Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glycosaminoglycan biosynthesis - heparan sulfate / heparin (mmu00534)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
B3galt6
KLA  ATP  ATP+KLA
 NM_080445 UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 (B3galt6), mRNA [NM_080445] KLA .81 .80 .75 .72 .67 .82 1.26
ATP .94 .95 1.24 1.05 .63 .73 1.11
KLA/ATP .74 .76 .84 .75 .67 .61 .61
B3gat3
KLA  ATP  ATP+KLA
 AK079723 0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430034G17 product:beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I), full insert sequence [AK079723] KLA 1.21 1.11 .94 .98 1.25 .98 .87
ATP .73 .53 .44 .56 1.39 1.36 .92
KLA/ATP .61 .59 .47 .75 1.73 1.08 .87
B3gat3
KLA  ATP  ATP+KLA
 NM_024256 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) (B3gat3), mRNA [NM_024256] KLA .95 1.03 1.06 .98 1.29 1.33 1.26
ATP 1.10 1.20 .96 1.25 .99 .86 1.13
KLA/ATP 1.13 1.12 .89 1.19 .99 .98 1.40
B4galt7
KLA  ATP  ATP+KLA
 NM_146045 xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) (B4galt7), mRNA [NM_146045] KLA .52 .55 .52 .57 .66 .82 1.05
ATP 1.00 1.02 .75 .66 .70 .83 1.48
KLA/ATP .53 .54 .49 .46 .49 .71 1.05
Ext1
KLA  ATP  ATP+KLA
 NM_010162 exostoses (multiple) 1 (Ext1), mRNA [NM_010162] KLA 8.02 9.48 10.78 9.03 6.83 4.24 1.43
ATP 1.00 .94 .88 1.62 4.37 4.32 1.35
KLA/ATP 9.43 9.15 8.69 10.86 8.81 4.92 3.46
Ext2
KLA  ATP  ATP+KLA
 NM_010163 exostoses (multiple) 2 (Ext2), mRNA [NM_010163] KLA .99 .95 .85 .85 .72 .67 .60
ATP 1.07 1.02 1.01 .90 .70 .49 .86
KLA/ATP .99 .91 .88 .85 .58 .50 .64
Extl1
KLA  ATP  ATP+KLA
 NM_019578 exostoses (multiple)-like 1 (Extl1), mRNA [NM_019578] KLA 1.03 1.03 1.03 .99 1.03 .95 .97
ATP 1.03 1.09 1.03 .94 .99 .98 1.02
KLA/ATP .99 1.01 1.01 1.07 .95 .92 .95
Extl2
KLA  ATP  ATP+KLA
 NM_021388 exostoses (multiple)-like 2 (Extl2), mRNA [NM_021388] KLA 1.36 1.48 1.15 1.02 .99 1.10 .79
ATP 1.09 1.00 .81 1.52 1.76 .97 1.13
KLA/ATP 1.63 1.39 1.03 1.04 .96 .73 .78
Extl3
KLA  ATP  ATP+KLA
 NM_018788 exostoses (multiple)-like 3 (Extl3), mRNA [NM_018788] KLA .83 .84 .88 .82 .79 .91 1.10
ATP .98 1.03 .90 .74 .63 .82 1.25
KLA/ATP .87 .87 .81 .70 .67 .73 1.10
Glce
KLA  ATP  ATP+KLA
 NM_033320 glucuronyl C5-epimerase (Glce), mRNA [NM_033320] KLA 1.00 .97 .88 .78 .59 .68 1.00
ATP 1.10 1.02 1.03 .95 2.32 2.94 2.07
KLA/ATP .95 .95 .94 .78 1.49 1.99 1.84
Hs2st1
KLA  ATP  ATP+KLA
 NM_011828 heparan sulfate 2-O-sulfotransferase 1 (Hs2st1), mRNA [NM_011828] KLA .95 .95 .92 .81 .72 .86 .82
ATP .94 .90 .74 .68 .85 1.49 2.10
KLA/ATP .90 .85 .70 .69 .91 1.54 1.37
Hs3st1
KLA  ATP  ATP+KLA
 NM_010474 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 (Hs3st1), mRNA [NM_010474] KLA .63 .67 .71 .76 .69 .78 .86
ATP 1.06 .96 .90 .92 .95 1.17 .87
KLA/ATP .72 .73 .77 .86 .82 1.09 .98
Hs3st2
KLA  ATP  ATP+KLA
 NM_001081327 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (Hs3st2), mRNA [NM_001081327] KLA 1.05 .90 .90 1.05 .99 1.02 .94
ATP .98 .98 1.04 1.05 .97 1.07 1.02
KLA/ATP 1.00 .88 1.00 1.04 1.03 1.03 1.02
Hs3st3a1
KLA  ATP  ATP+KLA
 NM_178870 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 (Hs3st3a1), mRNA [NM_178870] KLA 1.26 1.20 1.28 1.02 1.01 .99 1.02
ATP 1.01 1.00 1.00 .99 .97 1.00 1.00
KLA/ATP 1.26 1.29 1.14 1.05 1.01 .99 .99
Hs3st3b1
KLA  ATP  ATP+KLA
 NM_018805 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 (Hs3st3b1), mRNA [NM_018805] KLA 1.40 1.48 1.35 1.18 1.00 1.02 1.08
ATP .96 .92 1.10 1.08 1.08 1.02 1.09
KLA/ATP 1.51 1.48 1.41 1.12 1.18 1.18 1.08
Hs3st5
KLA  ATP  ATP+KLA
 AK086098 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930005L05 product:unclassifiable, full insert sequence. [AK086098] KLA .99 .98 1.03 1.00 .97 .98 1.02
ATP .92 1.06 .99 .98 .97 .98 .89
KLA/ATP .95 1.01 1.05 .95 .95 .90 1.07
Hs3st5
KLA  ATP  ATP+KLA
 NM_001081208 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 (Hs3st5), mRNA [NM_001081208] KLA .97 .94 .98 1.05 1.03 .97 1.01
ATP .97 .99 .99 1.04 .97 .88 .95
KLA/ATP .99 1.04 1.02 1.06 .97 1.01 1.00
Hs6st1
KLA  ATP  ATP+KLA
 NM_015818 heparan sulfate 6-O-sulfotransferase 1 (Hs6st1), mRNA [NM_015818] KLA .35 .29 .21 .29 .32 .42 .41
ATP .87 .70 .58 .58 .76 .79 .71
KLA/ATP .29 .21 .20 .28 .73 .94 .42
Hs6st2
KLA  ATP  ATP+KLA
 AK031649 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030470D11 product:heparan sulfate 6-O-sulfotransferase 2, full insert sequence. [AK031649] KLA .92 1.01 .91 1.00 .99 1.02 .92
ATP 1.00 .97 .98 .95 .95 1.04 1.03
KLA/ATP 1.05 .99 1.06 .95 .97 1.00 1.05
Hs6st2
KLA  ATP  ATP+KLA
 NM_001077202 heparan sulfate 6-O-sulfotransferase 2 (Hs6st2), transcript variant 1, mRNA [NM_001077202] KLA 1.00 1.02 .99 1.04 1.02 1.02 1.00
ATP 1.02 .98 .99 1.03 1.00 1.03 .95
KLA/ATP .99 1.02 .97 1.04 .99 1.06 1.01
Hs6st3
KLA  ATP  ATP+KLA
 NM_015820 heparan sulfate 6-O-sulfotransferase 3 (Hs6st3), mRNA [NM_015820] KLA 1.27 1.21 1.26 1.29 1.21 1.36 1.06
ATP .93 1.07 1.32 1.39 1.27 1.36 1.07
KLA/ATP 1.10 1.26 1.66 1.56 1.38 1.66 1.34
Mm.30978
KLA  ATP  ATP+KLA
 172072649 Unknown KLA .94 .97 .98 1.02 .98 .97 .96
ATP 1.07 .96 1.09 .95 .99 .92 .96
KLA/ATP .99 1.04 1.03 .98 1.03 1.00 .89
Mm.33244
2
KLA  ATP  ATP+KLA
 124487076 Unknown KLA .99 1.01 1.01 1.08 .98 .99 1.01
ATP 1.03 1.03 .99 1.04 1.06 1.00 .91
KLA/ATP 1.00 1.02 .96 .97 .96 1.05 .84
Mm.44390
8
KLA  ATP  ATP+KLA
 71043952 Unknown KLA .99 1.00 1.01 1.04 1.01 .98 1.06
ATP 1.03 .97 1.00 .94 .95 .98 .95
KLA/ATP .98 .98 .89 1.04 .94 .99 1.00
Mm.44577
7
KLA  ATP  ATP+KLA
 141802434 Unknown KLA 1.43 1.30 1.41 1.41 1.23 1.50 1.14
ATP .91 1.06 1.50 1.60 1.50 1.76 1.19
KLA/ATP 1.28 1.49 1.76 1.71 1.82 2.21 1.76
Mm.46142
7
KLA  ATP  ATP+KLA
 120407063 Unknown KLA .93 .93 .95 .88 .83 .83 .97
ATP 1.03 1.01 1.04 1.24 1.43 1.21 1.82
KLA/ATP .97 1.00 .91 .90 1.02 1.10 1.57
Mm.46566
7
KLA  ATP  ATP+KLA
 170172559 Unknown KLA 1.73 1.65 1.68 1.66 2.22 1.91 1.45
ATP 1.41 1.34 1.11 1.14 1.71 1.54 1.43
KLA/ATP 1.70 1.85 2.08 2.03 2.08 1.84 2.75
Ndst1
KLA  ATP  ATP+KLA
 AK004787 adult male lung cDNA, RIKEN full-length enriched library, clone:1200015G06 product:unclassifiable, full insert sequence. [AK004787] KLA .57 .59 .51 .41 .33 .35 .46
ATP .93 .82 1.09 .86 1.18 1.46 2.12
KLA/ATP .54 .58 .64 .58 1.19 1.35 1.57
Ndst1
KLA  ATP  ATP+KLA
 NM_008306 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (Ndst1), mRNA [NM_008306] KLA 1.04 1.05 1.03 1.00 1.04 .97 .96
ATP 1.07 1.09 .92 .97 .97 1.07 2.76
KLA/ATP 1.07 1.10 .85 .87 1.02 1.17 2.12
Ndst2
KLA  ATP  ATP+KLA
 NM_010811 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (Ndst2), mRNA [NM_010811] KLA 1.59 1.63 1.85 1.98 2.19 1.85 1.33
ATP 1.17 1.08 .72 .63 .85 1.06 1.80
KLA/ATP 1.78 1.61 1.03 1.13 1.68 1.70 1.96
Ndst3
KLA  ATP  ATP+KLA
 NM_031186 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 (Ndst3), mRNA [NM_031186] KLA 1.02 .98 1.02 .98 .96 .97 1.01
ATP .98 1.02 1.04 1.10 1.02 1.03 .89
KLA/ATP 1.09 1.11 .96 1.05 1.06 1.00 .91
Ndst4
KLA  ATP  ATP+KLA
 NM_022565 N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4 (Ndst4), mRNA [NM_022565] KLA .98 .95 .97 1.06 .98 .98 1.02
ATP 1.01 .97 1.02 .97 1.01 1.03 1.01
KLA/ATP .98 1.08 1.02 1.02 1.00 1.01 .95
Xylt1
KLA  ATP  ATP+KLA
 AJ539164 mRNA for xylosyltransferase I (Xylt1 gene) [AJ539164] KLA 1.45 1.45 1.17 1.46 1.28 1.39 1.06
ATP 1.02 1.09 1.29 1.22 1.25 1.39 1.12
KLA/ATP 1.37 1.48 1.52 1.66 1.35 1.52 1.31
Xylt2
KLA  ATP  ATP+KLA
 NM_145828 xylosyltransferase II (Xylt2), mRNA [NM_145828] KLA .81 .84 .84 .92 1.54 2.09 2.23
ATP 1.11 1.13 .82 .75 .48 .65 2.19
KLA/ATP .90 .90 .65 .63 .45 .68 3.07