Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

Search by fold change ratio | Search by KEGG pathway | Search by LIPID MAPS lipid pathway

Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Ether lipid metabolism (mmu00565)

Legend:graph_icon: View data/graphs for replicates
Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Agps
KLA  ATP  ATP+KLA
 NM_172666 alkylglycerone phosphate synthase (Agps), mRNA [NM_172666] KLA .97 1.04 1.08 .98 .98 1.11 1.31
ATP 1.03 1.09 1.21 1.08 .76 .98 1.18
KLA/ATP 1.02 1.09 1.05 .90 .71 .78 1.56
Cept1
KLA  ATP  ATP+KLA
 NM_133869 choline/ethanolaminephosphotransferase 1 (Cept1), mRNA [NM_133869] KLA 3.40 3.07 3.72 5.13 5.83 5.57 2.91
ATP 1.09 1.05 1.09 .81 1.14 2.16 1.37
KLA/ATP 3.35 3.19 4.07 2.89 3.10 3.27 4.09
Chpt1
KLA  ATP  ATP+KLA
 NM_144807 choline phosphotransferase 1 (Chpt1), mRNA [NM_144807] KLA 1.16 1.18 1.24 1.15 1.16 1.10 1.23
ATP 1.01 1.05 1.16 1.09 .99 .97 .98
KLA/ATP 1.20 1.15 1.13 1.18 1.17 1.33 1.25
D5Wsu178
e
KLA  ATP  ATP+KLA
 NM_027652 DNA segment, Chr 5, Wayne State University 178, expressed (D5Wsu178e), mRNA [NM_027652] KLA .78 .80 .72 .75 .69 .70 .96
ATP 1.03 1.09 1.13 1.04 1.22 1.10 .91
KLA/ATP .78 .82 .72 .80 .96 .87 .73
Enpp2
KLA  ATP  ATP+KLA
 NM_015744 ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2), mRNA [NM_015744] KLA 1.04 1.06 1.22 1.37 1.63 1.36 1.34
ATP 1.01 .93 1.01 1.03 1.04 .96 1.11
KLA/ATP 1.10 1.10 1.17 1.12 1.13 1.19 1.47
Enpp6
KLA  ATP  ATP+KLA
 NM_177304 ectonucleotide pyrophosphatase/phosphodiesterase 6 (Enpp6), mRNA [NM_177304] KLA .97 .97 1.04 .94 .97 1.02 1.05
ATP 1.02 .99 .98 .92 .92 .89 1.14
KLA/ATP .96 1.03 .92 .92 .88 .98 1.37
Hrasls3
KLA  ATP  ATP+KLA
 AK052657 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630015C01 product:H-REV 107 PROTEIN homolog [Rattus norvegicus], full insert sequence. [AK052657] KLA 4.07 4.01 2.57 2.26 1.94 1.66 1.10
ATP .93 .92 1.00 .96 .95 .99 1.08
KLA/ATP 3.36 2.63 1.76 1.26 1.41 1.22 1.27
Hrasls3
KLA  ATP  ATP+KLA
 NM_139269 HRAS like suppressor 3 (Hrasls3), mRNA [NM_139269] KLA 11.37 10.85 12.50 16.13 13.98 17.12 6.64
ATP .86 .78 .96 .89 .84 .99 1.03
KLA/ATP 8.90 10.50 15.81 13.10 11.95 11.16 10.19
Lpcat1
KLA  ATP  ATP+KLA
 AK155286 NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630214O14 product:Hypothetical phospholipid and glycerol acyltransferase, full insert sequence [AK155286] KLA .94 .83 1.02 .83 1.42 .92 .90
ATP 1.33 1.28 1.03 .82 1.24 .58 .81
KLA/ATP 1.16 1.13 .83 .60 .71 .53 .50
Lpcat2
KLA  ATP  ATP+KLA
 NM_173014 lysophosphatidylcholine acyltransferase 2 (Lpcat2), mRNA [NM_173014] KLA 1.61 1.75 1.91 2.26 3.20 3.80 3.31
ATP 1.06 1.08 1.21 1.23 1.11 1.94 1.31
KLA/ATP 1.61 1.55 1.72 1.65 1.14 1.27 2.62
Mm.16006
7
KLA  ATP  ATP+KLA
 124487226 Unknown KLA .90 .88 .87 .85 .80 .85 .64
ATP .95 .95 1.00 .94 1.00 .91 .67
KLA/ATP .89 .86 .93 .82 .85 .84 .63
Mm.25025
6
KLA  ATP  ATP+KLA
 168480135 Unknown KLA 1.63 1.36 1.96 2.39 3.43 2.97 1.72
ATP 1.10 1.03 1.12 1.16 1.09 1.09 1.12
KLA/ATP 1.53 1.63 1.74 1.70 1.45 1.62 2.76
Mm.28873
KLA  ATP  ATP+KLA
 110431340 Unknown KLA .79 .72 .69 .71 .44 .32 .37
ATP .89 .88 1.17 .98 1.11 .98 .73
KLA/ATP .67 .72 .87 .74 .75 .53 .30
Mm.33050
7
KLA  ATP  ATP+KLA
 67906182 Unknown KLA .94 .98 .99 1.03 1.05 1.07 .98
ATP .95 1.02 .97 .98 .99 1.05 1.02
KLA/ATP 1.02 1.05 1.01 1.03 .99 .98 .97
Mm.33438
KLA  ATP  ATP+KLA
 46402174 Unknown KLA 1.14 1.18 1.15 .97 .93 .89 .84
ATP 1.02 1.20 2.15 1.34 .98 .89 .86
KLA/ATP 1.23 1.19 .91 1.16 .78 .90 .86
Mm.71913
KLA  ATP  ATP+KLA
 118130231 Unknown KLA .93 1.00 1.06 .97 .95 .98 1.04
ATP 1.00 .98 1.08 1.02 .92 .90 .99
KLA/ATP .99 1.01 1.00 .99 .99 .99 1.01
Pafah1b1
KLA  ATP  ATP+KLA
 AK147229 cDNA, RIKEN full-length enriched library, clone:M421028C14 product:platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit, full insert sequence [AK147229] KLA .96 .98 .98 1.06 1.15 1.11 1.14
ATP 1.37 1.70 1.99 1.78 1.62 1.20 1.11
KLA/ATP 1.44 1.62 1.71 1.45 1.48 1.12 1.21
Pafah1b1
KLA  ATP  ATP+KLA
 NM_013625 platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit (Pafah1b1), mRNA [NM_013625] KLA .91 .87 .93 .99 1.14 1.21 1.00
ATP 1.00 1.18 1.06 .73 .96 .65 .40
KLA/ATP .82 .80 .87 .71 1.10 .90 .41
Pafah1b2
KLA  ATP  ATP+KLA
 NM_008775 platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit (Pafah1b2), mRNA [NM_008775] KLA 1.71 1.86 1.93 1.95 2.18 1.98 1.74
ATP 1.10 1.18 1.04 1.04 1.16 1.73 1.68
KLA/ATP 1.82 1.83 1.66 1.81 1.60 1.70 1.90
Pafah1b3
KLA  ATP  ATP+KLA
 NM_008776 platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit (Pafah1b3), mRNA [NM_008776] KLA .87 .90 .84 .76 .75 .62 .71
ATP 1.05 1.14 1.00 1.24 .98 .69 1.00
KLA/ATP .91 .91 .80 1.02 .83 .64 .83
Pafah2
KLA  ATP  ATP+KLA
 NM_133880 platelet-activating factor acetylhydrolase 2 (Pafah2), mRNA [NM_133880] KLA .66 .65 .67 .62 .59 .62 .81
ATP 1.07 .90 .68 .48 .56 .91 .78
KLA/ATP .75 .59 .52 .39 .44 .46 .50
Pla2g10
KLA  ATP  ATP+KLA
 NM_011987 phospholipase A2, group X (Pla2g10), mRNA [NM_011987] KLA .99 1.11 1.02 .99 1.00 1.01 1.02
ATP 1.02 .97 1.01 1.03 1.00 1.02 1.04
KLA/ATP 1.04 .96 .95 1.04 1.06 1.05 1.01
Pla2g12a
KLA  ATP  ATP+KLA
 NM_023196 phospholipase A2, group XIIA (Pla2g12a), transcript variant 1, mRNA [NM_023196] KLA 1.03 1.06 .97 1.00 .78 .75 .92
ATP .91 .99 1.29 1.30 1.20 1.48 1.71
KLA/ATP .92 .99 1.19 1.16 1.06 1.12 1.36
Pla2g12a
KLA  ATP  ATP+KLA
 NM_183423 phospholipase A2, group XIIA (Pla2g12a), transcript variant 2, mRNA [NM_183423] KLA .90 1.00 .87 .95 .76 .68 .88
ATP .96 .94 1.26 1.24 1.19 1.47 1.88
KLA/ATP .89 .90 1.08 1.07 1.06 1.02 1.59
Pla2g12b
KLA  ATP  ATP+KLA
 NM_023530 phospholipase A2, group XIIB (Pla2g12b), mRNA [NM_023530] KLA .98 .95 1.05 .99 1.03 .99 .94
ATP 1.02 1.04 1.07 1.05 .92 1.04 1.00
KLA/ATP .98 .92 1.10 1.11 1.09 1.03 1.04
Pla2g1b
KLA  ATP  ATP+KLA
 NM_011107 phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.00 1.01 1.01 1.11 1.00 1.28 1.00
ATP .98 1.03 1.09 1.03 1.01 1.02 1.04
KLA/ATP .93 .94 1.01 1.00 .94 1.09 1.07
Pla2g2a
KLA  ATP  ATP+KLA
 NM_001082531 phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), mRNA [NM_001082531] KLA 1.08 .99 1.00 1.06 .98 1.01 .94
ATP 1.07 .98 1.04 1.06 .90 .98 .98
KLA/ATP .98 1.03 1.00 1.04 .94 .97 .96
Pla2g2c
KLA  ATP  ATP+KLA
 NM_008868 phospholipase A2, group IIC (Pla2g2c), mRNA [NM_008868] KLA .98 .99 1.05 .98 1.01 1.00 1.04
ATP 1.08 1.06 1.09 .93 .92 .92 1.00
KLA/ATP 1.03 1.04 1.02 1.04 .98 1.01 1.02
Pla2g2d
KLA  ATP  ATP+KLA
 NM_011109 phospholipase A2, group IID (Pla2g2d), mRNA [NM_011109] KLA 1.02 1.02 .99 .99 1.00 1.01 1.00
ATP .95 1.11 1.10 1.11 .98 .99 1.12
KLA/ATP 1.02 1.00 1.19 1.11 1.00 .96 1.01
Pla2g2e
KLA  ATP  ATP+KLA
 NM_012044 phospholipase A2, group IIE (Pla2g2e), mRNA [NM_012044] KLA .78 .75 .74 .72 .62 .69 1.40
ATP 1.06 1.00 .92 1.04 .83 .76 3.74
KLA/ATP .78 .80 .69 .74 .70 .74 2.24
Pla2g2f
KLA  ATP  ATP+KLA
 NM_012045 phospholipase A2, group IIF (Pla2g2f), mRNA [NM_012045] KLA 1.02 .99 1.03 1.01 1.00 .95 .99
ATP 1.01 1.06 1.11 .97 1.09 1.11 .99
KLA/ATP 1.10 1.05 1.04 .95 1.04 1.01 .96
Pla2g3
KLA  ATP  ATP+KLA
 NM_172791 phospholipase A2, group III (Pla2g3), mRNA [NM_172791] KLA 1.04 1.05 1.02 1.01 1.04 1.11 1.00
ATP .96 .97 1.10 .91 .99 .97 1.08
KLA/ATP 1.03 1.11 1.10 .98 .95 .98 1.07
Pla2g4a
KLA  ATP  ATP+KLA
 NM_008869 phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a), mRNA [NM_008869] KLA 3.93 4.49 4.86 6.40 6.44 3.10 1.68
ATP 1.13 1.36 1.27 1.30 1.02 5.37 1.47
KLA/ATP 3.64 4.45 4.76 7.11 2.96 4.08 2.60
Pla2g4b
KLA  ATP  ATP+KLA
 NM_145378 phospholipase A2, group IVB (cytosolic) (Pla2g4b), mRNA [NM_145378] KLA 1.09 1.18 .95 1.01 .97 .97 .77
ATP 1.05 1.14 1.28 .94 .88 1.18 .70
KLA/ATP 1.23 1.43 1.21 1.02 1.15 1.16 .78
Pla2g4c
KLA  ATP  ATP+KLA
 AK145339 1 cell embryo 1 cell cDNA, RIKEN full-length enriched library, clone:I0C0013F18 product:weakly similar to Cytosolic phospholipase A2 gamma [Homo sapiens], full insert sequence [AK145339] KLA 1.09 1.21 1.33 1.17 1.26 1.30 1.05
ATP .97 1.06 1.00 .98 .98 .98 1.05
KLA/ATP 1.19 1.16 1.18 1.13 1.04 1.02 1.06
Pla2g4c
KLA  ATP  ATP+KLA
 NM_001004762 phospholipase A2, group IVC (cytosolic, calcium-independent) (Pla2g4c), mRNA [NM_001004762] KLA .93 1.00 .94 .93 .94 .94 .96
ATP .98 .96 1.13 .97 .99 .89 .96
KLA/ATP 1.01 1.01 1.07 1.01 .94 1.01 .92
Pla2g4e
KLA  ATP  ATP+KLA
 AK049063 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230096D22 product:hypothetical Lysophospholipase catalytic domain containing protein, full insert sequence. [AK049063] KLA 1.03 1.09 1.01 1.01 1.06 .94 1.05
ATP 1.03 1.00 1.06 1.01 .96 1.05 1.05
KLA/ATP .98 1.00 1.01 .98 1.03 .95 1.01
Pla2g4e
KLA  ATP  ATP+KLA
 NM_177845 phospholipase A2, group IVE (Pla2g4e), mRNA [NM_177845] KLA .97 .95 1.01 .97 1.02 1.03 1.05
ATP .98 .99 1.00 1.10 .98 1.00 1.02
KLA/ATP 1.05 .93 .96 1.03 1.08 1.05 .99
Pla2g4f
KLA  ATP  ATP+KLA
 NM_001024145 phospholipase A2, group IVF (Pla2g4f), mRNA [NM_001024145] KLA 1.08 .99 1.04 1.02 1.04 .98 1.01
ATP .99 1.04 .99 1.03 1.12 1.01 1.25
KLA/ATP .97 1.04 1.10 1.06 1.04 1.03 1.03
Pla2g5
KLA  ATP  ATP+KLA
 NM_011110 phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110] KLA .65 .62 .56 .53 .62 1.60 3.01
ATP .90 .82 .88 1.69 1.82 1.26 6.32
KLA/ATP .63 .59 .65 .63 .91 1.56 5.59
Pla2g6
KLA  ATP  ATP+KLA
 NM_016915 phospholipase A2, group VI (Pla2g6), mRNA [NM_016915] KLA .60 .59 .56 .60 .94 1.31 1.59
ATP 1.10 1.14 .95 1.05 1.06 1.13 1.14
KLA/ATP .63 .56 .54 .56 .71 .97 1.55
Pla2g7
KLA  ATP  ATP+KLA
 NM_013737 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (Pla2g7), mRNA [NM_013737] KLA 1.26 1.32 1.43 1.47 1.87 2.52 4.77
ATP 1.07 1.11 .94 1.24 1.14 3.60 7.17
KLA/ATP 1.38 1.44 1.13 1.63 1.40 4.09 10.65
Plb1
KLA  ATP  ATP+KLA
 AK015993 adult male testis cDNA, RIKEN full-length enriched library, clone:4930539A06 product:weakly similar to PHOSPHOLIPASE B [Rattus norvegicus], full insert sequence. [AK015993] KLA .99 .99 1.05 1.02 1.03 1.07 1.02
ATP 1.04 1.03 1.07 1.06 1.09 1.01 1.02
KLA/ATP 1.07 1.00 .96 1.09 1.05 1.08 1.01
Plb1
KLA  ATP  ATP+KLA
 AK087596 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230021C09 product:hypothetical protein, full insert sequence. [AK087596] KLA .93 .99 .99 1.07 .98 1.00 .98
ATP 1.08 1.00 .97 1.07 1.04 1.09 .96
KLA/ATP 1.06 .96 1.00 .98 1.04 1.06 .98
Plb1
KLA  ATP  ATP+KLA
 NM_001081407 phospholipase B1 (Plb1), mRNA [NM_001081407] KLA 1.05 1.09 1.05 1.04 1.05 1.03 .85
ATP .96 1.03 1.02 .95 1.06 1.01 .92
KLA/ATP 1.00 1.00 1.09 1.00 .97 .99 .86
Pld1
KLA  ATP  ATP+KLA
 NM_008875 phospholipase D1 (Pld1), mRNA [NM_008875] KLA .71 .73 .67 .73 .88 .96 1.25
ATP .99 .88 .73 .68 .45 1.23 1.12
KLA/ATP .70 .67 .58 .59 .48 .91 1.48
Pld2
KLA  ATP  ATP+KLA
 NM_008876 phospholipase D2 (Pld2), mRNA [NM_008876] KLA .51 .54 .48 .51 .73 .79 1.02
ATP 1.06 1.10 .88 1.03 1.04 1.29 1.00
KLA/ATP .63 .52 .40 .57 .65 1.03 1.35
Pld3
KLA  ATP  ATP+KLA
 NM_011116 phospholipase D family, member 3 (Pld3), mRNA [NM_011116] KLA .81 .84 .90 .75 .75 .70 .82
ATP 1.06 1.14 .81 1.15 1.12 .97 1.32
KLA/ATP .94 .92 .73 1.01 .94 1.05 1.20
Pld4
KLA  ATP  ATP+KLA
 NM_178911 phospholipase D family, member 4 (Pld4), mRNA [NM_178911] KLA .66 .73 .82 .67 .90 1.14 1.94
ATP 1.08 1.24 .87 1.26 .86 .50 .75
KLA/ATP .84 .83 .51 .83 .56 .61 1.00
Ppap2a
KLA  ATP  ATP+KLA
 NM_008903 phosphatidic acid phosphatase 2a (Ppap2a), transcript variant 2, mRNA [NM_008903] KLA 2.62 2.86 4.01 5.61 7.84 10.88 16.35
ATP 1.01 1.02 1.09 1.28 1.27 2.38 1.44
KLA/ATP 2.78 2.78 2.99 3.43 2.85 3.59 6.59
Ppap2b
KLA  ATP  ATP+KLA
 NM_080555 phosphatidic acid phosphatase type 2B (Ppap2b), mRNA [NM_080555] KLA 2.73 2.72 2.65 2.39 1.07 1.48 3.26
ATP .99 .97 1.60 2.76 18.64 27.23 9.19
KLA/ATP 2.69 2.80 4.36 4.20 14.33 15.32 17.91
Ppap2c
KLA  ATP  ATP+KLA
 NM_015817 phosphatidic acid phosphatase type 2c (Ppap2c), mRNA [NM_015817] KLA .94 .88 .91 .79 .65 .46 .51
ATP 1.01 1.03 1.00 1.12 1.24 .90 .83
KLA/ATP .95 .93 .87 .95 .79 .63 .43