KLA .67 .67 .63 .55 .48 .54 .67
ATP .95 .97 1.05 1.12 .95 .70 .77
KLA/ATP .67 .67 .69 .70 .77 .59 .46
Npl
KLA  ATP  ATP+KLA
 NM_028749 N-acetylneuraminate pyruvate lyase (Npl), mRNA [NM_028749] KLA .97 1.02 .94 .77 .69 .40 .27
ATP 1.04 1.08 1.15 1.37 1.11 .62 .49
KLA/ATP 1.05 1.05 1.04 1.23 .85 .54 .23
Pgm1
KLA  ATP  ATP+KLA
 NM_025700 phosphoglucomutase 1 (Pgm1), mRNA [NM_025700] KLA 1.08 1.03 .95 .75 .59 .55 .73
ATP 1.02 1.23 1.22 1.42 1.07 .75 1.01
KLA/ATP 1.01 1.10 .84 1.12 .69 .61 .51
Pgm2
KLA  ATP  ATP+KLA
 NM_028132 phosphoglucomutase 2 (Pgm2), mRNA [NM_028132] KLA 1.13 1.21 1.26 1.48 1.52 1.81 1.81
ATP .90 .92 1.07 .99 .80 1.60 1.17
KLA/ATP 1.01 1.16 1.40 1.25 1.48 1.99 1.94
Pgm3
KLA  ATP  ATP+KLA
 NM_028352 phosphoglucomutase 3 (Pgm3), mRNA [NM_028352] KLA 1.01 1.06 .96 .97 .85 .73 .86
ATP 1.01 1.06 1.06 1.00 1.07 .94 .81
KLA/ATP 1.01 1.04 1.08 1.01 .82 .68 .60
Pmm1
KLA  ATP  ATP+KLA
 NM_013872 phosphomannomutase 1 (Pmm1), mRNA [NM_013872] KLA .55 .55 .47 .42 .36 .34 .70
ATP 1.03 1.07 1.03 1.09 .86 .49 .80
KLA/ATP .57 .56 .55 .54 .46 .36 .44
Pmm2
KLA  ATP  ATP+KLA
 NM_016881 phosphomannomutase 2 (Pmm2), mRNA [NM_016881] KLA 1.22 1.31 1.38 1.28 1.64 1.62 1.69
ATP 1.11 1.26 .84 1.15 .84 1.12 1.63
KLA/ATP 1.39 1.48 .86 1.51 .92 1.24 2.24
Renbp
KLA  ATP  ATP+KLA
 NM_023132 renin binding protein (Renbp), mRNA [NM_023132] KLA .71 .84 .77 .68 .76 .83 .84
ATP 1.09 1.21 .79 1.15 1.06 .84 1.33
KLA/ATP .97 .88 .59 1.01 .80 .79 1.16
Tsta3
KLA  ATP  ATP+KLA
 NM_031201 tissue specific transplantation antigen P35B (Tsta3), mRNA [NM_031201] KLA 1.02 1.05 1.08 1.10 1.15 1.34 1.35
ATP .94 1.05 .99 1.14 .93 .96 1.14
KLA/ATP 1.09 1.11 1.02 1.21 1.08 1.13 1.51
Uap1
KLA  ATP  ATP+KLA
 NM_133806 UDP-N-acetylglucosamine pyrophosphorylase 1 (Uap1), mRNA [NM_133806] KLA 1.24 1.12 1.16 .89 .68 .63 .80
ATP 1.23 1.30 1.14 1.56 1.37 .94 .98
KLA/ATP 1.31 1.37 1.08 1.53 .98 .79 .71
Uap1l1
KLA  ATP  ATP+KLA
 BC043307 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1, mRNA (cDNA clone IMAGE:5042946), partial cds [BC043307] KLA .74 .74 .70 .74 .71 .74 .78
ATP .93 .96 1.11 1.38 1.45 1.06 .86
KLA/ATP .76 .72 .71 1.18 1.19 1.01 .65
Uap1l1
KLA  ATP  ATP+KLA
 NM_001033293 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (Uap1l1), mRNA [NM_001033293] KLA .72 .78 .76 .62 .76 .63 .92
ATP 1.17 1.36 .78 1.25 .91 .56 1.59
KLA/ATP .90 .92 .45 .84 .49 .45 .80
Ugdh
KLA  ATP  ATP+KLA
 NM_009466 UDP-glucose dehydrogenase (Ugdh), mRNA [NM_009466] KLA 1.04 1.06 .96 .95 1.09 1.54 1.30
ATP .99 1.06 .89 .91 1.31 3.29 1.49
KLA/ATP 1.04 .98 .73 .85 1.38 2.91 1.59
Ugp2
KLA  ATP  ATP+KLA
 NM_139297 UDP-glucose pyrophosphorylase 2 (Ugp2), mRNA [NM_139297] KLA .94 1.01 .95 .96 .88 1.01 1.02
ATP .97 .98 1.03 .92 .94 1.19 .82
KLA/ATP .93 .94 .85 .78 .82 1.20 .96