Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Pyruvate metabolism (mmu00620)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
2310005E
10Rik
KLA  ATP  ATP+KLA
 BC026843 RIKEN cDNA 2310005E10 gene, mRNA (cDNA clone IMAGE:4487182), complete cds. [BC026843] KLA .70 .65 .65 .65 .83 .90 .89
ATP 1.00 .95 .75 .31 .29 .58 .80
KLA/ATP .69 .54 .49 .28 .36 .56 .53
2310005E
10Rik
KLA  ATP  ATP+KLA
 NM_172398 RIKEN cDNA 2310005E10 gene (2310005E10Rik), mRNA [NM_172398] KLA .78 .71 .71 .71 .69 .90 .82
ATP 1.01 .95 1.18 .89 .68 .44 .62
KLA/ATP .71 .70 .88 .67 .60 .59 .63
Acaca
KLA  ATP  ATP+KLA
 NM_133360 acetyl-Coenzyme A carboxylase alpha (Acaca), mRNA [NM_133360] KLA .99 .94 .95 .93 .95 1.00 1.00
ATP .98 .97 .96 .93 .92 .96 .99
KLA/ATP 1.01 .96 .99 .92 .93 .94 .91
Acacb
KLA  ATP  ATP+KLA
 NM_133904 acetyl-Coenzyme A carboxylase beta (Acacb), mRNA [NM_133904] KLA 1.01 .93 1.00 .99 .95 1.03 .92
ATP .96 1.04 1.05 .98 1.04 1.11 1.05
KLA/ATP .90 1.01 1.05 1.03 .97 .96 1.08
Acat1
KLA  ATP  ATP+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
ATP .89 .88 1.21 .99 .67 .36 .47
KLA/ATP .86 .97 1.18 .90 .64 .42 .35
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Acot12
KLA  ATP  ATP+KLA
 NM_028790 acyl-CoA thioesterase 12 (Acot12), mRNA [NM_028790] KLA 1.02 1.00 1.26 .97 1.01 1.05 1.05
ATP 1.03 1.04 1.03 1.09 1.04 1.06 1.01
KLA/ATP 1.01 .97 1.02 1.13 1.08 1.01 1.01
Acss1
KLA  ATP  ATP+KLA
 NM_080575 acyl-CoA synthetase short-chain family member 1 (Acss1), nuclear gene encoding mitochondrial protein, mRNA [NM_080575] KLA .45 .41 .45 .62 .70 1.05 .43
ATP .95 .89 1.35 .86 .81 .57 .55
KLA/ATP .38 .37 .61 .51 1.13 1.17 .38
Acss2
KLA  ATP  ATP+KLA
 AK003738 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110017C11 product:acetyl-Coenzyme A synthetase 1 (AMP forming), full insert sequence. [AK003738] KLA 1.03 .94 1.02 .97 .93 1.01 1.16
ATP 1.05 .97 .98 1.03 .95 1.31 1.40
KLA/ATP .88 1.02 1.01 .93 .93 1.02 1.12
Acss2
KLA  ATP  ATP+KLA
 NM_019811 acyl-CoA synthetase short-chain family member 2 (Acss2), mRNA [NM_019811] KLA 1.19 1.23 1.40 1.49 1.68 1.67 1.82
ATP 1.10 1.19 1.13 1.16 1.06 3.14 2.63
KLA/ATP 1.27 1.35 1.37 1.42 1.47 3.47 2.86
Acyp1
KLA  ATP  ATP+KLA
 NM_025421 acylphosphatase 1, erythrocyte (common) type (Acyp1), mRNA [NM_025421] KLA .81 .79 .78 .79 .65 .61 .69
ATP .91 .87 1.45 1.34 1.19 .60 .74
KLA/ATP .77 .88 1.30 1.16 1.05 .53 .67
Acyp2
KLA  ATP  ATP+KLA
 NM_029344 acylphosphatase 2, muscle type (Acyp2), mRNA [NM_029344] KLA 1.64 1.48 1.74 1.82 1.61 1.81 1.76
ATP .88 .97 1.21 1.19 .93 1.14 1.46
KLA/ATP 1.30 1.44 1.41 1.59 1.52 1.28 1.56
AK033595
KLA  ATP  ATP+KLA
 AK033595 adult male cecum cDNA, RIKEN full-length enriched library, clone:9130022D06 product:unclassifiable, full insert sequence [AK033595] KLA .70 .76 .71 .63 .63 .64 .78
ATP .98 1.07 .80 .72 .93 .69 .59
KLA/ATP .72 .70 .63 .67 .94 .81 .57
Akr1b3
KLA  ATP  ATP+KLA
 AK054167 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230024H01 product:unclassifiable, full insert sequence [AK054167] KLA 1.06 .92 .98 1.01 1.02 1.04 .96
ATP 1.08 1.02 .99 .97 1.09 1.02 .99
KLA/ATP .99 1.01 .97 .99 1.02 .99 1.08
Akr1b3
KLA  ATP  ATP+KLA
 NM_009658 aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3), mRNA [NM_009658] KLA .97 .99 .96 .91 .92 .93 .77
ATP 1.08 1.13 1.09 1.15 1.00 1.03 1.18
KLA/ATP 1.06 .98 .95 1.15 .89 .88 .82
Akr1b7
KLA  ATP  ATP+KLA
 NM_009731 aldo-keto reductase family 1, member B7 (Akr1b7), mRNA [NM_009731] KLA .92 .93 .93 .93 .97 .96 .84
ATP .97 1.01 .93 .88 .85 .95 .88
KLA/ATP .86 .92 .92 .82 .85 .94 1.02
Akr1b8
KLA  ATP  ATP+KLA
 NM_008012 aldo-keto reductase family 1, member B8 (Akr1b8), mRNA [NM_008012] KLA .64 .56 .49 .46 .31 .25 .25
ATP .95 .97 1.17 .90 .85 2.25 2.02
KLA/ATP .55 .53 .63 .47 .50 1.00 2.18
Aldh1b1
KLA  ATP  ATP+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA 7.51 7.83 9.27 11.57 11.10 10.78 4.79
ATP .93 .91 .90 .89 .73 2.27 2.30
KLA/ATP 6.45 7.40 9.33 9.54 8.82 12.15 10.67
Aldh2
KLA  ATP  ATP+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA .62 .65 .59 .60 .63 .64 .49
ATP 1.01 .91 1.06 .93 1.18 .93 .41
KLA/ATP .70 .68 .70 .84 1.16 .96 .45
Aldh2
KLA  ATP  ATP+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA .74 .81 .77 .65 .60 .53 .50
ATP .98 1.10 .90 1.17 1.04 .82 .60
KLA/ATP .84 .86 .77 .82 .72 .66 .51
Aldh3a2
KLA  ATP  ATP+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA .86 .83 .79 .79 .80 .97 1.00
ATP .93 .98 .94 .89 .77 .87 1.02
KLA/ATP .78 .81 .67 .72 .65 .81 .97
Aldh7a1
KLA  ATP  ATP+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA .98 1.03 1.08 1.12 1.08 .94 .99
ATP 1.01 1.03 1.00 1.03 .98 .82 .91
KLA/ATP 1.15 1.12 1.01 1.02 .90 .89 .83
Aldh9a1
KLA  ATP  ATP+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA .64 .64 .67 .48 .42 .24 .33
ATP 1.07 1.02 .75 .94 .68 .46 .42
KLA/ATP .72 .65 .43 .55 .37 .31 .24
Dlat
KLA  ATP  ATP+KLA
 NM_145614 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), mRNA [NM_145614] KLA 1.00 1.05 1.03 .95 .87 .83 1.15
ATP .94 1.01 1.22 1.09 .80 .57 .91
KLA/ATP .96 1.01 1.05 .98 .70 .48 .54
Dld
KLA  ATP  ATP+KLA
 NM_007861 dihydrolipoamide dehydrogenase (Dld), mRNA [NM_007861] KLA 1.60 1.66 1.84 1.66 1.47 1.16 1.17
ATP 1.05 1.08 1.21 1.06 1.15 1.24 .93
KLA/ATP 1.52 1.63 1.65 1.42 1.17 1.05 .79
Dld
KLA  ATP  ATP+KLA
 U73445 dihydrolipoamide dehydrogenase (Dld) mRNA, complete cds. [U73445] KLA 1.48 1.43 1.43 1.47 1.25 1.05 1.16
ATP .94 .93 1.18 .86 1.02 1.46 .97
KLA/ATP 1.39 1.37 1.50 1.10 1.11 1.14 .85
Glo1
KLA  ATP  ATP+KLA
 NM_025374 glyoxalase 1 (Glo1), transcript variant 1, mRNA [NM_025374] KLA .94 .95 .91 .85 .76 .66 .70
ATP .97 1.02 1.18 1.24 .98 .78 .89
KLA/ATP .92 1.01 1.09 1.07 .89 .64 .59
Grhpr
KLA  ATP  ATP+KLA
 NM_080289 glyoxylate reductase/hydroxypyruvate reductase (Grhpr), mRNA [NM_080289] KLA .82 .79 .68 .60 .42 .28 .56
ATP .93 .99 1.24 1.33 .91 .54 .71
KLA/ATP .74 .78 .84 .86 .61 .31 .39
Hagh
KLA  ATP  ATP+KLA
 NM_024284 hydroxyacyl glutathione hydrolase (Hagh), mRNA [NM_024284] KLA .76 .69 .59 .64 .53 .63 .82
ATP .84 .83 1.26 1.16 1.07 .79 .93
KLA/ATP .68 .73 .95 .85 .92 .72 .47
Haghl
KLA  ATP  ATP+KLA
 NM_026897 hydroxyacylglutathione hydrolase-like (Haghl), mRNA [NM_026897] KLA .50 .47 .41 .41 .38 .49 1.07
ATP .86 .81 .80 .85 .59 .41 1.17
KLA/ATP .46 .47 .40 .44 .37 .36 .68
Ldha
KLA  ATP  ATP+KLA
 NM_010699 lactate dehydrogenase A (Ldha), mRNA [NM_010699] KLA .89 .80 .84 .93 .96 1.04 1.23
ATP 1.05 1.04 .96 .87 1.21 1.43 1.11
KLA/ATP .93 .87 .87 .93 1.24 1.53 .96
Ldhal6b
KLA  ATP  ATP+KLA
 NM_175349 lactate dehydrogenase A-like 6B (Ldhal6b), mRNA [NM_175349] KLA .89 .90 .94 .92 1.04 1.11 1.20
ATP .99 .91 .90 .88 .90 .88 1.17
KLA/ATP .93 .97 .87 .89 .91 1.00 1.20
Ldhb
KLA  ATP  ATP+KLA
 NM_008492 lactate dehydrogenase B (Ldhb), mRNA [NM_008492] KLA 1.00 .97 .96 1.00 .78 .63 .39
ATP .84 .89 1.11 1.24 1.01 .67 .47
KLA/ATP .94 1.03 1.35 1.92 1.40 .85 .47
Ldhc
KLA  ATP  ATP+KLA
 NM_013580 lactate dehydrogenase C (Ldhc), mRNA [NM_013580] KLA .98 1.02 1.04 1.02 .97 .95 .99
ATP 1.02 1.00 .97 .96 1.00 1.00 .95
KLA/ATP .96 1.10 1.07 .95 1.03 1.06 1.03
Ldhd
KLA  ATP  ATP+KLA
 NM_027570 lactate dehydrogenase D (Ldhd), nuclear gene encoding mitochondrial protein, mRNA [NM_027570] KLA 1.03 .96 1.01 .94 .93 .87 .94
ATP 1.01 1.04 .99 .95 .92 .90 1.02
KLA/ATP 1.04 1.01 .96 .95 .91 .79 .92
Mdh1
KLA  ATP  ATP+KLA
 AK077724 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730556L21 product:unclassifiable, full insert sequence [AK077724] KLA .85 .75 .69 .67 .72 .81 .82
ATP .93 .83 .61 .59 .72 .72 .88
KLA/ATP .79 .76 .67 .58 .74 .74 .80
Mdh1
KLA  ATP  ATP+KLA
 NM_008618 malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618] KLA .79 .72 .66 .66 .52 .49 .57
ATP .98 1.00 1.17 1.09 .96 .70 .66
KLA/ATP .70 .73 .92 .78 .76 .65 .52
Mdh2
KLA  ATP  ATP+KLA
 NM_008617 malate dehydrogenase 2, NAD (mitochondrial) (Mdh2), nuclear gene encoding mitochondrial protein, mRNA [NM_008617] KLA .90 .91 .81 .86 .81 .91 1.26
ATP .96 .86 1.04 .80 1.01 1.36 1.33
KLA/ATP .87 .79 1.04 .71 .95 1.04 .95
Me1
KLA  ATP  ATP+KLA
 NM_008615 malic enzyme 1, NADP(+)-dependent, cytosolic (Me1), mRNA [NM_008615] KLA .95 1.01 1.01 .81 .71 .71 1.97
ATP .94 1.03 1.19 1.09 .93 1.48 .67
KLA/ATP .98 .96 1.04 .89 .65 .87 1.05
Me2
KLA  ATP  ATP+KLA
 NM_145494 malic enzyme 2, NAD(+)-dependent, mitochondrial (Me2), nuclear gene encoding mitochondrial protein, mRNA [NM_145494] KLA .86 .82 .80 .75 .64 .55 .85
ATP 1.03 1.03 .80 .85 .96 .89 .73
KLA/ATP .85 .80 .60 .57 .79 1.03 .53
Me3
KLA  ATP  ATP+KLA
 AK036221 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630046K15 product:unclassifiable, full insert sequence. [AK036221] KLA 1.04 .98 .99 1.02 1.01 .99 .96
ATP 1.02 1.02 1.01 .98 1.00 .95 1.04
KLA/ATP .98 .99 1.00 1.01 .99 .99 1.00
Me3
KLA  ATP  ATP+KLA
 NM_181407 malic enzyme 3, NADP(+)-dependent, mitochondrial (Me3), nuclear gene encoding mitochondrial protein, mRNA [NM_181407] KLA .97 1.00 .99 .96 .94 .99 .99
ATP 1.01 1.03 .98 .98 .96 .95 1.03
KLA/ATP .98 1.01 .98 .96 1.00 .98 .97
Mm.1845
KLA  ATP  ATP+KLA
 142351600 Unknown KLA .93 .92 .89 .81 .76 .84 .65
ATP 1.01 .94 1.08 1.00 .77 1.95 1.13
KLA/ATP .91 .84 .85 .81 .59 .66 .77
Mm.29323
3
KLA  ATP  ATP+KLA
 118130035 Unknown KLA .98 1.04 .98 1.05 1.07 .97 .95
ATP 1.02 1.04 1.01 1.02 1.00 1.00 1.00
KLA/ATP 1.03 1.00 .98 .96 1.10 1.03 .98
Mm.37812
8
KLA  ATP  ATP+KLA
 162139826 Unknown KLA .94 .92 .89 .82 .67 .71 1.85
ATP .88 .91 1.28 .99 .92 1.81 .61
KLA/ATP .85 .89 1.10 .81 .72 .96 1.14
Pck2
KLA  ATP  ATP+KLA
 NM_028994 phosphoenolpyruvate carboxykinase 2 (mitochondrial) (Pck2), nuclear gene encoding mitochondrial protein, mRNA [NM_028994] KLA .40 .37 .32 .28 .37 .56 .55
ATP .99 .96 .86 .94 1.02 .57 .77
KLA/ATP .40 .37 .31 .35 .42 .35 .46
Pcx
KLA  ATP  ATP+KLA
 NM_008797 pyruvate carboxylase (Pcx), nuclear gene encoding mitochondrial protein, mRNA [NM_008797] KLA 1.28 1.34 1.44 1.30 1.34 1.23 .91
ATP 1.11 1.09 1.19 1.29 1.19 1.49 1.16
KLA/ATP 1.34 1.41 1.63 1.53 1.39 1.05 1.15
Pdha1
KLA  ATP  ATP+KLA
 NM_008810 pyruvate dehydrogenase E1 alpha 1 (Pdha1), nuclear gene encoding mitochondrial protein, mRNA [NM_008810] KLA .92 .96 .94 .92 .94 1.04 1.18
ATP .98 1.03 1.14 1.10 1.02 1.05 .91
KLA/ATP .93 .93 .97 .94 .81 .82 .69
Pdha2
KLA  ATP  ATP+KLA
 NM_008811 pyruvate dehydrogenase E1 alpha 2 (Pdha2), mRNA [NM_008811] KLA 1.04 .95 .98 .99 1.00 1.04 .98
ATP 1.00 .97 .95 1.00 1.01 .99 1.01
KLA/ATP 1.05 1.07 .91 1.02 .98 1.00 1.05
Pdhb
KLA  ATP  ATP+KLA
 NM_024221 pyruvate dehydrogenase (lipoamide) beta (Pdhb), mRNA [NM_024221] KLA 1.14 1.05 1.00 .97 1.03 .90 .88
ATP 1.08 1.10 1.12 1.23 1.24 1.24 1.21
KLA/ATP 1.01 1.16 1.13 1.21 1.23 1.44 1.26
Pdhx
KLA  ATP  ATP+KLA
 NM_175094 pyruvate dehydrogenase complex, component X (Pdhx), nuclear gene encoding mitochondrial protein, mRNA [NM_175094] KLA 1.15 1.12 1.12 1.12 1.07 1.14 1.12
ATP 1.04 1.02 1.14 .94 1.03 1.30 .98
KLA/ATP 1.25 1.20 1.26 1.05 1.08 1.38 .89
Pklr
KLA  ATP  ATP+KLA
 NM_013631 pyruvate kinase liver and red blood cell (Pklr), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_013631] KLA 1.06 1.01 1.12 1.00 .98 1.01 1.07
ATP .98 .94 1.05 1.06 1.01 1.06 1.10
KLA/ATP .97 1.00 1.04 .95 .89 1.05 .97
Pkm2
KLA  ATP  ATP+KLA
 D38379 mRNA for pyruvate kinase M, complete cds. [D38379] KLA .80 .83 .94 .67 .95 .95 1.42
ATP 1.22 1.30 .83 1.14 .99 1.23 2.53
KLA/ATP .99 1.03 .61 .83 .70 1.16 2.54
Pkm2
KLA  ATP  ATP+KLA
 NM_011099 pyruvate kinase, muscle (Pkm2), mRNA [NM_011099] KLA .84 .89 .95 .72 .92 1.03 1.34
ATP 1.05 1.23 .83 1.13 .96 1.20 2.14
KLA/ATP .98 .97 .64 .89 .73 1.20 2.32