Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate (mmu00532)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2010209O
12Rik
KLA  ATP  ATP+KLA
 NM_133913 RIKEN cDNA 2010209O12 gene (2010209O12Rik), mRNA [NM_133913] KLA .68 .70 .69 .66 .96 1.31 1.28
ATP 1.04 1.16 .86 .85 .97 2.50 2.50
KLA/ATP .76 .73 .51 .58 .55 1.46 2.34
4631426J
05Rik
KLA  ATP  ATP+KLA
 NM_029935 RIKEN cDNA 4631426J05 gene (4631426J05Rik), mRNA [NM_029935] KLA 1.77 2.08 2.63 2.06 1.96 1.94 1.82
ATP 1.03 1.05 1.05 1.08 1.22 1.47 1.09
KLA/ATP 1.97 2.19 1.94 1.65 1.63 2.03 1.85
B3galt6
KLA  ATP  ATP+KLA
 NM_080445 UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 (B3galt6), mRNA [NM_080445] KLA .81 .80 .75 .72 .67 .82 1.26
ATP .94 .95 1.24 1.05 .63 .73 1.11
KLA/ATP .74 .76 .84 .75 .67 .61 .61
B3gat3
KLA  ATP  ATP+KLA
 AK079723 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430034G17 product:beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I), full insert sequence [AK079723] KLA 1.21 1.11 .94 .98 1.25 .98 .87
ATP .73 .53 .44 .56 1.39 1.36 .92
KLA/ATP .61 .59 .47 .75 1.73 1.08 .87
B3gat3
KLA  ATP  ATP+KLA
 NM_024256 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) (B3gat3), mRNA [NM_024256] KLA .95 1.03 1.06 .98 1.29 1.33 1.26
ATP 1.10 1.20 .96 1.25 .99 .86 1.13
KLA/ATP 1.13 1.12 .89 1.19 .99 .98 1.40
B4galt7
KLA  ATP  ATP+KLA
 NM_146045 xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) (B4galt7), mRNA [NM_146045] KLA .52 .55 .52 .57 .66 .82 1.05
ATP 1.00 1.02 .75 .66 .70 .83 1.48
KLA/ATP .53 .54 .49 .46 .49 .71 1.05
Chpf
KLA  ATP  ATP+KLA
 NM_001001566 chondroitin polymerizing factor (Chpf), transcript variant 1, mRNA [NM_001001566] KLA 1.22 1.19 1.09 1.18 1.71 2.50 3.34
ATP 1.06 1.08 1.08 .97 1.05 1.69 3.23
KLA/ATP 1.12 1.19 1.20 1.18 1.23 1.54 2.83
Chst11
KLA  ATP  ATP+KLA
 NM_021439 carbohydrate sulfotransferase 11 (Chst11), mRNA [NM_021439] KLA 1.26 1.30 1.19 1.08 1.28 1.35 .63
ATP 1.05 1.23 1.16 1.10 2.16 4.45 2.87
KLA/ATP 1.48 1.47 1.17 1.21 1.51 3.33 3.04
Chst12
KLA  ATP  ATP+KLA
 NM_021528 carbohydrate sulfotransferase 12 (Chst12), mRNA [NM_021528] KLA .30 .28 .31 .45 .65 .78 .81
ATP 1.09 1.12 1.17 1.01 .59 1.01 1.06
KLA/ATP .28 .31 .37 .40 .65 .95 1.20
Chst13
KLA  ATP  ATP+KLA
 XM_978459 gb|PREDICTED: Mus musculus carbohydrate (chondroitin 4) sulfotransferase 13 (Chst13), mRNA [XM_978459] KLA .89 1.03 .99 1.02 .98 .99 .97
ATP .99 1.03 1.00 .99 .98 .89 .97
KLA/ATP .99 1.00 .99 .96 .97 .99 .99
Chst14
KLA  ATP  ATP+KLA
 NM_028117 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (Chst14), mRNA [NM_028117] KLA .76 .85 1.06 1.67 1.83 1.29 1.00
ATP 1.01 1.00 1.00 .98 .65 .43 .98
KLA/ATP .77 .74 .80 .97 .97 .57 .60
Chst3
KLA  ATP  ATP+KLA
 NM_016803 carbohydrate (chondroitin 6/keratan) sulfotransferase 3 (Chst3), mRNA [NM_016803] KLA .65 .61 .57 .62 .60 .62 .59
ATP .96 .89 .92 .86 .99 .73 .71
KLA/ATP .67 .67 .64 .63 .77 .79 .73
Chst7
KLA  ATP  ATP+KLA
 NM_021715 carbohydrate (N-acetylglucosamino) sulfotransferase 7 (Chst7), mRNA [NM_021715] KLA 8.89 9.37 8.80 11.28 7.73 2.38 .72
ATP .92 .89 .97 .86 .97 1.20 .22
KLA/ATP 8.26 8.70 10.47 8.12 5.69 2.99 .34
Chsy1
KLA  ATP  ATP+KLA
 NM_001081163 carbohydrate (chondroitin) synthase 1 (Chsy1), mRNA [NM_001081163] KLA .48 .42 .32 .36 .30 .44 .73
ATP .87 .88 1.09 .66 .54 1.20 .79
KLA/ATP .39 .39 .50 .37 .48 .47 .36
Chsy3
KLA  ATP  ATP+KLA
 AK043732 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830026G02 product:hypothetical protein, full insert sequence. [AK043732] KLA 1.07 1.05 1.07 .97 1.00 1.04 .98
ATP 1.00 .92 .99 1.01 1.04 1.02 1.03
KLA/ATP 1.02 1.04 .95 .97 1.01 1.06 .98
Chsy3
KLA  ATP  ATP+KLA
 NM_001081328 chondroitin sulfate synthase 3 (Chsy3), mRNA [NM_001081328] KLA 1.11 1.07 1.03 1.01 1.01 .99 1.04
ATP 1.01 1.00 1.05 1.00 1.01 .98 1.02
KLA/ATP 1.10 1.07 .97 .98 .99 1.03 .99
Csgalnac
t1
KLA  ATP  ATP+KLA
 NM_172753 chondroitin sulfate N-acetylgalactosaminyltransferase 1 (Csgalnact1), mRNA [NM_172753] KLA 1.01 .98 .84 .94 .95 .94 1.02
ATP .97 1.00 .98 .93 .92 1.00 1.03
KLA/ATP .99 .94 .94 .86 .94 .93 1.04
Csgalnac
t2
KLA  ATP  ATP+KLA
 NM_030165 chondroitin sulfate N-acetylgalactosaminyltransferase 2 (Csgalnact2), mRNA [NM_030165] KLA .41 .41 .39 .42 .41 .65 .65
ATP .94 .95 1.04 .77 1.00 1.01 .98
KLA/ATP .35 .37 .38 .32 .70 1.01 .79
Dse
KLA  ATP  ATP+KLA
 NM_172508 dermatan sulfate epimerase (Dse), mRNA [NM_172508] KLA 4.51 4.22 4.21 3.25 2.18 1.50 1.26
ATP 1.04 1.26 1.07 1.08 .92 .85 .88
KLA/ATP 3.97 4.74 3.69 4.03 1.65 .68 .90
Mm.21358
2
KLA  ATP  ATP+KLA
 158508649 Unknown KLA 2.07 2.16 2.63 2.34 2.23 2.45 2.28
ATP 1.02 1.02 1.10 1.18 1.34 1.70 1.06
KLA/ATP 2.15 2.38 2.05 1.90 1.80 2.30 1.96
Mm.26057
7
KLA  ATP  ATP+KLA
 48525358 Unknown KLA 1.29 1.49 1.41 1.57 2.51 5.49 8.27
ATP .97 .93 1.09 1.12 1.36 2.94 7.70
KLA/ATP 1.32 1.32 1.61 1.48 1.89 2.90 8.20
Mm.46142
7
KLA  ATP  ATP+KLA
 120407063 Unknown KLA .93 .93 .95 .88 .83 .83 .97
ATP 1.03 1.01 1.04 1.24 1.43 1.21 1.82
KLA/ATP .97 1.00 .91 .90 1.02 1.10 1.57
Ust
KLA  ATP  ATP+KLA
 NM_177387 uronyl-2-sulfotransferase (Ust), mRNA [NM_177387] KLA 1.08 1.07 .97 .94 .99 1.33 1.94
ATP 1.01 .94 .99 .95 .93 .93 .92
KLA/ATP 1.07 1.08 1.03 .95 .87 .86 1.04
Xylt1
KLA  ATP  ATP+KLA
 AJ539164 mRNA for xylosyltransferase I (Xylt1 gene) [AJ539164] KLA 1.45 1.45 1.17 1.46 1.28 1.39 1.06
ATP 1.02 1.09 1.29 1.22 1.25 1.39 1.12
KLA/ATP 1.37 1.48 1.52 1.66 1.35 1.52 1.31
Xylt2
KLA  ATP  ATP+KLA
 NM_145828 xylosyltransferase II (Xylt2), mRNA [NM_145828] KLA .81 .84 .84 .92 1.54 2.09 2.23
ATP 1.11 1.13 .82 .75 .48 .65 2.19
KLA/ATP .90 .90 .65 .63 .45 .68 3.07