Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: alpha-Linolenic acid metabolism (mmu00592)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Acaa1a
KLA  ATP  ATP+KLA
 NM_130864 acetyl-Coenzyme A acyltransferase 1A (Acaa1a), mRNA [NM_130864] KLA 1.53 1.60 1.88 2.07 2.41 2.64 1.82
ATP 1.07 .99 .98 1.10 .94 .83 1.58
KLA/ATP 1.64 1.64 1.73 1.75 1.61 1.39 1.85
Acaa1b
KLA  ATP  ATP+KLA
 NM_146230 acetyl-Coenzyme A acyltransferase 1B (Acaa1b), mRNA [NM_146230] KLA 1.52 1.66 1.93 2.04 2.32 2.51 1.83
ATP 1.04 .95 1.06 1.12 1.03 .93 1.59
KLA/ATP 1.76 1.72 1.76 1.95 1.76 1.51 1.86
Acox1
KLA  ATP  ATP+KLA
 NM_015729 acyl-Coenzyme A oxidase 1, palmitoyl (Acox1), mRNA [NM_015729] KLA .79 .81 .78 .68 .66 .69 .82
ATP .97 1.09 .93 .90 .81 .78 1.22
KLA/ATP .81 .82 .69 .68 .59 .70 .88
Acox3
KLA  ATP  ATP+KLA
 NM_030721 acyl-Coenzyme A oxidase 3, pristanoyl (Acox3), mRNA [NM_030721] KLA .56 .56 .63 .55 .50 .48 .68
ATP 1.10 1.00 .85 .76 .87 .44 .73
KLA/ATP .61 .66 .57 .49 .57 .48 .47
Fads2
KLA  ATP  ATP+KLA
 NM_019699 fatty acid desaturase 2 (Fads2), mRNA [NM_019699] KLA .84 .82 .87 .71 .55 .37 .31
ATP 1.04 1.10 1.03 1.27 .98 .58 .49
KLA/ATP .84 .83 .86 .97 .72 .44 .23
Hrasls3
KLA  ATP  ATP+KLA
 AK052657 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630015C01 product:H-REV 107 PROTEIN homolog [Rattus norvegicus], full insert sequence. [AK052657] KLA 4.07 4.01 2.57 2.26 1.94 1.66 1.10
ATP .93 .92 1.00 .96 .95 .99 1.08
KLA/ATP 3.36 2.63 1.76 1.26 1.41 1.22 1.27
Hrasls3
KLA  ATP  ATP+KLA
 NM_139269 HRAS like suppressor 3 (Hrasls3), mRNA [NM_139269] KLA 11.37 10.85 12.50 16.13 13.98 17.12 6.64
ATP .86 .78 .96 .89 .84 .99 1.03
KLA/ATP 8.90 10.50 15.81 13.10 11.95 11.16 10.19
Mm.16006
7
KLA  ATP  ATP+KLA
 124487226 Unknown KLA .90 .88 .87 .85 .80 .85 .64
ATP .95 .95 1.00 .94 1.00 .91 .67
KLA/ATP .89 .86 .93 .82 .85 .84 .63
Mm.29150
3
KLA  ATP  ATP+KLA
 34328333 Unknown KLA .61 .60 .60 .53 .51 .56 .69
ATP 1.05 .96 .93 .75 .81 .44 .78
KLA/ATP .66 .58 .67 .52 .58 .47 .55
Mm.33050
7
KLA  ATP  ATP+KLA
 67906182 Unknown KLA .94 .98 .99 1.03 1.05 1.07 .98
ATP .95 1.02 .97 .98 .99 1.05 1.02
KLA/ATP 1.02 1.05 1.01 1.03 .99 .98 .97
Mm.71913
KLA  ATP  ATP+KLA
 118130231 Unknown KLA .93 1.00 1.06 .97 .95 .98 1.04
ATP 1.00 .98 1.08 1.02 .92 .90 .99
KLA/ATP .99 1.01 1.00 .99 .99 .99 1.01
Pla2g10
KLA  ATP  ATP+KLA
 NM_011987 phospholipase A2, group X (Pla2g10), mRNA [NM_011987] KLA .99 1.11 1.02 .99 1.00 1.01 1.02
ATP 1.02 .97 1.01 1.03 1.00 1.02 1.04
KLA/ATP 1.04 .96 .95 1.04 1.06 1.05 1.01
Pla2g12a
KLA  ATP  ATP+KLA
 NM_023196 phospholipase A2, group XIIA (Pla2g12a), transcript variant 1, mRNA [NM_023196] KLA 1.03 1.06 .97 1.00 .78 .75 .92
ATP .91 .99 1.29 1.30 1.20 1.48 1.71
KLA/ATP .92 .99 1.19 1.16 1.06 1.12 1.36
Pla2g12a
KLA  ATP  ATP+KLA
 NM_183423 phospholipase A2, group XIIA (Pla2g12a), transcript variant 2, mRNA [NM_183423] KLA .90 1.00 .87 .95 .76 .68 .88
ATP .96 .94 1.26 1.24 1.19 1.47 1.88
KLA/ATP .89 .90 1.08 1.07 1.06 1.02 1.59
Pla2g12b
KLA  ATP  ATP+KLA
 NM_023530 phospholipase A2, group XIIB (Pla2g12b), mRNA [NM_023530] KLA .98 .95 1.05 .99 1.03 .99 .94
ATP 1.02 1.04 1.07 1.05 .92 1.04 1.00
KLA/ATP .98 .92 1.10 1.11 1.09 1.03 1.04
Pla2g1b
KLA  ATP  ATP+KLA
 NM_011107 phospholipase A2, group IB, pancreas (Pla2g1b), mRNA [NM_011107] KLA 1.00 1.01 1.01 1.11 1.00 1.28 1.00
ATP .98 1.03 1.09 1.03 1.01 1.02 1.04
KLA/ATP .93 .94 1.01 1.00 .94 1.09 1.07
Pla2g2a
KLA  ATP  ATP+KLA
 NM_001082531 phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), mRNA [NM_001082531] KLA 1.08 .99 1.00 1.06 .98 1.01 .94
ATP 1.07 .98 1.04 1.06 .90 .98 .98
KLA/ATP .98 1.03 1.00 1.04 .94 .97 .96
Pla2g2c
KLA  ATP  ATP+KLA
 NM_008868 phospholipase A2, group IIC (Pla2g2c), mRNA [NM_008868] KLA .98 .99 1.05 .98 1.01 1.00 1.04
ATP 1.08 1.06 1.09 .93 .92 .92 1.00
KLA/ATP 1.03 1.04 1.02 1.04 .98 1.01 1.02
Pla2g2d
KLA  ATP  ATP+KLA
 NM_011109 phospholipase A2, group IID (Pla2g2d), mRNA [NM_011109] KLA 1.02 1.02 .99 .99 1.00 1.01 1.00
ATP .95 1.11 1.10 1.11 .98 .99 1.12
KLA/ATP 1.02 1.00 1.19 1.11 1.00 .96 1.01
Pla2g2e
KLA  ATP  ATP+KLA
 NM_012044 phospholipase A2, group IIE (Pla2g2e), mRNA [NM_012044] KLA .78 .75 .74 .72 .62 .69 1.40
ATP 1.06 1.00 .92 1.04 .83 .76 3.74
KLA/ATP .78 .80 .69 .74 .70 .74 2.24
Pla2g2f
KLA  ATP  ATP+KLA
 NM_012045 phospholipase A2, group IIF (Pla2g2f), mRNA [NM_012045] KLA 1.02 .99 1.03 1.01 1.00 .95 .99
ATP 1.01 1.06 1.11 .97 1.09 1.11 .99
KLA/ATP 1.10 1.05 1.04 .95 1.04 1.01 .96
Pla2g3
KLA  ATP  ATP+KLA
 NM_172791 phospholipase A2, group III (Pla2g3), mRNA [NM_172791] KLA 1.04 1.05 1.02 1.01 1.04 1.11 1.00
ATP .96 .97 1.10 .91 .99 .97 1.08
KLA/ATP 1.03 1.11 1.10 .98 .95 .98 1.07
Pla2g4a
KLA  ATP  ATP+KLA
 NM_008869 phospholipase A2, group IVA (cytosolic, calcium-dependent) (Pla2g4a), mRNA [NM_008869] KLA 3.93 4.49 4.86 6.40 6.44 3.10 1.68
ATP 1.13 1.36 1.27 1.30 1.02 5.37 1.47
KLA/ATP 3.64 4.45 4.76 7.11 2.96 4.08 2.60
Pla2g4b
KLA  ATP  ATP+KLA
 NM_145378 phospholipase A2, group IVB (cytosolic) (Pla2g4b), mRNA [NM_145378] KLA 1.09 1.18 .95 1.01 .97 .97 .77
ATP 1.05 1.14 1.28 .94 .88 1.18 .70
KLA/ATP 1.23 1.43 1.21 1.02 1.15 1.16 .78
Pla2g4c
KLA  ATP  ATP+KLA
 AK145339 1 cell embryo 1 cell cDNA, RIKEN full-length enriched library, clone:I0C0013F18 product:weakly similar to Cytosolic phospholipase A2 gamma [Homo sapiens], full insert sequence [AK145339] KLA 1.09 1.21 1.33 1.17 1.26 1.30 1.05
ATP .97 1.06 1.00 .98 .98 .98 1.05
KLA/ATP 1.19 1.16 1.18 1.13 1.04 1.02 1.06
Pla2g4c
KLA  ATP  ATP+KLA
 NM_001004762 phospholipase A2, group IVC (cytosolic, calcium-independent) (Pla2g4c), mRNA [NM_001004762] KLA .93 1.00 .94 .93 .94 .94 .96
ATP .98 .96 1.13 .97 .99 .89 .96
KLA/ATP 1.01 1.01 1.07 1.01 .94 1.01 .92
Pla2g4e
KLA  ATP  ATP+KLA
 AK049063 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230096D22 product:hypothetical Lysophospholipase catalytic domain containing protein, full insert sequence. [AK049063] KLA 1.03 1.09 1.01 1.01 1.06 .94 1.05
ATP 1.03 1.00 1.06 1.01 .96 1.05 1.05
KLA/ATP .98 1.00 1.01 .98 1.03 .95 1.01
Pla2g4e
KLA  ATP  ATP+KLA
 NM_177845 phospholipase A2, group IVE (Pla2g4e), mRNA [NM_177845] KLA .97 .95 1.01 .97 1.02 1.03 1.05
ATP .98 .99 1.00 1.10 .98 1.00 1.02
KLA/ATP 1.05 .93 .96 1.03 1.08 1.05 .99
Pla2g4f
KLA  ATP  ATP+KLA
 NM_001024145 phospholipase A2, group IVF (Pla2g4f), mRNA [NM_001024145] KLA 1.08 .99 1.04 1.02 1.04 .98 1.01
ATP .99 1.04 .99 1.03 1.12 1.01 1.25
KLA/ATP .97 1.04 1.10 1.06 1.04 1.03 1.03
Pla2g5
KLA  ATP  ATP+KLA
 NM_011110 phospholipase A2, group V (Pla2g5), transcript variant 2, mRNA [NM_011110] KLA .65 .62 .56 .53 .62 1.60 3.01
ATP .90 .82 .88 1.69 1.82 1.26 6.32
KLA/ATP .63 .59 .65 .63 .91 1.56 5.59
Pla2g6
KLA  ATP  ATP+KLA
 NM_016915 phospholipase A2, group VI (Pla2g6), mRNA [NM_016915] KLA .60 .59 .56 .60 .94 1.31 1.59
ATP 1.10 1.14 .95 1.05 1.06 1.13 1.14
KLA/ATP .63 .56 .54 .56 .71 .97 1.55
Plb1
KLA  ATP  ATP+KLA
 AK015993 adult male testis cDNA, RIKEN full-length enriched library, clone:4930539A06 product:weakly similar to PHOSPHOLIPASE B [Rattus norvegicus], full insert sequence. [AK015993] KLA .99 .99 1.05 1.02 1.03 1.07 1.02
ATP 1.04 1.03 1.07 1.06 1.09 1.01 1.02
KLA/ATP 1.07 1.00 .96 1.09 1.05 1.08 1.01
Plb1
KLA  ATP  ATP+KLA
 AK087596 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230021C09 product:hypothetical protein, full insert sequence. [AK087596] KLA .93 .99 .99 1.07 .98 1.00 .98
ATP 1.08 1.00 .97 1.07 1.04 1.09 .96
KLA/ATP 1.06 .96 1.00 .98 1.04 1.06 .98
Plb1
KLA  ATP  ATP+KLA
 NM_001081407 phospholipase B1 (Plb1), mRNA [NM_001081407] KLA 1.05 1.09 1.05 1.04 1.05 1.03 .85
ATP .96 1.03 1.02 .95 1.06 1.01 .92
KLA/ATP 1.00 1.00 1.09 1.00 .97 .99 .86