Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glycosaminoglycan biosynthesis - keratan sulfate (mmu00533)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
B3gnt1
KLA  ATP  ATP+KLA
 NM_175383 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3gnt1), mRNA [NM_175383] KLA .65 .62 .59 .58 .52 .53 .68
ATP .95 .97 1.14 1.07 .70 .60 1.38
KLA/ATP .66 .65 .72 .63 .51 .56 .86
B3gnt2
KLA  ATP  ATP+KLA
 NM_016888 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3gnt2), mRNA [NM_016888] KLA 6.47 6.07 7.88 5.30 4.92 2.72 2.46
ATP 1.22 1.39 1.13 1.57 3.07 2.25 2.06
KLA/ATP 7.06 7.52 5.27 7.28 4.11 2.44 1.98
B3gnt7
KLA  ATP  ATP+KLA
 AK042632 7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730012C22 product:unclassifiable, full insert sequence. [AK042632] KLA .98 .97 .88 .98 .95 .90 .99
ATP 1.00 .96 .98 .95 .96 1.04 .98
KLA/ATP .98 .93 1.00 .91 .91 .96 .93
B3gnt7
KLA  ATP  ATP+KLA
 NM_145222 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3gnt7), mRNA [NM_145222] KLA 1.03 1.06 1.15 .87 .91 .76 .76
ATP 1.05 .98 .85 .86 .81 .78 .76
KLA/ATP 1.18 1.22 .95 .84 .82 .85 .67
B4galt1
KLA  ATP  ATP+KLA
 NM_022305 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), mRNA [NM_022305] KLA .58 .56 .55 .59 .75 1.18 1.17
ATP 1.10 1.15 1.07 1.14 1.05 .71 1.11
KLA/ATP .60 .62 .62 .66 .74 .71 1.10
B4galt2
KLA  ATP  ATP+KLA
 NM_017377 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (B4galt2), mRNA [NM_017377] KLA 1.02 .98 .98 1.02 1.04 1.04 1.00
ATP .98 1.01 1.09 1.64 1.22 .96 .94
KLA/ATP .98 1.03 1.04 1.25 1.10 1.00 1.01
B4galt3
KLA  ATP  ATP+KLA
 BC021830 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3, mRNA (cDNA clone IMAGE:3978260), **** WARNING: chimeric clone ****. [BC021830] KLA .94 .90 .98 1.03 .97 .92 1.01
ATP .89 .82 .99 .87 .86 .91 .94
KLA/ATP .94 .93 .95 .97 .91 .96 .97
B4galt3
KLA  ATP  ATP+KLA
 NM_020579 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 (B4galt3), mRNA [NM_020579] KLA 2.83 2.66 2.21 1.34 .99 1.02 1.09
ATP 1.08 1.11 .77 .64 1.24 1.15 1.12
KLA/ATP 3.28 2.99 2.00 1.55 2.04 2.13 1.47
B4galt4
KLA  ATP  ATP+KLA
 NM_019804 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 (B4galt4), mRNA [NM_019804] KLA .88 .92 .89 .94 .68 .49 .40
ATP .93 .93 1.09 .94 .56 .38 .47
KLA/ATP .91 .86 .98 .94 .78 .45 .30
Chst1
KLA  ATP  ATP+KLA
 NM_023850 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (Chst1), mRNA [NM_023850] KLA 1.23 1.34 1.52 1.51 2.06 1.71 1.57
ATP 1.09 .95 .94 .94 .86 1.01 .64
KLA/ATP 1.27 1.24 1.21 1.23 1.42 1.62 .89
Chst2
KLA  ATP  ATP+KLA
 NM_018763 carbohydrate sulfotransferase 2 (Chst2), mRNA [NM_018763] KLA 1.01 1.02 .98 1.04 1.03 1.03 1.06
ATP .99 .98 1.02 1.04 1.02 1.04 1.02
KLA/ATP 1.03 1.03 .96 .95 1.03 1.04 1.01
Chst4
KLA  ATP  ATP+KLA
 NM_011998 carbohydrate (chondroitin 6/keratan) sulfotransferase 4 (Chst4), mRNA [NM_011998] KLA 1.02 1.04 1.04 1.08 1.11 1.02 1.10
ATP 1.00 1.01 1.06 1.04 1.01 1.01 1.01
KLA/ATP 1.06 1.06 1.02 1.00 1.01 1.05 1.10
Chst5
KLA  ATP  ATP+KLA
 AF176840 intestine N-acetylglucosamine 6-O-sulfotransferase (I-GlcNAc-6-ST) mRNA, complete cds. [AF176840] KLA .97 1.02 1.06 1.02 1.00 .97 1.04
ATP .89 .90 1.02 1.13 .91 1.02 .89
KLA/ATP .97 1.13 1.00 1.03 1.04 .98 .97
Fut8
KLA  ATP  ATP+KLA
 NM_016893 fucosyltransferase 8 (Fut8), mRNA [NM_016893] KLA 1.94 2.07 2.76 2.41 2.70 1.87 1.31
ATP 1.04 1.15 1.04 1.06 .69 .88 1.12
KLA/ATP 1.99 2.22 1.76 2.02 1.28 1.78 1.60
St3gal1
KLA  ATP  ATP+KLA
 NM_009177 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (St3gal1), mRNA [NM_009177] KLA 9.07 8.10 8.07 8.61 6.32 6.17 4.65
ATP .97 .87 1.27 4.14 10.38 21.66 8.10
KLA/ATP 8.21 8.67 10.15 8.82 11.00 12.94 21.26
St3gal2
KLA  ATP  ATP+KLA
 NM_009179 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (St3gal2), mRNA [NM_009179] KLA .70 .72 .72 .65 .58 .53 .65
ATP .96 .96 .88 .76 .61 .60 1.17
KLA/ATP .75 .71 .67 .63 .50 .47 .68
St3gal3
KLA  ATP  ATP+KLA
 NM_009176 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (St3gal3), mRNA [NM_009176] KLA 2.87 3.30 2.81 2.78 2.43 1.70 1.08
ATP 1.01 1.10 .89 1.11 .69 .91 .76
KLA/ATP 3.12 3.19 2.25 2.60 1.52 1.00 .98