Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glycosphingolipid biosynthesis - lacto and neolacto series (mmu00601)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Abo
KLA  ATP  ATP+KLA
 NM_030718 ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) (Abo), mRNA [NM_030718] KLA 1.07 .93 .95 1.01 1.00 .97 .92
ATP .96 .95 .98 1.03 1.02 1.00 1.06
KLA/ATP 1.00 .96 1.05 1.07 1.04 .94 .99
B3galt1
KLA  ATP  ATP+KLA
 NM_020283 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 (B3galt1), mRNA [NM_020283] KLA 1.02 1.01 .99 1.00 1.04 .97 1.04
ATP .95 1.03 1.00 .98 .98 1.02 1.00
KLA/ATP .95 .96 1.00 1.02 1.00 1.03 1.01
B3galt2
KLA  ATP  ATP+KLA
 NM_020025 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 (B3galt2), mRNA [NM_020025] KLA 1.03 1.03 1.00 1.02 1.01 1.02 1.06
ATP 1.06 1.04 .99 1.07 1.03 1.04 1.03
KLA/ATP 1.03 .99 1.07 1.04 1.00 1.11 1.03
B3galt5
KLA  ATP  ATP+KLA
 NM_033149 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3galt5), transcript variant 1, mRNA [NM_033149] KLA .78 .84 .81 .88 .86 .90 .80
ATP 1.03 .88 1.08 .91 .87 .73 .83
KLA/ATP .85 .80 .85 .85 .96 .89 .72
B3gnt1
KLA  ATP  ATP+KLA
 NM_175383 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3gnt1), mRNA [NM_175383] KLA .65 .62 .59 .58 .52 .53 .68
ATP .95 .97 1.14 1.07 .70 .60 1.38
KLA/ATP .66 .65 .72 .63 .51 .56 .86
B3gnt2
KLA  ATP  ATP+KLA
 NM_016888 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3gnt2), mRNA [NM_016888] KLA 6.47 6.07 7.88 5.30 4.92 2.72 2.46
ATP 1.22 1.39 1.13 1.57 3.07 2.25 2.06
KLA/ATP 7.06 7.52 5.27 7.28 4.11 2.44 1.98
B3gnt3
KLA  ATP  ATP+KLA
 NM_028189 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (B3gnt3), mRNA [NM_028189] KLA 1.13 1.04 1.04 1.01 .99 .79 .72
ATP 1.09 1.20 1.06 1.35 .93 .72 1.38
KLA/ATP 1.17 1.16 1.11 1.28 .82 .78 1.13
B3gnt4
KLA  ATP  ATP+KLA
 NM_198611 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 (B3gnt4), mRNA [NM_198611] KLA 1.17 1.22 1.16 1.14 1.07 1.04 .99
ATP 1.01 1.04 1.01 .98 .99 1.02 .92
KLA/ATP 1.14 1.20 1.15 1.10 1.12 1.08 1.15
B3gnt5
KLA  ATP  ATP+KLA
 NM_054052 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (B3gnt5), mRNA [NM_054052] KLA 1.10 1.13 1.09 1.05 .95 .97 .94
ATP 1.04 1.03 1.08 1.20 1.53 1.55 1.34
KLA/ATP 1.08 1.17 1.07 1.08 1.18 1.58 2.54
B4galt1
KLA  ATP  ATP+KLA
 NM_022305 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), mRNA [NM_022305] KLA .58 .56 .55 .59 .75 1.18 1.17
ATP 1.10 1.15 1.07 1.14 1.05 .71 1.11
KLA/ATP .60 .62 .62 .66 .74 .71 1.10
B4galt2
KLA  ATP  ATP+KLA
 NM_017377 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (B4galt2), mRNA [NM_017377] KLA 1.02 .98 .98 1.02 1.04 1.04 1.00
ATP .98 1.01 1.09 1.64 1.22 .96 .94
KLA/ATP .98 1.03 1.04 1.25 1.10 1.00 1.01
B4galt3
KLA  ATP  ATP+KLA
 BC021830 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3, mRNA (cDNA clone IMAGE:3978260), **** WARNING: chimeric clone ****. [BC021830] KLA .94 .90 .98 1.03 .97 .92 1.01
ATP .89 .82 .99 .87 .86 .91 .94
KLA/ATP .94 .93 .95 .97 .91 .96 .97
B4galt3
KLA  ATP  ATP+KLA
 NM_020579 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 (B4galt3), mRNA [NM_020579] KLA 2.83 2.66 2.21 1.34 .99 1.02 1.09
ATP 1.08 1.11 .77 .64 1.24 1.15 1.12
KLA/ATP 3.28 2.99 2.00 1.55 2.04 2.13 1.47
B4galt4
KLA  ATP  ATP+KLA
 NM_019804 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 (B4galt4), mRNA [NM_019804] KLA .88 .92 .89 .94 .68 .49 .40
ATP .93 .93 1.09 .94 .56 .38 .47
KLA/ATP .91 .86 .98 .94 .78 .45 .30
Fut1
KLA  ATP  ATP+KLA
 NM_008051 fucosyltransferase 1 (Fut1), mRNA [NM_008051] KLA .94 1.00 .99 1.00 .97 .98 1.00
ATP 1.05 .97 1.00 .99 1.04 1.00 .98
KLA/ATP 1.01 1.02 .99 1.02 1.06 1.04 .99
Fut2
KLA  ATP  ATP+KLA
 NM_018876 fucosyltransferase 2 (Fut2), mRNA [NM_018876] KLA .97 .97 1.01 1.02 .98 1.04 1.01
ATP 1.05 1.00 .97 .99 1.05 1.02 1.07
KLA/ATP 1.00 .99 1.03 1.00 1.03 .99 1.07
Fut4
KLA  ATP  ATP+KLA
 NM_010242 fucosyltransferase 4 (Fut4), mRNA [NM_010242] KLA .90 .81 .83 .74 .60 .54 .76
ATP 1.13 .97 .68 .48 1.03 .99 .60
KLA/ATP .89 .89 .65 .50 .67 .78 .43
Fut7
KLA  ATP  ATP+KLA
 NM_013524 fucosyltransferase 7 (Fut7), mRNA [NM_013524] KLA .32 .32 .32 .49 .61 .56 .53
ATP .95 .77 .83 .56 .29 .40 .60
KLA/ATP .28 .28 .35 .29 .29 .26 .40
Fut9
KLA  ATP  ATP+KLA
 NM_010243 fucosyltransferase 9 (Fut9), mRNA [NM_010243] KLA .99 .99 1.02 1.02 1.02 1.02 .98
ATP .99 1.01 .99 .98 1.01 .99 1.04
KLA/ATP 1.00 .97 1.06 1.00 .96 1.01 .96
Gcnt2
KLA  ATP  ATP+KLA
 NM_133219 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (Gcnt2), transcript variant 3, mRNA [NM_133219] KLA 2.85 3.32 3.45 3.25 3.04 2.61 1.40
ATP 1.04 1.11 1.09 1.14 1.36 2.40 1.76
KLA/ATP 3.01 3.24 2.59 2.73 2.30 2.47 2.34
Ggta1
KLA  ATP  ATP+KLA
 NM_010283 glycoprotein galactosyltransferase alpha 1, 3 (Ggta1), mRNA [NM_010283] KLA 1.37 1.56 2.12 2.55 2.95 2.13 1.24
ATP 1.02 .96 .62 .42 1.18 3.47 6.33
KLA/ATP 1.53 1.44 .97 .86 1.72 1.82 4.69
Sec1
KLA  ATP  ATP+KLA
 NM_019934 secretory blood group 1 (Sec1), mRNA [NM_019934] KLA 1.01 1.02 .90 1.00 1.02 1.02 1.05
ATP .99 1.00 .98 1.04 1.00 1.02 1.03
KLA/ATP 1.02 1.04 1.01 .97 .97 1.01 1.13
St3gal3
KLA  ATP  ATP+KLA
 NM_009176 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (St3gal3), mRNA [NM_009176] KLA 2.87 3.30 2.81 2.78 2.43 1.70 1.08
ATP 1.01 1.10 .89 1.11 .69 .91 .76
KLA/ATP 3.12 3.19 2.25 2.60 1.52 1.00 .98
St3gal4
KLA  ATP  ATP+KLA
 NM_009178 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (St3gal4), mRNA [NM_009178] KLA 1.75 1.88 2.01 2.31 2.72 1.78 .99
ATP .93 .96 1.01 1.14 .93 .92 .70
KLA/ATP 1.61 1.68 1.65 1.72 1.29 1.01 .95
St3gal6
KLA  ATP  ATP+KLA
 NM_018784 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 (St3gal6), mRNA [NM_018784] KLA .95 .89 1.03 1.00 1.09 1.11 .75
ATP .96 .95 1.35 1.11 .88 .47 .44
KLA/ATP .88 .92 1.18 1.06 .98 .87 .71
St8sia1
KLA  ATP  ATP+KLA
 NM_011374 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (St8sia1), mRNA [NM_011374] KLA .96 .94 .94 .99 .94 .93 .91
ATP 1.04 .99 1.05 1.02 .95 .93 .86
KLA/ATP .93 .90 .98 .95 .94 .90 .87