Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glycosphingolipid biosynthesis - ganglio series (mmu00604)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
AK085642
KLA  ATP  ATP+KLA
 AK085642 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630050A03 product:unclassifiable, full insert sequence [AK085642] KLA 1.09 1.00 .97 1.00 1.05 1.05 1.04
ATP 1.01 .95 .99 1.01 1.03 1.03 .98
KLA/ATP .98 1.03 .99 1.02 1.08 1.03 1.02
AK209324
KLA  ATP  ATP+KLA
 AK209324 cDNA, clone:Y2G0114L23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000060207, based on BLAT search. [AK209324] KLA .48 .51 .55 .57 .80 .90 1.17
ATP 1.01 .96 .73 .60 .76 .78 1.24
KLA/ATP .54 .46 .42 .54 .76 .76 .73
B3galt4
KLA  ATP  ATP+KLA
 NM_019420 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 (B3galt4), mRNA [NM_019420] KLA .77 .78 .99 1.07 1.51 1.56 1.56
ATP 1.08 1.12 .94 .81 .46 1.04 1.44
KLA/ATP .90 .88 .74 .85 .64 .97 1.21
B4galnt1
KLA  ATP  ATP+KLA
 BC022180 beta-1,4-N-acetyl-galactosaminyl transferase 1, mRNA (cDNA clone IMAGE:4006866), complete cds. [BC022180] KLA .96 .90 .91 .98 .85 .63 .76
ATP 1.00 .91 1.19 1.19 1.01 .78 1.38
KLA/ATP .95 .90 1.11 1.03 .90 .76 .90
B4galnt1
KLA  ATP  ATP+KLA
 NM_008080 beta-1,4-N-acetyl-galactosaminyl transferase 1 (B4galnt1), mRNA [NM_008080] KLA .72 .81 .80 .67 .64 .51 .63
ATP 1.01 1.16 .85 1.04 .67 .50 .82
KLA/ATP .87 .87 .52 .81 .49 .41 .57
Glb1
KLA  ATP  ATP+KLA
 NM_009752 galactosidase, beta 1 (Glb1), mRNA [NM_009752] KLA .93 .96 1.02 .85 .86 .81 .80
ATP 1.03 1.10 1.01 1.13 .97 .82 .75
KLA/ATP 1.08 1.04 .86 1.06 .81 .81 .66
Hexa
KLA  ATP  ATP+KLA
 NM_010421 hexosaminidase A (Hexa), mRNA [NM_010421] KLA .74 .76 .70 .63 .57 .52 .51
ATP .98 1.04 .82 .81 .68 .52 .64
KLA/ATP .76 .78 .63 .60 .48 .37 .31
Hexb
KLA  ATP  ATP+KLA
 NM_010422 hexosaminidase B (Hexb), mRNA [NM_010422] KLA .82 .90 .81 .70 .64 .64 .71
ATP .95 1.03 1.11 .83 .72 .58 .63
KLA/ATP .80 .83 .77 .68 .53 .45 .50
Slc33a1
KLA  ATP  ATP+KLA
 NM_015728 solute carrier family 33 (acetyl-CoA transporter), member 1 (Slc33a1), mRNA [NM_015728] KLA 1.19 1.11 1.28 1.14 1.15 .93 .98
ATP 1.09 1.08 .68 .65 .44 .55 .82
KLA/ATP 1.15 1.11 .74 .74 .50 .52 .63
St3gal1
KLA  ATP  ATP+KLA
 NM_009177 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (St3gal1), mRNA [NM_009177] KLA 9.07 8.10 8.07 8.61 6.32 6.17 4.65
ATP .97 .87 1.27 4.14 10.38 21.66 8.10
KLA/ATP 8.21 8.67 10.15 8.82 11.00 12.94 21.26
St3gal2
KLA  ATP  ATP+KLA
 NM_009179 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (St3gal2), mRNA [NM_009179] KLA .70 .72 .72 .65 .58 .53 .65
ATP .96 .96 .88 .76 .61 .60 1.17
KLA/ATP .75 .71 .67 .63 .50 .47 .68
St3gal5
KLA  ATP  ATP+KLA
 NM_011375 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (St3gal5), transcript variant 2, mRNA [NM_011375] KLA 1.10 1.09 1.17 1.35 1.33 1.52 1.63
ATP .91 .91 1.00 .84 .59 .29 .98
KLA/ATP .97 1.08 1.24 .95 .88 .56 1.54
St6galna
c3
KLA  ATP  ATP+KLA
 NM_011372 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (St6galnac3), mRNA [NM_011372] KLA .99 .99 .97 1.00 1.02 1.02 .97
ATP 1.03 .94 1.01 1.00 .97 1.09 1.03
KLA/ATP .96 .90 .98 1.01 1.00 1.01 .99
St6galna
c4
KLA  ATP  ATP+KLA
 NM_011373 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 (St6galnac4), mRNA [NM_011373] KLA 1.26 1.24 1.31 1.41 1.55 1.34 .98
ATP 1.04 1.02 1.00 1.57 4.04 2.62 1.71
KLA/ATP 1.41 1.29 1.17 1.68 3.23 3.18 1.50
St6galna
c5
KLA  ATP  ATP+KLA
 NM_012028 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (St6galnac5), mRNA [NM_012028] KLA 1.03 1.06 1.04 1.01 1.01 .99 1.03
ATP .99 .98 1.04 1.05 1.04 1.05 .98
KLA/ATP .98 .96 1.05 1.04 1.05 1.05 1.02
St6galna
c6
KLA  ATP  ATP+KLA
 AK035447 adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530049M17 product:sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F, full insert sequen KLA 1.01 1.04 .90 .95 .98 .92 1.00
ATP .94 .92 .91 1.41 1.24 1.11 1.26
KLA/ATP .91 .95 .99 1.34 1.20 .98 1.19
St6galna
c6
KLA  ATP  ATP+KLA
 NM_016973 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (St6galnac6), transcript variant 1, mRNA [NM_016973] KLA .71 .71 .70 .64 .64 .65 .68
ATP .98 1.01 .88 1.12 1.17 1.09 1.08
KLA/ATP .71 .71 .71 1.05 1.38 .90 1.03
St8sia1
KLA  ATP  ATP+KLA
 NM_011374 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (St8sia1), mRNA [NM_011374] KLA .96 .94 .94 .99 .94 .93 .91
ATP 1.04 .99 1.05 1.02 .95 .93 .86
KLA/ATP .93 .90 .98 .95 .94 .90 .87
St8sia5
KLA  ATP  ATP+KLA
 NM_153124 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (St8sia5), transcript variant 2, mRNA [NM_153124] KLA 1.25 1.32 1.17 1.33 1.11 1.31 1.81
ATP 1.00 .94 1.28 1.48 2.83 2.97 1.73
KLA/ATP 1.27 1.24 1.49 1.47 2.95 3.30 2.99
St8sia5
KLA  ATP  ATP+KLA
 X98014 gb|M.musculus mRNA for alpha-2,8-sialyltransferase. [X98014] KLA .97 1.08 1.01 .97 1.07 1.06 1.19
ATP 1.00 1.05 1.01 1.04 1.64 1.66 1.25
KLA/ATP .96 .92 1.04 1.10 1.37 1.73 1.60