Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Glyoxylate and dicarboxylate metabolism (mmu00630)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
1700012G
19Rik
KLA  ATP  ATP+KLA
 AK012010 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610311O05 product:hypothetical HAD-like structure containing protein, full insert sequence [AK012010] KLA .45 .39 .37 .43 .48 .64 .62
ATP .93 1.05 .88 .90 .63 .67 .56
KLA/ATP .43 .42 .42 .46 .49 .50 .37
1700012G
19Rik
KLA  ATP  ATP+KLA
 NM_025954 RIKEN cDNA 1700012G19 gene (1700012G19Rik), mRNA [NM_025954] KLA .34 .35 .28 .34 .42 .59 .70
ATP .92 .91 .88 .79 .70 1.27 .92
KLA/ATP .35 .33 .34 .32 .47 .80 .66
Acat1
KLA  ATP  ATP+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
ATP .89 .88 1.21 .99 .67 .36 .47
KLA/ATP .86 .97 1.18 .90 .64 .42 .35
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Aco1
KLA  ATP  ATP+KLA
 NM_007386 aconitase 1 (Aco1), mRNA [NM_007386] KLA .82 .85 .80 .78 .73 .74 .84
ATP 1.02 1.07 1.04 .96 .95 .88 .83
KLA/ATP .83 .86 .81 .80 .76 .73 .62
Aco2
KLA  ATP  ATP+KLA
 AK029122 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732494K09 product:hypothetical protein, full insert sequence [AK029122] KLA 1.02 1.02 .99 .98 .97 1.04 .83
ATP .98 1.04 1.05 .95 .95 1.02 1.00
KLA/ATP .96 .95 1.00 1.04 1.06 1.03 .99
Aco2
KLA  ATP  ATP+KLA
 NM_080633 aconitase 2, mitochondrial (Aco2), nuclear gene encoding mitochondrial protein, mRNA [NM_080633] KLA .93 .96 .97 .91 .97 .99 1.07
ATP 1.05 1.04 .98 .92 .90 .83 .99
KLA/ATP 1.01 1.06 .86 .89 .83 .93 .93
Afmid
KLA  ATP  ATP+KLA
 NM_027827 arylformamidase (Afmid), mRNA [NM_027827] KLA .85 .95 .89 .82 1.00 1.22 1.18
ATP 1.06 1.11 1.05 1.16 1.11 .95 .69
KLA/ATP .96 1.09 .95 1.06 1.00 .99 .91
Agxt
KLA  ATP  ATP+KLA
 NM_016702 alanine-glyoxylate aminotransferase (Agxt), mRNA [NM_016702] KLA 1.01 .95 .96 1.05 1.01 .98 .94
ATP .95 1.03 1.03 .99 .97 .96 1.05
KLA/ATP .94 .99 1.01 1.01 .96 .92 .96
Cat
KLA  ATP  ATP+KLA
 NM_009804 catalase (Cat), mRNA [NM_009804] KLA .63 .67 .67 .45 .36 .21 .43
ATP 1.10 1.25 .91 1.01 .78 1.28 .84
KLA/ATP .75 .69 .43 .59 .35 .72 .87
Cs
KLA  ATP  ATP+KLA
 NM_026444 citrate synthase (Cs), nuclear gene encoding mitochondrial protein, mRNA [NM_026444] KLA 1.09 1.07 1.04 1.05 1.08 1.15 1.14
ATP .91 .93 1.02 .90 .90 1.08 1.38
KLA/ATP .99 1.04 1.09 .98 .98 .90 1.13
Csl
KLA  ATP  ATP+KLA
 NM_027945 citrate synthase like (Csl), mRNA [NM_027945] KLA 1.41 1.32 1.35 1.51 1.61 1.39 1.58
ATP 1.17 1.15 .98 1.23 1.18 1.33 2.00
KLA/ATP 1.32 1.53 1.45 1.59 1.13 1.14 1.77
Gcsh
KLA  ATP  ATP+KLA
 NM_026572 glycine cleavage system protein H (aminomethyl carrier) (Gcsh), mRNA [NM_026572] KLA .66 .67 .59 .56 .40 .36 .64
ATP .99 1.02 1.19 1.39 1.40 .83 .82
KLA/ATP .62 .67 .73 .73 .73 .55 .48
Glul
KLA  ATP  ATP+KLA
 NM_008131 glutamate-ammonia ligase (glutamine synthetase) (Glul), mRNA [NM_008131] KLA .58 .54 .47 .41 .30 .31 .40
ATP .96 .99 1.46 2.55 2.16 2.88 1.34
KLA/ATP .57 .56 .83 1.52 1.27 1.20 .97
Glul
KLA  ATP  ATP+KLA
 X16314 gb|M.musculus mRNA for glutamine synthetase. [X16314] KLA .86 .95 .79 .87 .78 .99 .83
ATP .95 1.03 1.09 1.27 1.14 1.37 1.00
KLA/ATP .88 .97 .89 1.12 1.01 1.19 .91
Glyctk
KLA  ATP  ATP+KLA
 NM_174846 glycerate kinase (Glyctk), transcript variant 1, mRNA [NM_174846] KLA .98 1.05 1.12 1.07 1.13 1.16 1.11
ATP 1.04 1.07 .93 .93 .72 .97 1.22
KLA/ATP 1.02 1.02 .94 .89 .82 1.00 1.26
Grhpr
KLA  ATP  ATP+KLA
 NM_080289 glyoxylate reductase/hydroxypyruvate reductase (Grhpr), mRNA [NM_080289] KLA .82 .79 .68 .60 .42 .28 .56
ATP .93 .99 1.24 1.33 .91 .54 .71
KLA/ATP .74 .78 .84 .86 .61 .31 .39
Hao1
KLA  ATP  ATP+KLA
 AF104312 glycolate oxidase mRNA, complete cds. [AF104312] KLA .85 .89 .77 .82 .79 .79 1.13
ATP .88 .99 .95 1.90 1.11 .82 1.22
KLA/ATP .86 .81 .72 1.28 1.14 .91 1.07
Hao3
KLA  ATP  ATP+KLA
 NM_019545 hydroxyacid oxidase (glycolate oxidase) 3 (Hao3), mRNA [NM_019545] KLA 1.03 1.03 1.00 1.08 .97 .99 .94
ATP 1.04 1.01 1.03 .97 1.07 1.01 1.01
KLA/ATP 1.00 .97 1.03 .98 1.01 1.02 1.04
Hyi
KLA  ATP  ATP+KLA
 NM_026601 hydroxypyruvate isomerase homolog (E. coli) (Hyi), mRNA [NM_026601] KLA .37 .43 .38 .50 .53 .54 .87
ATP .92 .68 .59 .59 .52 .42 .44
KLA/ATP .41 .36 .42 .33 .36 .32 .34
Mcee
KLA  ATP  ATP+KLA
 NM_028626 methylmalonyl CoA epimerase (Mcee), mRNA [NM_028626] KLA .94 .93 .88 .92 .77 .71 .87
ATP .93 .97 1.28 1.51 1.31 .87 .80
KLA/ATP .88 .96 1.18 1.37 1.28 .95 .83
Mdh1
KLA  ATP  ATP+KLA
 AK077724 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730556L21 product:unclassifiable, full insert sequence [AK077724] KLA .85 .75 .69 .67 .72 .81 .82
ATP .93 .83 .61 .59 .72 .72 .88
KLA/ATP .79 .76 .67 .58 .74 .74 .80
Mdh1
KLA  ATP  ATP+KLA
 NM_008618 malate dehydrogenase 1, NAD (soluble) (Mdh1), mRNA [NM_008618] KLA .79 .72 .66 .66 .52 .49 .57
ATP .98 1.00 1.17 1.09 .96 .70 .66
KLA/ATP .70 .73 .92 .78 .76 .65 .52
Mdh2
KLA  ATP  ATP+KLA
 NM_008617 malate dehydrogenase 2, NAD (mitochondrial) (Mdh2), nuclear gene encoding mitochondrial protein, mRNA [NM_008617] KLA .90 .91 .81 .86 .81 .91 1.26
ATP .96 .86 1.04 .80 1.01 1.36 1.33
KLA/ATP .87 .79 1.04 .71 .95 1.04 .95
Mm.27395
8
KLA  ATP  ATP+KLA
 31560783 Unknown KLA .84 .82 .82 .88 1.05 1.14 1.07
ATP 1.36 1.47 1.11 1.14 1.07 .85 .81
KLA/ATP .97 .93 .90 1.13 1.05 .99 1.01
Mm.29323
3
KLA  ATP  ATP+KLA
 118130035 Unknown KLA .98 1.04 .98 1.05 1.07 .97 .95
ATP 1.02 1.04 1.01 1.02 1.00 1.00 1.00
KLA/ATP 1.03 1.00 .98 .96 1.10 1.03 .98
Mut
KLA  ATP  ATP+KLA
 X51941 gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941] KLA .57 .56 .51 .56 .55 .63 .69
ATP .89 .83 1.05 .71 .41 .29 .88
KLA/ATP .52 .51 .62 .40 .29 .23 .38
Pcca
KLA  ATP  ATP+KLA
 NM_144844 propionyl-Coenzyme A carboxylase, alpha polypeptide (Pcca), mRNA [NM_144844] KLA 1.00 1.07 1.11 1.16 1.07 1.01 .68
ATP .90 .97 1.10 1.14 .93 .53 .60
KLA/ATP .99 1.12 1.16 1.19 .84 .59 .56
Pccb
KLA  ATP  ATP+KLA
 NM_025835 propionyl Coenzyme A carboxylase, beta polypeptide (Pccb), mRNA [NM_025835] KLA .76 .77 .67 .65 .45 .41 .42
ATP .97 1.12 .94 1.15 .90 .51 .37
KLA/ATP .83 .82 .80 .88 .65 .46 .28
Shmt1
KLA  ATP  ATP+KLA
 NM_009171 serine hydroxymethyltransferase 1 (soluble) (Shmt1), mRNA [NM_009171] KLA .85 .89 .82 .83 .82 .88 .83
ATP .93 .81 .85 .82 .85 .86 .72
KLA/ATP .81 .83 .91 .86 .85 .86 .72
Shmt2
KLA  ATP  ATP+KLA
 NM_028230 serine hydroxymethyltransferase 2 (mitochondrial) (Shmt2), nuclear gene encoding mitochondrial protein, mRNA [NM_028230] KLA .82 .90 .78 .63 .51 .39 .63
ATP 1.04 1.21 .97 1.44 1.32 .85 .64
KLA/ATP .94 .92 .62 1.01 .59 .49 .32