Microarray analysis of bone marrow-derived macrophage cells treated with Kdo2-lipid A (KLA) and ATP

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Kdo2-Lipid A / ATP gene array data - treatment:control ratios

KEGG pathway: Butanoate metabolism (mmu00650)

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Gene symbol    Time course plot Accession Description Treatment 15min 30min 1hr 2hr 4hr 8hr 20hr
Aacs
KLA  ATP  ATP+KLA
 NM_030210 acetoacetyl-CoA synthetase (Aacs), mRNA [NM_030210] KLA .57 .53 .52 .53 .54 .48 .64
ATP .99 1.02 .88 .88 .76 1.01 1.01
KLA/ATP .54 .54 .45 .51 .52 .61 .40
Abat
KLA  ATP  ATP+KLA
 AK083062 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530041H11 product:hypothetical protein, full insert sequence. [AK083062] KLA 1.01 1.09 .97 .99 1.03 1.02 1.06
ATP .96 .99 1.00 1.11 1.04 .98 1.06
KLA/ATP 1.06 1.03 .96 1.06 1.10 1.06 .96
Abat
KLA  ATP  ATP+KLA
 NM_172961 4-aminobutyrate aminotransferase (Abat), nuclear gene encoding mitochondrial protein, mRNA [NM_172961] KLA 1.03 .96 .97 1.00 .92 .97 .96
ATP .97 .93 1.07 1.04 .97 .99 .98
KLA/ATP 1.03 1.01 1.00 .98 .94 .89 .97
Acads
KLA  ATP  ATP+KLA
 NM_007383 acyl-Coenzyme A dehydrogenase, short chain (Acads), nuclear gene encoding mitochondrial protein, mRNA [NM_007383] KLA .76 .78 .76 .69 .71 .71 .70
ATP 1.02 1.11 1.01 1.28 .75 .58 .79
KLA/ATP .80 .76 .66 .82 .56 .56 .53
Acat1
KLA  ATP  ATP+KLA
 NM_144784 acetyl-Coenzyme A acetyltransferase 1 (Acat1), nuclear gene encoding mitochondrial protein, mRNA [NM_144784] KLA 1.04 .99 .95 .99 .81 .83 .51
ATP .89 .88 1.21 .99 .67 .36 .47
KLA/ATP .86 .97 1.18 .90 .64 .42 .35
Acat2
KLA  ATP  ATP+KLA
 NM_009338 acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA [NM_009338] KLA 1.14 1.13 1.22 1.29 1.10 .93 .81
ATP 1.04 1.05 1.16 1.35 1.20 1.53 1.16
KLA/ATP 1.19 1.19 1.41 1.29 1.13 .92 .71
Acsm1
KLA  ATP  ATP+KLA
 NM_054094 acyl-CoA synthetase medium-chain family member 1 (Acsm1), mRNA [NM_054094] KLA .98 1.04 .95 1.00 1.04 .99 .97
ATP 1.04 1.04 1.03 .94 1.00 1.00 .97
KLA/ATP .98 .99 1.04 .98 .95 .95 .98
Acsm2
KLA  ATP  ATP+KLA
 AK165449 adult male kidney cDNA, RIKEN full-length enriched library, clone:F530004J10 product:unclassifiable, full insert sequence [AK165449] KLA 1.00 .98 .96 1.04 1.06 .98 .97
ATP 1.02 .98 1.01 1.07 .94 .99 1.02
KLA/ATP 1.07 1.06 1.05 1.03 1.01 .97 1.00
Acsm2
KLA  ATP  ATP+KLA
 NM_146197 acyl-CoA synthetase medium-chain family member 2 (Acsm2), mRNA [NM_146197] KLA .99 .98 .95 .99 .99 1.02 1.02
ATP .99 .95 1.03 .99 .99 1.02 1.03
KLA/ATP 1.01 1.03 .98 .99 .97 .95 1.00
Acsm3
KLA  ATP  ATP+KLA
 NM_212441 acyl-CoA synthetase medium-chain family member 3 (Acsm3), transcript variant 2, mRNA [NM_212441] KLA 1.02 .99 .98 .96 1.00 1.00 .96
ATP .96 1.01 .98 .87 .95 .98 .93
KLA/ATP 1.00 1.01 .92 .98 .89 .95 1.06
Acsm4
KLA  ATP  ATP+KLA
 NM_178414 acyl-CoA synthetase medium-chain family member 4 (Acsm4), mRNA [NM_178414] KLA 1.09 1.03 .95 1.05 1.01 1.00 .96
ATP .91 1.05 .92 .96 .93 1.05 1.04
KLA/ATP .95 .95 1.00 .97 .98 .99 .99
Acsm5
KLA  ATP  ATP+KLA
 NM_178758 acyl-CoA synthetase medium-chain family member 5 (Acsm5), mRNA [NM_178758] KLA .96 .98 1.04 1.00 1.04 1.05 1.01
ATP 1.01 1.00 1.01 1.02 .94 1.05 1.00
KLA/ATP .97 1.05 1.04 1.01 1.07 1.00 .96
Aldh5a1
KLA  ATP  ATP+KLA
 AK051603 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130059J11 product:succinate-semialdehyde dehydrogenase (EC 1.2.1.24) (fragment) homolog [Rattus norvegicus], full insert sequence. [AK051603] KLA 1.04 .99 1.06 1.03 1.01 1.09 1.08
ATP .94 .93 1.01 1.04 1.06 1.10 1.02
KLA/ATP 1.00 1.03 .83 1.02 1.06 1.03 1.04
Aldh5a1
KLA  ATP  ATP+KLA
 NM_172532 aldhehyde dehydrogenase family 5, subfamily A1 (Aldh5a1), mRNA [NM_172532] KLA .99 .98 .84 .95 .81 .63 .52
ATP .92 .83 1.21 1.06 .90 .70 .57
KLA/ATP .92 .96 1.24 .95 .89 .62 .59
Bdh1
KLA  ATP  ATP+KLA
 NM_001122683 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), transcript variant 2, mRNA [NM_001122683] KLA .89 .82 .80 .87 .90 .92 1.01
ATP .94 1.00 .89 .90 .82 .91 1.24
KLA/ATP .84 .82 .88 .76 .90 .88 .91
Bdh1
KLA  ATP  ATP+KLA
 NM_175177 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA [NM_175177] KLA .61 .62 .57 .76 .75 .63 .64
ATP .95 .95 1.24 1.06 .81 1.28 1.87
KLA/ATP .57 .65 .78 .64 .63 .81 .70
Bdh2
KLA  ATP  ATP+KLA
 NM_027208 3-hydroxybutyrate dehydrogenase, type 2 (Bdh2), mRNA [NM_027208] KLA .85 .86 .78 .83 .75 .88 .83
ATP .95 .96 1.24 1.15 1.27 1.15 .95
KLA/ATP .82 .86 1.01 .97 1.04 1.05 1.09
Echs1
KLA  ATP  ATP+KLA
 NM_053119 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial (Echs1), nuclear gene encoding mitochondrial protein, mRNA [NM_053119] KLA .57 .55 .52 .54 .60 .82 .90
ATP .99 .97 1.07 1.15 .77 .37 .81
KLA/ATP .55 .56 .55 .66 .53 .39 .41
Ehhadh
KLA  ATP  ATP+KLA
 NM_023737 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase (Ehhadh), mRNA [NM_023737] KLA .74 .77 .80 .88 .71 .67 .74
ATP 1.02 1.06 1.04 .90 .70 .84 .83
KLA/ATP .79 .81 .80 .65 .59 .79 .55
Gad1
KLA  ATP  ATP+KLA
 AK054554 10 days neonate olfactory brain cDNA, RIKEN full-length enriched library, clone:E530004P22 product:glutamic acid decarboxylase 1, full insert sequence. [AK054554] KLA 1.03 1.00 1.00 1.00 1.00 .98 1.10
ATP 1.03 .91 1.01 1.05 .99 .97 1.08
KLA/ATP .97 .99 .99 1.10 1.02 1.09 .96
Gad1
KLA  ATP  ATP+KLA
 NM_008077 glutamic acid decarboxylase 1 (Gad1), mRNA [NM_008077] KLA 1.03 .99 1.00 1.01 1.01 .97 .99
ATP 1.02 1.02 1.01 .99 1.02 1.03 .98
KLA/ATP .96 1.03 1.04 .99 .99 1.04 1.01
Gad2
KLA  ATP  ATP+KLA
 NM_008078 glutamic acid decarboxylase 2 (Gad2), mRNA [NM_008078] KLA 1.03 1.07 1.11 1.11 1.04 .99 1.07
ATP .97 .99 1.02 1.02 1.01 .95 .97
KLA/ATP 1.05 1.08 1.04 1.01 1.00 1.06 1.00
Hadh
KLA  ATP  ATP+KLA
 NM_008212 hydroxyacyl-Coenzyme A dehydrogenase (Hadh), nuclear gene encoding mitochondrial protein, mRNA [NM_008212] KLA .75 .75 .72 .64 .54 .37 .49
ATP 1.12 1.19 1.08 1.28 .96 .43 .41
KLA/ATP .76 .81 .68 .85 .56 .42 .21
Hadha
KLA  ATP  ATP+KLA
 AK050856 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030026J11 product:hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit, full insert KLA .96 .92 .91 .80 .97 .92 .90
ATP .72 .64 .63 .71 .91 .93 .93
KLA/ATP .79 .72 .68 .73 .87 .90 .88
Hadha
KLA  ATP  ATP+KLA
 NM_178878 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha), nuclear gene encoding mitochondrial protein, mRNA [NM_178878] KLA 1.10 1.17 1.36 1.16 1.23 1.10 1.00
ATP 1.16 1.22 1.03 1.40 1.09 .79 1.11
KLA/ATP 1.33 1.35 1.16 1.41 1.00 .92 1.31
Hmgcl
KLA  ATP  ATP+KLA
 NM_008254 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl), mRNA [NM_008254] KLA .37 .34 .39 .48 .63 .86 .71
ATP .87 .84 .93 .82 .69 .91 1.21
KLA/ATP .32 .33 .38 .38 .71 1.31 1.25
Hmgcs1
KLA  ATP  ATP+KLA
 AK078743 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030402P03 product:similar to hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) (fragment) [Gallus gallus], full insert sequence. [AK078743] KLA 1.06 1.08 .98 .81 .88 .71 .86
ATP 1.39 1.87 10.43 2.82 1.19 1.14 1.09
KLA/ATP 1.36 1.59 5.22 1.83 1.21 .75 .66
Hmgcs1
KLA  ATP  ATP+KLA
 NM_145942 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Hmgcs1), mRNA [NM_145942] KLA 1.16 1.10 1.26 1.16 .88 .63 .69
ATP 1.01 1.10 1.87 2.36 1.98 .89 .97
KLA/ATP 1.12 1.20 1.33 1.69 1.39 .67 .51
Hmgcs2
KLA  ATP  ATP+KLA
 NM_008256 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (Hmgcs2), nuclear gene encoding mitochondrial protein, mRNA [NM_008256] KLA .92 1.10 1.00 .99 1.08 1.06 1.14
ATP .99 1.02 1.00 1.00 .98 1.08 .92
KLA/ATP .99 1.00 1.00 1.03 1.28 1.06 1.00
L2hgdh
KLA  ATP  ATP+KLA
 NM_145443 L-2-hydroxyglutarate dehydrogenase (L2hgdh), nuclear gene encoding mitochondrial protein, mRNA [NM_145443] KLA .50 .43 .41 .42 .40 .46 .50
ATP .91 .97 1.01 .68 .51 .61 .47
KLA/ATP .48 .43 .49 .44 .46 .51 .35
Mm.18966
0
KLA  ATP  ATP+KLA
 160358826 Unknown KLA 1.06 1.13 1.05 1.05 1.02 1.02 .98
ATP 1.01 1.05 1.33 1.61 1.40 1.19 1.10
KLA/ATP 1.04 1.02 1.18 1.50 1.38 1.22 1.48
Mm.29323
3
KLA  ATP  ATP+KLA
 118130035 Unknown KLA .98 1.04 .98 1.05 1.07 .97 .95
ATP 1.02 1.04 1.01 1.02 1.00 1.00 1.00
KLA/ATP 1.03 1.00 .98 .96 1.10 1.03 .98
Oxct1
KLA  ATP  ATP+KLA
 NM_024188 3-oxoacid CoA transferase 1 (Oxct1), nuclear gene encoding mitochondrial protein, mRNA [NM_024188] KLA .91 .98 1.06 1.09 .95 .90 .46
ATP 1.00 .98 1.03 .93 .82 .43 .79
KLA/ATP .89 .94 1.18 .97 .97 .67 .33
Oxct2a
KLA  ATP  ATP+KLA
 NM_022033 3-oxoacid CoA transferase 2A (Oxct2a), mRNA [NM_022033] KLA 1.05 1.04 1.09 1.03 .98 1.05 1.07
ATP 1.03 1.00 1.02 1.31 1.14 1.10 .97
KLA/ATP 1.04 1.07 1.01 1.19 1.12 1.06 1.19
Pdha1
KLA  ATP  ATP+KLA
 NM_008810 pyruvate dehydrogenase E1 alpha 1 (Pdha1), nuclear gene encoding mitochondrial protein, mRNA [NM_008810] KLA .92 .96 .94 .92 .94 1.04 1.18
ATP .98 1.03 1.14 1.10 1.02 1.05 .91
KLA/ATP .93 .93 .97 .94 .81 .82 .69
Pdha2
KLA  ATP  ATP+KLA
 NM_008811 pyruvate dehydrogenase E1 alpha 2 (Pdha2), mRNA [NM_008811] KLA 1.04 .95 .98 .99 1.00 1.04 .98
ATP 1.00 .97 .95 1.00 1.01 .99 1.01
KLA/ATP 1.05 1.07 .91 1.02 .98 1.00 1.05
Pdhb
KLA  ATP  ATP+KLA
 NM_024221 pyruvate dehydrogenase (lipoamide) beta (Pdhb), mRNA [NM_024221] KLA 1.14 1.05 1.00 .97 1.03 .90 .88
ATP 1.08 1.10 1.12 1.23 1.24 1.24 1.21
KLA/ATP 1.01 1.16 1.13 1.21 1.23 1.44 1.26