Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Propanoate metabolism (mmu00640)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Abat
KLA  ATP  ATP+KLA
 AK083062 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530041H11 product:hypothetical protein, full insert sequence. [AK083062] KLA 1.01 1.09 .97 .99 1.03 1.02 1.06
ATP .96 .99 1.00 1.11 1.04 .98 1.06
KLA/ATP 1.06 1.03 .96 1.06 1.10 1.06 .96
Abat
KLA  ATP  ATP+KLA
 NM_172961 4-aminobutyrate aminotransferase (Abat), nuclear gene encoding mitochondrial protein, mRNA [NM_172961] KLA 1.03 .96 .97 1.00 .92 .97 .96
ATP .97 .93 1.07 1.04 .97 .99 .98
KLA/ATP 1.03 1.01 1.00 .98 .94 .89 .97
Acaca
KLA  ATP  ATP+KLA
 NM_133360 acetyl-Coenzyme A carboxylase alpha (Acaca), mRNA [NM_133360] KLA .99 .94 .95 .93 .95 1.00 1.00
ATP .98 .97 .96 .93 .92 .96 .99
KLA/ATP 1.01 .96 .99 .92 .93 .94 .91
Acacb
KLA  ATP  ATP+KLA
 NM_133904 acetyl-Coenzyme A carboxylase beta (Acacb), mRNA [NM_133904] KLA 1.01 .93 1.00 .99 .95 1.03 .92
ATP .96 1.04 1.05 .98 1.04 1.11 1.05
KLA/ATP .90 1.01 1.05 1.03 .97 .96 1.08
Acadm
KLA  ATP  ATP+KLA
 NM_007382 acyl-Coenzyme A dehydrogenase, medium chain (Acadm), nuclear gene encoding mitochondrial protein, mRNA [NM_007382] KLA .57 .50 .50 .37 .34 .34 .54
ATP 1.09 1.08 1.16 .92 .67 .43 .51
KLA/ATP .55 .56 .57 .46 .41 .36 .29
Acat1
KLA  ATP  ATP+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
ATP .89 .88 1.21 .99 .67 .36 .47
KLA/ATP .86 .97 1.18 .90 .64 .42 .35
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Acss1
KLA  ATP  ATP+KLA
 NM_080575 acyl-CoA synthetase short-chain family member 1 (Acss1), nuclear gene encoding mitochondrial protein, mRNA [NM_080575] KLA .45 .41 .45 .62 .70 1.05 .43
ATP .95 .89 1.35 .86 .81 .57 .55
KLA/ATP .38 .37 .61 .51 1.13 1.17 .38
Acss2
KLA  ATP  ATP+KLA
 AK003738 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110017C11 product:acetyl-Coenzyme A synthetase 1 (AMP forming), full insert sequence. [AK003738] KLA 1.03 .94 1.02 .97 .93 1.01 1.16
ATP 1.05 .97 .98 1.03 .95 1.31 1.40
KLA/ATP .88 1.02 1.01 .93 .93 1.02 1.12
Acss2
KLA  ATP  ATP+KLA
 NM_019811 acyl-CoA synthetase short-chain family member 2 (Acss2), mRNA [NM_019811] KLA 1.19 1.23 1.40 1.49 1.68 1.67 1.82
ATP 1.10 1.19 1.13 1.16 1.06 3.14 2.63
KLA/ATP 1.27 1.35 1.37 1.42 1.47 3.47 2.86
Acss3
KLA  ATP  ATP+KLA
 NM_198636 acyl-CoA synthetase short-chain family member 3 (Acss3), mRNA [NM_198636] KLA .99 .98 .92 1.01 .99 1.03 .98
ATP .98 1.06 1.01 .97 .98 1.04 1.00
KLA/ATP .96 .97 1.05 1.01 .91 .98 1.04
Aldh1b1
KLA  ATP  ATP+KLA
 NM_028270 aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA [NM_028270] KLA 7.51 7.83 9.27 11.57 11.10 10.78 4.79
ATP .93 .91 .90 .89 .73 2.27 2.30
KLA/ATP 6.45 7.40 9.33 9.54 8.82 12.15 10.67
Aldh2
KLA  ATP  ATP+KLA
 AK163452 adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230105J09 product:aldehyde dehydrogenase 2, mitochondrial, full insert sequence [AK163452] KLA .62 .65 .59 .60 .63 .64 .49
ATP 1.01 .91 1.06 .93 1.18 .93 .41
KLA/ATP .70 .68 .70 .84 1.16 .96 .45
Aldh2
KLA  ATP  ATP+KLA
 NM_009656 aldehyde dehydrogenase 2, mitochondrial (Aldh2), nuclear gene encoding mitochondrial protein, mRNA [NM_009656] KLA .74 .81 .77 .65 .60 .53 .50
ATP .98 1.10 .90 1.17 1.04 .82 .60
KLA/ATP .84 .86 .77 .82 .72 .66 .51
Aldh3a2
KLA  ATP  ATP+KLA
 NM_007437 aldehyde dehydrogenase family 3, subfamily A2 (Aldh3a2), mRNA [NM_007437] KLA .86 .83 .79 .79 .80 .97 1.00
ATP .93 .98 .94 .89 .77 .87 1.02
KLA/ATP .78 .81 .67 .72 .65 .81 .97
Aldh6a1
KLA  ATP  ATP+KLA
 NM_134042 aldehyde dehydrogenase family 6, subfamily A1 (Aldh6a1), nuclear gene encoding mitochondrial protein, mRNA [NM_134042] KLA 1.02 .97 .98 1.15 1.31 1.39 .67
ATP .96 .92 1.21 .87 .64 .54 .55
KLA/ATP .82 .97 1.04 .87 .80 .59 .36
Aldh7a1
KLA  ATP  ATP+KLA
 NM_138600 aldehyde dehydrogenase family 7, member A1 (Aldh7a1), mRNA [NM_138600] KLA .98 1.03 1.08 1.12 1.08 .94 .99
ATP 1.01 1.03 1.00 1.03 .98 .82 .91
KLA/ATP 1.15 1.12 1.01 1.02 .90 .89 .83
Aldh9a1
KLA  ATP  ATP+KLA
 NM_019993 aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1), mRNA [NM_019993] KLA .64 .64 .67 .48 .42 .24 .33
ATP 1.07 1.02 .75 .94 .68 .46 .42
KLA/ATP .72 .65 .43 .55 .37 .31 .24
Echs1
KLA  ATP  ATP+KLA
 NM_053119 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119] KLA .57 .55 .52 .54 .60 .82 .90
ATP .99 .97 1.07 1.15 .77 .37 .81
KLA/ATP .55 .56 .55 .66 .53 .39 .41
Ehhadh
KLA  ATP  ATP+KLA
 NM_023737 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737] KLA .74 .77 .80 .88 .71 .67 .74
ATP 1.02 1.06 1.04 .90 .70 .84 .83
KLA/ATP .79 .81 .80 .65 .59 .79 .55
Hadha
KLA  ATP  ATP+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA .96 .92 .91 .80 .97 .92 .90
ATP .72 .64 .63 .71 .91 .93 .93
KLA/ATP .79 .72 .68 .73 .87 .90 .88
Hadha
KLA  ATP  ATP+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.10 1.17 1.36 1.16 1.23 1.10 1.00
ATP 1.16 1.22 1.03 1.40 1.09 .79 1.11
KLA/ATP 1.33 1.35 1.16 1.41 1.00 .92 1.31
Hibch
KLA  ATP  ATP+KLA
 NM_146108 3-hydroxyisobutyryl-Coenzyme A hydrolase (Hibch), mRNA [NM_146108] KLA .47 .44 .40 .33 .30 .39 .82
ATP .92 .92 1.45 1.12 .69 .61 .91
KLA/ATP .42 .41 .56 .40 .34 .45 .55
Ldha
KLA  ATP  ATP+KLA
 NM_010699 lactate dehydrogenase A (Ldha), mRNA [NM_010699] KLA .89 .80 .84 .93 .96 1.04 1.23
ATP 1.05 1.04 .96 .87 1.21 1.43 1.11
KLA/ATP .93 .87 .87 .93 1.24 1.53 .96
Ldhal6b
KLA  ATP  ATP+KLA
 NM_175349 lactate dehydrogenase A-like 6B (Ldhal6b), mRNA [NM_175349] KLA .89 .90 .94 .92 1.04 1.11 1.20
ATP .99 .91 .90 .88 .90 .88 1.17
KLA/ATP .93 .97 .87 .89 .91 1.00 1.20
Ldhb
KLA  ATP  ATP+KLA
 NM_008492 lactate dehydrogenase B (Ldhb), mRNA [NM_008492] KLA 1.00 .97 .96 1.00 .78 .63 .39
ATP .84 .89 1.11 1.24 1.01 .67 .47
KLA/ATP .94 1.03 1.35 1.92 1.40 .85 .47
Ldhc
KLA  ATP  ATP+KLA
 NM_013580 lactate dehydrogenase C (Ldhc), mRNA [NM_013580] KLA .98 1.02 1.04 1.02 .97 .95 .99
ATP 1.02 1.00 .97 .96 1.00 1.00 .95
KLA/ATP .96 1.10 1.07 .95 1.03 1.06 1.03
Mcee
KLA  ATP  ATP+KLA
 NM_028626 methylmalonyl CoA epimerase (Mcee), mRNA [NM_028626] KLA .94 .93 .88 .92 .77 .71 .87
ATP .93 .97 1.28 1.51 1.31 .87 .80
KLA/ATP .88 .96 1.18 1.37 1.28 .95 .83
Mlycd
KLA  ATP  ATP+KLA
 NM_019966 malonyl-CoA decarboxylase (Mlycd), nuclear gene encoding mitochondrial protein, mRNA [NM_019966] KLA .77 .70 .74 .89 .75 .81 .66
ATP 1.01 .91 1.04 .78 .38 .62 .81
KLA/ATP .66 .66 .80 .56 .44 .57 .74
Mm.29323
3
KLA  ATP  ATP+KLA
 118130035 Unknown KLA .98 1.04 .98 1.05 1.07 .97 .95
ATP 1.02 1.04 1.01 1.02 1.00 1.00 1.00
KLA/ATP 1.03 1.00 .98 .96 1.10 1.03 .98
Mut
KLA  ATP  ATP+KLA
 X51941 gb|Mouse mRNA for methylmalonyl CoA mutase (EC 5.4.99.2) [X51941] KLA .57 .56 .51 .56 .55 .63 .69
ATP .89 .83 1.05 .71 .41 .29 .88
KLA/ATP .52 .51 .62 .40 .29 .23 .38
Pcca
KLA  ATP  ATP+KLA
 NM_144844 propionyl-Coenzyme A carboxylase, alpha polypeptide (Pcca), mRNA [NM_144844] KLA 1.00 1.07 1.11 1.16 1.07 1.01 .68
ATP .90 .97 1.10 1.14 .93 .53 .60
KLA/ATP .99 1.12 1.16 1.19 .84 .59 .56
Pccb
KLA  ATP  ATP+KLA
 NM_025835 propionyl Coenzyme A carboxylase, beta polypeptide (Pccb), mRNA [NM_025835] KLA .76 .77 .67 .65 .45 .41 .42
ATP .97 1.12 .94 1.15 .90 .51 .37
KLA/ATP .83 .82 .80 .88 .65 .46 .28
Sucla2
KLA  ATP  ATP+KLA
 AK016060 adult male testis cDNA, RIKEN full-length enriched library, clone:4930547K18 product:unclassifiable, full insert sequence. [AK016060] KLA .92 1.07 .96 1.02 .97 .95 1.02
ATP 1.08 1.02 1.00 1.06 .92 1.01 .94
KLA/ATP .94 1.04 1.04 .96 .94 .94 .90
Sucla2
KLA  ATP  ATP+KLA
 NM_011506 succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2), nuclear gene encoding mitochondrial protein, mRNA [NM_011506] KLA 1.10 1.02 1.00 1.06 .87 .81 .86
ATP .98 .95 1.30 1.02 .93 .69 .72
KLA/ATP .98 1.02 1.35 1.04 1.00 .61 .52
Suclg1
KLA  ATP  ATP+KLA
 NM_019879 succinate-CoA ligase, GDP-forming, alpha subunit (Suclg1), mRNA [NM_019879] KLA .87 .88 .81 .81 .84 .79 .89
ATP 1.14 1.06 1.05 1.06 .87 .41 .81
KLA/ATP .93 .92 .92 .92 .76 .49 .49
Suclg2
KLA  ATP  ATP+KLA
 NM_011507 succinate-Coenzyme A ligase, GDP-forming, beta subunit (Suclg2), mRNA [NM_011507] KLA .99 1.07 1.08 .88 .74 .49 .67
ATP 1.00 1.14 1.15 1.44 .91 .37 .45
KLA/ATP 1.08 1.08 .94 1.18 .65 .40 .35